Soluplus micelles for acyclovir ocular delivery: formulation and cornea and sclera permeability

Ocular Drug Delivery Barriers—Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

Bachu, R. D., Chowdhury, P., Al-Saedi, Z. H. F., Karla, P. K., & Boddu, S. H. S. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10010028 · Cited by 425 · see citing works

Antimicrobial peptides and wound healing: biological and therapeutic considerations

Mangoni, M. L., McDermott, A. M., & ZASLOFF, M. A. (2016) · Experimental Dermatology · doi:10.1111/exd.12929 · Cited by 416 · see citing works

Drug delivery for posterior segment eye disease.

Geroski, D. H., & Edelhauser, H. F. (2000) · PubMed · Cited by 341 · see citing works

The Solubility–Permeability Interplay and Its Implications in Formulation Design and Development for Poorly Soluble Drugs

Dahan, A., & Miller, J. M. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9337-6 · Cited by 303 · see citing works

Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera.

Hämäläinen, K. M., Kananen, K., Auriola, S. O. K., Kontturi, K., & Urtti, A. O. (1997) · PubMed · Cited by 266 · see citing works

An Inquiry into the Molecular Basis of HSV Latency and Reactivation

Roizman, B., & Whitley, R. J. (2013) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155654 · Cited by 235 · see citing works

Physicochemical Determinants of Drug Diffusion Across the Conjunctiva, Sclera, and Cornea

Ahmed, I., Gokhale, R. D., Shah, M. V., & Patton, T. F. (1987) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600760802 · Cited by 197 · see citing works

An overview of current techniques for ocular toxicity testing

Wilson, S. L., Ahearne, M., & Hopkinson, A. (2014) · Toxicology · doi:10.1016/j.tox.2014.11.003 · Cited by 186 · see citing works

Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis

Wilhelmus, K. R. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002898.pub5 · Cited by 185 · see citing works

Herpes Zoster Eye Complications: Rates and Trends

Yawn, B. P., Wollan, P. C., Sauver, J. L. S., & Butterfield, L. C. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.03.014 · Cited by 175 · see citing works

Soft contact lenses functionalized with pendant cyclodextrins for controlled drug delivery

dos Santos, J.-F. R., Alvarez‐Lorenzo, C., Silva, M., Balsa, L., Couceiro, J., Torres-Labandeira, J.-J., & Concheiro, Á. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.11.016 · Cited by 160 · see citing works

Herpes simplex keratitis: challenges in diagnosis and clinical management

Azher, T. N., Yin, X.-T., Tajfirouz, D. A., Huang, A., & Stuart, P. M. (2017) · Clinical ophthalmology · doi:10.2147/opth.s80475 · Cited by 157 · see citing works

Management of Herpes Simplex Virus Stromal Keratitis: An Evidence-based Review

Knickelbein, J. E., Hendricks, R. L., & Charukamnoetkanok, P. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2008.12.004 · Cited by 156 · see citing works

Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents

Tsatsos, M., MacGregor, C., Athanasiadis, I. K., Moschos, M. M., Hossain, P. N., & Anderson, D. F. (2016) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.12785 · Cited by 156 · see citing works

Nanocarrier mediated retinal drug delivery: overcoming ocular barriers to treat posterior eye diseases

Bisht, R., Mandal, A., Jaiswal, J. K., & Rupenthal, I. D. (2017) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1473 · Cited by 142 · see citing works

Ocular HSV-1 Latency, Reactivation and Recurrent Disease

Toma, H. S., Murina, A., Areaux, R. G., Neumann, D. M., Bhattacharjee, P. S., Foster, T. P., Kaufman, H. E., & Hill, J. M. (2008) · Seminars in Ophthalmology · doi:10.1080/08820530802111085 · Cited by 141 · see citing works

Poloxamer 407/TPGS mixed micelles as promising carriers for cyclosporine ocular delivery

Grimaudo, M. A., Pescina, S., Padula, C., Santi, P., Concheiro, A., Alvarez-Lorenzo, C., & Nicoli, S. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00939 · Cited by 138 · see citing works

α-Lipoic acid in soluplus(®) polymeric nanomicelles for ocular treatment of diabetes-associated corneal diseases

Alvarez-Rivera, F., Fernández-Villanueva, D., Concheiro, A., & Alvarez-Lorenzo, C. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.03.006 · Cited by 127 · see citing works

Human Microbiota and Ophthalmic Disease.

Lu, L. J., & Liu, J. (2016) · PubMed Central · Cited by 117 · see citing works

Ocular Herpes Simplex Virus: How are Latency, Reactivation, Recurrent Disease and Therapy Interrelated?

