Fragile X mental retardation protein (FMRP) interacting proteins exhibit different expression patterns during development
Abstract
Fragile X syndrome is caused by the lack of expression of fragile X mental retardation protein (FMRP), an RNA-binding protein involved in mRNA transport and translation. FMRP is a component of mRNA ribonucleoprotein complexes and it can interact with a range of proteins either directly or indirectly, as demonstrated by two-hybrid selection and co-immunoprecipitation, respectively. Most of FMRP-interacting proteins are RNA-binding proteins such as FXR1P, FXR2P and 82-FIP. Interestingly, FMRP can also interact directly with the cytoplasmic proteins CYFIP1 and CYFIP2, which do not bind RNA and link FMRP to the RhoGTPase pathway. The interaction with these different proteins may modulate the functions of FMRP by influencing its affinity to RNA and by affecting the FMRP ability of cytoskeleton remodeling through Rho/Rac GTPases. To better define the relationship of FMRP with its interacting proteins during brain development, we have analyzed the expression pattern of FMRP and its interacting proteins in the cortex, striatum, hippocampus and cerebellum at different ages in wild type (WT) mice. FMRP and FXR2P were strongly expressed during the first week and gradually decreased thereafter, more rapidly in the cerebellum than in the cortex. FXR1P was also expressed early and showed a reduction at later stages of development with a similar developmental pattern in these two regions. CYFIP1 was expressed at all ages and peaked in the third post-natal week. In contrast, CYFIP2 and 82-FI…
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The expression of CYFIP1 and CYFIP2 appears differently modulated in different brain regions during post-natal brain development, while the three FXR proteins have the same expression pattern during development.
“(ii) the expression of the two proteins appears differently modulated in different brain regions during post-natal brain development, while the three FXR proteins have the same expression pattern during development (Bonaccorso et al., 2015);”
From New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes (2017) · cites this paper as Bonaccorso et al., 2015
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“, 2009), a large number of studies focused on the role of these proteins both within neurons and during neuronal development (Abekhoukh and Bardoni, 2014; Bonaccorso et al., 2015) because of the functional links of these proteins to Received 3 April 2016; Accepted 2 February 2017 1Université Côte d’Azur, Nice, France.”
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Liu, X., Kumar, V., Tsai, N.-P., & Auerbach, B. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.805929 · Cited by 53 · see citing works
- Authors
- Bonaccorso, C. M., Spatuzza, M., Di Marco, B., Gloria, A., Barrancotto, G., Cupo, A., Musumeci, S. A., D'Antoni, S., Bardoni, B., & Catania, M. V.
- Affiliations
- Oasi Maria SS (IT)
- Institute of Neurological Sciences (IT)
- Institute of Neurological Sciences, CNR Catania Italy
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Catania, M.V.
- Venue
- International Journal of Developmental Neuroscience
- Publisher
- Wiley
- Published
- 2015-02-11
- Volume
- 42
- Issue
- 1
- Pages
- 15-23
- ISSN
- 0736-5748 (ISSN-L)
- 1873-474X
- OpenAlex
- W1986381972
- Cited by
- 52
- References
- 10
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 4
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- FMRP, fragile X syndrome, FXR1P, CYFIP1, CYFIP2, brain development, postnatal development, mRNA-binding proteins, cytoskeletal remodeling, RNA-binding proteins, gene expression patterns, mouse brain
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Animals, Newborn, Brain, Cells, Cultured, Glial Fibrillary Acidic Protein, Hippocampus, Microtubule-Associated Proteins, Nerve Tissue Proteins, Neurons, RNA-Binding Proteins, Mice, Knockout, Gene Expression Regulation, Developmental, Mice, Fragile X Messenger Ribonucleoprotein 1
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