Cited by 251Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanismsRNA Research and Splicing

The fragile X mental retardation protein is associated with ribosomes

Khandjian, Edouard W., Corbin, François, Woerly, Stephane, Rousseau, François·1996·Nature Genetics

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Crossref · 10.1038/ng0196-91

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  • FMRP co-immunoprecipitated with rpP0-containing complexes, as did ribosomal proteins rpL5 and rpS6, demonstrating a direct association of FMRP with ribosome-containing complexes.

    “FMRP co-IP’d with rpP0-containing complexes, as did the ribosomal proteins rpL5 and rpS6 (Figure 7H), demonstrating a direct association of FMRP with ribosome-containing complexes, reminiscent of previous findings in cultured cells (Khandjian et al., 1996; Siomi et al., 1996).”

    From FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism (2011) · cites this paper as Khandjian et al., 1996

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Authors
Khandjian, E. W., Corbin, F., Woerly, S., & Rousseau, F.
Affiliations
Hôpital Saint-François d'Assise (CA)
Venue
Nature Genetics
Published
1996-01
Volume
12
Issue
1
Pages
91-93
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
OpenAlex
W2026456570
Cited by
251
References
30
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 10 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 12 · 2013: 8 · 2012: 5
FWCI
9.81
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Genetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
FMRP, fragile X syndrome, ribosome association, 60S ribosomal subunit, CGG repeat expansion, FMR1 gene silencing, RNA-binding proteins, translation machinery, neurons, polysomes
MeSH terms
Animals, Cell Compartmentation, Fragile X Syndrome, HeLa Cells, Humans, Nerve Tissue Proteins, Protein Binding, Ribosomes, Protein Biosynthesis, 3T3 Cells, RNA-Binding Proteins, Fluorescent Antibody Technique, Indirect, Mice, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein

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