Cited by 270Antimicrobial Resistance in StaphylococcusNeutrophil, Myeloperoxidase and Oxidative MechanismsStreptococcal Infections and Treatments

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Host Defense and Pathogenesis in Staphylococcus aureus Infections

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DeLeo, Frank R., Diep, Binh An, Otto, Michael·2009·Infectious Disease Clinics of North America

DOI 10.1016/j.idc.2008.10.003PMC PMC2748223

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Abstract

Staphylococcus aureus is the most abundant cause of bacterial infections in the United States. As such, the pathogen has devised means to circumvent destruction by the innate immune system. Neutrophils are a critical component of innate immunity and the primary cellular defense against S aureus infections. This article reviews human neutrophil function in the context of S aureus virulence mechanisms and provides an overview of community-associated methicillin-resistant S aureus pathogenicity.

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Background
The L-Arginine-Nitric Oxide Pathway
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“Recently, novel cytolytic peptides have been found in S aureus, the a-type PSMs, which are encoded in an operon on the genomes of all sequenced S aureus strains.26 The a-helical and amphipathic a-type PSMs have pronounced in vitro and in vivo leukocidal activity, in addition to proinflammatory and chemotactic activiti…”
BackgroundMethodInfluential
Methicillin-Resistant S. aureus Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285 · cited 2×
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Background
Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus
Diep, B. A., Gill, S. R., Chang, R. F., Phan, T. H., Chen, J. H., Davidson, M. G., Lin, F., Lin, J., Carleton, H. A., Mongodin, E. F., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68231-7 · Cited by 1,633 · cited 4×
“Nonetheless, the emergence of multi-drug resistant isolates of USA300 with resistance to clindamycin [13,98], and the potential to acquire even more antibiotic resistance, present a further complication in staphylococcal disease management.”
BackgroundInfluentialSelf-citation
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Background
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Background

