Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859 · see citing works

Salmon provides fast and bias-aware quantification of transcript expression

Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700 · see citing works

Cell Signaling by Receptor Tyrosine Kinases

Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929 · see citing works

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works

AKT/PKB signaling: navigating downstream

Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115 · see citing works

AKT/PKB Signaling: Navigating the Network

Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772 · see citing works

The PI3K Pathway in Human Disease

Fruman, D. A., Chiu, H., Hopkins, B. D., Bagrodia, S., Cantley, L. C., & Abraham, R. T. (2017) · Cell · doi:10.1016/j.cell.2017.07.029 · Cited by 2,749 · see citing works

Independent optical excitation of distinct neural populations

Klapoetke, N. C., Murata, Y., Kim, S. S., Pulver, S. R., Birdsey-Benson, A., Cho, Y. K., Morimoto, T. K., Chuong, A. S., Carpenter, E. J., Tian, Z., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2836 · Cited by 2,344 · see citing works

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works

Filopodia: molecular architecture and cellular functions

Mattila, P. K., & Lappalainen, P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2406 · Cited by 1,699 · see citing works

Genes and molecular pathways underpinning ciliopathies

Reiter, J. F., & Leroux, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.60 · Cited by 1,588 · see citing works

Cell-signalling dynamics in time and space

Kholodenko, B. N. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1838 · Cited by 1,347 · see citing works

Ciliopathies

Hildebrandt, F., Benzing, T., & Katsanis, N. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1010172 · Cited by 1,331 · see citing works

A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling

Hippenmeyer, S., Pecho‐Vrieseling, E., Sigrist, M., Portmann, T., Laengle, C., Ladle, D. R., & Arber, S. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030159 · Cited by 1,059 · see citing works

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

Gradinaru, V., Zhang, F., Ramakrishnan, C., Mattis, J., Prakash, R., Diester, I., Goshen, I., Thompson, K. R., & Deisseroth, K. A. (2010) · Cell · doi:10.1016/j.cell.2010.02.037 · Cited by 999 · see citing works

Pten Regulates Neuronal Arborization and Social Interaction in Mice

Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works

The Graded Response to Sonic Hedgehog Depends on Cilia Architecture

Caspary, T., Larkins, C. E., & Anderson, K. V. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.004 · Cited by 729 · see citing works

Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice

Goebbels, S., Bormuth, I., Bode, U., Hermanson, O., Schwab, M. H., & Nave, K. (2006) · genesis · doi:10.1002/dvg.20256 · Cited by 579 · see citing works

Primary cilia are specialized calcium signalling organelles

Delling, M., DeCaen, P. G., Doerner, J. F., Febvay, S., & Clapham, D. E. (2013) · Nature · doi:10.1038/nature12833 · Cited by 497 · see citing works

Joubert Syndrome and related disorders

Brancati, F., Dallapiccola, B., & Valente, E. M. (2010) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-5-20 · Cited by 468 · see citing works

Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil Bacterium Beggiatoa

Stierl, M., Stumpf, P. S., Udwari, D., Gueta, R., Hagedorn, R., Losi, A., Gärtner, W., Petereit, L., Efetova, M., Schwärzel, M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.185496 · Cited by 423 · see citing works

Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?

Nachury, M. V., Seeley, E. S., & Jin, H. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113337 · Cited by 423 · see citing works

Lamellipodial Versus Filopodial Mode of the Actin Nanomachinery

Mejillano, M. R., Kojima, S.-I., Applewhite, D. A., Gertler, F. B., Svitkina, T. M., & Borisy, G. G. (2004) · Cell · doi:10.1016/j.cell.2004.07.019 · Cited by 420 · see citing works

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

Bielas, S. L., Silhavy, J. L., Brancati, F., Kisseleva, M. V., Al‐Gazali, L., Sztriha, L., Bayoumi, R., Zaki, M. S., Aleem, A. K. A., Rosti, R. Ö., et al. (2009) · Nature Genetics · doi:10.1038/ng.423 · Cited by 397 · see citing works

Intraflagellar transport is essential for endochondral bone formation

Haycraft, C. J., Zhang, Q., Song, B., Jackson, W. S., Detloff, P. J., Serra, R. A., & Yoder, B. K. (2006) · Development · doi:10.1242/dev.02732 · Cited by 395 · see citing works

Mutations in the Cilia Gene ARL13B Lead to the Classical Form of Joubert Syndrome

Cantagrel, V., Silhavy, J. L., Bielas, S. L., Swistun, D., Marsh, S., Bertrand, J. Y., Audollent, S., Attié‐Bitach, T., Holden, K. R., Dobyns, W. B., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.06.023 · Cited by 391 · see citing works

Joubert syndrome: congenital cerebellar ataxia with the molar tooth

Romani, M., Micalizzi, A., & Valente, E. M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70136-4 · Cited by 386 · see citing works

Development, specification, and diversity of callosal projection neurons

Fame, R. M., MacDonald, J. L., & Macklis, J. D. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2010.10.002 · Cited by 381 · see citing works

Neurotrophins and Netrins Require Calcineurin/NFAT Signaling to Stimulate Outgrowth of Embryonic Axons

Graef, I. A., Wang, F., Charron, F., Chen, L., Neilson, J., Tessier-Lavigne, M., & Crabtree, G. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00390-8 · Cited by 379 · see citing works

Dynamic regulation of axon guidance

Yu, T. W., & Bargmann, C. I. (2001) · Nature Neuroscience · doi:10.1038/nn748 · Cited by 350 · see citing works

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

Jacoby, M., Cox, J. J., Gayral, S., Hampshire, D. J., Ayub, M., Blockmans, M., Pernot, E., Kisseleva, M. V., Compère, P., Schiffmann, S. N., et al. (2009) · Nature Genetics · doi:10.1038/ng.427 · Cited by 339 · see citing works

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision

Phua, S. C., Chiba, S., Suzuki, M., Su, E., Roberson, E. C., Pusapati, G. V., Setou, M., Rohatgi, R., Reiter, J. F., Ikegami, K., et al. (2017) · Cell · doi:10.1016/j.cell.2016.12.032 · Cited by 339 · see citing works

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

Garcia-Gonzalo, F. R., Phua, S. C., Roberson, E. C., Garcia, G., Abedin, M., Schurmans, S., Inoue, T., & Reiter, J. F. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.08.001 · Cited by 330 · see citing works

Optogenetic control of phosphoinositide metabolism

Idevall‐Hagren, O., Dickson, E. J., Hille, B., Toomre, D. K., & Camilli, P. V. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211305109 · Cited by 320 · see citing works