Al-Dujaili, L. J., Clerkin, P. P., Clément, C., McFerrin, H. E., Bhattacharjee, P. S., Varnell, E. D., Kaufman, H. E., & Hill, J. M. (2011) · Future Microbiology · doi:10.2217/fmb.11.73 · Cited by 114 · see citing works

Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance

James, S. H., & Prichard, M. N. (2014) · Current Opinion in Virology · doi:10.1016/j.coviro.2014.06.003 · Cited by 112 · see citing works

Diversity of Microbial Species Implicated in Keratitis: A Review

Karsten, E., Watson, S. L., & Foster, L. J. R. (2012) · The Open Ophthalmology Journal · doi:10.2174/1874364101206010110 · Cited by 108 · see citing works

Herpesvirus: an underestimated virus

Rechenchoski, D. Z., Galhardi, L. C. F., Linhares, R. E. C., & Nozawa, C. (2016) · Folia Microbiologica · doi:10.1007/s12223-016-0482-7 · Cited by 107 · see citing works

Host Defense at the Ocular Surface

Pearlman, E. M., Sun, Y., Roy, S., Karmakar, M., Hise, A. G., Szczotka‐Flynn, L. B., Ghannoum, M. A., Chinnery, H. R., McMenamin, P. G., & Rietsch, A. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2012.749400 · Cited by 105 · see citing works

Human cytomegalovirus retinitis: pathogenicity, immune evasion and persistence

Scholz, M., Doerr, H. W., & Cinatl, J. J. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(03)00066-0 · Cited by 97 · see citing works

Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes

Loc’h, C., Žakelj, S., Kristl, A., Nagel, S., Guthoff, R. F., Weitschies, W., & Seidlitz, A. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.05.007 · Cited by 88 · see citing works

Improved oral bioavailability and anticancer efficacy on breast cancer of paclitaxel via Novel Soluplus®—Solutol® HS15 binary mixed micelles system

Hou, J., Sun, E., Sun, C., Wang, J., Yang, L., Jia, X., & Zhang, Z. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.08.045 · Cited by 88 · see citing works

Positively charged micelles based on a triblock copolymer demonstrate enhanced corneal penetration

Li, J., Li, Z., Zhou, T., Zhang, J., Xia, H., Li, H., He, J., He, S., & Wang, L. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s90347 · Cited by 87 · see citing works

Pharmacokinetics of oral acyclovir (Zovirax) in the eye.

Hung, S. O., Patterson, A., & Rees, P. J. (1984) · British Journal of Ophthalmology · doi:10.1136/bjo.68.3.192 · Cited by 81 · see citing works

Characterization of Human Sclera Barrier Properties for Transscleral Delivery of Bevacizumab and Ranibizumab

Wen, H., Hao, J., & Li, S. K. (2012) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23387 · Cited by 80 · see citing works

Nanomicelle formulation for topical delivery of cyclosporine A into the cornea: in vitro mechanism and in vivo permeation evaluation

Guo, C., Zhang, Y., Yang, Z., Li, M., Li, F., Cui, F., Liu, T., Shi, W., & Wu, X. (2015) · Scientific Reports · doi:10.1038/srep12968 · Cited by 80 · see citing works

Epalrestat-loaded silicone hydrogels as contact lenses to address diabetic-eye complications

Alvarez-Rivera, F., Concheiro, Á., & Alvarez‐Lorenzo, C. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.10.016 · Cited by 79 · see citing works

Aqueous nanomicellar formulation for topical delivery of biotinylated lipid prodrug of acyclovir: formulation development and ocular biocompatibility

Vadlapudi, A. D., Cholkar, K., Vadlapatla, R. K., & Mitra, A. K. (2014) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2013.0157 · Cited by 62 · see citing works

Topical formulation of self-assembled antiviral prodrug nanomicelles for targeted retinal delivery

Mandal, A., Cholkar, K., Khurana, V., Shah, A., Agrahari, V., Bisht, R., Pal, D., & Mitra, A. K. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00128 · Cited by 60 · see citing works

Influence of drug loading and type of ointment base on the in vitro performance of acyclovir ophthalmic ointment

Al-Ghabeish, M., Xu, X., Krishnaiah, Y. S. R., Rahman, Z., Yang, Y., & Khan, M. A. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.08.096 · Cited by 46 · see citing works

Transcorneal Permeation of l- and d-Aspartate Ester Prodrugs of Acyclovir: Delineation of Passive Diffusion Versus Transporter Involvement

Majumdar, S., Hingorani, T., Srirangam, R., Gadepalli, R. S., Rimoldi, J. M., & Repka, M. A. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9730-0 · Cited by 46 · see citing works

Herpes simplex keratitis

Hill, G., Ku, E. S., & Dwarakanathan, S. (2014) · Disease-a-Month · doi:10.1016/j.disamonth.2014.03.003 · Cited by 40 · see citing works

Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the Eye

Mayhew, R. G. E., & Longnecker, R. (2017) · Journal of Virology · doi:10.1128/jvi.00115-17 · Cited by 36 · see citing works

Ocular herpes: the pathophysiology, management and treatment of herpetic eye diseases

Zhu, L., & Zhu, H. (2014) · Virologica Sinica · doi:10.1007/s12250-014-3539-2 · Cited by 35 · see citing works

Assay of acyclovir in human skin layers by high-performance liquid chromatography

Volpato, N. M., Santi, P., Laureri, C. F., & Colombo, P. (1997) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(97)00091-5 · Cited by 35 · see citing works

