Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles
Abstract
Co-encapsulated doxorubicin (DOX) and curcumin (CUR) in poly(butyl cyanoacrylate) nanoparticles (PBCA-NPs) were prepared with emulsion polymerization and interfacial polymerization. The mean particle size and mean zeta potential of CUR-DOX-PBCA-NPs were 133 ± 5.34 nm in diameter and +32.23 ± 4.56 mV, respectively. The entrapment efficiencies of doxorubicin and curcumin were 49.98 ± 3.32% and 94.52 ± 3.14%, respectively. Anticancer activities and reversal efficacy of the formulations and various combination approaches were assessed using 3-[4,5-dimethylthiazol-2-yl] 2,5-diphenyltetrazolium bromide assay and western blotting. The results showed that the dual-agent loaded PBCA-NPs system had the similar cytotoxicity to co-administration of two single-agent loaded PBCA-NPs (DOX-PBCA-NPs+CUR-PBCA-NPs), which was slightly higher than that of the free drug combination (DOX+CUR) and one free drug/another agent loaded PBCA-NPs combination (DOX+CUR-PBCA-NPs or CUR+DOX-PBCA-NPs). The simultaneous administration of doxorubicin and curcumin achieved the highest reversal efficacy and down-regulation of P-glycoprotein in MCF-7/ADR cell lines, an MCF-7 breast carcer cell line resistant to adriamycin. Multidrug resistance can be enhanced by combination delivery of encapsulated cytotoxic drugs and reversal agents.
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Anticancer drugs encapsulated in polymeric micelles have shown better accumulation in the targeted site, reducing side effects on noncancerous tissues.
“Especially, anticancer drugs encapsulated in polymeric micelles have shown a better accumulation in the targeted site, thus reducing side effects on noncancerous tissues [46,47,48].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [46]
Cites
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543 · see citing works
Anticancer potential of curcumin: preclinical and clinical studies.
Aggarwal, B. B., Kumar, A. J., & Bharti, A. C. (2003) · PubMed · Cited by 2,550 · see citing works
Cheng, A., Hsu, C., Lin, J., Hsu, M. M., Ho, Y., Shen, T. S., Ko, J. Y., Lin, J.-T., Lin, B., Ming-Shiang, W., et al. (2001) · PubMed · Cited by 2,071 · see citing works
Aggarwal, B. B., & Harikumar, K. B. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.010 · Cited by 2,043 · see citing works
Kunnumakkara, A. B., Anand, P., & Aggarwal, B. B. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.009 · Cited by 1,074 · see citing works
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications
Vauthier, C., Dubernet, C., Fattal, E., Pinto‐Alphandary, H., & Couvreur, P. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(03)00041-3 · Cited by 528 · see citing works
Targeted nanoparticles for cancer therapy
Gu, F., Karnik, R., Wang, A. Z., Alexis, F., Levy‐Nissenbaum, E., Hong, S., Langer, R., & Farokhzad, O. C. (2007) · Nano Today · doi:10.1016/s1748-0132(07)70083-x · Cited by 512 · see citing works
Ganta, S., & Amiji, M. M. (2009) · Molecular Pharmaceutics · doi:10.1021/mp800240j · Cited by 489 · see citing works
Targeted Nanoparticles for Cancer Therapy
Reddy, G. S. N. (2021) · Journal of Bioanalysis & Biomedicine · Cited by 401 · see citing works
Notarbartolo, M., Poma, P., Perri, D., Dusonchet, L., Cervello, M., & D’Alessandro, N. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.10.051 · Cited by 317 · see citing works
Nanomedicinal Strategies to Treat Multidrug-Resistant Tumors: Current Progress
Dong, X., & Mumper, R. J. (2010) · Nanomedicine · doi:10.2217/nnm.10.35 · Cited by 314 · see citing works
ABC-transporters: implications on drug resistance from microorganisms to human cancers
Lage, H. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(03)00203-6 · Cited by 299 · see citing works
Dong, X., Mattingly, C. A., Tseng, M. T., Cho, M. J., Liu, Y., Adams, V. R., & Mumper, R. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2747 · Cited by 291 · see citing works
Soma, C. E., Dubernet, C., Bentolila, D., Benita, S., & Couvreur, P. (2000) · Biomaterials · doi:10.1016/s0142-9612(99)00125-8 · Cited by 281 · see citing works
Degradation of poly (isobutyl cyanoacrylate) nanoparticles
Lenaerts, V., Couvreur, P., Christiaens-Leyh, D., Joiris, E., Roland, M., Rollmann, B., & Speiser, P. P. (1984) · Biomaterials · doi:10.1016/0142-9612(84)90002-4 · Cited by 272 · see citing works