Direct recording and molecular identification of the calcium channel of primary cilia

DeCaen, P. G., Delling, M., Vien, T. N., & Clapham, D. E. (2013) · Nature · doi:10.1038/nature12832 · Cited by 306 · see citing works

Branch management: mechanisms of axon branching in the developing vertebrate CNS

Kalil, K., & Dent, E. W. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3650 · Cited by 300 · see citing works

Primary Cilia in the Developing and Mature Brain

Guemez-Gamboa, A., Coufal, N. G., & Gleeson, J. G. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.024 · Cited by 296 · cited 1× · see citing works

Netrin-1 and Semaphorin 3A Promote or Inhibit Cortical Axon Branching, Respectively, by Reorganization of the Cytoskeleton

Dent, E. W., Barnes, A. M., Tang, F., & Kalil, K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4963-03.2004 · Cited by 290 · see citing works

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

Chávez, M., Ena, S., Van Sande, J., de Kerchove d’Exaerde, A., Schurmans, S., & Schiffmann, S. N. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.016 · Cited by 276 · see citing works

Arl13b in Primary Cilia Regulates the Migration and Placement of Interneurons in the Developing Cerebral Cortex

Higginbotham, H., Eom, T.-Y., Mariani, L. E., Bachleda, A., Hirt, J., Ghukasyan, V., Cusack, C. L., Lai, C., Caspary, T., & Anton, E. S. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.09.019 · Cited by 254 · see citing works

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity

Siljee, J. E., Wang, Y., Bernard, A. A., Ersoy, B. A., Zhang, S., Marley, A., Von Zastrow, M., Reiter, J. F., & Vaisse, C. (2018) · Nature Genetics · doi:10.1038/s41588-017-0020-9 · Cited by 247 · see citing works

Growth Cone Travel in Space and Time: the Cellular Ensemble of Cytoskeleton, Adhesion, and Membrane

Vitriol, E. A., & Zheng, J. Q. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.005 · Cited by 229 · see citing works

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

Humbert, M. C., Weihbrecht, K., Searby, C. C., Li, Y., Pope, R. M., Sheffield, V. C., & Seo, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210916109 · Cited by 228 · see citing works

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

Hilgendorf, K. I., Johnson, C. T., & Jackson, P. K. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.02.008 · Cited by 224 · see citing works

Ins and outs of GPCR signaling in primary cilia

Schou, K. B., Pedersen, L. B., & Christensen, S. T. (2015) · The EMBO Reports · doi:10.15252/embr.201540530 · Cited by 221 · see citing works

Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation

Higginbotham, H., Guo, J., Yokota, Y., Umberger, N. L., Su, C.-Y., Li, J., Verma, N., Hirt, J., Ghukasyan, V., Caspary, T., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3451 · Cited by 216 · see citing works

Neuregulin 1–erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex

Schmid, R. S., McGrath, B., Berechid, B. E., Boyles, B., Marchionni, M. A., Šestan, N., & Anton, E. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630496100 · Cited by 211 · see citing works

PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

Sánchez‐Alegría, K., Flores‐León, M., Ávila-Muñoz, E., Rodríguez-Corona, N., & Arias, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123725 · Cited by 209 · see citing works

Developmental regulation of axon branching in the vertebrate nervous system

Gibson, D. A., & Ma, L. (2010) · Development · doi:10.1242/dev.046441 · Cited by 207 · see citing works

Human Genetic Disorders of Axon GuidancePreprint

Engle, E. C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001784 · Cited by 201 · see citing works

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

Franco, I., Gulluni, F., Campa, C. C., Costa, C., Margaria, J. P., Ciraolo, E., Martini, M., Monteyne, D., Luca, E. D., Germena, G., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.01.022 · Cited by 199 · see citing works

Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

Christensen, S. T., Clement, C. A., Satir, P., & Pedersen, L. B. (2012) · The Journal of Pathology · doi:10.1002/path.3004 · Cited by 181 · see citing works

Cellular Strategies of Axonal PathfindingPreprint

Raper, J. A., & Mason, C. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001933 · Cited by 177 · see citing works

Lateral Propagation of EGF Signaling after Local Stimulation Is Dependent on Receptor Density

Sakaue-Sawano, A., Takayama, S., Matsuda, M., & Miyawaki, A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00224-1 · Cited by 171 · see citing works

The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence

Follit, J. A., Li, L., Vucica, Y., & Pazour, G. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200910096 · Cited by 168 · see citing works

Modeling Human Disease in Humans: The Ciliopathies

Novarino, G., Akizu, N., & Gleeson, J. G. (2011) · Cell · doi:10.1016/j.cell.2011.09.014 · Cited by 159 · see citing works

Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes

Zhu, D., Shi, S., Wang, H., & Liao, K. (2009) · Journal of Cell Science · doi:10.1242/jcs.046276 · Cited by 156 · see citing works

The ciliopathies in neuronal development: a clinical approach to investigation of Joubert syndrome and Joubert syndrome‐related disorders

SATTAR, S., & GLEESON, J. G. (2011) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2011.04021.x · Cited by 155 · see citing works

Dysregulation of the IGF‐I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders

Chen, J., Alberts, I., & Li, X. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.03.006 · Cited by 151 · see citing works

Diffusion Tensor Imaging in Joubert Syndrome

Poretti, A., Boltshauser, E., Loenneker, T., Valente, E. M., Brancati, F., Il'yasov, K. A., & Huisman, T. A. G. M. (2007) · American Journal of Neuroradiology · doi:10.3174/ajnr.a0703 · Cited by 147 · see citing works

Wiring the Brain: The Biology of Neuronal GuidancePreprint

Chédotal, A., & Richards, L. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001917 · Cited by 147 · see citing works

Arborization of Dendrites by Developing Neocortical Neurons Is Dependent on Primary Cilia and Type 3 Adenylyl Cyclase

Guadiana, S. M., Semple-Rowland, S., Daroszewski, D., Madorsky, I., Breunig, J. J., Mykytyn, K., & Sarkisian, M. R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2906-12.2013 · Cited by 144 · see citing works

G-protein-coupled receptors, Hedgehog signaling and primary cilia

Mukhopadhyay, S., & Rohatgi, R. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.05.002 · Cited by 142 · see citing works

