The fragile X mental retardation protein is associated with ribosomes
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FMRP co-immunoprecipitated with rpP0-containing complexes, as did ribosomal proteins rpL5 and rpS6, demonstrating a direct association of FMRP with ribosome-containing complexes.
“FMRP co-IP’d with rpP0-containing complexes, as did the ribosomal proteins rpL5 and rpS6 (Figure 7H), demonstrating a direct association of FMRP with ribosome-containing complexes, reminiscent of previous findings in cultured cells (Khandjian et al., 1996; Siomi et al., 1996).”
From FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism (2011) · cites this paper as Khandjian et al., 1996
Cites
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481 · see citing works
Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome
Oberlé, I., Rousseau, F., Heitz, D., Kretz, C., Devys, D., Hanauer, A., Boué, J., Bertheas, M. F., & Mandel, J. L. (1991) · Science · doi:10.1126/science.252.5009.1097 · Cited by 1,499 · see citing works
Self-citationAbsence of expression of the FMR-1 gene in fragile X syndrome
Pieretti, M., Zhang, F., Fu, Y.-H., Warren, S. T., Oostra, B. A., Caskey, C. T., & Nelson, D. L. (1991) · Cell · doi:10.1016/0092-8674(91)90125-i · Cited by 1,476 · see citing works
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,075 · see citing works
Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG)n
Kremer, E., Pritchard, M., Lynch, M., Yu, S., Holman, K., Baker, E., Warren, S., Schlessinger, D., Sutherland, G., & Richards, R. (1991) · Science · doi:10.1126/science.1675488 · Cited by 929 · see citing works
Devys, D., Lutz, Y., Rouyer, N., Bellocq, J., & Mandel, J. (1993) · Nature Genetics · doi:10.1038/ng0893-335 · Cited by 781 · see citing works
Ross, M. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-2-286_5 · Cited by 758 · see citing works
FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding
Ashley, C. T., Wilkinson, K. D., Reines, D., & Warren, S. T. (1993) · Science · doi:10.1126/science.7692601 · Cited by 741 · see citing works
Lerner, E. A., Lerner, M. R., Janeway, C. A., & STEITZ, J. A. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.2737 · Cited by 718 · see citing works
DNA methylation represses <i>FMR-1</i> transcription in fragile X syndrome
Sutcliffe, J. S., Nelson, D. L., Zhang, F., Pieretti, M., Caskey, C. T., Saxe, D., & Warren, S. T. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.6.397 · Cited by 680 · see citing works
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.
Siomi, H., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1993) · Cell · doi:10.1016/0092-8674(93)90420-u · Cited by 641 · see citing works
Moldave, K. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.005333 · Cited by 541 · see citing works
Regulation of Translation in Eukaryotic Systems
Kozak, M. (1992) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.08.110192.001213 · Cited by 467 · see citing works
Siomi, H., Choi, M., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1994) · Cell · doi:10.1016/0092-8674(94)90232-1 · Cited by 446 · see citing works
Dissociation of Mammalian Polyribosomes into Subunits by Puromycin
Blobel, G., & Sabatini, D. M. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.2.390 · Cited by 440 · see citing works
Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome
Hinds, H. L., Ashley, C. T., Sutcliffe, J. S., Nelson, D. L., Warren, S. T., Housman, D. E., & Schalling, M. (1993) · Nature Genetics · doi:10.1038/ng0193-36 · Cited by 396 · see citing works
Characterization and localization of the FMR-1 gene product associated with fragile X syndrome
Verheij, C., Bakker, C. E., de Graaff, E., Keulemans, J., Willemsen, R., Verkerk, A. J. M. H., Galjaard, H., Reuser, A. J. J., Hoogeveen, A. T., & Oostra, B. A. (1993) · Nature · doi:10.1038/363722a0 · Cited by 343 · see citing works
Abitbol, M. M., Ménini, C., Delezoide, A., Rhyner, T. A., Vekemans, M. J. J., & Mallet, J. J. (1993) · Nature Genetics · doi:10.1038/ng0693-147 · Cited by 284 · see citing works
FXR1, an autosomal homolog of the fragile X mental retardation gene.