Song, X. R., Cai, Z., Zheng, Y., He, G., Cui, F. Y., Gong, D. Q., Hou, S. X., Xiong, S. J., Lei, X. J., & Wei, Y. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.02.018 · Cited by 210 · see citing works
Development and evaluation of penciclovir-loaded solid lipid nanoparticles for topical delivery
Lv, Q., Yu, A., Xi, Y., Li, H., Song, Z., Cui, J., Cao, F., & Zhai, G. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.01.014 · Cited by 205 · see citing works
Duan, J., Zhang, Y., Han, S., Chen, Y., Li, B., Liao, M., Chen, W., Deng, X., Zhao, J., & Huang, B. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.08.033 · Cited by 175 · see citing works
Self-citationWu, J. H., Lu, Y., Lee, A., Pan, X., Yang, X., Zhao, X. B., & Lee, R. J. (2007) · PubMed · Cited by 172 · see citing works
de Verdière, A., Dubernet, C., Némati, F., Soma, E., Appel, M., Ferté, J., Bernard, S., Puisieux, F., & Couvreur, P. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.362 · Cited by 168 · see citing works
Behan, N. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00286-6 · Cited by 162 · see citing works
In vitro model for the degradation of alkylcyanoacrylate nanoparticles
Müller, R. H., Lherm, C., Herbert, J., & Couvreur, P. (1990) · Biomaterials · doi:10.1016/0142-9612(90)90084-4 · Cited by 138 · see citing works
Doxorubicin-loaded solid lipid nanoparticles to overcome multidrug resistance in cancer therapy
Kang, K. W., Chun, M., Kim, O., Subedi, R. K., Ahn, S., Yoon, J., & Choi, H. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.12.006 · Cited by 136 · see citing works
Toxicity of Polyalkylcyanoacrylate Nanoparticles I: Free Nanoparticles
Kante, B., Couvreur, P., Dubois-Krack, G., de Meester, C., Guiot, P., Roland, M., Mercier, M., & Speiseru, P. (1982) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600710716 · Cited by 121 · see citing works
Ebert, B., Seidel, A., & Lampen, A. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl147 · Cited by 119 · see citing works
Ambruosi, A., Gelperina, S. E., Khalansky, A. S., Tanski, S., Theisen, A., & Kreuter, J. (2006) · Journal of Microencapsulation · doi:10.1080/02652040600788080 · Cited by 100 · see citing works
Tang, H., Murphy, C. J., Zhang, B., Shen, Y., Sui, M., Kirk, E. A. V., Feng, X., & Murdoch, W. J. (2010) · Nanomedicine · doi:10.2217/nnm.10.67 · Cited by 97 · see citing works
Hou, X., Takahashi, K., Tanaka, K., Tougou, K., Qiu, F., Komatsu, K., Takahashi, K., & Azuma, J. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.03.010 · Cited by 85 · see citing works
In vitro degradation of insulin-loaded poly (n-butylcyanoacrylate) nanoparticles
Sullivan, C. O., & Birkinshaw, C. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.11.001 · Cited by 82 · see citing works
Molecular Weights of Free and Drug-Loaded Nanoparticles
Vansnick, L., Couvreur, P., Christiaens-Leyh, D., & Roland, M. (1985) · Pharmaceutical Research · doi:10.1023/a:1016366022712 · Cited by 72 · see citing works
Graf, A., McDowell, A., & Rades, T. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902870413 · Cited by 67 · see citing works
Mitra, A., & Lin, S. (2003) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021341 · Cited by 67 · see citing works
Reddy, L. H., Sharma, R. K., & Murthy, R. S. R. (2004) · Journal of drug targeting · doi:10.1080/10611860400011406 · Cited by 60 · see citing works
Sun (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s2714 · Cited by 56 · see citing works
Andjelković, T., Pešić, M., Banković, J., Tanić, N., Marković, I., & Ruždijić, S. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.7.6036 · Cited by 48 · see citing works
Improved preparation and physical studies of polybutylcyanoacrylate nanocapsules
Wohlgemuth, W. M. M. (2000) · Journal of Microencapsulation · doi:10.1080/026520400405697 · Cited by 39 · see citing works
Angelini, G. D. (1994) · Oncology Reports · doi:10.3892/or_00000067 · Cited by 38 · see citing works
Flagged first, then by citations
1 of the 38 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Naksuriya, O., Okonogi, S., Schiffelers, R. M., & Hennink, W. E. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.090 · Cited by 844 · see citing works
Biopolymer nano-particles and natural nano-carriers for nano-encapsulation of phenolic compounds
Esfanjani, A. F., & Jafari, S. M. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.06.053 · Cited by 547 · see citing works
Recent progress in nanomedicine for enhanced cancer chemotherapy
