The DOI matches its Crossref record; 314 of the 314 references it cites were found in a registry or an index.
Physicochemical properties of mucus and their impact on transmucosal drug delivery
Open accessAbstract
Mucus is a selective barrier to particles and molecules, preventing penetration to the epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery have recently been made and have emphasized that an understanding of the basic structure, viscoelastic properties, and interactions of mucus is of great value in the design of efficient drug delivery systems. Mucins, the primary non-aqueous component of mucus, are polymers carrying a complex and heterogeneous structure with domains that undergo a variety of molecular interactions, such as hydrophilic/hydrophobic, hydrogen bonds and electrostatic interactions. These properties are directly relevant to the numerous mucin-associated diseases, as well as delivering drugs across the mucus barrier. Therefore, in this review we discuss regional differences in mucus composition, mucus physicochemical properties, such as pore size, viscoelasticity, pH, and ionic strength. These factors are also discussed with respect to changes in mucus properties as a function of disease state. Collectively, the review seeks to provide a state of the art roadmap for researchers who must contend with this critical barrier to drug delivery.
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“However, formulations that cannot penetrate mucous layers and biofilms have low pulmonary bioavailability due to rapid enzymatic deactivation, sequestration and elimination by coughing 22,29 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [22]
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Nanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520
Gänger, S., & Schindowski, K. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030116 · Cited by 447
Di Cola, E., Cantu’, L., Brocca, P., Rondelli, V., Fadda, G. C., Canelli, E., Martelli, P., Clementino, A., Sonvico, F., Bettini, R., et al. (2019) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2019.110439 · Cited by 36
Rampedi, P. N., Ogunrombi, M. O., & Adeleke, O. A. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16060712 · Cited by 15
Metadata
- Authors
- Leal, J., Smyth, H. D. C., & Ghosh, D.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Ghosh, Debadyuti
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 532
- Issue
- 1
- Pages
- 555-572
- ISSN
- 0378-5173 (ISSN-L)
- PMC
- PMC5744044
- OpenAlex
- W2754709330
- Cited by
- 560
- References
- 314
- Citations by year
- 2026: 72 · 2025: 98 · 2024: 87 · 2023: 68 · 2022: 72 · 2021: 66 · 2020: 57 · 2019: 25 · 2018: 14 · 2017: 1
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- International Journal of Pharmaceutics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL138251)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- mucus, mucosal drug delivery, mucin, mucus barrier, viscoelasticity, pore size, pH, ionic strength, mucosal epithelium, drug delivery systems
- MeSH terms
- Humans, Mucins, Mucus, Viscosity, Drug Delivery Systems, Hydrophobic and Hydrophilic Interactions
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