Developmental disruptions underlying brain abnormalities in ciliopathies

Guo, J., Higginbotham, H., Li, J., Nichols, J., Hirt, J., Ghukasyan, V., & Anton, E. S. (2015) · Nature Communications · doi:10.1038/ncomms8857 · Cited by 140 · see citing works

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

Choi, Y.-H., Suzuki, A., Hajarnis, S., Ma, Z., Chapin, H. C., Caplan, M. J., Pontoglio, M., Somlo, S., & Igarashi, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016214108 · Cited by 139 · see citing works

Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity

Guo, J., Otis, J. M., Higginbotham, H., Monckton, C., Cheng, J., Asokan, A., Mykytyn, K., Caspary, T., Stuber, G. D., & Anton, E. S. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.07.010 · Cited by 136 · see citing works

NFAT signaling in neural development and axon growth

Nguyen, T., & Di Giovanni, S. (2008) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.10.004 · Cited by 135 · see citing works

The molecular genetics of Joubert syndrome and related ciliopathies: The challenges of genetic and phenotypic heterogeneity

Parisi, M. A. (2019) · Translational Science of Rare Diseases · doi:10.3233/trd-190041 · Cited by 129 · see citing works

Robust Neuronal Symmetry Breaking by Ras-Triggered Local Positive Feedback

Fivaz, M. L., Bandara, S., Inoue, T., & Meyer, T. (2008) · Current Biology · doi:10.1016/j.cub.2007.11.051 · Cited by 128 · see citing works

Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia

Su, S. H., Phua, S. C., DeRose, R., Chiba, S., Narita, K., Kalugin, P. N., Katada, T., Kontani, K., Takeda, S., & Inoue, T. (2013) · Nature Methods · doi:10.1038/nmeth.2647 · Cited by 128 · see citing works

Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing

Parra, L. M., & Zou, Y. (2009) · Nature Neuroscience · doi:10.1038/nn.2457 · Cited by 122 · see citing works

INPP5E regulates phosphoinositide-dependent cilia transition zone function

Dyson, J. M., Conduit, S. E., Feeney, S. J., Hakim, S., DiTommaso, T., Fulcher, A. J., Sriratana, A., Ramm, G., Horan, K., Gurung, R., et al. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201511055 · Cited by 115 · see citing works

Dynamic phospholipid signaling by G protein-coupled receptors

Weernink, P. A. O., Li, H., Jakobs, K. H., & Schmidt, M. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.012 · Cited by 114 · see citing works

Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model

McIntyre, J. C., Davis, E. E., Joiner, A. M., Williams, C. L., Tsai, I.-C., Jenkins, P. M., McEwen, D. P., Zhang, L., Escobado, J., Thomas, S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2860 · Cited by 113 · see citing works

Controlling fertilization and cAMP signaling in sperm by optogenetics

Jansen, V., Alvarez, L., Balbach, M., Strünker, T., Hegemann, P., Kaupp, U. B., & Wachten, D. (2015) · eLife · doi:10.7554/elife.05161 · Cited by 112 · see citing works

Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits

Spangler, S. M., & Bruchas, M. R. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.11.001 · Cited by 107 · see citing works

G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation

Gavi, S., Shumay, E., Wang, H., & Malbon, C. C. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.01.006 · Cited by 101 · see citing works

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

Welf, E. S., Ahmed, S., Johnson, H. E., Melvin, A. T., & Haugh, J. M. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201108152 · Cited by 100 · see citing works

Development and distribution of neuronal cilia in mouse neocortex

Arellano, J. I., Guadiana, S. M., Breunig, J. J., Rakic, P., & Sarkisian, M. R. (2012) · Journal of Comparative Neurology · doi:10.1002/cne.22793 · Cited by 97 · see citing works

Joubert syndrome: brain and spinal cord malformations in genotyped cases and implications for neurodevelopmental functions of primary cilia

Juric‐Sekhar, G., Adkins, J. R., Doherty, D., & Hevner, R. F. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0951-2 · Cited by 92 · see citing works

Protocadherin-17 Mediates Collective Axon Extension by Recruiting Actin Regulator Complexes to Interaxonal Contacts

Hayashi, S., Inoue, Y., Kiyonari, H., Abe, T., Misaki, K., Moriguchi, H., Tanaka, Y., & Takeichi, M. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.07.015 · Cited by 88 · see citing works

Protocadherin 17 Regulates Presynaptic Assembly in Topographic Corticobasal Ganglia Circuits

Hoshina, N., Tanimura, A., Yamasaki, M., Inoue, T., Fukabori, R., Kuroda, T., Yokoyama, K., Tezuka, T., Sagara, H., Hirano, S., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.031 · Cited by 81 · see citing works

Nap1-Regulated Neuronal Cytoskeletal Dynamics Is Essential for the Final Differentiation of Neurons in Cerebral Cortex

Yokota, Y., Ring, C., Chong, R., Pevny, L., & Anton, E. S. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.016 · Cited by 77 · see citing works

Inositol Polyphosphate Phosphatases in Human Disease

Hakim, S., Bertucci, M. C., Conduit, S. E., Vuong, D. L., & Mitchell, C. A. (2012) · Current topics in microbiology and immunology · doi:10.1007/978-94-007-5025-8_12 · Cited by 76 · see citing works

A Simple Cell-Based Assay Reveals That Diverse Neuropsychiatric Risk Genes Converge on Primary Cilia

Marley, A., & von Zastrow, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046647 · Cited by 76 · see citing works

INPP5E interacts with AURKA, linking phosphoinositide signalling to primary cilium stability

Plotnikova, O. V., Seo, S., Cottle, D. L., Conduit, S. E., Hakim, S., Dyson, J. M., Mitchell, C. A., & Smyth, I. (2014) · Journal of Cell Science · doi:10.1242/jcs.161323 · Cited by 73 · see citing works

Arl13b regulates Shh signaling from both inside and outside the cilium

Mariani, L. E., Bijlsma, M. F., Ivanova, A., Suciu, S. K., Kahn, R., & Caspary, T. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-03-0189 · Cited by 73 · see citing works

A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain

Puram, S. V., Kim, A. H., Ikeuchi, Y., Wilson‐Grady, J., Merdes, A., Gygi, S. P., & Bonni, A. (2011) · Nature Neuroscience · doi:10.1038/nn.2857 · Cited by 71 · see citing works

Protocadherin-17 Mediates Collective Axon Extension by Recruiting Actin Regulator Complexes to Interaxonal Contacts

Hayashi, S., Inoue, Y., Kiyonari, H., Abe, T., Misaki, K., Moriguchi, H., Tanaka, Y., & Takeichi, M. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.07.009 · Cited by 71 · see citing works

Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function

Cioni, J.-M., Wong, H. H., Bressan, D., Kodama, L., Harris, W. A., & Holt, C. E. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.027 · Cited by 67 · see citing works

The Development of Neuronal Polarity: A Retrospective View

Banker, G. A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1372-16.2018 · Cited by 67 · see citing works

Arl13b regulates endocytic recycling traffic

Barral, D. C., Garg, S., Casalou, C., Watts, G. F. M., Sandoval, J. L., Ramalho, J. S., Hsu, V. W., & Brenner, M. B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218272110 · Cited by 65 · see citing works

Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases

Eramo, M. J., & Mitchell, C. A. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150214 · Cited by 65 · see citing works

Inositol polyphosphate 5‐phosphatases; new players in the regulation of cilia and ciliopathies

Conduit, S. E., Dyson, J. M., & Mitchell, C. A. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.07.037 · Cited by 63 · see citing works

Orphan GPCRs and Neuromodulation

Civelli, O. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.009 · Cited by 61 · see citing works

Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control

Omori, Y., Chaya, T., Yoshida, S., Irie, S., Tsujii, T., & Furukawa, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128422 · Cited by 60 · see citing works

Neuronal Primary Cilia: An Underappreciated Signaling and Sensory Organelle in the Brain

Green, J. A., & Mykytyn, K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.203 · Cited by 59 · see citing works

An optogenetic system for interrogating the temporal dynamics of Akt

Katsura, Y., Kubota, H., Kunida, K., Kanno, A., Kuroda, S., & Ozawa, T. (2015) · Scientific Reports · doi:10.1038/srep14589 · Cited by 58 · see citing works

Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity

Thomas, S., Cantagrel, V., Mariani, L., Serre, V., Lee, J., Elkhartoufi, N., de Lonlay, P., Desguerre, I., Münnich, A., Boddaert, N., et al. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.156 · Cited by 56 · see citing works

A chemical-genetic approach for precise spatio-temporal control of cellular signaling

Dong, S., Allen, J., Farrell, M. S., & Roth, B. L. (2010) · Molecular BioSystems · doi:10.1039/c002568m · Cited by 55 · see citing works

Asymmetric PI(3,4,5)P 3 and Akt Signaling Mediates Chemotaxis of Axonal Growth Cones

Henle, S. J., Wang, G. X., Liang, E. T., Wu, M., Poo, M.-M., & Henley, J. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0216-11.2011 · Cited by 52 · see citing works

What axons tell each other: axon–axon signaling in nerve and circuit assembly

Wang, L., & Marquardt, T. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.08.004 · Cited by 49 · see citing works

Frizzled receptors signal through G proteins

Nichols, A. S., Floyd, D. H., Bruinsma, S. P., Narzinski, K., & Baranski, T. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.03.009 · Cited by 49 · see citing works

Inositol Polyphosphate 5‐Phosphatases

Erneux, C., Giuriato, S., & Pesesse, X. (2002) · Wiley Encyclopedia of Molecular Medicine · doi:10.1002/0471203076.emm1060 · Cited by 44 · see citing works

Influences of Primary Cilia on Cortical Morphogenesis and Neuronal Subtype Maturation

Sarkisian, M. R., & Guadiana, S. M. (2014) · The Neuroscientist · doi:10.1177/1073858414531074 · Cited by 44 · see citing works

Structural insights into the small G-protein Arl13B and implications for Joubert syndrome

Miertzschke, M., Koerner, C., Spoerner, M., & Wittinghofer, A. (2013) · Biochemical Journal · doi:10.1042/bj20131097 · Cited by 41 · see citing works

Temporal deletion of Arl13b reveals that a mispatterned neural tube corrects cell fate over time

Su, C.-Y., Bay, S., Mariani, L. E., Hillman, M. J., & Caspary, T. (2012) · Development · doi:10.1242/dev.082321 · Cited by 41 · see citing works

Axon Guidance Mechanisms for Establishment of Callosal Connections

Nishikimi, M., Oishi, K., & Nakajima, K. (2013) · Neural Plasticity · doi:10.1155/2013/149060 · Cited by 37 · see citing works

Peripheral Gene Therapeutic Rescue of an Olfactory Ciliopathy Restores Sensory Input, Axonal Pathfinding, and Odor-Guided Behavior

Green, W. W., Uytingco, C. R., Ukhanov, K., Kolb, Z., Moretta, J. C., McIntyre, J. C., & Martens, J. R. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0084-18.2018 · Cited by 36 · see citing works

An intelligent nano-antenna: Primary cilium harnesses TRP channels to decode polymodal stimuli

Phua, S. C., Lin, Y., & Inoue, T. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.03.005 · Cited by 35 · see citing works

Structural abnormalities of the brain other than molar tooth sign in joubert syndrome related disorders

Senocak, E., Oğuz, K. K., Haliloğlu, G., Topçu, M., & Cila, A. (2009) · Diagnostic and Interventional Radiology · doi:10.4261/1305-3825.dir.2673-09.1 · Cited by 33 · see citing works

Beyond the cytoskeleton: The emerging role of organelles and membrane remodeling in the regulation of axon collateral branches

Winkle, C. C., Taylor, K. L., Dent, E. W., Gallo, G., Greif, K. F., & Gupton, S. L. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22398 · Cited by 31 · see citing works

Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity

Umberger, N. L., Caspary, T., & Bettencourt‐Dias, M. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-05-0952 · Cited by 28 · see citing works

A BAC transgenic mouse model to analyze the function of astroglial SPARCL1 (SC1) in the central nervous system

Weimer, J. M., Stanco, A., Cheng, J., Vargo, A. C., Voora, S., & Anton, E. S. (2008) · Glia · doi:10.1002/glia.20666 · Cited by 16 · see citing works

Joubert syndrome and related disorders, prenatal diagnosis with ultrasound and magnetic resonance imaging

İskender, C., Tarım, E., & Alkan, Ö. (2011) · Journal of the Turkish-German Gynecological Association · doi:10.5152/jtgga.2011.75 · Cited by 11 · see citing works

A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity

Rafiullah, R., Long, A. B., Ivanova, A., Ali, H., Berkel, S., Mustafa, G., Paramasivam, N., Schlesner, M., Wiemann, S., Wade, R. C., et al. (2017) · European Journal of Human Genetics · doi:10.1038/s41431-017-0031-0 · Cited by 11 · see citing works