Siomi, M. C., Siomi, H., Sauer, W. H., Srinivasan, S., Nussbaum, R. L., & Dreyfuss, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07237.x · Cited by 237 · see citing works
Bloom and Fawcett: A Textbook of Histology
Hill, R. B. (1986) · JAMA · doi:10.1001/jama.1986.03380100140043 · Cited by 220 · see citing works
Sittler, A., Devys, D., Weber, C., & Mandel, J.-L. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.1.95 · Cited by 198 · see citing works
Khandjian, E. W., Anny, F., Thibodeau, A., Tremblay, S., Côté, F., Devys, D., Mandel, J.-L., & Rousseau, F. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.5.783 · Cited by 141 · see citing works
Self-citationZiemiecki, A., Müller, R., Fu, X., Hynes, N. E., & Kozma, S. C. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08095.x · Cited by 86 · see citing works
Characterization of FMR1 proteins isolated from different tissues
Verhelj, C., de Graaff, E., Bakker, C. E., Willemsen, R., Willems, P. J., Meijer, N., GALJAARD, H., Reuser, A. J. J., Oostra, B. A., & Hoogeveen, A. T. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.5.895 · Cited by 85 · see citing works
Tissue-specific expression of a FMR1/β-galactosidase fusion gene in transgenic mice
Hergersberg, M., Matsuo, K., Gassmann, M., Schaffner, W., Lüscher, B., Rülicke, T., & Aguzzi, A. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.3.359 · Cited by 71 · see citing works
Turnover of protein in the nervous system
Lajtha, Á., & Dunlop, D. S. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90030-8 · Cited by 66 · see citing works
Siegmann, M., & Thomas, G. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(87)46037-0 · Cited by 37 · see citing works
Ogata, K., & Terao, K. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)59110-1 · Cited by 22 · see citing works
Central nervous system function in systemic lupus erythematosus
Elkon, K. B., Weissbach, H., & Brot, N. (1990) · Neurochemical Research · doi:10.1007/bf00969925 · Cited by 6 · see citing works
Ogata, K., & Terao, K. (1981) · Elsevier eBooks · doi:10.1016/b978-0-12-504180-5.50061-4 · Cited by 2 · see citing works
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FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072 · see citing works
Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109 · see citing works
Hagerman, R. J., Berry-Kravis, E., Hazlett, H. C., Bailey, D. B., Moine, H., Kooy, R. F., Tassone, F., Gantois, I., Sonenberg, N., Mandel, J. L., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.65 · Cited by 838 · see citing works
Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
Ramboz, S., Oosting, R. S., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M. M., Mann, J. J., Brunner, D., & Hen, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14476 · Cited by 813 · see citing works
Zalfa, F., Giorgi, M., Primerano, B., Moro, A., Di Penta, A., Reis, S., Oostra, B., & Bagni, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00079-5 · Cited by 676 · see citing works
Weiler, I. J., Irwin, S. A., Klintsova, A. Y., Spencer, C. M., Brazelton, A. D., Miyashiro, K., Comery, T. A., Patel, B., Eberwine, J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5395 · Cited by 644 · see citing works
Zhang, Y., Bailey, A. M., Matthies, H. J. G., Renden, R., Smith, M. A., Speese, S. D., Rubin, G. M., & Broadie, K. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00589-x · Cited by 641 · see citing works
Feng, Y., Gutekunst, C.-A., Eberhart, D. E., Yi, H., Warren, S. T., & Hersch, S. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01539.1997 · Cited by 532 · see citing works
Feng, Y., Absher, D., Eberhart, D. E., Brown, V., Malter, H. E., & Warren, S. T. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80012-x · Cited by 511 · see citing works
A Decade of Molecular Studies of Fragile X Syndrome
O'Donnell, W. T., & Warren, S. T. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142909 · Cited by 481 · see citing works
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
Bagni, C., & Greenough, W. T. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1667 · Cited by 475 · see citing works
Eberhart, D. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.8.1083 · Cited by 390 · see citing works
The molecular biology of FMRP: new insights into fragile X syndrome
Richter, J. D., & Zhao, X. (2021) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00432-0 · Cited by 390 · see citing works
The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)
Bhakar, A. L., Dölen, G., & Bear, M. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153138 · Cited by 370 · see citing works
Mazrouï, R. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.24.3007 · Cited by 369 · see citing works