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Recurrent Community-associated Staphylococcus aureus Infections in Children Presenting to Texas Children’s Hospital in Houston, Texas
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Background
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Hsieh, R. C., Liu, R., Burgin, D. J., & Otto, M. J. (2023) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2023.2242585 · Cited by 24
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BackgroundSelf-citation
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Background
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“(e risk factors that have been associated with the emergence ofMRSA infections amongHIV infected individuals are not practically understood well but may be due to some possible risk factors, such as living conditions, prior hospitalization, use of fluoroquinolones and third generation cephalosporin antibiotics, intrav…”
Background
Antioxidant Functions of Nitric Oxide Synthase in a Methicillin SensitiveStaphylococcus aureus
Vaish, M., & Singh, V. K. (2013) · International Journal of Microbiology · doi:10.1155/2013/312146 · Cited by 21
“It produces antioxidant enzymes such as superoxide dismutase that converts superoxide anion to H 2 O 2 , catalase that converts H 2 O 2 to water and oxygen, and alkyl hydroperoxide reductases that detoxify H 2 O 2 , peroxynitrites and hydroperoxides [10, 11].”
Background
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SARS-CoV-2 infection predisposes patients to coinfection with Staphylococcus aureus
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“Further studies to unravel the interface between S. aureus, host infection susceptibility and innate immunity are important for a more extensive understanding of the pathogenesis of SSIs [9] .”
Background
Influence of Intra‐articular Neutrophils on the Effects of Photodynamic Therapy for Murine MRSA Arthritis
Tanaka, M., Kinoshita, M., Yoshihara, Y., Shinomiya, N., Seki, S., Nemoto, K., & Morimoto, Y. (2009) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2009.00658.x · Cited by 18
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“All strains of Staphylococcus aureus can produce compounds that may attack innate and adaptive immunity (24).”
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Qiu, H.-J., Sun, X., Sun, M., He, C., Li, Z., & Liu, Z. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2014.919018 · Cited by 17
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“aureus can evade killing by phagocytic cells to some extent by neutralizing the antimicrobial components present in the phagosome (17).”
Background
Effect of extracellular vesicles from S. aureus-challenged human neutrophils on macrophages
Allen, E. R., Lempke, S. L., Miller, M. M., Bush, D. M., Braswell, B. G., Estes, C. L., Benedict, E. L., Mahon, A. R., Sabo, S. L., & Greenlee-Wacker, M. C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ab0320-156r · Cited by 19
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment
Fuscaldi, L. L., Júnior, J. T. D. A., dos Santos, D. M., Boff, D., de Oliveira, V. L. S., Gomes, K. A. G. G., Cruz, R. D. C., de Oliveira, P. L., Magalhães, P. P., Cisalpino, P. S., et al. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220966963 · Cited by 16
“Neutrophils are the first cells to reach infected sites, controlling infection due to their arsenal to fight against pathogens.(25,26) Thus, the higher amount of neutrophils in the joint of positive control mice indicates an intense inflammatory response.”
Background
Expression of Four Methionine Sulfoxide Reductases in Staphylococcus aureus
Singh, K., & Singh, V. K. (2012) · International Journal of Microbiology · doi:10.1155/2012/719594 · Cited by 16
“aureus produces antioxidant enzymes such as superoxide dismutases that convert superoxide anion to hydrogen peroxide, catalase that converts hydrogen peroxide to water and oxygen, alkyl hydroperoxide reductases that detoxify hydrogen peroxide, peroxynitrites and hydroperoxides, and the carotenoid pigment staphyloxanth…”
BackgroundInfluential
Genome-wide comparison of four MRSA clinical isolates from Germany and Hungary
Naorem, R. S., Blom, J., & Fekete, C. (2021) · PeerJ · doi:10.7717/peerj.10185 · Cited by 14
Review—Electrochemical Aptasensor for Pathogenic Bacteria Detection
Pham, T.-T. D., Tu, L. M. T. P. P. L. M., Park, J., & Cho, S. (2022) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/ac82cd · Cited by 14
Staphylococcus aureus PSM peptides induce tolerogenic dendritic cells upon treatment with ligands of extracellular and intracellular TLRs
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Gene Expression Profiling of Dendritic Cells Reveals Important Mechanisms Associated with Predisposition to Staphylococcus Infections
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“Staphylococcus aureus is a common bacterium causing diseases in a wide range of host species [1–4].”
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Effect of Resveratrol and Curcumin on Gene Expression of Methicillin-Resistant Staphylococcus aureus (MRSA) Toxins
El-Mahdy, A. M., Alqahtani, M., Almukainzi, M., Alghoribi, M. F., & Abdel-Rhman, S. H. (2023) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2309.09001 · Cited by 13
Host-induced cell wall remodeling impairs opsonophagocytosis of Staphylococcus aureus by neutrophils
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Complement Receptor 3 Contributes to the Sexual Dimorphism in Neutrophil Killing of Staphylococcus aureus
Pokhrel, S., Triplett, K. D., Daly, S. M., Joyner, J. A., Sharma, G., Hathaway, H. J., Prossnitz, E. R., & Hall, P. R. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000545 · Cited by 14
“Neutrophils play a critical role in confinement and clearance of the pathogen, leading to resolution of the infection (3, 4, 8, 52).”
Background
Phage display for the detection, analysis, disinfection, and prevention of Staphylococcus aureus
Tian, L., Jackson, K. J., Chan, M., Saif, A., He, L., Didar, T. F., & Hosseinidoust, Z. (2022) · Smart Medicine · doi:10.1002/smmd.20220015 · Cited by 13
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BackgroundSelf-citation
