Proportion of cervical excision for cervical intraepithelial neoplasia as a predictor of pregnancy outcomes
Abstract
Objective To assess how the proportion of the cervical volume/length removed during treatment for cervical intraepithelial neoplasia (CIN) varies and whether this correlates to the pregnancy duration at delivery. Methods The present prospective observational study included 142 women undergoing CIN treatment at a university hospital during 2009-2013. The pretreatment and post-treatment cervical dimensions and cone size were measured with magnetic resonance imaging, three-dimensional transvaginal ultrasonography, or two-dimensional transvaginal ultrasonography, and the correlation between pregnancy outcomes and the relative proportion of the cervix excised was assessed. Results Pretreatment cervical volumes and cone volumes varied substantially (range 11-40 cm(3) and 0.6-8 cm(3), respectively). The proportion of the volume excised ranged from 2.2% to 39.4%. Sixteen (11%) women conceived following treatment; 12 had a live birth (seven at term, three preterm). The pregnancy duration at delivery was significantly correlated with the proportion of the cervical volume (r=-0.9; P Conclusion The pretreatment cervical dimensions and the proportions of the volume/length excised vary substantially, and the latter correlates with the pregnancy duration. Assessment of the proportion excised might help to stratify women at risk who need intensive surveillance when pregnant.
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The risk of prematurity in subsequent pregnancies increases with increasing treatment radicality and length of cone excised.
“The risk of prematurity in subsequent pregnancies has been known to increase with increasing treatment radicality and length of cone excised.”
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- Authors
- Kyrgiou, M., Valasoulis, G., Stasinou, S., Founta, C., Athanasiou, A., Bennett, P., & Paraskevadis, E.
- Affiliations
- Imperial College Healthcare NHS Trust (GB)
- Worthing Hospital (GB)
- Hammersmith Hospital (GB)
- Gateshead Health NHS Foundation Trust (GB)
- University Hospital of Ioannina (GR)
- Corresponding author
- Kyrgiou, Maria
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 2014-10-02
- Volume
- 128
- Issue
- 2
- Pages
- 141-147
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- 1879-3479
- OpenAlex
- W1989967236
- Cited by
- 74
- References
- 27
- Citations by year
- 2026: 3 · 2024: 5 · 2023: 3 · 2022: 14 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 1
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-07-19)
- Open access
- closed
- Licence
- Locations
- International Journal of Gynecology & Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Research and Development of the University of Ioannina, Ioannina, Greece
- Imperial Healthcare NHS Trust NIHR Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- cervical intraepithelial neoplasia, conization, pregnancy outcomes, gestational age at delivery, live birth, preterm birth, pregnancy surveillance
- MeSH terms
- Adult, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Female, Hospitals, University, Humans, Infant, Newborn, Magnetic Resonance Imaging, Pregnancy, Pregnancy Complications, Neoplastic, Pregnancy Outcome, Prospective Studies, Imaging, Three-Dimensional, Young Adult
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