Translational control in synaptic plasticity and cognitive dysfunction
Buffington, S. A., Huang, W., & Costa-Mattioli, M. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014100 · Cited by 348 · see citing works
Fragile X premutations and (TA)n estrogen receptor polymorphism in women with ovarian dysfunction
Syrrou, M., Georgiou, I. A., Patsalis, P. C., Bouba, I., Adonakis, G., & Pagoulatos, G. N. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990528)84:3 · Cited by 33 · see citing works
RNA and microRNAs in fragile X mental retardation
Jin, P., Alisch, R. S., & Warren, S. T. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1048 · Cited by 344 · see citing works
Fragile X mice develop sensory hyperreactivity to auditory stimuli
Chen, L., & Toth, M. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00036-7 · Cited by 345 · see citing works
BRCA1 interacts with components of the histone deacetylase complex
Yarden, R. I., & Brody, L. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.4983 · Cited by 328 · see citing works
Phosphorylation influences the translation state of FMRP-associated polyribosomes
Ceman, S., O'Donnell, W. T., Reed, M., Patton, S., Pohl, J., & Warren, S. T. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg350 · Cited by 327 · see citing works
Trinucleotide Repeats: Mechanisms and Pathophysiology
Cummings, C. J., & Zoghbi, H. Y. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.281 · Cited by 326 · see citing works
Paradee, W., Melikian, H. E., Rasmussen, D. L., Kenneson, A., Conn, P. J., & Warren, S. T. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00285-7 · Cited by 305 · see citing works
Darnell, J. C., Fraser, C. E., Mostovetsky, O., Stefani, G., Jones, T. A., Eddy, S. R., & Darnell, R. B. (2005) · Genes & Development · doi:10.1101/gad.1276805 · Cited by 287 · see citing works
(Over)correction of FMR1 deficiency with YAC transgenics: behavioral and physical features
Peier, A. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.8.1145 · Cited by 285 · see citing works
Wan, L., Dockendorff, T. C., Jongens, T. A., & Dreyfuss, G. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.22.8536-8547.2000 · Cited by 280 · see citing works
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells
Stefani, G., Fraser, C. E., Darnell, J. C., & Darnell, R. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2306-04.2004 · Cited by 274 · see citing works
Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions
Nussbacher, J. K., Tabet, R., Yeo, G. W.-M., & Lagier‐Tourenne, C. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.014 · Cited by 264 · see citing works
Siomi, M. C., Zhang, Y., Siomi, H., & Dreyfuss, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3825 · Cited by 271 · see citing works
Vries, B. B. A. D., Halley, D. J. J., Oostra, B. A., & Niermeijer, M. F. (1998) · Journal of Medical Genetics · doi:10.1136/jmg.35.7.579 · Cited by 260 · see citing works
Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome
Krueger, D. D., & Bear, M. F. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-061109-134644 · Cited by 259 · see citing works
Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome
Chen, E., Sharma, M. R., Shi, X., Agrawal, R. K., & Joseph, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.023 · Cited by 240 · see citing works
Corbin, F. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.9.1465 · Cited by 235 · see citing works
Self-citationRNA TRANSPORT AND LOCAL CONTROL OF TRANSLATION
Kindler, S., Wang, H., Richter, D., & Tiedge, H. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.120653 · Cited by 215 · see citing works
The State of Synapses in Fragile X Syndrome
Pfeiffer, B. E., & Huber, K. M. (2009) · The Neuroscientist · doi:10.1177/1073858409333075 · Cited by 214 · see citing works
Molecular Insights into mRNA Transport and Local Translation in the Mammalian Nervous System
Kiebler, M. A., & DesGroseillers, L. (2000) · Neuron · doi:10.1016/s0896-6273(00)80868-5 · Cited by 202 · see citing works
Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis
Tamanini, F. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.8.1315 · Cited by 198 · see citing works
Brown, V., Small, K. M., Lakkis, L., Feng, Y., Gunter, C., Wilkinson, K. D., & Warren, S. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15521 · Cited by 192 · see citing works
The ubiquitous nature of RNA chaperone proteins
Cristofari, G., & Darlix, J. (2002) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(02)72071-0 · Cited by 179 · see citing works
Khandjian, E. W., Huot, M.-E., Tremblay, S., Davidovic, L., Mazroui, R., & Bardoni, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405398101 · Cited by 178 · see citing works
The GABAA receptor: a novel target for treatment of fragile X?