Gene Expression Profiles of Main Olfactory Epithelium in Adenylyl Cyclase 3 Knockout Mice

Wang, Z., Zhou, Y., Luo, Y., Zhang, J., Zhai, Y., Yang, D. J., Zhang, Z., Li, Y., Storm, D. R., & Ma, R. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226107 · Cited by 9 · see citing works

A Paradigm-Changing Surprise from Dentate Gyrus Granule Cells— Cilium-Localized p75NTR May Drive Their Progenitor Cell Proliferation

Armato, U., Chakravarthy, B., Chiarini, A., Prà, I. D., & Whitfield, J. F. (2011) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000e104 · Cited by 3 · see citing works

Cilia, ciliopathies and hedgehog-related forebrain developmental disorders

Andreu‐Cervera, A., Catala, M., & Schneider‐Maunoury, S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105236 · Cited by 112 · see citing works

Cerebellum Lecture: the Cerebellar Nuclei—Core of the Cerebellum

Kebschull, J. M., Casoni, F., Consalez, G. G., Goldowitz, D., Hawkes, R. B., Ruigrok, T. J. H., Schilling, K., Wingate, R. J. T., Wu, J. P. H., Yeung, J., et al. (2023) · The Cerebellum · doi:10.1007/s12311-022-01506-0 · Cited by 89 · see citing works

Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex

Wu, J. Y., Cho, S.-J., Descant, K. D., Li, P. H., Shapson-Coe, A., Januszewski, M., Berger, D. R., Meyer, C., Casingal, C. R., Huda, A., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.032 · Cited by 81 · see citing works

Emerging principles of primary cilia dynamics in controlling tissue organization and function

Gopalakrishnan, J., Feistel, K., Friedrich, B. M., Grapin‐Botton, A., Jurisch‐Yaksi, N., Mass, E., Mick, D. U., Müller, R., May‐Simera, H., Schermer, B., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2023113891 · Cited by 79 · see citing works

Clinical and Molecular Diagnosis of Joubert Syndrome and Related Disorders

Devi, A. R. R., Naushad, S. M., & Lingappa, L. (2020) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2020.01.012 · Cited by 77 · see citing works

Signal transduction in primary cilia – analyzing and manipulating GPCR and second messenger signaling

Wachten, D., & Mick, D. U. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107836 · Cited by 77 · see citing works

The Joubert–Meckel–Nephronophthisis Spectrum of Ciliopathies

Weghe, J. C. V. D., Gómez, A. E., & Doherty, D. (2022) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-121321-093528 · Cited by 67 · see citing works

The multifaceted roles of primary cilia in the development of the cerebral cortex

Hasenpusch-Theil, K., & Theil, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.630161 · Cited by 66 · see citing works

Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons

Tereshko, L., Gao, Y., Cary, B. A., Turrigiano, G. G., & Sengupta, P. (2021) · eLife · doi:10.7554/elife.65427 · Cited by 60 · see citing works

The essential role of primary cilia in cerebral cortical development and disorders

Liu, S., Trupiano, M. X., Simon, J. M., Guo, J., & Anton, E. S. (2021) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.11.003 · Cited by 59 · see citing works

Cilia, neural development and disease

Suciu, S. K., & Caspary, T. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.07.014 · Cited by 58 · see citing works

Ultrastructural differences impact cilia shape and external exposure across cell classes in the visual cortex

Ott, C. M., Torres, R., Kuan, T. S., Kuan, A. T., Buchanan, J., Elabbady, L., Seshamani, S., Bodor, Á. L., Collman, F., Bock, D. D., et al. (2024) · Current Biology · doi:10.1016/j.cub.2024.04.043 · Cited by 56 · see citing works

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

Hansen, J. N., Kaiser, F., Klausen, C., Stüven, B., Chong, R., Bönigk, W., Mick, D. U., Möglich, A., Jurisch‐Yaksi, N., Schmidt, F. I., et al. (2020) · eLife · doi:10.7554/elife.57907 · Cited by 55 · see citing works

Rethinking the cilia hypothesis of hydrocephalus

Duy, P. Q., Greenberg, A. B. W., Butler, W. E., & Kahle, K. T. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105913 · Cited by 51 · see citing works

Bi-allelic loss-of-function variants in KIF21A cause severe fetal akinesia with arthrogryposis multiplex

Falb, R. J., Müller, A. J., Klein, W., Grimmel, M., Grasshoff, U., Spranger, S., Stöbe, P., Gauck, D., Kuechler, A., Dikow, N., et al. (2021) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2021-108064 · Cited by 45 · see citing works

Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain

Vinopal, S., Dupraz, S., Alfadil, E., Pietralla, T., Bendre, S., Stieß, M., Falk, S., Ortega, G. C., Maghelli, N., Tolić, I. M., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.01.020 · Cited by 44 · see citing works

Primary cilia signaling in astrocytes mediates development and regional-specific functional specification

Wang, L., Guo, Q., Acharya, S., Zheng, X., Huynh, V., Whitmore, B., Yimit, A., Malhotra, M., Chatterji, S., Rosin, N., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01726-z · Cited by 33 · see citing works

Revisiting and refining roles of neural guidance cues in circuit assembly

Dorskind, J. M., & Kolodkin, A. L. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.07.005 · Cited by 33 · see citing works

Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner

Hwang, S., Somatilaka, B. N., White, K., & Mukhopadhyay, S. (2021) · eLife · doi:10.7554/elife.67121 · Cited by 28 · see citing works

Primary cilia promote the differentiation of human neurons through the WNT signaling pathway

Coschiera, A., Yoshihara, M., Lauter, G., Ezer, S., Pucci, M., Li, H., Kavšek, A., Riedel, C. G., Kere, J., & Swoboda, P. (2024) · BMC Biology · doi:10.1186/s12915-024-01845-w · Cited by 26 · see citing works

Ciliary signaling in stem cells in health and disease: Hedgehog pathway and beyond

Shimada, I. S., & Kato, Y. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.04.011 · Cited by 24 · see citing works

Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation

Fabra-Beser, J., de Araújo, J. A. M., Coelho, D. M., Goff, L. A., Costa, M. R., Müller, U., & Gil, C. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2905-20.2021 · Cited by 23 · see citing works

Primary cilia in the postnatal brain: Subcellular compartments for organizing neuromodulatory signaling

Tereshko, L., Turrigiano, G. G., & Sengupta, P. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102533 · Cited by 23 · see citing works

