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Cited by 207

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Insect MicroRNAs: Biogenesis, expression profiling and biological functions

Open access
Lucas, Keira, Raikhel, Alexander S.·2013·Insect Biochemistry and Molecular Biology

Abstract

MicroRNAs (miRNA) are a class of endogenous regulatory RNA molecules 21-24 nucleotides in length that modulate gene expression at the post-transcriptional level via base pairing to target sites within messenger RNAs (mRNA). Typically, the miRNA “seed sequence” (nucleotides 2-8 at the 5′ end) binds complementary seed match sites within the 3′ untranslated region of mRNAs, resulting in either translational inhibition or mRNA degradation. MicroRNAs were first discovered in Caenorhabditis elegans and were shown to be involved in the timed regulation of developmental events. Since their discovery in the 1990s, thousands of potential miRNAs have since been identified in various organisms through small RNA cloning methods and/or computational prediction, and have been shown to play functionally important roles of gene regulation in invertebrates, vertebrates, plants, fungi and viruses. Numerous functions of miRNAs identified in Drosophila melanogaster have demonstrated a great significance of these regulatory molecules. However, elucidation of miRNA roles in non-drosophilid insects presents a challenging and important task.

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Metadata

Authors
Lucas, K., & Raikhel, A. S.
Venue
Insect Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2013-01
Volume
43
Issue
1
Pages
24-38
ISSN
0965-1748 (ISSN-L)
OpenAlex
W1999309921
Cited by
207
References
19
FWCI
2.64
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Insect MicroRNAs: Biogenesis, expression profiling and biological functions. https://app.cochat.ai/papers/10.1016/j.ibmb.2012.10.009
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Lucas, K., & Raikhel, A. S. (2013). Insect MicroRNAs: Biogenesis, expression profiling and biological functions. Insect Biochemistry and Molecular Biology. https://doi.org/10.1016/j.ibmb.2012.10.009

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