Wei, G., Wang, Y., Yang, G. Y., Wang, Y., & Ju, R. (2021) · Theranostics · doi:10.7150/thno.57828 · Cited by 468 · see citing works
Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
Zhang, W., Mehta, A., Tong, Z., Esser, L., & Voelcker, N. H. (2021) · Advanced Science · doi:10.1002/advs.202003937 · Cited by 430 · see citing works
Natural product-based nanoformulations for cancer therapy: Opportunities and challenges
Kashyap, D., Tuli, H. S., Yerer, M. B., Sharma, A. K., Sak, K., Srivastava, S., Pandey, A., Garg, V. K., Sethi, G., & Bishayee, A. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.014 · Cited by 400 · see citing works
Niosomes: A review on niosomal research in the last decade
Bhardwaj, P., Tripathi, P., Gupta, R., & Pandey, S. S. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101581 · Cited by 367 · see citing works
Recent advances of controlled drug delivery using microfluidic platforms
Sanjay, S. T., Zhou, W., Dou, M., Tavakoli, H., Ma, L., Xu, F., & Li, X. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.013 · Cited by 365 · see citing works
Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
Avramović, N., Mandić, B., Savic-Radojevic, A. R., & Simic, T. P. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040298 · Cited by 298 · see citing works
The Promise of Nanotechnology in Personalized Medicine
Alghamdi, M. A., Fallica, A. N., Virzì, N. F., Kesharwani, P., Pittalà, V., & Greish, K. F. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12050673 · Cited by 313 · see citing works
Different strategies to overcome multidrug resistance in cancer
Manju, S., & Gong, S. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.06.004 · Cited by 250 · see citing works
Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer
Tan, B. L., & Norhaizan, M. E. (2019) · Molecules · doi:10.3390/molecules24142527 · Cited by 246 · see citing works
Controlled Drug Release from Nanoengineered Polysaccharides
Bayer, I. S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051364 · Cited by 231 · see citing works
Recent advances in curcumin nanoformulation for cancer therapy
Lee, W., Loo, C., Young, P. M., Traini, D., Mason, R. S., & Rohanizadeh, R. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.916686 · Cited by 230 · see citing works
Rationally designed nanovehicles to overcome cancer chemoresistance
Livney, Y. D., & Assaraf, Y. G. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.006 · Cited by 205 · see citing works
Zhang, J., Li, J., Shi, Z., Yang, Y., Xie, X., Lee, S. M., Wang, Y., Leong, K. W., & Chen, M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.04.029 · Cited by 195 · see citing works
Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review
Mohajeri, M., & Sahebkar, A. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.12.005 · Cited by 195 · see citing works
Alemi, A., Reza, J. Z., Haghiralsadat, F., Jaliani, H. Z., Karamallah, M. H., Hosseini, S. A., & Karamallah, S. H. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0351-4 · Cited by 194 · see citing works
Curcumin Nanomedicine: A Road to Cancer Therapeutics
Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805289219 · Cited by 193 · see citing works
Kim, J., Yung, B. C., Kim, W. J., & Chen, X. S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.12.026 · Cited by 190 · see citing works
Nanoformulations for combination or cascade anticancer therapy
Miao, L., Guo, S., Lin, C. M., Liu, Q., & Huang, L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.003 · Cited by 178 · see citing works
Zhang, J., Hu, K., Di, L., Wang, P., Liu, Z., Zhang, J., Yue, P., Song, W., Zhang, J., Chen, T., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113964 · Cited by 177 · see citing works
Self-citationCastillo, R. R., Colilla, M., & Vallet‐Regí, M. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1211637 · Cited by 177 · see citing works
Zhao, X., Chen, Q., Li, Y.-S., Tang, H., Liu, W., & Yang, X. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.003 · Cited by 167 · see citing works
Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives
Khatoon, E., Banik, K., Harsha, C., Sailo, B. L., Thakur, K. K., Khwairakpam, A. D., Vikkurthi, R., Devi, T. B., Gupta, S. C., & Kunnumakkara, A. B. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.06.014 · Cited by 163 · see citing works
Ngwabebhoh, F. A., Erdağı, S. İ., & Yıldız, U. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.08.079 · Cited by 162 · see citing works
Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
Mohanta, V., Madras, G., & Patil, S. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am505681e · Cited by 155 · see citing works
Barui, S., Saha, S., Mondal, G., Haseena, S., & Chaudhuri, A. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.074 · Cited by 134 · see citing works
Naderinezhad, S., Amoabediny, G., & Haghiralsadat, F. (2017) · RSC Advances · doi:10.1039/c7ra01736g · Cited by 131 · see citing works
Tahir, N., Madni, A., Correia, A., Rehman, M., Balasubramanian, V., Khan, M. M., & Santos, H. A. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s209325 · Cited by 129 · see citing works
Liu, W., Zhao, X., Chen, Q., Li, Y.-S., Tang, H., Liu, X., & Yang, X. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s73322 · Cited by 126 · see citing works
Overcoming Chemotherapy Resistance in Metastatic Cancer: A Comprehensive Review
Eslami, M., Memarsadeghi, O., Davarpanah, A., Arti, A., Nayernia, K., & Behnam, B. (2024) · Biomedicines · doi:10.3390/biomedicines12010183 · Cited by 132 · see citing works
Gomez‐Zepeda, D., Taghi, M., Scherrmann, J., Declèves, X., & Menet, M. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics12010020 · Cited by 124 · see citing works
Feng, Q., Sun, J., & Jiang, X. (2016) · Nanoscale · doi:10.1039/c5nr07964k · Cited by 123 · see citing works
Fang, J., Lai, Y., Chiu, T., Chen, Y., Hu, S., & Chen, S. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300598 · Cited by 120 · see citing works
Self-citationSadeghi, R., Moosavi‐Movahedi, A. A., Emam‐Djomeh, Z., Kalbasi, A., Razavi, S. H., Karimi, M., & Kokini, J. L. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-014-2565-1 · Cited by 115 · see citing works
Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives
Lopes-Rodrigues, V., Sousa, E., & Vasconcelos, M. H. (2016) · Pharmaceuticals · doi:10.3390/ph9040071 · Cited by 115 · see citing works
Nano-sized polymers and liposomes designed to deliver combination therapy for cancer
Eldar‐Boock, A., Polyak, D., Scomparin, A., & Satchi‐Fainaro, R. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.04.014 · Cited by 112 · see citing works
Zhang, Y., Hou, Z., Ge, Y., Deng, K., Liu, B., Li, X., Li, Q., Cheng, Z., Ma, P., Li, C., et al. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b05522 · Cited by 110 · see citing works
Self-citationGharieh, A., Khoee, S., & Mahdavian, A. R. (2019) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2019.04.010 · Cited by 107 · see citing works
Ashrafizadeh, M., Hushmandi, K., Mirzaei, S., Bokaie, S., Bigham, A., Makvandi, P., Rabiee, N., Thakur, V. K., Kumar, A. P., Sharifi, E., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10325 · Cited by 108 · see citing works
Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer
Yadav, P., Ambudkar, S. V., & Prasad, N. R. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01626-z · Cited by 109 · see citing works
Pan, J., Rostamizadeh, K., Filipczak, N., & Torchilin, V. P. (2019) · Molecules · doi:10.3390/molecules24061035 · Cited by 104 · see citing works
Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications
Udompornmongkol, P., & Chiang, B. (2015) · Journal of Biomaterials Applications · doi:10.1177/0885328215594479 · Cited by 103 · see citing works
Kong, F., Wang, W., Xi, M., Duan, X., & Wang, Y. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s80297 · Cited by 100 · see citing works
Danafar, H., Davaran, S., Rostamizadeh, K., Valizadeh, H., & Hamidi, M. (2014) · Europe PMC (PubMed Central) · doi:10.5681/apb.2014.074 · Cited by 100 · see citing works
Polymer assembly: Promising carriers as co-delivery systems for cancer therapy
Li, N., Zhao, L., Qi, L., Li, Z., & Luan, Y. (2015) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.10.009 · Cited by 96 · see citing works
Ma, W., Guo, Q., Li, Y., Wang, X., Wang, J., & Tu, P. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.11.033 · Cited by 96 · see citing works
Self-citationCurcumin as tyrosine kinase inhibitor in cancer treatment
Golonko, A., Lewandowska, H., Świsłocka, R., Jasińska, U., Priebe, W., & Lewandowski, W. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.07.015 · Cited by 96 · see citing works
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs
Tesauro, D., Accardo, A., Aloj, L., Morelli, G., & Aurilio, M. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s53593 · Cited by 93 · see citing works
Cancer-linked targets modulated by curcumin.
