Predictors of preterm birth
Abstract
Objective: This is a systematic review to assess published scientific evidence on preterm birth predictors. Methods: An Internet search for predictors of preterm birth was performed and the evidence level of each method was evaluated. Results: There is strong evidence that preterm birth can be predicted using vaginal sonography to evaluate cervical characteristics, fetal fibronectin in cervicovaginal secretions and interleukin‐6 in amniotic fluid. There is consistent evidence that digital cervical examination is a weak predictor, and controversy regarding home uterine activity monitoring. There is scanty evidence about the predictive ability of maternal history and perceptions of symptoms since the study design fails to provide high evidence level. Conclusion: Cervical evaluation by vaginal sonography, fetal fibronectin and interleukin‐6 are the best methods for predicting preterm birth.
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Vaginal bleeding caused by placental abruption or placenta preavia is associated with a very high risk of preterm delivery, and first- or second-trimester bleeding not associated with either is also associated with subsequent preterm birth.
“Vaginal bleeding caused by placental abruption or placenta preavia is associated with a very high risk of preterm delivery, but bleeding in the first and second trimesters that is not associated with either placental abruption or placenta preavia is also associated with subsequent preterm birth.43”
From Epidemiology and causes of preterm birth (2008) · cites this paper as [43]
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- Authors
- Krupa, F. G., Faltin, D., Cecatti, J. G., Surita, F. G. C., & Souza, J. P.
- Affiliations
- Universidade Estadual de Campinas (UNICAMP) (BR)
- University of Geneva (CH)
- Corresponding author
- Cecatti, J.G.
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 2006-05-24
- Volume
- 94
- Issue
- 1
- Pages
- 5-11
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- 1879-3479
- OpenAlex
- W2127757901
- Cited by
- 97
- References
- 68
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 10 · 2013: 5 · 2012: 7
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Gynecology & Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- preterm birth, preterm birth prediction, vaginal sonography, cervical length, fetal fibronectin, cervicovaginal secretions, interleukin-6, amniotic fluid, uterine activity monitoring, maternal history
- MeSH terms
- Amniotic Fluid, Female, Fetus, Fibronectins, Humans, Infant, Newborn, Magnetic Resonance Imaging, Predictive Value of Tests, Pregnancy, Uterine Contraction, Uterus, Vagina, Interleukin-6, Ultrasonography, Prenatal, Monitoring, Ambulatory, Premature Birth
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