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Cited by 135Signaling Pathways in DiseaseAxon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

NFAT signaling in neural development and axon growth

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Nguyen, Tuan, Di Giovanni, Simone·2008·International Journal of Developmental Neuroscience
DOI 10.1016/j.ijdevneu.2007.10.004PMC PMC2267928
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Abstract

The NFAT (nuclear factor of activated T‐cells) family of transcription factors functions as integrators of multiple signaling pathways by binding to chromatin in combination with other transcription factors and coactivators to regulate genes central for many developmental systems. Recent experimental evidence has shown that the calcineurin/NFAT signaling pathway is important in axonal growth and guidance during vertebrate development. In fact, studies with triple NFATc2/c3/c4 mutant mice demonstrate that the extension and organization of sensory axon projection and commissural axon growth are both dependent upon NFAT activity. Neurotrophin and L‐type calcium channel signaling modulate intracellular calcium levels to regulate the nuclear import and transcriptional activity of NFAT by activating the phosphatase calcineurin. The rephosphorylation and subsequent export of NFAT from the nucleus is mediated by several kinases, including GSK‐3β, which contribute to the fine tuning of NFAT transcriptional activity in neurons. However, currently, no direct transcriptional targets for NFAT have been identified in a chromatin environment in the nervous system. Undiscovered are also the binding partners of NFAT that might combinatorially regulate specific genes important for neuronal development. This review will discuss the current knowledge related to NFAT signaling in the nervous system development and the potential for future research directions.

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  • Different neuronal cell types express different NFAT isoforms.

    “However, recent studies have shown that neurons also express NFAT and that different neuronal cell types express different NFAT isoforms (67–70).”

    From LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies (2020) · cites this paper as [68]

    The Introduction describes NFATc4 activity in hippocampal neurons, and the References list a study of NFATc1 in sympathetic ganglion neurons. These passages support examples of different isoforms in different neuronal populations, but the review does not establish a general pattern of cell-type-specific isoform expression. No page numbers were provided in our copy. (LLM, conf=0.76)

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  • Neurons also express NFAT.

    “However, recent studies have shown that neurons also express NFAT and that different neuronal cell types express different NFAT isoforms (67–70).”

    From LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies (2020) · cites this paper as [68]

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Authors
Nguyen, T., & Di Giovanni, S.
Affiliations
  • Hertie Institute for Clinical Brain Research (DE)
  • Laboratory for NeuroRegeneration and Repair Hertie Institute for Clinical Brain Research University of Tuebingen Tuebingen Germany
Corresponding author
Nguyen, Tuan
ORCID
Nguyen, Tuan
Venue
International Journal of Developmental Neuroscience
Publisher
Wiley
Published
2007-11-17
Volume
26
Issue
2
Pages
141-145
ISSN
  • 0736-5748 (ISSN-L)
  • 1873-474X
DOI
10.1016/j.ijdevneu.2007.10.004
PMC
PMC2267928
OpenAlex
W2067110557
Cited by
135
References
1
Citations by year
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FWCI
0.59
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Developmental Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (R21 NS052640)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
NFAT signaling, calcineurin, axon growth, axon guidance, neural development, commissural axons, neurotrophins, L-type calcium channels, intracellular calcium, GSK3β, transcriptional regulation
MeSH terms
Glycogen Synthase Kinase 3 beta, Animals, Cell Differentiation, Central Nervous System, Signal Transduction, Calcineurin, Calcium Signaling, Growth Cones, Active Transport, Cell Nucleus, Glycogen Synthase Kinase 3, NFATC Transcription Factors, Mice

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