Expression of CXCR1 (IL-8 receptor A) in splenic, peritoneal macrophages and resident bone marrow cells after acute live or heat killed Staphylococcus aureus stimulation in mice
Bishayi, B., Nandi, A., Dey, R., & Adhikary, R. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.05.028 · Cited by 13
The Splicing Factor RNA-Binding Fox Protein 1 Mediates the Cellular Immune Response in Drosophila melanogaster
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Dağı, H. T., Fındık, D., Demırel, G., & Arslan, U. (2015) · Balkan Medical Journal · doi:10.5152/balkanmedj.2015.150186 · Cited by 13
“Toxins such as α-hemolysin or PVL cause cytolysis of leukocytes and erythrocytes (24).”
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Repurposing inhibitors of phosphoinositide 3-kinase as adjuvant therapeutics for bacterial infections
Fleeman, R. M. (2023) · Frontiers in Antibiotics · doi:10.3389/frabi.2023.1135485 · Cited by 11
“Staphylococcus aureus is a dangerous pathogen with community acquired infections easily spread due to their ability to invade healthy individuals (Boyle-Vavra and Daum, 2007; DeLeo et al., 2009; Bukharie, 2010; Yoong and Pier, 2010; Turner et al., 2019).”
Background
Immune Evasion byStaphylococcus aureus
de Jong, N. W. M., van Kessel, K. P. M., & van Strijp, J. A. G. (2019) · ASM Press eBooks · doi:10.1128/9781683670131.ch39 · Cited by 12
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Role of PemI in the Staphylococcus aureus PemIK toxin–antitoxin complex: PemI controls PemK by acting as a PemK loop mimic
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“Interestingly, the target sequence (U ↓ AUU) of PemK is found in a considerable number of mRNA transcripts encoding proteins involved in virulence but not in the cell translation machinery (17,21– 24).”
The effect of immunoregulation of Streptococcus lactis L16 strain upon Staphylococcus aureus infection
Wang, M., Gong, S., Du, S., Zhu, Y., Rong, F., Pan, R., Yang, D., Li, C., Ren, D., & Jin, N. (2017) · BMC Microbiology · doi:10.1186/s12866-017-1038-y · Cited by 10
Electrochemical label free sensing of human IgG – Protein A interaction
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“Neutrophils can also kill bacteria through phagocytosis [32].”
Background
Synthesis of novel series of heterocyclic compounds having two azoles against Methicillin-sensitive Staphylococcus aureus
Alamri, A., Alafnan, A., Huwaimel, B., Abouzied, A. S., Alanazi, J., Alghamdi, A., Alrofaidi, M. A., Alanazi, M., Alshehri, A., Hagbani, T. A., et al. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.134863 · Cited by 10
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Zinc Deprivation as a Promising Approach for Combating Methicillin-Resistant Staphylococcus aureus: A Pilot Study
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“aureus evade the host immune system [9].”
The Influence of Antibiotic Resistance on Innate Immune Responses to Staphylococcus aureus Infection
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“Community-associated MRSA (CA-MRSA) appeared in the 1990s and is currently a major problem in many countries worldwide [197,198].”
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Características generales del Staphylococcus aureus
Cervantes-García, E., García-González, R., & Salazar-Schettino, P. M. (2014) · Revista Latinoamericana de Patología Clínica y Medicina de Laboratorio · Cited by 12
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New Applications and Analysis of (E)-Azastilbenes in Environmental Samples
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The bacillithiol pathway is required for biofilm formation in Staphylococcus aureus
Gulati, M., Thomas, J. M., Ennis, C. L., Hernday, A. D., Rawat, M., & Nobile, C. J. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106657 · Cited by 11
Immunological parameters of macrophages infected by methicillin resistant/sensitive Staphylococcus aureus
de Morais, N. G., da Costa, T. B., de Almeida, T. M., Severo, M. S., & de Castro, C. M. M. B. (2013) · Jornal Brasileiro de Patologia e Medicina Laboratorial · doi:10.1590/s1676-24442013000200002 · Cited by 8
“According to Deleo et al.((3)), there are two possible interactions between bacterium-phagocyte.”
Background
Linezolid Exerts Greater Bacterial Clearance but No Modification of Host Lung Gene Expression Profiling: A Mouse MRSA Pneumonia Model
Chen, J., Feng, G., Song, Y., Wardenburg, J. B., Lin, S. M., Inoshima, I., Otto, M. J., & Wunderink, R. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067994 · Cited by 8
“USA300 CA-MRSA wild-type LAC strain [13,14] was used in this study.”
BackgroundInfluentialSelf-citation
Opportunities for the development of novel therapies based on host-microbial interactions
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Authors: DeLeo, F. R., Diep, B. A., & Otto, M.
Affiliations: National Institutes of Health (US)
University of California, San Francisco (US)
Corresponding author: DeLeo, Frank R.
ORCID: DeLeo, Frank R.
Diep, Binh An
Otto, Michael
Venue: Infectious Disease Clinics of North America
Publisher: Elsevier BV
Published: 2009-03
Volume: 23
Issue: 1
Pages: 17-34
ISSN: 0891-5520 (ISSN-L)
DOI: 10.1016/j.idc.2008.10.003
PMC: PMC2748223
OpenAlex: W2084838489
Cited by: 269
References: 103
Citations by year: 2026: 6 · 2025: 7 · 2024: 13 · 2023: 16 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 21 · 2018: 13 · 2017: 10 · 2016: 10 · 2015: 20 · 2014: 18 · 2013: 21 · 2012: 21
FWCI: 2.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Infectious Disease Clinics of North America (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (Z01AI000900)
Topics: Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
Keywords: Staphylococcus aureus, host defense, innate immunity, neutrophils, virulence mechanisms, community-associated methicillin-resistant Staphylococcus aureus, pathogenesis, bacterial infection
MeSH terms: Humans, Neutrophils, Staphylococcal Infections, Staphylococcus aureus, Virulence, Virulence Factors

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Host Defense and Pathogenesis in Staphylococcus aureus Infections

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