Hasima, N., & Aggarwal, B. B. (2012) · PubMed Central · Cited by 92 · see citing works
Cockle Shell-Derived Calcium Carbonate (Aragonite) Nanoparticles: A Dynamite to Nanomedicine
Mailafiya, M. M., Abubakar, K., Danmaigoro, A., Chiroma, S. M., Rahim, E. B. A., Moklas, M. A. M., & Zakaria, Z. A. B. (2019) · Applied Sciences · doi:10.3390/app9142897 · Cited by 89 · see citing works
Cui, T., Zhang, S., & Sun, H. (2017) · Oncology Reports · doi:10.3892/or.2017.5345 · Cited by 88 · see citing works
Ahmad, M. Z., Alkahtani, S. A., Akhter, S., Ahmad, F. J., Ahmad, J., Akhtar, M. S., Mohsin, N., & Abdel‐Wahab, B. A. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1055570 · Cited by 87 · see citing works
Heidari, A. (2017) · Archives of Biotechnology and Biomedicine · doi:10.29328/journal.hjb.1001007 · Cited by 85 · see citing works
Ma, W., Wang, J., Guo, Q., & Tu, P. (2015) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2015.04.007 · Cited by 80 · see citing works
Self-citationWang, Y., Dou, L., He, H., Zhang, Y., & Shen, Q. (2014) · Molecular Pharmaceutics · doi:10.1021/mp400547u · Cited by 78 · see citing works
Self-citationThe potential of multi-compound nanoparticles to bypass drug resistance in cancer
Silva, C. G. D., Peters, G. J., OSSENDORP, F. A., & Cruz, L. J. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3427-1 · Cited by 78 · see citing works
Heidari, A. (2018) · International Journal of Advanced Chemistry · doi:10.14419/ijac.v6i2.12528 · Cited by 78 · see citing works
Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience
Shabani, L., Abbasi, M., Azarnew, Z., Amani, A. M., & Vaez, A. (2023) · BioMedical Engineering OnLine · doi:10.1186/s12938-022-01062-y · Cited by 80 · see citing works
Gagliardi, A., Bonacci, S., Paolino, D., Celia, C., Procopio, A., Fresta, M., & Cosco, D. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02422 · Cited by 78 · see citing works
Wang, J., Ma, W., & Tu, P. (2015) · Macromolecular Bioscience · doi:10.1002/mabi.201500043 · Cited by 77 · see citing works
Self-citationSesărman, A., Tefas, L. R., Sylvester, B., Licărete, E., Rauca, V. F., Lupuţ, L., Pătraș, L., Porav, A. S., Banciu, M., & Porfire, A. S. (2018) · Drug Delivery and Translational Research · doi:10.1007/s13346-018-00598-8 · Cited by 77 · see citing works
Chitosan: A versatile bio-platform for breast cancer theranostics
Madamsetty, V. S., Tavakol, S., Moghassemi, S., Dadashzadeh, A., Schneible, J. D., Fatemi, I., Shirvani, A., Zarrabi, A., Azedi, F., Dehshahri, A., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.12.012 · Cited by 74 · see citing works
Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy
Liew, H. S., Mai, C., Zulkefeli, M., Madheswaran, T., Kiew, L. V., Delsuc, N., & Low, M. L. (2020) · Molecules · doi:10.3390/molecules25184176 · Cited by 75 · see citing works
Heidari, A. (2018) · Journal of Advances in Nanomaterials · doi:10.22606/jan.2018.31001 · Cited by 74 · see citing works
Delivery of natural phenolic compounds for the potential treatment of lung cancer
Muller, A. G., Sarker, S. D., Saleem, I. Y., & Hutcheon, G. A. (2019) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-019-00267-2 · Cited by 73 · see citing works
Song, Y. H., De, R., & Lee, K. T. (2023) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2023.103008 · Cited by 75 · see citing works
Prados, J. C., Cabeza, L., Ortíz, R., Arias, J. L., Adolfina, M. A., Entrena, J. M., Luque, R., & Melguizo, C. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s74378 · Cited by 71 · see citing works
Recent Progress in Studying Curcumin and its Nano-preparations for Cancer Therapy
Liu, J., Chen, S., Lv, L., Song, L., Guo, S., & Huang, S. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805289327 · Cited by 68 · see citing works
