Cited by 194Nanoparticle-Based Drug DeliveryDrug Transport and Resistance MechanismsAdvanced Drug Delivery Systems

Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles

Duan, Jinghua, Mansour, Heidi M., Zhang, Yangde, Deng, Xingming, Chen, Yuxiang, Wang, Jiwei, Pan, Yifeng, Zhao, Jinfeng·2012·International Journal of Pharmaceutics

Abstract

Co-encapsulated doxorubicin (DOX) and curcumin (CUR) in poly(butyl cyanoacrylate) nanoparticles (PBCA-NPs) were prepared with emulsion polymerization and interfacial polymerization. The mean particle size and mean zeta potential of CUR-DOX-PBCA-NPs were 133 ± 5.34 nm in diameter and +32.23 ± 4.56 mV, respectively. The entrapment efficiencies of doxorubicin and curcumin were 49.98 ± 3.32% and 94.52 ± 3.14%, respectively. Anticancer activities and reversal efficacy of the formulations and various combination approaches were assessed using 3-[4,5-dimethylthiazol-2-yl] 2,5-diphenyltetrazolium bromide assay and western blotting. The results showed that the dual-agent loaded PBCA-NPs system had the similar cytotoxicity to co-administration of two single-agent loaded PBCA-NPs (DOX-PBCA-NPs+CUR-PBCA-NPs), which was slightly higher than that of the free drug combination (DOX+CUR) and one free drug/another agent loaded PBCA-NPs combination (DOX+CUR-PBCA-NPs or CUR+DOX-PBCA-NPs). The simultaneous administration of doxorubicin and curcumin achieved the highest reversal efficacy and down-regulation of P-glycoprotein in MCF-7/ADR cell lines, an MCF-7 breast carcer cell line resistant to adriamycin. Multidrug resistance can be enhanced by combination delivery of encapsulated cytotoxic drugs and reversal agents.

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Crossref · 10.1016/j.ijpharm.2012.01.020

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  • Anticancer drugs encapsulated in polymeric micelles have shown better accumulation in the targeted site, reducing side effects on noncancerous tissues.

    “Especially, anticancer drugs encapsulated in polymeric micelles have shown a better accumulation in the targeted site, thus reducing side effects on noncancerous tissues [46,47,48].”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [46]

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Authors
Duan, J., Mansour, H. M., Zhang, Y., Deng, X., Chen, Y., Wang, J., Pan, Y., & Zhao, J.
Affiliations
  • Central South University (CN)
  • University of Kentucky (US)
  • Emory University (US)
Corresponding author
Zhao, Jinfeng
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2012-04
Volume
426
Issue
1-2
Pages
193-201
ISSN
0378-5173 (ISSN-L)
OpenAlex
W2005475049
Cited by
194
References
38
Citations by year
2026: 3 · 2025: 9 · 2024: 11 · 2023: 8 · 2022: 8 · 2021: 9 · 2020: 19 · 2019: 22 · 2018: 18 · 2017: 18 · 2016: 17 · 2015: 19 · 2014: 16 · 2013: 12 · 2012: 5
FWCI
6.74
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Pharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Lotus Scholars Program (200734)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
multidrug resistance reversal, doxorubicin, curcumin, chitosan, co-encapsulation, MCF-7/ADR cells, breast cancer, anticancer drug delivery, combination chemotherapy
MeSH terms
Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Chromatography, Gel, Curcumin, Doxorubicin, Drug Carriers, Drug Combinations, Drug Compounding, Enbucrilate, Female, Humans, Particle Size, Technology, Pharmaceutical, Down-Regulation, Spectroscopy, Fourier Transform Infrared, Drug Resistance, Multiple, ATP Binding Cassette Transporter, Subfamily B, Drug Resistance, Neoplasm, ATP Binding Cassette Transporter, Subfamily B, Member 1, Nanotechnology, Cell Line, Tumor, Chitosan, Nanoparticles

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