Influence of Permeant Lipophilicity on Permeation Across Human Sclera

Wen, H., Hao, J., & Li, S. K. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0237-0 · Cited by 29 · see citing works

Sclérites et épisclérites : prise en charge diagnostique et thérapeutique

Héron, E., Gutzwiller-Fontaine, M., & Bourcier, T. (2014) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2014.02.004 · Cited by 27 · see citing works

In This Issue: Immunology of the Eye—Inside and Out

Caspi, R. R. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2012.750138 · Cited by 20 · see citing works

Corneal and Scleral Permeability of Quinolones—A Pharmacokinetics Study

Tai, M., Lu, D., & Chiang, C. (2003) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/108076803322660468 · Cited by 11 · see citing works

Preparation of O’O-lauroyl Chitosan and Self-assembly Micellar Solubilization of Acyclovir

Tan, F. (2017) · DEStech Transactions on Engineering and Technology Research · doi:10.12783/dtetr/emme2016/9794 · Cited by 1 · see citing works

Nanoformulated Codelivery of Quercetin and Alantolactone Promotes an Antitumor Response through Synergistic Immunogenic Cell Death for Microsatellite-Stable Colorectal Cancer

Zhang, J., Shen, L., Li, X., Song, W., Liu, Y., & Huang, L. (2019) · ACS Nano · doi:10.1021/acsnano.9b02875 · Cited by 158 · see citing works

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Liu, L.-C., Chen, Y., & Lu, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015352 · Cited by 141 · see citing works

Bilosomes nanocarriers for improved oral bioavailability of acyclovir: A complete characterization through in vitro, ex-vivo and in vivo assessment

Saifi, Z., Rizwanullah, M., Mir, S. R., & Amin, S. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101634 · Cited by 136 · see citing works

Soluplus® polymeric nanomicelles improve solubility of BCS-class II drugs

Pignatello, R., Corsaro, R., Bonaccorso, A., Zingale, E., Carbone, C., & Musumeci, T. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01182-x · Cited by 118 · see citing works

An overview on nanoparticle-based strategies to fight viral infections with a focus on COVID-19

Yasamineh, S., Kalajahi, H. G., Yasamineh, P., Yazdani, Y., Gholizadeh, O., Tabatabaie, R., Afkhami, H., Davodabadi, F., farkhad, A. K., Pahlevan, D., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01625-0 · Cited by 102 · see citing works

Micellisation Mechanism and Behaviour of Soluplus®–Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System

Alopaeus, J. F., Hagesæther, E., & Tho, I. (2019) · Pharmaceuticals · doi:10.3390/ph12010015 · Cited by 94 · see citing works

New micelle myricetin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment

Sun, F., Zheng, Z., Lan, J., Li, X., Li, M., Song, K., & Wu, X. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1622608 · Cited by 85 · see citing works

Topical application of polymeric nanomicelles in ophthalmology: a review on research efforts for the noninvasive delivery of ocular therapeutics

Grimaudo, M. A., Pescina, S., Padula, C., Santi, P., Concheiro, A., Alvarez-Lorenzo, C., & Nicoli, S. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1597848 · Cited by 78 · see citing works

Prodrugs and nanomicelles to overcome ocular barriers for drug penetration

Gote, V., Michael, A., & Pal, D. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2020.1803278 · Cited by 73 · see citing works

Pulmonary delivery of rifampicin-loaded soluplus micelles against Mycobacterium tuberculosis

Grotz, E., Tateosian, N. L., Salgueiro, J., Bernabeu, E., González, L., Manca, M. L., Amiano, N. O., Valenti, D., Manconi, M., García, V., et al. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101170 · Cited by 71 · see citing works

Soluplus® as a solubilizing excipient for poorly water-soluble drugs: Recent advances in formulation strategies and pharmaceutical product features

Attia, M. S., Elshahat, A., Hamdy, A., Fathi, A. M., Emad-Eldin, M., Ghazy, F.-E. S., Chopra, H., & Ibrahim, T. M. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104519 · Cited by 67 · see citing works

Advancement on Sustained Antiviral Ocular Drug Delivery for Herpes Simplex Virus Keratitis: Recent Update on Potential Investigation

Pandey, M., Choudhury, H., Aziz, A. A., Bhattamisra, S. K., Gorain, B., Su, J. S. T., Tan, C. L., Chin, W. Y., & Yip, K. Y. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics13010001 · Cited by 64 · see citing works

Cyclosporine-loaded micelles for ocular delivery: investigating the penetration mechanisms

Ghezzi, M., Ferraboschi, I., Delledonne, A., Pescina, S., Padula, C., Santi, P., Sissa, C., Terenziani, F., & Nicoli, S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.07.019 · Cited by 63 · see citing works

Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics

Chen, R., Wang, T., Song, J., Pu, D., He, D., Li, J., Yang, J., Li, K., Zhong, C., & Zhang, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s315705 · Cited by 61 · see citing works

Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

Li, Z., Liu, M., Ke, L., Wang, L.-J., Wu, C., Li, C., Li, Z., & Wu, Y.-L. (2021) · Nanoscale Advances · doi:10.1039/d1na00596k · Cited by 59 · see citing works

Cyclodextrin–Amphiphilic Copolymer Supramolecular Assemblies for the Ocular Delivery of Natamycin

Lorenzo-Veiga, B., Sigurðsson, H. H., Loftsson, Þ., & Alvarez‐Lorenzo, C. (2019) · Nanomaterials · doi:10.3390/nano9050745 · Cited by 53 · see citing works

γ-Cyclodextrin-based polypseudorotaxane hydrogels for ophthalmic delivery of flurbiprofen to treat anterior uveitis

Fang, G., Wang, Q., Yang, X., Yu, Q., Zhang, G., & Tang, B. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118889 · Cited by 50 · see citing works

Role of Polymeric Micelles in Ocular Drug Delivery: An Overview of Decades of Research

Binkhathlan, Z., Ali, R., Alomrani, A. H., Kalam, M. A., Alshamsan, A., & Lavasanifar, A. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00598 · Cited by 46 · see citing works

Preparation of Solid Dispersions of Simvastatin and Soluplus Using a Single-Step Organic Solvent-Free Supercritical Fluid Process for the Drug Solubility and Dissolution Rate Enhancement

Nandi, U., Ajiboye, A. L., Patel, P., Douroumis, D., & Trivedi, V. (2021) · Pharmaceuticals · doi:10.3390/ph14090846 · Cited by 45 · see citing works

Imprinted Contact Lenses for Ocular Administration of Antiviral Drugs

Varela-García, A., Gómez-Amoza, J. L., Concheiro, Á., & Alvarez‐Lorenzo, C. (2020) · Polymers · doi:10.3390/polym12092026 · Cited by 44 · see citing works

Atorvastatin-Eluting Contact Lenses: Effects of Molecular Imprinting and Sterilization on Drug Loading and Release

Pereira-da-Mota, A. F., Vivero-Lopez, M., Topete, A., Serro, A. P., Concheiro, Á., & Alvarez‐Lorenzo, C. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050606 · Cited by 41 · see citing works

Synergistic and antagonistic effects of various amphiphilic polymer combinations in enhancing griseofulvin release from ternary amorphous solid dispersions

Rahman, M., Coelho, A., Tarabokija, J., Ahmad, S., Radgman, K., & Bilgili, E. A. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105354 · Cited by 39 · see citing works

Ex vivo conjunctival retention and transconjunctival transport of poorly soluble drugs using polymeric micelles

Pescina, S., Grolli Lucca, L., Govoni, P., Padula, C., Del Favero, E., Cantù, L., Santi, P., & Nicoli, S. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090476 · Cited by 38 · see citing works

Micelles of progesterone for topical eye administration: interspecies and intertissues differences in Ex vivo ocular permeability

Alambiaga-Caravaca, A. M., Calatayud-Pascual, M. A., Rodilla, V., Concheiro, A., López-Castellano, A., & Alvarez-Lorenzo, C. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12080702 · Cited by 38 · see citing works

Recent development of polymer nanomicelles in the treatment of eye diseases

Cai, R., Zhang, L., & Hao, C. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1246974 · Cited by 40 · see citing works

New resveratrol micelle formulation for ocular delivery: characterization and in vitro / in vivo evaluation

Li, M., Zhang, L., Li, R., & Yan, M. (2020) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2020.1828909 · Cited by 37 · see citing works

Pluronic®/casein micelles for ophthalmic delivery of resveratrol: In vitro, ex vivo, and in vivo tests

Vivero-Lopez, M., Sparacino, C., Quelle‐Regaldie, A., Sanchez, L. E., Candal, E., Barreiro‐Iglesias, A., Huete‐Toral, F., Carracedo, G., Otero, A., Concheiro, Á., et al. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122281 · Cited by 37 · see citing works

Novel ultrasmall nanomicelles based on rebaudioside A: A potential nanoplatform for the ocular delivery of pterostilbene

Song, K., Xin, M., Zhang, F., Xie, W., Sun, M., & Wu, X. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119035 · Cited by 36 · see citing works

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

Piazzini, V., Vasarri, M., Degl’Innocenti, D., Guastini, A., Barletta, E., Salvatici, M. C., & Bergonzi, M. C. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11120655 · Cited by 35 · see citing works

In-situ nanomicelle forming microneedles of poly NIPAAm-b-poly glutamic acid for trans-scleral delivery of dexamethasone

Alimardani, V., Abolmaali, S. S., Yousefi, G., Nowroozzadeh, M. H., & Tamaddon, A. M. (2022) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2022.11.072 · Cited by 33 · see citing works

Understanding the self-assembly of the polymeric drug solubilizer Soluplus®

Mateos, H., Gentile, L., Murgia, S., Colafemmina, G., Collu, M., Smets, J., & Palazzo, G. (2021) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2021.12.016 · Cited by 32 · see citing works

Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier

Zhang, F., Chen, H., Lan, J., Song, K., & Wu, X. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108313 · Cited by 29 · see citing works

