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Fused-filament 3D printing (3DP) for fabrication of tablets
Open accessAbstract
The use of fused-filament 3D printing (FF 3DP) to fabricate individual tablets is demonstrated. The technology permits the manufacture of tablets containing drug doses tailored to individual patients, or to fabrication of tablets with specific drug-release profiles. Commercially produced polyvinyl alcohol (PVA) filament was loaded with a model drug (fluorescein) by swelling of the polymer in ethanolic drug solution. A final drug-loading of 0.29% w/w was achieved. Tablets of PVA/fluorescein (10 mm diameter) were printed using a 3D printer. It was found that changing the degree of infill percentage in the printer software varied the weight and volume of the printed tablets. The tablets were mechanically strong and no significant thermal degradation of the active occurred during printing. Dissolution tests were conducted in modified Hank's buffer. The results showed release profiles were dependent on the infill percentage used to print the tablet. The study indicates that FF 3DP has the potential to offer a new solution for fabricating personalized-dose medicines or unit dosage forms with controlled-release profiles. In addition, the low cost of FDM printers means the paradigm of extemporaneous or point-of-use manufacture of personalized-dose tablets is both feasible and attainable.
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Cited by
Recent progress in drug delivery
Li, C., Wang, J., Wang, Y., Gao, H., Wei, G., Huang, Y., Yu, H., Gan, Y., Wang, Y., Mei, L., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.003 · Cited by 818
Effect of geometry on drug release from 3D printed tablets
Goyanes, A., Robles Martinez, P., Buanz, A., Basit, A. W., & Gaisford, S. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.04.069 · Cited by 667
Self-citationSelective laser sintering (SLS) 3D printing of medicines
Fina, F., Goyanes, A., Gaisford, S., & Basit, A. W. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.06.082 · Cited by 577
Self-citationRecent Developments in Fused Deposition Modeling-Based 3D Printing of Polymers and Their Composites
Rahim, T. N. A. T., Abdullah, A. M., & Md Akil, H. (2019) · Polymer Reviews · doi:10.1080/15583724.2019.1597883 · Cited by 452
Melocchi, A., Parietti, F., Maroni, A., Foppoli, A., Gazzaniga, A., & Zema, L. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.036 · Cited by 409
Metadata
- Authors
- Goyanes, A., Buanz, A. B. M., Basit, A. W., & Gaisford, S.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 476
- Issue
- 1-2
- Pages
- 88-92
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2074015337
- Cited by
- 587
- References
- 0
- FWCI
- 32.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Goyanes, A., Buanz, A. B. M., Basit, A. W., & Gaisford, S. (2014). Fused-filament 3D printing (3DP) for fabrication of tablets. International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2014.09.044
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