Polymeric protective agents for nanoparticles in drug delivery and targeting
Mogoşanu, G. D., Grumezescu, A. M., Bejenaru, C., & Bejenaru, L. E. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.03.014 · Cited by 68 · see citing works
Li, W., Chiang, C., Huang, W.-C., Su, C.-W., Chiang, M.-Y., Chen, J.-Y., & Chen, S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.020 · Cited by 66 · see citing works
Saneja, A., Khare, V. R., Alam, N., Dubey, R. D., & Gupta, P. N. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.865014 · Cited by 65 · see citing works
Chemotherapeutic drugs induced female reproductive toxicity and treatment strategies
Bhardwaj, J. K., Bikal, P., & Sachdeva, S. N. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23371 · Cited by 63 · see citing works
Gu, Y., Li, J., Li, Y., Song, L., Li, D., Peng, L., Wan, Y., & Hua, S. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s118568 · Cited by 62 · see citing works
Polyphenols delivery by polymeric materials: challenges in cancer treatment
Vittorio, O., Curcio, M., Cojoc, M., Goya, G. F., Hampel, S., Iemma, F., Dubrovska, A., & Cirillo, G. (2017) · Drug Delivery · doi:10.1080/10717544.2016.1236846 · Cited by 62 · see citing works
Resveratrol as sensitizer in colorectal cancer plasticity
Brockmueller, A., Sajeev, A., Koklesová, L., Samuel, S. M., Kubatka, P., Büsselberg, D., Kunnumakkara, A. B., & Shakibaei, M. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10126-x · Cited by 61 · see citing works
Wang, L., Guan, H., Wang, Z., Xing, Y., Zhang, J., & Cai, K. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b01096 · Cited by 58 · see citing works
Neurotoxicity of antineoplastic drugs: Mechanisms, susceptibility, and neuroprotective strategies
Pellacani, C., & Eleftheriou, G. (2020) · Advances in Medical Sciences · doi:10.1016/j.advms.2020.04.001 · Cited by 58 · see citing works
Dey, S., Sherly, M. C. D., Rekha, M. R., & Sreenivasan, K. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.09.016 · Cited by 58 · see citing works
Grumezescu, A. M., Andronescu, E., Ficai, A., Bleoţu, C., Mihăiescu, D. E., & Chifiriuc, M. C. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.07.063 · Cited by 57 · see citing works
Zhu, X., Zhang, Y., Huang, H., Zhang, H., Hou, L., & Zhang, Z. (2016) · Journal of Biomaterials Applications · doi:10.1177/0885328215619583 · Cited by 57 · see citing works
Self-citationWang, S., Yang, W., Cui, J., Li, X., Dou, Y., Su, L., Chang, J. K., Wang, H., Li, X., & Zhang, B. (2015) · Biomaterials Science · doi:10.1039/c5bm00328h · Cited by 55 · see citing works
Prabhuraj, R. S., Bomb, K., Srivastava, R., & Bandyopadhyaya, R. (2020) · Journal of Polymer Research · doi:10.1007/s10965-020-02092-7 · Cited by 55 · see citing works
Ahmed, Z. S. O., Khan, E., Elias, N., Elshebiny, A., & Dou, Q. P. (2025) · Biomolecules · doi:10.3390/biom15050629 · Cited by 54 · see citing works
On-demand combinational delivery of curcumin and doxorubicin via a pH-labile micellar nanocarrier
Li, H., Li, M., Chen, C., Fan, A., Kong, D., Wang, Z., & Zhao, Y. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.09.022 · Cited by 54 · see citing works
Nanopharmacology in translational hematology and oncology
Berindan‐Neagoe, I., Braicu, C., Craciun, L., Irimie, A. I., & Takahashi, Y. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s60488 · Cited by 54 · see citing works
Deng, H., Zhao, X., Liu, J., Deng, L., Zhang, J., Liu, J., & Dong, A. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01939g · Cited by 52 · see citing works
Hong, W., Shi, H., Qiao, M., Zhang, Z., Yang, W., Dong, L., Xie, F., Zhao, C., & Li, K. (2017) · Scientific Reports · doi:10.1038/srep42465 · Cited by 52 · see citing works
