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Cited by 15Lipoproteins and Cardiovascular HealthCancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

A victory for statins or a defeat for diet policies? Cholesterol falls in Poland in the past decade: A modeling study

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Bandosz, Piotr, O'Flaherty, Martin, Rutkowski, Marcin, Kypridemos, Chris, Guzman-Castillo, Maria, Gillespie, Duncan O.S., Solnica, Bogdan, Pencina, Michael J. +3 more·2015·International Journal of Cardiology
DOI 10.1016/j.ijcard.2015.03.079
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Abstract

Aim The present study is aimed to examine whether recent changes in population total cholesterol (TC) levels in Poland might be attributed to increased use statins.Methods Two independent, nationally representative cross-sectional studies were conducted in adults aged 18-79 years in 2002 (n=2993, mean age 46.2 years) and 2011 (n=2413, mean age 45.8 years), including measurements of TC in venous blood samples. The mean change of TC between 2002 and 2011 was assessed. Then the expected therapeutic reduction in TC level in 2011 attributable to statins only was calculated based on already published statin effectiveness data. Uncertainty was quantified using probabilistic sensitivity analysis.Results Statin uptake in Poland rose to 11.2% in 2011 (95% Confidence Intervals (CI): 10% to 12.5%) and approximately 32% (95% CI: 28.4 to 36.0%) in subjects aged 60-79 years. Mean TC in Poland in 2002 was 5.35 mmol/l, and fell by 0.21 mmol/l (95% CI: 0.14 to 0.28) by 2011. This fall would have been only 0.03 mmol/l (95% CI: -0.04 to 0.10) for the total adult population and 0.06 mmol/l (95% CI: -0.09 to 0.22) in people aged 60-79 years if statins had not been used. Statin use thus apparently explained approximately 85% (95% CI: 49% to 120%) of the observed decrease.Conclusion Between 2002 and 2011, statin medications apparently explained a large part of the observed fall in population cholesterol level, suggesting very little changes in population TC attributed to dietary changes.

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  • In certain Western nations, statin use may account for a large proportion of declining blood cholesterol after 2000; however, due to relatively low use for primary prevention prior to this period, statins cannot explain the observed similar declines in blood cholesterol over the preceding 20-30 years.

    “In certain Western nations, statin use may account for a large proportion of declining blood cholesterol after 2000;347, 348 however, due to relatively low use for primary prevention prior to this period, statins cannot explain the observed similar declines in blood cholesterol over the preceding 20-30 years.”

    From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [347]

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Authors
Bandosz, P., O'Flaherty, M., Rutkowski, M., Kypridemos, C., Guzman-Castillo, M., Gillespie, D. O. S., Solnica, B., Pencina, M. J., Wyrzykowski, B., Capewell, S., & Zdrojewski, T.
Affiliations
  • University of Liverpool (GB)
  • Gdańsk Medical University (PL)
  • Jagiellonian University (PL)
  • Duke University (US)
Corresponding author
Bandosz, Piotr
ORCID
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
2015-04
Volume
185
Pages
313-319
ISSN
0167-5273 (ISSN-L)
DOI
10.1016/j.ijcard.2015.03.079
OpenAlex
W2124510871
Cited by
15
References
45
Citations by year
2026: 1 · 2023: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 1
FWCI
3.36
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
  • Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
  • Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion)
Funders
Polish Ministry of Health
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
statins, total cholesterol, dietary cholesterol, cholesterol-lowering therapy, Poland
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Cholesterol, Cross-Sectional Studies, Diet, Female, Humans, Male, Middle Aged, Models, Theoretical, Nutritional Status, Poland, Incidence, Risk Assessment, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Young Adult

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