D’Hulst, C., & Kooy, R. F. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.003 · Cited by 166 · see citing works
Darnell, J. C., Fraser, C., Mostovetsky, O., & Darnell, R. B. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp255 · Cited by 157 · see citing works
McConkie‐Rosell, A., Finucane, B. M., Cronister, A., Abrams, L. J., Bennett, R. L., & Pettersen, B. J. (2005) · Journal of Genetic Counseling · doi:10.1007/s10508-005-0002-3 · Cited by 161 · see citing works
Chen, L., Yun, S.-W., Seto, J., Liu, W., & Toth, M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00406-8 · Cited by 160 · see citing works
Xu, D., Shen, W., Guo, R., Xue, Y., Peng, W., Sima, J., Yang, J., Sharov, A. A., Srikantan, S., Yang, J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3479 · Cited by 146 · see citing works
A mouse model of the human Fragile X syndrome I304N mutation
Zang, J. B., Nosyreva, E. D., Spencer, C. M., Volk, L. J., Musunuru, K., Zhong, R., Stone, E. F., Yuva-Paylor, L. A., Huber, K. M., Paylor, R., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000758 · Cited by 138 · see citing works
FMRP is associated to the ribosomes via RNA
Tamanini, F. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.6.809 · Cited by 137 · see citing works
Larson, J., Jessen, R. E., Kim, D., Fine, A.-K. S., & du Hoffmann, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2638-05.2005 · Cited by 135 · see citing works
A nuclear role for the Fragile X mental retardation protein.
Fridell, R. A., Benson, R. E., Hua, J., Bogerd, H. P., & Cullen, B. R. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00924.x · Cited by 129 · see citing works
Cytoplasmic RNA-Binding Proteins and the Control of Complex Brain FunctionPreprint
Darnell, J. C., & Richter, J. D. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012344 · Cited by 124 · see citing works
Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model
Heulens, I., D’Hulst, C., Dam, D. V., Deyn, P. P. D., & Kooy, R. F. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.01.031 · Cited by 125 · see citing works
Chen, T., & Richard, S. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.8.4863 · Cited by 123 · see citing works
Knockout mouse model for Fxr2: a model for mental retardation
Bontekoe, C. J. M. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.5.487 · Cited by 120 · see citing works
Methylation regulates the intracellular protein-protein and protein-RNA interactions of FMRP
Dolzhanskaya, N., Merz, G., Aletta, J. M., & Denman, R. B. (2006) · Journal of Cell Science · doi:10.1242/jcs.02882 · Cited by 119 · see citing works
Santini, E., & Klann, E. (2014) · Science Signaling · doi:10.1126/scisignal.2005832 · Cited by 118 · see citing works
MOV10 and FMRP Regulate AGO2 Association with MicroRNA Recognition Elements
Kenny, P., Zhou, H., Kim, M., Skariah, G., Khetani, R. S., Drnevich, J. M., Arcila, M. L., Kosik, K. S., & Ceman, S. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.054 · Cited by 115 · see citing works
Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA
Blackwell, E., Zhang, X., & Ceman, S. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq007 · Cited by 117 · see citing works
TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules
Goulet, I., Boisvenue, S., Mokas, S., Mazrouï, R., & Côté, J. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn203 · Cited by 115 · see citing works
Novel isoforms of the fragile X related protein FXR1P are expressed during myogenesis
Khandjian, E. W. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.13.2121 · Cited by 114 · see citing works
Self-citationFragile X Syndrome: from molecular pathology to therapy
Maurin, T., Zongaro, S., & Bardoni, B. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.006 · Cited by 113 · see citing works
Tamanini, F., Bontekoe, C. J. M., Bakker, C. E., van Unen, L., Anar, B., Willemsen, R., Yoshida, M., GALJAARD, H., Oostra, B. A., & Hoogeveen, A. T. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.863 · Cited by 112 · see citing works
Smart, F. M., Aschrafi, A., Atkins, A. R., Owens, G. C., Pilotte, J., Cunningham, B. A., & Vanderklish, P. W. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04521.x · Cited by 109 · see citing works
