The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Host Defense and Pathogenesis in Staphylococcus aureus Infections
Open accessAbstract
Staphylococcus aureus is the most abundant cause of bacterial infections in the United States. As such, the pathogen has devised means to circumvent destruction by the innate immune system. Neutrophils are a critical component of innate immunity and the primary cellular defense against S aureus infections. This article reviews human neutrophil function in the context of S aureus virulence mechanisms and provides an overview of community-associated methicillin-resistant S aureus pathogenicity.
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“Peptidoglycan recognition protein (PGRP) plays a role in the neutrophil killing of Gram-positive bacteria [38], inhibiting their growth.”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [38]
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312 · cited 2×
“with pattern recognition receptors expressed on the neutrophil cell surface, including TLRs.(30) Neutrophil TLRs activate signal transduction pathways that prolong cell survival;(31) promote or enhance adhesion, phagocytosis, release of cytokines, chemokines, and ROS;(31,32) and trigger granule exocytosis,(33) thereby…”
BackgroundThe L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · cited 6×
“Recently, novel cytolytic peptides have been found in S aureus, the a-type PSMs, which are encoded in an operon on the genomes of all sequenced S aureus strains.26 The a-helical and amphipathic a-type PSMs have pronounced in vitro and in vivo leukocidal activity, in addition to proinflammatory and chemotactic activiti…”
BackgroundMethodInfluentialMethicillin-Resistant S. aureus Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285 · cited 2×
“Historically, CA S aureus infections almost always were caused by methicillin-susceptible S aureus (MSSA) rather than MRSA,(4) but this distribution has changed dramatically in the United States over the past 10 years.(6) Two reports in the late 1990s marked the beginning of a new era in MRSA epidemiology.”
BackgroundMethodMyeloperoxidase: friend and foe
Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282 · cited 1×
“These secondarily-derived products, including hypochlorous acid, hydroxyl radical, chloramines, and singlet oxygen, are effective microbicidal compounds [40-43].”
BackgroundExotoxins of Staphylococcus aureus
Dinges, M. M., Orwin, P. M., & Schlievert, P. M. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.1.16-34.2000 · Cited by 1,837 · cited 1×
“These toxins include the TSST, exfoliative toxins involved in staphylococcal scalded skin syndrome, and the staphylococcal enterotoxins (SEs).(78) Toxic shock syndrome (TSS) is a severe acute disease and may be of menstrual or nonmenstrual origin.”
BackgroundDiep, B. A., Gill, S. R., Chang, R. F., Phan, T. H., Chen, J. H., Davidson, M. G., Lin, F., Lin, J., Carleton, H. A., Mongodin, E. F., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68231-7 · Cited by 1,633 · cited 4×
“Nonetheless, the emergence of multi-drug resistant isolates of USA300 with resistance to clindamycin [13,98], and the potential to acquire even more antibiotic resistance, present a further complication in staphylococcal disease management.”
BackgroundInfluentialSelf-citationSavill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536 · cited 1×
“To that end, normal turnover of aging neutrophils occurs by spontaneous apoptosis and in the absence of an activating agent.(52) On the other hand, neutrophil apoptosis is accelerated significantly following phagocytosis,(53,54) and this phenomenon appears critical to the resolution of the inflammatory response (see F…”
BackgroundGillet, Y., Issartel, B., Vanhems, P., Fournet, J.-C., Lina, G., Bes, M., Vandenesch, F., Piémont, Y., Brousse, N., Floret, D., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07877-7 · Cited by 1,514 · cited 1×
“the PVL genes (lukS-PV and lukF-PV, abbreviated as lukS/F-PV) and fatal necrotizing pneumonia renewed and intensified interest in understanding the biological role of this bicomponent cytolytic toxin.(83) Epidemiologic data alone, however, are insufficient to establish whether PVL directly contributes to widespread di…”
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Cited by
Sorted by citations
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Waves of resistance: Staphylococcus aureus in the antibiotic era
Chambers, H. F., & DeLeo, F. R. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2200 · Cited by 2,718
“aureus produces many other molecules that promote host colonization, facilitate evasion of the innate immune system and alter immune response”
BackgroundSelf-citationCommunity-associated meticillin-resistant Staphylococcus aureus
DeLeo, F. R., Otto, M. J., Kreiswirth, B. N., & Chambers, H. F. “. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61999-1 · Cited by 1,534
Self-citationLöffler, B., Hussain, M., Grundmeier, M., Brück, M., Holzinger, D., Varga, G., Roth, J., Kahl, B. C., Proctor, R. A., & Peters, G. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000715 · Cited by 457
“Further on, it has been shown that phagocytosis significantly accelerates neutrophils apoptosis, which appears to contribute to the resolution of the inflammatory response [21,22].”
BackgroundRole of Pore-Forming Toxins in Bacterial Infectious Diseases
Los, F. C. O., Randis, T. M., Aroian, R. V., & Ratner, A. J. (2013) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00052-12 · Cited by 421
Metadata
- Authors
- DeLeo, F. R., Diep, B. A., & Otto, M.
- Affiliations
- National Institutes of Health (US)
- University of California, San Francisco (US)
- Corresponding author
- DeLeo, Frank R.
- Venue
- Infectious Disease Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 23
- Issue
- 1
- Pages
- 17-34
- ISSN
- 0891-5520 (ISSN-L)
- PMC
- PMC2748223
- OpenAlex
- W2084838489
- Cited by
- 269
- References
- 103
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 13 · 2023: 16 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 21 · 2018: 13 · 2017: 10 · 2016: 10 · 2015: 20 · 2014: 18 · 2013: 21 · 2012: 21
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infectious Disease Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (Z01AI000900)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
- Keywords
- Staphylococcus aureus, host defense, innate immunity, neutrophils, virulence mechanisms, community-associated methicillin-resistant Staphylococcus aureus, pathogenesis, bacterial infection
- MeSH terms
- Humans, Neutrophils, Staphylococcal Infections, Staphylococcus aureus, Virulence, Virulence Factors
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