Polymeric micelles and nanomedicines: Shaping the future of next generation therapeutic strategies for infectious diseases

Toscanini, M. A., Limeres, M. J., Garrido, A. V., Cagel, M., Bernabeu, E., Moretton, M. A., Chiappetta, D. A., & Cuestas, M. L. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102927 · Cited by 29 · see citing works

Copolymer micelle-administered melatonin ameliorates hyperosmolarity-induced ocular surface damage through regulating PINK1-mediated mitophagy

Xu, J., Chen, P., Zhao, G., Wei, S., Li, Q., Guo, C., Cao, Q., Wu, X., & Di, G. (2022) · Current Eye Research · doi:10.1080/02713683.2021.2022163 · Cited by 26 · see citing works

Contact lenses for pravastatin delivery to eye segments: Design and in vitro-in vivo correlations

Pereira-da-Mota, A. F., Vivero-Lopez, M., Serramito, M., Díaz-Gómez, L. A., Serro, A. P., Carracedo, G., Huete‐Toral, F., Concheiro, Á., & Alvarez‐Lorenzo, C. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.001 · Cited by 27 · see citing works

Polymeric Nanomicelles of Soluplus® as a Strategy for Enhancing the Solubility, Bioavailability and Efficacy of Poorly Soluble Active Compounds

Pignatello, R., & Corsaro, R. (2019) · Current Nanomedicine · doi:10.2174/2468187309666190314152451 · Cited by 26 · see citing works

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

Donato, C. D., Iacovino, R., Isernia, C., Malgieri, G., Varela-García, A., Concheiro, Á., & Alvarez‐Lorenzo, C. (2020) · Nanomaterials · doi:10.3390/nano10040613 · Cited by 27 · see citing works

Soluplus–TPGS Mixed Micelles as a Delivery System for Brigatinib: Characterization and In Vitro Evaluation

Ali, R., Qamar, W., Kalam, M. A., & Binkhathlan, Z. (2024) · ACS Omega · doi:10.1021/acsomega.4c06264 · Cited by 24 · see citing works

Cytosine-functionalized bioinspired hydrogels for ocular delivery of antioxidant transferulic acid

Varela-García, A., Concheiro, Á., & Alvarez‐Lorenzo, C. (2020) · Biomaterials Science · doi:10.1039/c9bm01582e · Cited by 22 · see citing works

Development of a Thermosensitive In-Situ Gel Formulations of Vancomycin Hydrochloride: Design, Preparation, In Vitro and In Vivo Evaluation

Bai, L., Lei, F., Luo, R. X., Fei, Q., Zheng, Z., He, N., & Gui, S. (2022) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2022.04.011 · Cited by 22 · see citing works

Functional block copolymer micelles based on poly (jasmine lactone) for improving the loading efficiency of weakly basic drugs

Ali, A. A., Bhadane, R. N., Asl, A. A., Wilén, C., Salo‐Ahen, O. M. H., Rosenholm, J. M., & Bansal, K. K. (2022) · RSC Advances · doi:10.1039/d2ra03962a · Cited by 23 · see citing works

Nanomaterials in the diagnosis and treatment of ophthalmic diseases

Ma, Y., Zhang, Z., Yu, Y., Wang, X., Liu, S., Sun, B., Cai, Z., Cui, W., Zhou, X., & Zhao, J. (2024) · Nano Today · doi:10.1016/j.nantod.2023.102117 · Cited by 23 · see citing works

Effect of melt extrudability and melt binding efficiency of polyvinyl caprolactam polyvinyl acetate polyethylene glycol graft copolymer (Soluplus®) on release pattern of hydrophilic and high dose drugs

Ayyub, K. T., Moravkar, K. K., Maniruzzaman, M., & Amin, P. D. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.01.126 · Cited by 21 · see citing works

Development and characterization of octreotide-modified curcumin plus docetaxel micelles for potential treatment of non-small-cell lung cancer

An, Q., Shi, C., Guo, H., Xie, S., Yang, Y., Liu, Y.-N., Liu, Z.-H., Chang-zheng, Z., & Niu, F. (2019) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2019.1647236 · Cited by 20 · see citing works

Graphene oxide reinforced nanocomposite oleogels improves corneal permeation of drugs

Hasda, A. M., Rathnam, S. S. V., Qureshi, D., Prasad, G., Mohanty, B., Banerjee, I., Shaikh, H., Anis, A., Sarkar, P., & Pal, K. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102024 · Cited by 20 · see citing works

Targeted Drug Delivery Systems for the Treatment of Glaucoma: Most Advanced Systems Review

Cegielska, O., & Sajkiewicz, P. (2019) · Polymers · doi:10.3390/polym11111742 · Cited by 19 · see citing works

Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema

Toffoletto, N., Salema‐Oom, M., Anguiano-Igea, S., Alvarez‐Lorenzo, C., Saramago, B., & Serro, A. P. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070976 · Cited by 19 · see citing works

