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Cited by 462

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Insight into 2019 novel coronavirus — An updated interim review and lessons from SARS-CoV and MERS-CoV

Open access
Xie, Mingxuan, Chen, Qiong·2020·International Journal of Infectious Diseases

Abstract

BACKGROUND: The rapid spread of the coronavirus disease 2019 (COVID-19), caused by a zoonotic beta-coronavirus entitled 2019 novel coronavirus (2019-nCoV), has become a global threat. Awareness of the biological features of 2019-nCoV should be updated in time and needs to be comprehensively summarized to help optimize control measures and make therapeutic decisions. METHODS: Based on recently published literature, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) infection. RESULTS: The genome of 2019-nCoV partially resembled SARS-CoV and MERS-CoV, and indicated a bat origin. The COVID-19 generally had a high reproductive number, a long incubation period, a short serial interval and a low case fatality rate (much higher in patients with comorbidities) than SARS and MERS. Clinical presentation and pathology of COVID-19 greatly resembled SARS and MERS, with less upper respiratory and gastrointestinal symptoms, and more exudative lesions in post-mortems. Potential treatments included remdesivir, chloroquine, tocilizumab, convalescent plasma and vaccine immunization (when possible). CONCLUSION: The initial experience from the current pandemic and lessons from the previous two pandemics can help improve future preparedness plans and combat disease progression.

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Metadata

Authors
Xie, M., & Chen, Q.
Venue
International Journal of Infectious Diseases
Publisher
Elsevier BV
Published
2020-05
Volume
94
Pages
119-124
ISSN
1201-9712 (ISSN-L)
OpenAlex
W3013552645
Cited by
462
References
50
FWCI
13.01
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Insight into 2019 novel coronavirus — An updated interim review and lessons from SARS-CoV and MERS-CoV. https://app.cochat.ai/papers/10.1016/j.ijid.2020.03.071
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Xie, M., & Chen, Q. (2020). Insight into 2019 novel coronavirus — An updated interim review and lessons from SARS-CoV and MERS-CoV. International Journal of Infectious Diseases. https://doi.org/10.1016/j.ijid.2020.03.071

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.