Multiple ciliary localization signals control INPP5E ciliary targeting

Cilleros-Rodriguez, D., Martin-Morales, R., Barbeito, P., Deb Roy, A., Loukil, A., Sierra-Rodero, B., Herranz, G., Pampliega, O., Redrejo-Rodriguez, M., Goetz, S. C., et al. (2022) · eLife · doi:10.7554/elife.78383 · Cited by 23 · see citing works

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

Creighton, B. A., Afriyie, S., Ajit, D., Casingal, C. R., Voos, K. M., Reger, J., Burch, A. M., Dyne, E. D., Bay, J., Huang, J. K., et al. (2021) · eLife · doi:10.7554/elife.69815 · Cited by 23 · see citing works

INPP5E controls ciliary localization of phospholipids and the odor response in olfactory sensory neurons

Ukhanov, K., Uytingco, C. R., Green, W. W., Zhang, L., Schurmans, S., & Martens, J. R. (2021) · Journal of Cell Science · doi:10.1242/jcs.258364 · Cited by 21 · see citing works

Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer's disease

Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01637-3 · Cited by 20 · see citing works

HTR6 and SSTR3 targeting to primary cilia

Barbeito, P., & Garcia-Gonzalo, F. R. (2021) · Biochemical Society Transactions · doi:10.1042/bst20191005 · Cited by 20 · see citing works

Identification of New Ciliary Signaling Pathways in the Brain and Insights into Neurological Disorders

Loukil, A., Ebright, E., Hamdi, K., Menzel, E., Uezu, A., Gao, Y., Soderling, S. H., & Goetz, S. C. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0800-24.2025 · Cited by 19 · see citing works

The developing brain by trimester

Govaert, P. P., Triulzi, F. M., & Dudink, J. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64239-4.00014-x · Cited by 19 · see citing works

Neuronal primary cilia integrate peripheral signals with metabolic drives

DeMars, K. M., Ross, M. R., Starr, A., & McIntyre, J. C. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1150232 · Cited by 19 · see citing works

Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis

Mastropasqua, F., Oksanen, M., Soldini, C., Alatar, S., Arora, A., Ballarino, R., Molinari, M., Agostini, F., Poulet, A., Watts, M. E., et al. (2023) · Biology Open · doi:10.1242/bio.060113 · Cited by 18 · see citing works

Smoothened and ARL13B are critical in mouse for superior cerebellar peduncle targeting

Suciu, S. K., Long, A. B., & Caspary, T. (2021) · Genetics · doi:10.1093/genetics/iyab084 · Cited by 18 · see citing works

The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish

Chebli, J., Rahmati, M., Lashley, T., Edeman, B., Oldfors, A., Zetterberg, H., & Abramsson, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-98487-7 · Cited by 17 · see citing works

Aurora A and AKT Kinase Signaling Associated with Primary Cilia

Nishimura, Y., Yamakawa, D., Shiromizu, T., & Inagaki, M. (2021) · Cells · doi:10.3390/cells10123602 · Cited by 17 · see citing works

A cell-autonomous role for primary cilium-mediated signaling in long-range commissural axon guidance

Dumoulin, A., Wilson, N. H., Tucker, K. L., & Stoeckli, E. T. (2024) · Development · doi:10.1242/dev.202788 · Cited by 17 · see citing works

Role of lipids in the control of autophagy and primary cilium signaling in neurons

Hernández‐Cáceres, M. P., Pinto-Núñez, D., Rivera, P., Burgos, P., Díaz‐Castro, F., Criollo, A., Yañez, M. J., & Morselli, E. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.377414 · Cited by 16 · see citing works

Differentiation of ciliated human midbrain-derived LUHMES neurons

Lauter, G., Coschiera, A., Yoshihara, M., Sugiaman‐Trapman, D., Ezer, S., Sethurathinam, S., Katayama, S., Kere, J., & Swoboda, P. (2020) · Journal of Cell Science · doi:10.1242/jcs.249789 · Cited by 14 · see citing works

Signatures of adaptive evolution in platyrrhine primate genomes

Byrne, H., Webster, T. H., Brosnan, S. F., Izar, P., & Lynch, J. W. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116681119 · Cited by 14 · see citing works

Primary Cilia: The New Face of Craniofacial Research

Moore, E. R. (2022) · Biomolecules · doi:10.3390/biom12121724 · Cited by 14 · see citing works

Neuron‐specific cilia loss differentially alters locomotor responses to amphetamine in mice

Ramos-Galarza, C., Roberts, J. B., Jasso, K. R., Eyck, T. W. T., Everett, T. J., Pozo, P., Setlow, B., & McIntyre, J. C. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24755 · Cited by 14 · see citing works

A clinical and radiographic comparison of caries diagnosed in approximal surfaces of posterior teeth in a low-risk population of 14-year-old children.

Llena, C., & Forner, L. (2005) · PubMed · Cited by 14 · see citing works

The primary cilia are associated with the axon initial segment in neurons

Wang, H., Li, Y., Li, X., Sun, Z., Yu, F., Pashang, A., Kulasiri, D., Li, H. W., Chen, H., Hou, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202407405 · Cited by 13 · see citing works

Primary cilia in neural development and disease

Zhang, R., Pan, S., Zhao, J., Wang, J., Yang, X., & Qi, Z. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107184 · Cited by 13 · see citing works

Lysosomal Function and Axon Guidance: Is There a Meaningful Liaison?

Manzoli, R., Badenetti, L., Rubin, M., & Moro, E. (2021) · Biomolecules · doi:10.3390/biom11020191 · Cited by 13 · see citing works

Uncovering cilia function in glial development

Bear, R. M., & Caspary, T. (2023) · Annals of Human Genetics · doi:10.1111/ahg.12519 · Cited by 13 · see citing works

Primary cilia signalling at a glance

Wachten, D., & Christensen, S. T. (2025) · Journal of Cell Science · doi:10.1242/jcs.264187 · Cited by 12 · see citing works

Ciliary membrane, localised lipid modification and cilia function

Dutta, P., & Ray, K. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30787 · Cited by 12 · see citing works

The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development

Chen, C., Hu, J., & Ling, K. (2022) · Journal of Developmental Biology · doi:10.3390/jdb10040051 · Cited by 12 · see citing works

Intron retention as an excellent marker for diagnosing depression and for discovering new potential pathways for drug intervention

Okada, N., Oshima, K., Maruko, A., Sekine, M., Ito, N., Wakasugi, A., Mori, E., Odaguchi, H., & Kobayashi, Y. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1450708 · Cited by 9 · see citing works