Fatimy, R. E., Davidovic, L., Tremblay, S., Jaglin, X. H., Dury, A. Y., Robert, C., Koninck, P. D., & Khandjian, É. W. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006192 · Cited by 107 · see citing works
Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome
Scharf, S. H., Jaeschke, G., Wettstein, J. G., & Lindemann, L. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2014.11.004 · Cited by 106 · see citing works
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons
Tabet, R., Moutin, E., Becker, J. A. J., Heintz, D., Fouillen, L., Flatter, E., Krężel, W., Alunni, V., Koebel, P., Dembélé, D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522631113 · Cited by 103 · see citing works
McNicoll, F., Müller-McNicoll, M., Cloutier, S., Boilard, N., Rochette, A., Dubé, M., & Papadopoulou, B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507511200 · Cited by 100 · see citing works
The fragile X syndrome: exploring its molecular basis and seeking a treatment
Bardoni, B., Davidovic, L., Bensaid, M., & Khandjian, É. W. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399406010751 · Cited by 100 · see citing works
Adinolfi, S., Bagni, C., Musco, G., Gibson, T. J., Mazzarella, L., & Pastore, A. (1999) · RNA · doi:10.1017/s1355838299990647 · Cited by 96 · see citing works
Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation
Qin, M., Kang, J. Y., & Smith, C. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242377399 · Cited by 93 · see citing works
LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway
Liu, L., Yue, H., Liu, Q., Yuan, J., Li, J., Wei, G., Chen, X., Lu, Y., Guo, M., Luo, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7487 · Cited by 91 · see citing works
Shah, S., Molinaro, G., Liu, B., Wang, R., Huber, K. M., & Richter, J. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.076 · Cited by 91 · see citing works
Sung, Y. J., Dolzhanskaya, N., Nolin, S. L., Brown, T., Currie, J. R., & Denman, R. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211117200 · Cited by 89 · see citing works
Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein
Bhogal, B., Jepson, J. E. C., Savva, Y. A., Pepper, A. S.-R., Reenan, R. A., & Jongens, T. A. (2011) · Nature Neuroscience · doi:10.1038/nn.2950 · Cited by 87 · see citing works
Tamanini, F., van Unen, L., Bakker, C. E., Sacchi, N., GALJAARD, H., Oostra, B. A., & Hoogeveen, A. T. (1999) · Biochemical Journal · doi:10.1042/bj3430517 · Cited by 88 · see citing works
Understanding fragile X syndrome: insights from animal models
Bakker, C. E., & Oostra, B. A. (2003) · Cytogenetic and Genome Research · doi:10.1159/000072845 · Cited by 87 · see citing works
Kallmann syndrome gene (KAL-X) is not mutated in schizophrenia
O’Neill, M. J., Brewer, W. J., Thornley, C., Copolov, D., Warne, G. L., Sinclair, A. H., Forrest, S., & Williamson, R. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990205)88:1 · Cited by 7 · see citing works
Siomi, M. C., Higashijima, K., Ishizuka, A., & Siomi, H. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8438-8447.2002 · Cited by 85 · see citing works
Disordered RNA chaperone proteins: from functions to disease
Iványi-Nagy, R., Davidovic, L., Khandjian, E. W., & Darlix, J. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5100-9 · Cited by 82 · see citing works
Self-citationMazrouï, R. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg335 · Cited by 82 · see citing works
Kozikowski, A. P., Shen, S., Pardo, M., Tavares, M. T., Szarics, D., Benoy, V., Zimprich, C., Kutil, Z., Zhang, G., Bařinka, C., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00600 · Cited by 80 · see citing works
Analysis of Domains Affecting Intracellular Localization of the FMRP Protein
Bardoni, B., Sittler, A., Shen, Y., & Mandel, J. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0142 · Cited by 80 · see citing works
Biology of the fragile X mental retardation protein, an RNA-binding protein
Khandjian, É. W. (1999) · Biochemistry and Cell Biology · doi:10.1139/bcb-77-4-331 · Cited by 79 · see citing works
Fragile X syndrome at the turn of the century
Kooy, R. F., Willemsen, R., & Oostra, B. A. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01674-9 · Cited by 79 · see citing works
Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knockout Mice
