Disturbed Sleep, a Novel Risk Factor for Preterm Birth?
Open accessAbstract
Objective: The etiology of preterm birth (PTB) is likely caused by multiple factors, which may include disturbed sleep. We evaluated whether sleep disturbance was associated with PTB and whether the association was affected by other psychosocial risk factors. Methods: Pregnant women ( n =217) for whom we had depression and sleep data at 20 or 30 weeks gestation and delivery information were evaluated. Logistic models were used to test the hypotheses that disturbed sleep was associated with PTB. Results: Time in bed at 20 weeks was significantly associated with risk for preterm delivery (odds ratio [OR] 1.43, 95% confidence interval [CI] 1.08-1.88). However, after controlling for depression/selective serotonin reuptake inhibitors (SSRI) status, history of PTB, age, employment, and marital status, this relationship was no longer significant (OR 1.26, 95% CI .92-1.71). No other relationships were significant. Conclusions: We report preliminary evidence suggesting that poor sleep may contribute to risk for PTB. Although it is speculative and additional work is needed to confirm or refute whether sleep is an independent or mediating risk factor for PTB, disturbed sleep does appear to play a role in adverse pregnancy outcomes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sleep disturbance in pregnant women can result in adverse outcomes for both the mother and the fetus.
“Sleep disturbance in pregnant women can result in adverse outcomes for both the mother and the fetus.156,157”
From Sleep, Health, and Society (2017) · cites this paper as [157]
Cites
Epidemiology and causes of preterm birth
Goldenberg, R. L., Culhane, J. F., Iams, J. D., & Romero, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60074-4 · Cited by 7,801 · see citing works
Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young Adults
Breslau, N., Roth, T., Rosenthal, L., & Andreski, P. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00188-3 · Cited by 1,831 · cited 2× · see citing works
“depression.(20,26,27) High-risk women, those with a history of depression, may be more vulnerable to the effects of sleep disturbance during pregnancy.”
BackgroundGangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., & Malaspina, D. (2006) · Hypertension · doi:10.1161/01.hyp.0000217362.34748.e0 · Cited by 1,284 · see citing works
Tsuno, N., Besset, A., & Ritchie, K. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1008 · Cited by 1,084 · see citing works
Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050 · see citing works
Birth Outcomes in Pregnant Women Taking Fluoxetine
Chambers, C., Johnson, K. A., Dick, L. M., Felix, R. J., & Jones, K. L. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351402 · Cited by 735 · see citing works
Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men
Buxton, O. M., Pavlova, M., Reid, E. W., Wang, W., Simonson, D. C., & Adler, G. K. (2010) · Diabetes · doi:10.2337/db09-0699 · Cited by 604 · see citing works
Self-Reported Sleep Duration is Associated with the Metabolic Syndrome in Midlife Adults
Hall, M. H., Muldoon, M. F., Jennings, J. R., Buysse, D. J., Flory, J. D., & Manuck, S. B. (2008) · Sleep · doi:10.1093/sleep/31.5.635 · Cited by 447 · see citing works
Goldenberg, R. L., Iams, J. D., Mercer, B. M., Meis, P. J., Moawad, A. H., Copper, R. L., Das, A. M., Thom, E. A., Johnson, F. F., McNellis, D., et al. (1998) · American Journal of Public Health · doi:10.2105/ajph.88.2.233 · Cited by 446 · see citing works
Parity and Sleep Patterns During and After Pregnancy
Lee, K., ZAFFKE, M. E., & MCENANY, G. (2000) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(99)00486-x · Cited by 445 · see citing works
Orr, S. T. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf131 · Cited by 444 · see citing works
Self-reported depression and negative pregnancy outcomes
Steer, R. A., Scholl, T. O., Hediger, M. L., & Fischer, R. L. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90149-h · Cited by 401 · see citing works
Sleep in late pregnancy predicts length of labor and type of delivery
Lee, K. A., & Gay, C. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.05.086 · Cited by 401 · see citing works
