Activity of echinocandins and triazoles against a contemporary (2012) worldwide collection of yeast and moulds collected from invasive infections

Castanheira, Mariana; Messer, Shawn A.; Jones, Ronald N.; Farrell, David J.; Pfaller, Michael A.

doi:10.1016/j.ijantimicag.2014.06.007

Cited by 67Antifungal resistance and susceptibilityFungal Plant Pathogen ControlYeasts and Rust Fungi Studies

Activity of echinocandins and triazoles against a contemporary (2012) worldwide collection of yeast and moulds collected from invasive infections

Castanheira, Mariana, Messer, Shawn A., Jones, Ronald N., Farrell, David J., Pfaller, Michael A.·2014·International Journal of Antimicrobial Agents

DOI 10.1016/j.ijantimicag.2014.06.007

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Abstract

In this study, 1717 fungal clinical isolates causing invasive fungal infections were evaluated against nine antifungal agents using Clinical and Laboratory Standards Institute (CLSI) reference broth microdilution methods. The isolates comprised 1487 Candida spp., 109 Aspergillus spp., 86 non-Candida yeasts (including 52 isolates of Cryptococcus neoformans) and 35 rare moulds obtained during 2012 from 72 hospitals worldwide. Echinocandin resistance among Candida spp. was low, and resistance rates to anidulafungin, caspofungin and micafungin varied from 0.0% to 2.8% among different species. Echinocandin-resistant Candida glabrata were shown to have fks mutations (fks2 HS1 F659Y, F659del, S663F and S663P), and fluconazole resistance was also observed in those strains. One Candida krusei and one Candida dubliniensis had L701M or S645P fks1 mutations, respectively. Candida tropicalis and C. glabrata had higher fluconazole resistance rates of 6.1% and 6.9%, respectively, compared with other Candida spp. Fluconazole-resistant C. tropicalis were collected in five countries (USA, China, Germany, Belgium and Thailand). Voriconazole was active against all Candida spp., inhibiting 91.2-99.7% of isolates using species-specific breakpoints. All agents except for the echinocandins and posaconazole were active against Cr. neoformans. Triazoles were active against other yeasts [MIC90 (minimum inhibitory concentration encompassing 90% of isolates tested), 2μg/mL]. The echinocandins and the mould-active triazoles were active against Aspergillus [MIC/MEC90 (minimum effective concentration encompassing 90% of isolates tested) range, 0.015-2μg/mL], but the activity of these agents was limited against uncommon mould species (MIC/MEC90 range, 4μg/mL to >16μg/mL).

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Authors: Castanheira, M., Messer, S. A., Jones, R. N., Farrell, D. J., & Pfaller, M. A.
Affiliations: JMI Laboratories (US)
Corresponding author: Pfaller, Michael A.
ORCID: Castanheira, Mariana
Messer, Shawn A.
Jones, Ronald N.
Pfaller, Michael A.
Venue: International Journal of Antimicrobial Agents
Publisher: Elsevier BV
Published: 2014-10
Volume: 44
Issue: 4
Pages: 320-326
ISSN: 0924-8579 (ISSN-L)
DOI: 10.1016/j.ijantimicag.2014.06.007
OpenAlex: W2100268297
Cited by: 66
References: 36
Citations by year: 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 12 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 11
FWCI: 5.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Antimicrobial Agents (publishedVersion)
PubMed (publishedVersion)
Funders: Pfizer Inc.
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: echinocandins, triazoles, antifungal susceptibility, invasive fungal infections, Candida, Aspergillus, Cryptococcus neoformans, echinocandin resistance, fluconazole resistance, voriconazole, anidulafungin, caspofungin, micafungin, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis
MeSH terms: Antifungal Agents, Fungi, Hospitals, Humans, Microbial Sensitivity Tests, Mycoses, Triazoles, Global Health, Echinocandins

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Activity of echinocandins and triazoles against a contemporary (2012) worldwide collection of yeast and moulds collected from invasive infections

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