Codelivery of Hydrophobic and Hydrophilic Drugs by Graphene-Decorated Magnetic Dendrimers
Pourjavadi, A., Asgari, S., Hosseini, S. H., & Akhlaghi, M. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b02710 · Cited by 52 · see citing works
Zhang, W., Li, C., Shen, C., Liu, Y., Zhao, X., Liu, Y., Zou, D., Gao, Z., & Yue, C. (2015) · Drug Delivery · doi:10.3109/10717544.2015.1035466 · Cited by 50 · see citing works
Pourjavadi, A., Asgari, S., & Hosseini, S. H. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101542 · Cited by 50 · see citing works
Bioactive Compounds: Multi-Targeting Silver Bullets for Preventing and Treating Breast Cancer
Muniraj, N., Siddharth, S., & Sharma, D. (2019) · Cancers · doi:10.3390/cancers11101563 · Cited by 49 · see citing works
Asghar, K., Qasim, M., Dharmapuri, G., & Das, D. (2017) · RSC Advances · doi:10.1039/c7ra03735j · Cited by 47 · see citing works
Sun, L., Deng, X., Yang, X., Li, Z., Wang, Z., Li, L., Wu, Q., Peng, F., Liu, L., & Gong, C. (2014) · RSC Advances · doi:10.1039/c4ra07453j · Cited by 46 · see citing works
Self-citationReddy, K. L., Sharma, P. K., Singh, A. K., Kumar, A., Shankar, K. R., Singh, Y., Garg, N., & Krishnan, V. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.11.007 · Cited by 46 · see citing works
Near-Infrared Light-Triggered Polymeric Nanomicelles for Cancer Therapy and Imaging
Li, L., Pang, X., & Liu, G. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00648 · Cited by 45 · see citing works
Gupta, P. K., Pappuru, S., Gupta, S., Patra, B., Chakraborty, D., & Verma, R. S. (2019) · Materials Science and Engineering: C · doi:10.1016/j.msec.2019.03.041 · Cited by 44 · see citing works
Polybutylcyanoacrylate nanocarriers as promising targeted drug delivery systems
Gao, S., Xu, Y., Asghar, S., Chen, M., Zou, L., Eltayeb, S. E., Huo, M., Ping, Q. N., & Xiao, Y. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1020426 · Cited by 42 · see citing works
Manatunga, D. C., de Silva, R. M., de Silva, K. M. N., Malavige, G. N., Wijeratne, D. T., Williams, G. R., Jayasinghe, C. D., & Udagama, P. V. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.04.001 · Cited by 42 · see citing works
- Authors
- Duan, J., Mansour, H. M., Zhang, Y., Deng, X., Chen, Y., Wang, J., Pan, Y., & Zhao, J.
- Affiliations
- Central South University (CN)
- University of Kentucky (US)
- Emory University (US)
- Corresponding author
- Zhao, Jinfeng
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 426
- Issue
- 1-2
- Pages
- 193-201
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2005475049
- Cited by
- 194
- References
- 38
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 11 · 2023: 8 · 2022: 8 · 2021: 9 · 2020: 19 · 2019: 22 · 2018: 18 · 2017: 18 · 2016: 17 · 2015: 19 · 2014: 16 · 2013: 12 · 2012: 5
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lotus Scholars Program (200734)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- multidrug resistance reversal, doxorubicin, curcumin, chitosan, co-encapsulation, MCF-7/ADR cells, breast cancer, anticancer drug delivery, combination chemotherapy
- MeSH terms
- Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Chromatography, Gel, Curcumin, Doxorubicin, Drug Carriers, Drug Combinations, Drug Compounding, Enbucrilate, Female, Humans, Particle Size, Technology, Pharmaceutical, Down-Regulation, Spectroscopy, Fourier Transform Infrared, Drug Resistance, Multiple, ATP Binding Cassette Transporter, Subfamily B, Drug Resistance, Neoplasm, ATP Binding Cassette Transporter, Subfamily B, Member 1, Nanotechnology, Cell Line, Tumor, Chitosan, Nanoparticles
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