Genetics behind Cerebral Disease with Ocular Comorbidity: Finding Parallels between the Brain and Eye Molecular Pathology

Chang, K.-J., Wu, H.-Y., Yarmishyn, A. A., Li, C.-Y., Hsiao, Y., Chi, Y., Lo, T.-C., Dai, H.-J., Yang, Y., Liu, D.-H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179707 · Cited by 9 · see citing works

Analysis of ciliary status via G-protein-coupled receptors localized on primary cilia

Kobayashi, Y., Hamamoto, A., & Saito, Y. (2020) · Microscopy · doi:10.1093/jmicro/dfaa035 · Cited by 9 · see citing works

Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish

D’Gama, P. P., Jeong, I., Nygård, A. M., Trinh, A., Yaksi, E., & Jurisch‐Yaksi, N. (2024) · iScience · doi:10.1016/j.isci.2024.110078 · Cited by 8 · see citing works

Mitochondrial control of ciliary gene expression and structure in striatal neurons

Ülgen, D. H., Chioino, A., Zanoletti, O., Quintana, A., Sanz, E., & Sandi, C. (2025) · The Journal of Physiology · doi:10.1113/jp287948 · Cited by 8 · see citing works

Down-Regulation of Inpp5e Associated With Abnormal Ciliogenesis During Embryonic Neurodevelopment Under Inositol Deficiency

Yue, H., Li, S., Qin, J., Gao, T., Lyu, J., Liu, Y., Wang, X., Guan, Z., Zhu, Z., Niu, B., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.579998 · Cited by 8 · see citing works

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Lu, M., Feng, R., Qin, Y., Deng, H., Lian, B., Yin, C., & Xiao, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.836527 · Cited by 8 · see citing works

Post-transcriptional and Post-translational Modifications of Primary Cilia: How to Fine Tune Your Neuronal Antenna

Rocha, C., & Prinos, P. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.809917 · Cited by 8 · see citing works

Medullary Tegmental Cap Dysplasia: Fetal and Postnatal Presentations of a Unique Brainstem Malformation

Gafner, M., Garel, C., Leibovitz, Z., Valence, S., Haratz, K. K., Oegema, R., Mancini, G. M. S., Héron, D., Bueltmann, E., Bürglen, L., et al. (2023) · American Journal of Neuroradiology · doi:10.3174/ajnr.a7805 · Cited by 7 · see citing works

A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia

Martins, M. M., Oliveira, A. R., Martins, S., Vieira, J. P., Perdigão, P. R. L., Fernandes, A. R., de Almeida, L. P., Palma, P., Sequeira, D. B., Santos, J. M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612603 · Cited by 7 · see citing works

Human LUHMES and NES cells as models for studying primary cilia in neurons

Coschiera, A., Watts, M. E., Kere, J., Tammimies, K., & Swoboda, P. (2023) · Methods in cell biology · doi:10.1016/bs.mcb.2022.12.012 · Cited by 6 · see citing works

Synapse and primary cilia dysfunctions in Autism Spectrum Disorders. Avenues to normalize these functions

Hauw, J., Hausser‐Hauw, C., & Barthélémy, C. (2024) · Revue Neurologique · doi:10.1016/j.neurol.2024.06.002 · Cited by 6 · see citing works

Cilia loss on distinct neuron populations differentially alters cocaine-induced locomotion and reward

Everett, T. J., Eyck, T. W. T., Wu, C., Shelowitz, A. L., Stansbury, S. M., Firek, A., Setlow, B., & McIntyre, J. C. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231219058 · Cited by 6 · see citing works

Hippocampal Inhibitory Interneuron‐Specific DREADDs Treatment Alters mTORC1 ‐ 4E ‐ BP Signaling and Impairs Memory Formation

Huang, Z., Mahmood, N., Lacaille, J., Wiebe, S. A., & Sonenberg, N. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70048 · Cited by 5 · see citing works

Novel compound heterozygous variants in the CSPP1 gene causes Joubert syndrome: case report and literature review of the CSPP1 gene’s pathogenic mechanism

Wei, C., Zhang, H., Fu, M., Ye, J., & Yao, B. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2024.1305754 · Cited by 5 · see citing works

The primary cilium gene CPLANE1 is required for peripheral nervous system development

Yusifov, E., Schaettin, M., Dumoulin, A., Bachmann‐Gagescu, R., & Stoeckli, E. T. (2024) · Developmental Biology · doi:10.1016/j.ydbio.2024.12.008 · Cited by 5 · see citing works

Proximity proteomics of primary cilia in human hypothalamic neuronsPreprint

Macarelli, V., Sroka, T. J., Hansen, J. N., Axelsson, U., Mick, D. U., & Merkle, F. T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.11.653368 · Cited by 5 · see citing works

Mechanisms underlying morphological and functional changes of cilia in fibroblasts derived from patients bearing ARL3 T31A and ARL3 T31A/C118F mutations

Zhang, X., Yao, S., Zhang, L., Yang, L., Yang, M., Guo, Q., Li, Y., Wang, Z., Lei, B., & Jin, X. (2024) · The FASEB Journal · doi:10.1096/fj.202301906r · Cited by 4 · see citing works

Neuronal guidance behaviours: the primary cilium perspective

Atkins, M., Fassier, C., & Nicol, X. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1612555 · Cited by 4 · see citing works

Tackling ciliary specialization to understand phenotypic variability in human primary ciliopathies

Bachmann‐Gagescu, R., & Sayer, J. A. (2025) · Journal of Cell Science · doi:10.1242/jcs.264177 · Cited by 4 · see citing works

Label-Free Visualization of Ciliary Rootlets in Mouse Brain

Murakami, Y., Nuriya, M., Hu, Z., Tomioka, M., Oketani, R., Hiramatsu, K., Leproux, P., Inoko, A., Honjoh, S., & Kano, H. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05851 · Cited by 4 · see citing works

Nanobody-directed targeting of optogenetic tools to study signaling in the primary ciliumPreprint

Hansen, J. N., Kaiser, F., Klausen, C., Stüven, B., Chong, R., Bönigk, W., Mick, D. U., Möglich, A., Jurisch‐Yaksi, N., Schmidt, F. I., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.04.933440 · Cited by 4 · see citing works

The role of primary cilia in physiological and pathological states of the central nervous system

Zhai, D., Zhou, X., Xu, Z., Chen, X., Li, Y., Li, J., Zhou, T., & Xie, S. (2025) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2025.11.011 · Cited by 3 · see citing works