Sharma, S. D., Metz, J. B., Li, H., Hobson, B. D., Hornstein, N. J., Sulzer, D., Tang, G., & Sims, P. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.086 · Cited by 71 · see citing works
The fragile X mental retardation protein has nucleic acid chaperone properties
Gabus, C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh535 · Cited by 74 · see citing works
The genetic basis of cognition
Flint, J. (1999) · Brain · doi:10.1093/brain/122.11.2015 · Cited by 74 · see citing works
La Protein Is Associated with Terminal Oligopyrimidine mRNAs in Actively Translating Polysomes
Cardinali, B., Carissimi, C., Gravina, P., & Pierandrei‐Amaldi, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300722200 · Cited by 73 · see citing works
Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions
Häfner, S. J., Jansson, M., Altinel, K., Andersen, K. L., Abay-Nørgaard, Z., Ménard, P., Fontenas, M., Sørensen, D. M., Gay, D. M., Arendrup, F. S., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.06.007 · Cited by 72 · see citing works
The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation
Francisco‐Velilla, R., Fernández-Chamorro, J., Ramajo, J., & Martı́nez-Salas, E. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw702 · Cited by 71 · see citing works
Musumeci, S. A., Calabrese, G., Bonaccorso, C. M., D'Antoni, S., Brouwer, J. R., Bakker, C. E., Elia, M., Ferri, R., Nelson, D. L., Oostra, B. A., et al. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.08.007 · Cited by 70 · see citing works
Castrén, M. L., & Ċastrén, E. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.018 · Cited by 68 · see citing works
Verma, V., Paul, A., Vishwanath, A. A., Vaidya, B., & Clement, J. P. (2019) · Open Biology · doi:10.1098/rsob.180265 · Cited by 65 · see citing works
Fathoming fragile X in fruit flies
Zhang, Y., & Broadie, K. S. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.11.003 · Cited by 66 · see citing works
Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins
Chen, E., & Joseph, S. (2015) · Biochimie · doi:10.1016/j.biochi.2015.02.005 · Cited by 63 · see citing works
Novel RNA-binding motif: The KH module
Adinolfi, S., Bagni, C., Morelli, M. A. C., Fraternali, F., Musco, G., & Pastore, A. (1999) · Biopolymers · doi:10.1002/(sici)1097-0282(1999)51:2 · Cited by 65 · see citing works
Kunde, S., Musante, L., Grimme, A., Fischer, U., Müller, E., Wanker, E. E., & Kalscheuer, V. M. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr430 · Cited by 64 · see citing works
Alternative Splicing in the Murine and Human FXR1 Genes
Kirkpatrick, L., McIlwain, K. A., & Nelson, D. L. (1999) · Genomics · doi:10.1006/geno.1999.5868 · Cited by 63 · see citing works
Zanotti, K. J., Lackey, P. E., Evans, G. L., & Mihailescu, M. (2006) · Biochemistry · doi:10.1021/bi060209a · Cited by 61 · see citing works
Drouin, R., Angers, M., Dallaire, N., Rose, T. M., Khandjian, E. W., & Rousseau, F. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.12.2051 · Cited by 61 · see citing works
Self-citationScreening for fragile X syndrome.
Murray, Cuckle, Taylor, & Hewison (1997) · Health Technology Assessment · doi:10.3310/hta1040 · Cited by 60 · see citing works
- Authors
- Khandjian, E. W., Corbin, F., Woerly, S., & Rousseau, F.
- Affiliations
- Hôpital Saint-François d'Assise (CA)
- Venue
- Nature Genetics
- Published
- 1996-01
- Volume
- 12
- Issue
- 1
- Pages
- 91-93
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2026456570
- Cited by
- 251
- References
- 30
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 10 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 6 · 2014: 12 · 2013: 8 · 2012: 5
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- FMRP, fragile X syndrome, ribosome association, 60S ribosomal subunit, CGG repeat expansion, FMR1 gene silencing, RNA-binding proteins, translation machinery, neurons, polysomes
- MeSH terms
- Animals, Cell Compartmentation, Fragile X Syndrome, HeLa Cells, Humans, Nerve Tissue Proteins, Protein Binding, Ribosomes, Protein Biosynthesis, 3T3 Cells, RNA-Binding Proteins, Fluorescent Antibody Technique, Indirect, Mice, Fragile X Messenger Ribonucleoprotein 1, Fragile X Mental Retardation Protein
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