Drug Delivery Systems for Infectious Eye Diseases: Advancements and Prospects

Mahaling, B., Baruah, N., & Dinabandhu, A. (2024) · Journal of Nanotheranostics · doi:10.3390/jnt5040010 · Cited by 18 · see citing works

Design, optimization, in vitro and in vivo evaluation of triamcinolone acetonide nanocrystals loaded in situ gel for topical ocular delivery

Khan, M. S., Ravi, P. R., & Dhavan, D. S. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113539 · Cited by 17 · see citing works

Asymmetry in Drug Permeability through the Cornea

Toffoletto, N., Chauhan, A., Alvarez‐Lorenzo, C., Saramago, B., & Serro, A. P. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050694 · Cited by 17 · see citing works

A Novel Eyes Topical Drug Delivery System: CsA-LNC for the Treatment of DED

Zhang, A., Sun, R., Ran, M., Deng, Y., Ge, Y. C., Zhu, Y., Tao, X., Shang, L., Gou, J., He, H., et al. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02872-2 · Cited by 16 · see citing works

Nanostructured Lipid Carriers Aimed to the Ocular Delivery of Mangiferin: In Vitro Evidence

Santonocito, D., Barbagallo, I. A., Distefano, A., Sferrazzo, G., Vivero-Lopez, M., Sarpietro, M. G., & Puglia, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030951 · Cited by 16 · see citing works

Recent progress in colloidal nanocarriers loaded in situ gel in ocular therapeutics

Chaudhari, P., Shetty, D., & Lewis, S. A. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103327 · Cited by 15 · see citing works

Ciprofloxacin self-dissolvable Soluplus based polymeric films: a novel proposal to improve the management of eye infections

Guillot, A. J., Petalas, D., Skondra, P., Rico, H., Garrigues, T., & Melero, A. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00887-1 · Cited by 14 · see citing works

Preparation and characterization of bear bile-loaded pH sensitive in-situ gel eye drops for ocular drug delivery.

Ni, X., Guo, Q., Zou, Y., Yang, X., Mohammad, I. S., Ding, Q., & Hu, H. (2020) · PubMed Central · doi:10.22038/ijbms.2020.45386.10562 · Cited by 14 · see citing works

Cancer cell membrane-modified Soluplus® micelles for gemcitabine delivery to pancreatic cancer using a prodrug approach

Pereira‐Silva, M., Díaz-Gómez, L. A., Blanco‐Fernandez, B., Ferreirós, A., Veiga, F., Concheiro, Á., Paiva‐Santos, A. C., & Alvarez‐Lorenzo, C. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124529 · Cited by 12 · see citing works

Electrospun scaffold based on poly(ethylene oxide)/poly(ε-caprolactone) for prolonged intravaginal antiviral drug release

Ahani, E., & Mianehro, A. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104856 · Cited by 12 · see citing works

Polymeric Micelles: A Novel Approach towards Nano-Drug Delivery System

Vinchurkar, R. H., & Kuchekar, A. B. (2021) · doi:10.13005/bbra/2947 · Cited by 12 · see citing works

Cyclosporine a Eluting Nano Drug Reservoir Film for the Management of Dry Eye Disease

Chaudhari, P., Ghate, V., Nampoothiri, M., & Lewis, S. A. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03104-9 · Cited by 11 · see citing works

Dexamethasone pharmacokinetics characteristics via sub-tenon microfluidic system in uveitis rabbits

Huang, X., Duan, Y., Zhao, L., Liu, S., Qin, D., Zhang, F., & Lin, D. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101639 · Cited by 10 · see citing works

Delivery of Fenofibrate to Ocular Tissues using 2-Hydroxypropyl-β-cyclodextrin-Based Micelles

Klahan, B., O’Reilly, N. J., Sigurðsson, H. H., Chauhan, A., Mering, S., & Fitzhenry, L. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125417 · Cited by 9 · see citing works

Biomimetic cancer cell membrane-enriched vitamin E-stapled gemcitabine-loaded TPGS micelles for pancreatic cancer therapy

Pereira‐Silva, M., Díaz-Gómez, L. A., Blanco‐Fernandez, B., Paiva‐Santos, A. C., Veiga, F., Concheiro, Á., & Alvarez‐Lorenzo, C. (2025) · Drug Delivery · doi:10.1080/10717544.2025.2527759 · Cited by 9 · see citing works

Nanomicellar eye drops: a review of recent advances

Paganini, V., Chetoni, P., Gangi, M. D., Monti, D., Tampucci, S., & Burgalassi, S. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2323208 · Cited by 9 · see citing works

Topical Ocular Administration of Progesterone Decreases Photoreceptor Cell Death in Retinal Degeneration Slow (rds) Mice

Alambiaga‐Caravaca, A. M., Cantó, A., Rodilla, V., Miranda, M., & López‐Castellano, A. (2022) · Pharmaceuticals · doi:10.3390/ph15030328 · Cited by 8 · see citing works

Topical hydrophilic gel with itraconazole-loaded polymeric nanomicelles improves wound healing in the treatment of feline sporotrichosis