Cilia at the Crossroads of Tumor Treating Fields and Chemotherapy

Deleyrolle, L. P., & Sarkisian, M. R. (2023) · Developmental Neuroscience · doi:10.1159/000529193 · Cited by 3 · see citing works

A Short Sequence Targets Transmembrane Proteins to Primary Cilia

Macarelli, V., Harding, E. C., Gershlick, D. C., & Merkle, F. T. (2024) · Cells · doi:10.3390/cells13131156 · Cited by 3 · see citing works

The role of ciliopathy-associated type 3 adenylyl cyclase in infanticidal behavior in virgin adult male mice

Wu, X., Yang, D. J., Zhou, Y., Li, S., & Wang, Z. (2022) · iScience · doi:10.1016/j.isci.2022.104534 · Cited by 3 · see citing works

Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neuronsPreprint

Brahmia, B., Naaldijk, Y., Sarkar, P., Parisiadou, L., & Hilfiker, S. (2024) · eLife · doi:10.7554/elife.101135.1 · Cited by 3 · see citing works

A ciliary synapse for “short-circuit” neuromodulation

Simon, D. J., & Levitz, J. (2022) · Cell · doi:10.1016/j.cell.2022.08.006 · Cited by 2 · see citing works

Shared and unique consequences of Joubert Syndrome gene dysfunction on the zebrafish central nervous system

Noble, A. R., Masek, M., Hofmann, C., Cuoco, A., Rusterholz, T. D. S., Özkoç, H., Greter, N. R., Phelps, I. G., Vladimirov, N., Kollmorgen, S., et al. (2024) · Biology Open · doi:10.1242/bio.060421 · Cited by 2 · see citing works

RBP-Driven RNA sorting and local translation establish the molecular identities of individual sensory axons

Silagi, E. S., Nduka, E., Paiz, J. H., Pazyra‐Murphy, M. F., Bhuiyan, S. A., Renthal, W. R., & Segal, R. A. (2026) · Nature Communications · doi:10.1038/s41467-026-77192-x · Cited by 2 · see citing works

Amyloid precursor protein localises to ependymal cilia in vertebrates and is required for ciliogenesis and brain development in zebrafishPreprint

Chebli, J., Rahmati, M., Lashley, T., Edeman, B., Oldfors, A., Zetterberg, H., & Abramsson, A. (2021) · Research Square · doi:10.21203/rs.3.rs-629681/v1 · Cited by 1 · see citing works

Primary Cilia and Brain Wiring, Connecting the Dots

Song, Q., & Gleeson, J. G. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.11.017

Physiological roles of amyloid precursor protein in vivo - zebrafish as a model

Chebli, J. (2021) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Optical Approaches for Dissecting GPCR Signaling

O’Neill, P., Copits, B. A., & Bruchas, M. R. (2022) · Wiley eBooks · doi:10.1002/9781119564782.ch25

Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neuronsPreprint

Brahmia, B., Naaldijk, Y., Sarkar, P., Parisiadou, L., & Hilfiker, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.16.603799

eLife Assessment: Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons

West, A. B. (2024) · eLife · doi:10.7554/elife.101135.1.sa3

Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neuronsPreprint

Brahmia, B., Naaldijk, Y., Sarkar, P., Parisiadou, L., & Hilfiker, S. (2024) · eLife · doi:10.7554/elife.101135

Functional impairments, known genetic disorders, and review reports of established and possible therapies for specific genetic diseases

Smith, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23648-8.00006-1

Additional file 9 of Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease

Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614915

Additional file 2 of Primary cilia promote the differentiation of human neurons through the WNT signaling pathway

Coschiera, A., Yoshihara, M., Lauter, G., Ezer, S., Pucci, M., Li, H., Kavšek, A., Riedel, C. G., Kere, J., & Swoboda, P. (2024) · Figshare · doi:10.6084/m9.figshare.25303175

Additional file 1 of Primary cilia promote the differentiation of human neurons through the WNT signaling pathway

Coschiera, A., Yoshihara, M., Lauter, G., Ezer, S., Pucci, M., Li, H., Kavšek, A., Riedel, C. G., Kere, J., & Swoboda, P. (2024) · Figshare · doi:10.6084/m9.figshare.25303088

Additional file 14 of Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease

Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614924

Additional file 7 of Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease

Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614909

Additional file 3 of Primary cilia promote the differentiation of human neurons through the WNT signaling pathway

Coschiera, A., Yoshihara, M., Lauter, G., Ezer, S., Pucci, M., Li, H., Kavšek, A., Riedel, C. G., Kere, J., & Swoboda, P. (2024) · Figshare · doi:10.6084/m9.figshare.26686062

Additional file 10 of Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease

Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614918

Additional file 13 of Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease

Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614921

Additional file 15 of Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease

Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614927

Additional file 1 of Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease

Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614906

Additional file 8 of Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer’s disease

Jang, J., Yeo, S., Baek, S., Jung, H. J., Lee, M. S., Choi, S. H., & Choe, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26614912

Kallmann syndrome with situs inversus: An unreported association

Gaikwad, P., & Saha, R. (2025) · IJEM Case Reports · doi:10.4103/ijemcr.ijemcr_37_25

INPP5E interactome reveals novel connections to growth factor signaling

Martin-Morales, R., Barbeito, P., Sierra‐Rodero, B., Jiménez, L., Holm, M. S., Grijalva-Bravo, A., Cilleros-Rodríguez, D., Ebert, L. K., Fernandez, M. C., Pedersen, L. B., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-03177-4

Primary Cilia and Brain Wiring, Connecting the Dots

Song, Q., & Gleeson, J. G. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.11.017

Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation

Higginbotham, H., Guo, J., Yokota, Y., Umberger, N. L., Su, C.-Y., Li, J., Verma, N., Hirt, J., Ghukasyan, V., Caspary, T., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3451 · Cited by 216 · see citing works

A new mouse model for the neurodevelopmental ciliopathy Joubert syndrome

Bachmann‐Gagescu, R. (2019) · The Journal of Pathology · doi:10.1002/path.5291 · Cited by 3 · see citing works

Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity

Guo, J., Otis, J. M., Higginbotham, H., Monckton, C., Cheng, J., Asokan, A., Mykytyn, K., Caspary, T., Stuber, G. D., & Anton, E. S. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.07.010 · Cited by 136 · see citing works

The role of primary cilia in neuronal function

Lee, J. H., & Gleeson, J. G. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.022 · Cited by 133 · see citing works