Major Depression and Antidepressant Treatment: Impact on Pregnancy and Neonatal Outcomes
Wisner, K. L., Sit, D. K. Y., Hanusa, B. H., Moses‐Kolko, E. L., Bogen, D. L., Hunker, D. F., Perel, J. M., Jones-Ivy, S., Bodnar, L. M., & Singer, L. T. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081170 · Cited by 400 · see citing works
Self-citationDayan, J., Creveuil, C., Marks, M. N., Conroy, S., Herlicoviez, M., Dreyfus, M., & Tordjman, S. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000244025.20549.bd · Cited by 356 · see citing works
Peacock, J. L., Bland, M., & ANDERSON, H. R. (1995) · BMJ · doi:10.1136/bmj.311.7004.531 · Cited by 343 · see citing works
Stress and Preterm Birth: Neuroendocrine, Immune/Inflammatory, and Vascular Mechanisms
Wadhwa, P. D., Culhane, J. F., Rauh, V., & Barve, S. S. (2001) · Maternal and Child Health Journal · doi:10.1023/a:1011353216619 · Cited by 336 · see citing works
Delivery outcome after the use of antidepressants in early pregnancy
Ericson, A., Källén, B. A. J., & Wiholm, B. ‐. (1999) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050664 · Cited by 284 · see citing works
Defining the problem: the epidemiology of preterm birth
LUMLEY, J. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1016/s1470-0328(03)00011-9 · Cited by 280 · see citing works
Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects
Irwin, M., Clark, C., Kennedy, B., Christian Gillin, J., & Ziegler, M. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00031-x · Cited by 268 · see citing works
Edinger, J. D., Olsen, M. K., Stechuchak, K. M., Means, M. K., Lineberger, M. D., Kirby, A. C., & Carney, C. E. (2009) · SLEEP · doi:10.1093/sleep/32.4.499 · Cited by 259 · see citing works
Khashu, M., Narayanan, M., Bhargava, S., & Osiovich, H. C. (2008) · PEDIATRICS · doi:10.1542/peds.2007-3743 · Cited by 247 · see citing works
Sleep disturbances during pregnancy
Mindell, J. A., & Jacobson, B. J. (2000) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/j.1552-6909.2000.tb02072.x · Cited by 239 · see citing works
Intra-individual variability in sleep duration and fragmentation: Associations with stress
Mezick, E. J., Matthews, K. A., Hall, M. H., Kamarck, T. W., Buysse, D. J., Owens, J. F., & Reís, S. E. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.005 · Cited by 239 · see citing works
Research agenda for preterm birth: Recommendations from the March of Dimes
Green, N., Damus, K. H., Simpson, J. L., Iams, J. D., Reece, E. A., Hobel, C. J., Merkatz, I. R., Greene, M. F., & Schwarz, R. H. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.02.106 · Cited by 208 · see citing works
Sleep disturbances and mood disorders: An epidemiologic perspective
Ford, D. E., & Cooper-Patrick, L. (2001) · Depression and Anxiety · doi:10.1002/da.1041 · Cited by 202 · see citing works
How Disturbed Sleep May Be a Risk Factor for Adverse Pregnancy Outcomes
Okun, M. L., Roberts, J. M., Marsland, A. L., & Hall, M. H. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e318195160e · Cited by 181 · see citing works
Self-citationMorgen, C. S., Bjørk, C., Andersen, P. K., Mortensen, L. H., & Andersen, A. N. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn112 · Cited by 175 · see citing works
Martin, J. A., Osterman, M. J. K., & Sutton, P. D. (2010) · PsycEXTRA Dataset · doi:10.1037/e665462010-001 · Cited by 167 · see citing works
Sleep disturbances in depressed pregnant women and their newborns
Field, T. M., Diego, M., Hernandez‐Reif, M., Figueiredo, B., Schanberg, S. M., & Kuhn, C. M. (2006) · Infant Behavior and Development · doi:10.1016/j.infbeh.2006.08.002 · Cited by 155 · see citing works
Changes in sleep quality, but not hormones predict time to postpartum depression recurrence
Okun, M. L., Luther, J., Prather, A. A., Perel, J. M., Wisniewski, S., & Wisner, K. L. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.07.015 · Cited by 154 · see citing works
Self-citationMedically Indicated Preterm Birth: Recognizing the Importance of the Problem
Ananth, C. V., & Vintzileos, A. M. (2008) · Clinics in Perinatology · doi:10.1016/j.clp.2007.11.001 · Cited by 153 · see citing works
