High clustering of acute HCV infections and high rate of associated STIs among Parisian HIV-positive male patients.
Open accessAbstract
Background Increasing incidence of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-positive men having sex with men (MSM) has been described in recent years. Phylogenetic analyses of acute HCV infections were undertaken to characterize the dynamics during the epidemic in Paris, and associated sexually transmitted infections (STIs) were evaluated.Methods Sanger sequencing of polymerase gene was performed. Maximum likelihood phylogenies were reconstructed using FastTree 2.1 under a GTR+CAT model. Transmission chains were defined as clades with a branch probability ≥0.80 and intraclade genetic distances <0.02 nucleotide substitutions per sites. STIs detected ≤1 month before HCV diagnosis were considered.Results Among the 85 studied patients, at least 81.2% were MSM. Respectively, 47.6%, 39.0%, 11.0% and 2.4% were infected with genotypes 1a, 4d, 3a and 2k. At least 91.8% were co-infected with HIV. HCV re-infection was evidenced for 24.7% of patients and STIs for 20.0% of patients. Twenty-two transmission chains were identified, including 52 acute hepatitis C (11 pairs and 11 clusters from three to seven patients).Conclusions These results revealed strong clustering of acute HCV infections. Thus, rapid treatment of both chronic and acute infections is needed among this population to decrease the prevalence of HCV, in combination with preventive behavioural interventions.
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Increasing incidence of acute HCV infection among MSM with HIV infection has been reported in multiple U.S. and European cities.
“Increasing incidence of acute HCV infection among MSM with HIV infection has been reported in multiple U.S. (96,236,239,1339) and European cities (237,1340–1342).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1342]
An association exists between HCV infection and high-risk and traumatic sexual practices and concurrent genital ulcerative disease or STI-related proctitis among MSM with HIV.
“An association exists with high-risk and traumatic sexual practices (e.g., condomless receptive anal intercourse or receptive fisting) and concurrent genital ulcerative disease or STI-related proctitis (237,1342).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1342]
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- Authors
- Todesco, E., Day, N., Amiel, C., Elaerts, S., Schneider, V., Roudière, L., Hué, S., Liotier, J.-Y., Bottero, J., L'Yavanc, T., Ohayon, M., Gosset, D., Thibault, V., Surgers, L., Chas, J., Akhavan, S., Velter, A., Katlama, C., Kreplak, G., Marcelin, A.-G., & Valantin, M.-A.
- Affiliations
- Inserm (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- London School of Hygiene & Tropical Medicine (GB)
- Sorbonne Université (FR)
- Santé Publique France (FR)
- ORCID
- Venue
- International Journal of Antimicrobial Agents
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 53
- Issue
- 5
- Pages
- 678-681
- ISSN
- 0924-8579 (ISSN-L)
- OpenAlex
- W2913236606
- Cited by
- 7
- References
- 21
- Citations by year
- 2023: 2 · 2022: 3 · 2021: 1 · 2019: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- International Journal of Antimicrobial Agents (acceptedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- acute hepatitis C, HIV/HCV coinfection, men who have sex with men, sexually transmitted infections, HCV genotype distribution, HCV reinfection, transmission chains, phylogenetic clustering, Paris
- MeSH terms
- Adult, Genotype, Hepatitis C, Humans, Male, Middle Aged, Paris, Phylogeny, Retrospective Studies, Sexually Transmitted Diseases, HIV Infections, Prevalence, Cluster Analysis, Hepacivirus, Sequence Analysis, DNA, Molecular Epidemiology, Homosexuality, Male, Disease Transmission, Infectious
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