Santiago, M. G., da Silva, C. D., de Souza, B. M., Assis, B. R. D., Pinto, P. N., Keller, K. M., Vilela, R., de Oliveira, C. S. F., & Goulart, G. A. C. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122619 · Cited by 8 · see citing works

Binary Polymeric Surfactant Mixtures for the Development of Novel Loteprednol Etabonate Nanomicellar Eyedrops

Tampucci, S., Monti, D., Burgalassi, S., Terreni, E., Paganini, V., Gangi, M. D., & Chetoni, P. (2023) · Pharmaceuticals · doi:10.3390/ph16060864 · Cited by 8 · see citing works

Lapatinib-loaded nanocolloidal polymeric micelles for the efficient treatment of breast cancer

Bonde, G. V., Ajmal, G., Kumari, Y. S., Mittal, P., & Mishra, B. (2020) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2020.10903 · Cited by 8 · see citing works

A water-soluble drug nanoparticle-loaded in situ gel for enhanced precorneal retention and its transduction mechanism of pharmacodynamic effects

Zhang, Y., Xiao, Z., Li, Q., Ke, Y., Gu, X., Pan, K., Long, Q., Guo, Y., Yu, X. J., Teng, X., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.125150 · Cited by 8 · see citing works

Efavirenz Repurposing Challenges: A Novel Nanomicelle-Based Antiviral Therapy Against Mosquito-Borne Flaviviruses

Maldonado, S., Fuentes, P., Bernabeu, E., Bertera, F. M., Opezzo, J. A. W., Lagomarsino, E., Lee, H. J., R., F. M., Choi, M. R., Salgueiro, M. J., et al. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020241 · Cited by 7 · see citing works

Comprehensive analysis of the structural and interfacial properties of Soluplus® micelles: Implications for optimizing drug encapsulation and stability

Desai, S., Bhalani, D., Vyas, J., Milyaeva, O. Y., Modi, S. D., Ray, D., Aswal, V. K., & Pillai, S. A. (2025) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2025.136656 · Cited by 7 · see citing works

In situ saxs characterization of thermoresponsive behavior of a poly(ethylene glycol)-graft-(poly(vinyl caprolactam)-co-poly(vinyl acetate)) amphiphilic graft copolymer

Kennedy, M. A., Zhang, Y., & Bhatia, S. R. (2022) · Nanotechnology · doi:10.1088/1361-6528/acab6d · Cited by 7 · see citing works

From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics

Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7 · see citing works

Drug Delivery Technologies for the Treatment of Age‐Related Macular Degeneration

Rodriguez‐Cruz, J. J., Cutrufello, J., Lam, M., Nallaparaju, S., & Peppas, N. A. (2025) · Advanced Science · doi:10.1002/advs.202503212 · Cited by 6 · see citing works

Development of binary dispersions and nanocomposites of irbesartan with enhanced antihypertensive activity

Puri, V., Nagpal, M., Sharma, A., Thakur, G. S., Singh, M., & Aggarwal, G. (2019) · Bioimpacts · doi:10.34172/bi.2020.34 · Cited by 6 · see citing works

Ocular polymeric nanomicelles for the posterior eye segment in the management of retinoblastoma: formulation, optimization, <i>in vitro</i> and <i>ex vivo</i> evaluations

Ansari, M., Kulkarni, Y. A., & Singh, K. (2025) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2025.2469321 · Cited by 5 · see citing works

Clinical strategies to prevent recurrence of Herpes simplex and Herpes zoster following ocular surgery: A comprehensive review with practical guidelines

Ghafarian, S., Samavat, B., Lee, K. S., Sheikhghomi, S., Cheraghpour, K., Shukla, D., Djalilian, A. R., Chodosh, J., & Soleimani, M. (2025) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2025.02.002 · Cited by 5 · see citing works

Innovative bilayered buccal films: A paediatric-friendly dosage form for transmucosal azithromycin delivery

Bondi, G., D’Abbrunzo, I., Hasa, D., Parolin, C., Vitali, B., Bertoni, S., Imbriano, A., Pagano, C., Fratini, C., Sabbatini, B., et al. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126164 · Cited by 5 · see citing works

Ex-vivo skin retention of crisaborole from microemulsion and micellar formulations

Concini, A., Nicoli, S., Pescina, S., Sissa, C., Santi, P., & Padula, C. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106082 · Cited by 6 · see citing works

Comparative Study of Dexamethasone-Loaded Thermoresponsive In Situ Gels and Polymeric Micelles for Ocular Drug Delivery

Szalai, B., Jójárt‐Laczkovich, O., Kovács, A., Berkó, S., Sipos, B., Katona, G., & Budai-Szűcs, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178414 · Cited by 5 · see citing works

Steering the Clinical Translation of Delivery Systems for Drugs and Health Products

Pignatello, R., & Matricardi, P. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040350 · Cited by 5 · see citing works

A Review on Polymeric Nano Micelles Based Delivery to the Posterior Segment of the Eye