Faraut, B., Boudjeltia, K. Z., Dyzma, M., Rousseau, A., David, E., Stenuit, P., Franck, T. J., Antwerpen, P. V., Vanhaeverbeek, M., & Kerkhofs, M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.08.001 · Cited by 153 · see citing works
Ursin, R., Bjorvatn, B., & Holsten, F. (2005) · SLEEP · doi:10.1093/sleep/28.10.1260 · Cited by 145 · see citing works
Wolfson, A. R., Crowley, S. J., Anwer, U., & Bassett, J. L. (2003) · Behavioral Sleep Medicine · doi:10.1207/s15402010bsm0101_6 · Cited by 134 · see citing works
Sleep Complaints in Late Pregnancy and the Recurrence of Postpartum Depression
Okun, M. L., Hanusa, B. H., Hall, M. H., & Wisner, K. L. (2009) · Behavioral Sleep Medicine · doi:10.1080/15402000902762394 · Cited by 126 · see citing works
Self-citationSleep disturbances in depression and the effects of antidepressants
Argyropoulos, S., & Wilson, S. J. (2005) · International Review of Psychiatry · doi:10.1080/09540260500104458 · Cited by 123 · see citing works
Factors associated with objective (actigraphic) and subjective sleep quality in young adult women
Tworoger, S. S., Davis, S., Vitiello, M. V., Lentz, M. J., & McTiernan, A. (2005) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2005.03.008 · Cited by 120 · see citing works
Disturbed sleep is associated with increased C-reactive protein in young women
Okun, M. L., Coussons‐Read, M. E., & Hall, M. H. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.10.008 · Cited by 117 · see citing works
Self-citationBorn a Bit Too Early: Recent Trends in Late Preterm Births
Martin, J. A., Kirmeyer, S., Osterman, M. J. K., & Shepherd, R. A. (2009) · PsycEXTRA Dataset · doi:10.1037/e665292010-001 · Cited by 115 · see citing works
Sleep disturbances in depressed and nondepressed pregnant women
Okun, M. L., Kiewra, K., Luther, J. F., Wisniewski, S. R., & Wisner, K. L. (2011) · Depression and Anxiety · doi:10.1002/da.20828 · Cited by 112 · see citing works
Self-citationSleep Disturbance in Late Pregnancy and Early Labor
Beebe, K. R., & Lee, K. A. (2007) · The Journal of Perinatal & Neonatal Nursing · doi:10.1097/01.jpn.0000270626.66369.26 · Cited by 101 · see citing works
Krupa, F. G., Faltin, D., Cecatti, J. G., Surita, F. G. C., & Souza, J. P. (2006) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2006.03.022 · Cited by 97 · see citing works
Antidepressant Use During Pregnancy and the Risk of Preterm Delivery and Fetal Growth Restriction
Toh, S., Mitchell, A. A., Louik, C., Werler, M. M., Chambers, C., & Hernández–Dı́az, S. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181bf344c · Cited by 85 · see citing works
Patterns of cytokine profiles differ with pregnancy outcome and ethnicity
Velez, D. R., Fortunato, S. J., Morgan, N., et al. (2008) · Human Reproduction · doi:10.1093/humrep/den170 · Cited by 80 · see citing works
Pregnancy-related affective episodes among women with recurrent depression
Frank, E., Kupfer, D. J., Jacob, M., Blumenthal, S. J., & Db, J. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.3.288 · Cited by 74 · see citing works
Sleep and treatment response in depression: new findings using power spectral analysis
Buysse, D. J., Hall, M., Begley, A., Cherry, C. R., Houck, P. R., Land, S., Ombao, H., Kupfer, D. J., & Frank, E. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00270-0 · Cited by 72 · see citing works
The Effects of Antidepressants on Sleep in Patients with Depression
Armitage, R. (2000) · The Canadian Journal of Psychiatry · doi:10.1177/070674370004500903 · Cited by 71 · see citing works
Depression and insomnia in women
Krystal, A. D. (2004) · Clinical cornerstone · doi:10.1016/s1098-3597(04)80022-x · Cited by 63 · see citing works
Landis, C. A., Lentz, M. J., Tsuji, J. M., Buchwald, D., & Shaver, J. L. F. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.11.001 · Cited by 59 · see citing works
Biomarkers of inflammation and placental dysfunction are associated with subsequent preterm birth
Bastek, J. A., Brown, A. G., Anton, L., Srinivas, S. K., D'addio, A., & Elovitz, M. A. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2010.511340 · Cited by 56 · see citing works
Antidepressants and Sleep: A Review
Holshoe, J. M. (2009) · Perspectives In Psychiatric Care · doi:10.1111/j.1744-6163.2009.00221.x · Cited by 51 · see citing works
Disturbed sleep and preterm birth: a potential relationship?
