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Cited by 456Diet and metabolism studiesFatty Acid Research and HealthCoconut Research and Applications

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Medium-chain triglycerides

Marten, Berit, Pfeuffer, Maria, Schrezenmeir, Jürgen·2006·International Dairy Journal
DOI 10.1016/j.idairyj.2006.06.015
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Abstract

Medium-chain fatty acids (MCFAs) comprise saturated fatty acids with 6-10 carbons. Besides synthetic medium-chain triglyceride (MCT) oils there are natural sources, like coconut oil and dairy fat. Compared with long-chain fatty acids (LCFAs), the chemical and physical properties of MCFAs show substantial metabolic differences. MCFAs do not require binding to proteins such as fatty-acid binding protein, fatty acid transport protein, and/or fatty acid translocase (FAT, homolog to human platelet CD36). MCFAs are a preferred source of energy (β-oxidation). MCFAs are also incorporated into adipose tissue triglycerides, and may influence adipose tissue and other systemic functions more substantially than previously assumed. MCTs reduce fat mass, through down-regulation of adipogenic genes as well as peroxisome proliferator activated receptor-γ. Recent studies confirmed the potential of MCFAs to reduce body weight and particularly body fat. This effect was not transient. MCFAs reduce lipoprotein secretion and attenuate postprandial triglyceride response. It was, however, frequently observed that MCTs increase fasting cholesterol and triglyceride levels. But, given in moderate amounts, in diets with moderate fat supply, MCFAs may actually reduce fasting lipid levels more than oils rich in mono- or polyunsaturated fatty acids. The same is true for glucose levels. MCTs improved several features contributing to enhanced insulin sensitivity. Under certain in vitro conditions, MCTs exert…

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Crossref · 10.1016/j.idairyj.2006.06.015

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Metadata

Authors
Marten, B., Pfeuffer, M., & Schrezenmeir, J.
Corresponding author
Pfeuffer, Maria
ORCID
Schrezenmeir, Jürgen
Venue
International Dairy Journal
Publisher
Elsevier BV
Published
2006-11
Volume
16
Issue
11
Pages
1374-1382
ISSN
0958-6946 (ISSN-L)
DOI
10.1016/j.idairyj.2006.06.015
OpenAlex
W2010109211
Cited by
456
References
85
Citations by year
2026: 16 · 2025: 20 · 2024: 22 · 2023: 28 · 2022: 43 · 2021: 39 · 2020: 47 · 2019: 28 · 2018: 26 · 2017: 36 · 2016: 34 · 2015: 17 · 2014: 11 · 2013: 21 · 2012: 15
FWCI
5.27
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Dairy Journal (publishedVersion)
  • OpenAgrar (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Coconut Research and Applications
Keywords
medium-chain triglycerides, medium-chain fatty acids, coconut oil, milk fat, fatty acid metabolism, adipose tissue, PPARγ, lipoprotein secretion, postprandial triglycerides, insulin sensitivity, glucose metabolism, pro-inflammatory effects, hepatotoxicity, intestinal injury, fat loss

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