CoChat
Sign Up
Cited by 161Atrial Fibrillation Management and OutcomesAcute Ischemic Stroke ManagementCardiovascular and Diving-Related Complications

The DOI matches its Crossref record; 21 of the 23 references it cites were found in a registry or an index.

Asymptomatic versus symptomatic atrial fibrillation: A systematic review of age/gender differences and cardiovascular outcomes

Open access
Xiong, Qinmei, Proietti, Marco, Senoo, Keitaro, Lip, Gregory Y.H.·2015·International Journal of Cardiology
DOI 10.1016/j.ijcard.2015.05.011
Open this paper in CoChat — free account

Abstract

Up to 40% of atrial fibrillation (AF) patients are asymptomatic. Despite this, scarce data are available about asymptomatic AF, with regard to its clinical profile and relationship to cerebrovascular and cardiovascular risks. Our objective was to conduct a systematic review and meta-analysis was to study the relationship between age and gender with asymptomatic AF and to establish whether patients with asymptomatic AF have a higher risk of death (all-cause and cardiovascular) and stroke/systemic thromboembolism, when compared to symptomatic AF patients. After a comprehensive search, 6 studies (2 randomized clinical trials and 4 observational studies) were entered in the meta-analysis. Despite significant heterogeneity, our data show that the prevalence of females amongst asymptomatic AF group was significantly less compared to the symptomatic AF group (RR, 0.57; 95% CI: 0.52-0.64). No difference in age between asymptomatic and symptomatic AF patients (P=0.72) was seen. No differences were found in all-cause death between patients with asymptomatic and symptomatic AF (RR, 1.38; 95% CI: 0.82-2.17), nor in cardiovascular death (RR, 0.85; 95% CI: 0.53-1.36) or stroke/thromboembolism (RR, 1.72 95% CI: 0.59-5.08). Asymptomatic AF is more associated with male sex, irrespective of age. Both general and cardiovascular death risks as well as thromboembolic risk do not seem to be affected by the asymptomatic clinical status. Symptomatic status should not determine our approach to stroke prevention and other cardiovascular prevention therapies, amongst patients with AF.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.ijcard.2015.05.011

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Citations

Cites

Show all 23 references

Research works printed but not linked: 1

  1. Anon. Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions — Methods Guide — Chapter|AHRQ Effective Health Care Program.

Cited by

Sorted by citations

Items 101–161 of 161

Related

See all

Metadata

Authors
Xiong, Q., Proietti, M., Senoo, K., & Lip, G. Y. H.
Affiliations
Birmingham City Hospital (GB)
Corresponding author
Proietti, Marco
ORCID
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
2015-07
Volume
191
Pages
172-177
ISSN
0167-5273 (ISSN-L)
DOI
10.1016/j.ijcard.2015.05.011
OpenAlex
W1496114842
Cited by
161
References
23
Citations by year
2026: 9 · 2025: 10 · 2024: 15 · 2023: 7 · 2022: 14 · 2021: 28 · 2020: 15 · 2019: 21 · 2018: 7 · 2017: 17 · 2016: 14 · 2015: 4
FWCI
2.40
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
Keywords
asymptomatic atrial fibrillation, symptomatic atrial fibrillation, sex differences, age differences, all-cause mortality, cardiovascular mortality, stroke, systemic thromboembolism, stroke prevention, cardiovascular risk
MeSH terms
Age Factors, Atrial Fibrillation, Female, Humans, Male, Sex Characteristics, Randomized Controlled Trials as Topic, Treatment Outcome, Asymptomatic Diseases, Observational Studies as Topic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review