Strange, L. B., Kp, P., Ml, M., Strickland, O. L., & Bliwise, D. L. (2009) · PubMed · Cited by 50 · see citing works
Ekholm, E. M. K., Polo, O. J., Rauhala, E., & Ekblad, U. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)91698-6 · Cited by 47 · see citing works
Current Research in Preterm Birth
Williamson, D., Abe, K., Bean, C. J., Ferré, C. D., Henderson, Z., & Lackritz, E. (2008) · Journal of Women s Health · doi:10.1089/jwh.2008.1045 · Cited by 39 · see citing works
Çakırbay, H., Bilici, M., Kavakçı, Ö., ÇEBI, A., GÜLER, M., & Tan, Ü. (2004) · International Journal of Neuroscience · doi:10.1080/00207450490269471 · Cited by 35 · see citing works
Lichstein, K. (2006) · Sleep Medicine · doi:10.1016/j.sleep.2006.03.004 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Grandner, M. A. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.10.012 · Cited by 720 · see citing works
Lu, Q., Zhang, X., Wang, Y., Li, J., Xu, Y., Song, X., Su, S., Zhu, X., Vitiello, M. V., Shi, J., et al. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101436 · Cited by 311 · see citing works
Warland, J., Dorrian, J., Morrison, J. L., & O'Brien, L. M. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.03.004 · Cited by 224 · see citing works
Chronic sleep loss during pregnancy as a determinant of stress: impact on pregnancy outcome
Palagini, L., Gemignani, A., Banti, S., Manconi, M., Mauri, M., & Riemann, D. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.02.013 · Cited by 220 · see citing works
Sleep duration and quality, and risk of gestational diabetes mellitus in pregnant Chinese women
Wang, H., Leng, J., Li, W., Wang, L., Zhang, C., Li, W., Liu, H., Zhang, S., Chan, J., Hu, G., et al. (2017) · Diabetic Medicine · doi:10.1111/dme.13155 · Cited by 75 · see citing works
Wang, L., & Jin, F. (2020) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-020-2814-5 · Cited by 73 · see citing works
Izci-Balserak, B., & Pien, G. W. (2014) · Current Diabetes Reports · doi:10.1007/s11892-013-0459-8 · Cited by 52 · see citing works
Effect of sleep disorders on threatened premature delivery
Ota, H., Hasegawa, J., & Sekizawa, A. (2017) · Journal of Perinatal Medicine · doi:10.1515/jpm-2015-0149 · Cited by 9 · see citing works
- Authors
- Okun, M. L., Luther, J. F., Wisniewski, S. R., Sit, D., Prairie, B. A., & Wisner, K. L.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Okun, Michele L.
- Venue
- Journal of Women's Health
- Publisher
- SAGE Publications
- Published
- 2012-01
- Volume
- 21
- Issue
- 1
- Pages
- 54-60
- ISSN
- 1059-7115 (ISSN-L)
- 1540-9996
- 1931-843X
- PMC
- PMC3256561
- OpenAlex
- W2076740430
- Cited by
- 61
- References
- 58
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 8 · 2019: 7 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 7
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Women s Health (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- Case Western Reserve University
- National Institutes of Health
- U.S. Public Health Service (R00-08013)
- National Institute of Mental Health (R01MH060335)
- National Institute of Nursing Research
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- sleep disorders, preterm birth, pregnancy, maternal depression, selective serotonin reuptake inhibitors, time in bed, psychosocial risk factors, adverse pregnancy outcomes
- MeSH terms
- Adult, Depression, Female, Humans, Infant, Newborn, Infant, Premature, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Third, Prenatal Care, Risk Factors, Sleep Wake Disorders, Comorbidity, Causality, Odds Ratio, Premature Birth, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