Devi, S., Bhatt, S., Saini, V., Kumar, M., & Deep, A. (2020) · Nanoscience &amp Nanotechnology-Asia · doi:10.2174/2210681209666190717162913 · Cited by 5 · see citing works

The possible techniques that used to improve the bioavailablity, pharmacological activity, solubility and permeability of anti-viral drugs: Insight for COVID-19 antiviral drugs

Hashim, G. M., Hameed, G. S., & Hanna, D. B. (2023) · Al Mustansiriyah Journal of Pharmaceutical Sciences · doi:10.32947/ajps.v23i3.1040 · Cited by 4 · see citing works

Development and optimization of Soluplus®/Pluronic-based polymeric micelles for bicalutamide delivery: characterization, lyophilization, stability, and cellular studies

Özaksun, N. T., Tayyar, T., Özdemir, A., Ark, M., & İnceçayır, T. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107395 · Cited by 3 · see citing works

Strategies for delivery of antiviral agents

Khwaza, V., Buyana, B., Nqoro, X., Peter, S., Mbese, Z., Feketshane, Z., Alven, S., & Aderibigbe, B. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91814-5.00018-0 · Cited by 3 · see citing works

Optimization and evaluation of polymeric mixed nanomicelles for ocular delivery to the posterior eye segment

Ansari, M., Kulkarni, Y. A., & Singh, K. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106605 · Cited by 3 · see citing works

Management and control of intraocular pressure applying macitentan hydrogel film formulation: improved effect of surfactant and cosurfactant system

Hota, S. S., Nandi, S., & Mallick, S. (2022) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-021-00428-2 · Cited by 2 · see citing works

Overcoming barriers in formulating practically insoluble loteprednol etabonate in ophthalmic nanoemulsion

Ljubica, J., Dukovski, B. J., Krtalić, I., Juretić, M., Kučuk, M. S., Petriček, I., Špoljarić, D., Bočkor, L., Kocbek, P., Hafner, A., et al. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107077 · Cited by 1 · see citing works

An overview of novel formulations for ocular viral infections: focused on nanomedicines

Verma, S., Nainwal, N., & Juyal, D. (2025) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2025.2515998 · Cited by 1 · see citing works

Hydrophilic and Amphiphilic Macromolecules as Modulators of the Physical Stability and Bioavailability of Piribedil: A Study on Binary Mixtures and Micellar Systems

Orszulak, L., Minecka, A., Bernat, R., Lamrani, T., Jurkiewicz, K., Hachuła, B., Tarnacka, M., Geppert‐Rybczyńska, M., Zubko, M., Staniszewska, M., et al. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00276 · Cited by 1 · see citing works

Recent approaches to combat various infections in eye

Sharma, P., & Rani, A. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns5.10842

Dose-Sparing Topical Administration: FK506-Loaded Nano-Micelles Achieve Efficient Therapy in a Murine Model of Vernal Keratoconjunctivitis

Liang, Z., Lu, P., Tao, Y., Zhang, Z., Song, F., 夏慧芸, He, J., Yao, X., Dong, F., Zhang, J., et al. (2026) · Pharmaceuticals · doi:10.3390/ph19060826

Smart Polymer‐Based Drug Delivery Systems for Managing Infective Conjunctivitis: Advances and Future Prospects

Linkang, X., Maki, M. A. A., Tayyab, S., Thakur, S. S., Kumar, P., Karwasra, R., Behare, M. H., Sharma, N., Kamal, W. H. B. W., Kobi, O., et al. (2026) · Nano Select · doi:10.1002/nano.70110

Acyclovir Loaded Solid Lipid Nanoparticulate Gel for Ocular Delivery: Optimization by using Factorial Design

Majumdar, S., Swain, S., Rao, M. E. B., Chakraborty, P., & Das, S. S. (2021) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.55.1s.43 · Cited by 5 · see citing works

Formulation And Characterization of a Carbopol Proniosome Gel to Enhance Corneal Delivery of Acyclovir In HSV-1 Keratitis

Sankula, K. R., Kunam, V., Prathibha, C. V., Shaikh, W. A. G., Sharma, B., Bharathi, D., Patil, P. M., & Waghmare, N. (2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.13s.46

Enhanced Trans-Corneal Permeability of Valacyclovir by Polymethacrylic Acid Copolymers Based Ocular Microspheres: In Vivo Evaluation of Estimated Pharmacokinetic/Pharmacodynamic Indices and Simulation of Aqueous Humor Drug Concentration-Time Profile

Kapanigowda, U. G., Sreeharsha, N., Ramaiah, B., Boggarapu, P. R., & Subramanian, R. (2015) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-015-9239-0 · Cited by 7 · see citing works

Acyclovir-containing liposomes for potential ocular delivery

Law, S. L., Huang, K.-J., & Chiang, C. ‐. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00192-3 · Cited by 202 · see citing works

Development of Acyclovir-loaded Bovine Serum Albumin Nanoparticles for Ocular Drug Delivery

Noomwong, P., Ratanasak, W., Polnok, A., & Sarisuta, N. (2012) · International Journal of Phytomedicine · Cited by 7 · see citing works