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Prodrugs and nanomicelles to overcome ocular barriers for drug penetration

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Pulmonary delivery of rifampicin-loaded soluplus micelles against Mycobacterium tuberculosis

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Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system

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Production of liposomes loaded with antioxidants using a supercritical CO2 assisted process

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Recent advance of nanoparticle-based topical drug delivery to the posterior segment of the eye

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Micelle-nanogel platform for ferulic acid ocular delivery

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Topical formulation of self-assembled antiviral prodrug nanomicelles for targeted retinal delivery

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Innovative Strategies for Drug Delivery to the Ocular Posterior Segment

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Emerging advances in P-glycoprotein inhibitory nanomaterials for drug delivery

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Research progress of natural product-based nanomaterials for the treatment of inflammation-related diseases

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Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

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Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases

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Assessing the viability of Soluplus® self-assembled nanocolloids for sustained delivery of highly hydrophobic lapatinib (anticancer agent): Optimisation and in-vitro characterisation

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Development of dexamethasone-loaded mixed polymeric micelles for nasal delivery

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Cyclodextrin–Amphiphilic Copolymer Supramolecular Assemblies for the Ocular Delivery of Natamycin

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Alpha‐lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes

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Optimization and evaluation of Oridonin-loaded Soluplus ® -Pluronic P105 mixed micelles for oral administration

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Self-Assembly of Soluplus in Aqueous Solutions: Characterization and Prospectives on Perfume Encapsulation

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Role of Polymeric Micelles in Ocular Drug Delivery: An Overview of Decades of Research

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Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

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In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation

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Atorvastatin-Eluting Contact Lenses: Effects of Molecular Imprinting and Sterilization on Drug Loading and Release

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Recent development of polymer nanomicelles in the treatment of eye diseases

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Development and characterization of curcumin-loaded solid self-emulsifying drug delivery system (SEDDS) by spray drying using Soluplus® as solid carrier

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Micelles of progesterone for topical eye administration: interspecies and intertissues differences in Ex vivo ocular permeability

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Mucoadhesive gellan gum-based and carboxymethyl cellulose -based hydrogels containing gemcitabine and papain for bladder cancer treatment

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New resveratrol micelle formulation for ocular delivery: characterization and in vitro / in vivo evaluation

Li, M., Zhang, L., Li, R., & Yan, M. (2020) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2020.1828909 · Cited by 37 · see citing works

Pluronic®/casein micelles for ophthalmic delivery of resveratrol: In vitro, ex vivo, and in vivo tests

Vivero-Lopez, M., Sparacino, C., Quelle‐Regaldie, A., Sanchez, L. E., Candal, E., Barreiro‐Iglesias, A., Huete‐Toral, F., Carracedo, G., Otero, A., Concheiro, Á., et al. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122281 · Cited by 37 · see citing works

Cyclodextrin-based poly(pseudo)rotaxanes for transdermal delivery of carvedilol

Taveira, S. F., Varela-García, A., Souza, B. D. S., Marreto, R. N., Martín‐Pastor, M., Concheiro, Á., & Alvarez‐Lorenzo, C. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.08.017 · Cited by 36 · see citing works

Progesterone, Lipoic Acid, and Sulforaphane as Promising Antioxidants for Retinal Diseases: A Review

Hernández‐Rabaza, V., López‐Pedrajas, R., & Almansa, I. (2019) · Antioxidants · doi:10.3390/antiox8030053 · Cited by 36 · see citing works

Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection

Мухаррамовна, Б. Г., Oshitari, T., Baba, T., & Yamamoto, S. (2016) · BioMed Research International · doi:10.1155/2016/5140823 · Cited by 35 · see citing works

Design and Evaluation of Ophthalmic Delivery Formulations

Soni, V., Pandey, V., Tiwari, R., Asati, S., & Tekade, R. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817909-3.00013-3 · Cited by 35 · see citing works

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

Piazzini, V., Vasarri, M., Degl’Innocenti, D., Guastini, A., Barletta, E., Salvatici, M. C., & Bergonzi, M. C. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11120655 · Cited by 35 · see citing works

Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study

Santonocito, D., Vivero-Lopez, M., Lauro, M. R., Torrisi, C., Castelli, F., Sarpietro, M. G., & Puglia, C. (2022) · Molecules · doi:10.3390/molecules27041328 · Cited by 32 · see citing works

Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement

Parikh, A. R., Kathawala, K., Tan, C. C., Garg, S., & Zhou, X. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s161940 · Cited by 32 · see citing works

Understanding the self-assembly of the polymeric drug solubilizer Soluplus®

Mateos, H., Gentile, L., Murgia, S., Colafemmina, G., Collu, M., Smets, J., & Palazzo, G. (2021) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2021.12.016 · Cited by 32 · see citing works

Hydrogels for diabetic eyes: Naltrexone loading, release profiles and cornea penetration

Alvarez-Rivera, F., Serro, A. P., Silva, D., Concheiro, Á., & Alvarez‐Lorenzo, C. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110092 · Cited by 30 · see citing works

Development and Evaluation of a Water Soluble Fluorometholone Eye Drop Formulation Employing Polymeric Micelle

Noh, G., Keum, T., Seo, J., Choi, J., Bastola, R., Lamichhane, S., Park, B., Choi, Y. W., & Lee, S. K. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040208 · Cited by 30 · see citing works

An Update on Novel Ocular Nanosystems with Possible Benefits in the Treatment of Corneal Neovascularization

Zhang, C., Yin, Y., Zhao, J., Li, Y., Wang, Y., Zhang, Z., Niu, L., & Zheng, Y. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s375570 · Cited by 29 · see citing works

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

Donato, C. D., Iacovino, R., Isernia, C., Malgieri, G., Varela-García, A., Concheiro, Á., & Alvarez‐Lorenzo, C. (2020) · Nanomaterials · doi:10.3390/nano10040613 · Cited by 27 · see citing works

Polymeric Nanomicelles of Soluplus® as a Strategy for Enhancing the Solubility, Bioavailability and Efficacy of Poorly Soluble Active Compounds

Pignatello, R., & Corsaro, R. (2019) · Current Nanomedicine · doi:10.2174/2468187309666190314152451 · Cited by 26 · see citing works

The effect of a-Lipoic acid (ALA) on oxidative stress, inflammation, and apoptosis in high glucose–induced human corneal epithelial cells

Li, Z., Han, Y., Ji, Y., Sun, K., Chen, Y., & Hu, K. (2022) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-022-05784-6 · Cited by 25 · see citing works

Structure-Performance Relationships of Temperature-Responsive PLGA-PEG-PLGA Gels for Sustained Release of Bone Morphogenetic Protein-2

Santoveña-Estévez, A., Monzón, C., Alvarez‐Lorenzo, C., del Rosario, C., Delgado, A., Évora, C., Concheiro, Á., Llabrés, M., & Fariña, J. B. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.07.007 · Cited by 25 · see citing works

Stimulatory Effects of Soluplus® on Flufenamic Acid β-Cyclodextrin Supramolecular Complex: Physicochemical Characterization and Pre-clinical Anti-inflammatory Assessment

Alshehri, S., Imam, S. S., Altamimi, M. A., Hussain, A., Shakeel, F., & Alshehri, A. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01684-2 · Cited by 25 · see citing works

Recent advances and prospects of nanoparticle-based drug delivery for diabetic ocular complications

Wang, S., Yang, H., Zheng, J., Tong, A., Mu, S., Wang, D., Zhao, M., & Li, J. (2025) · Theranostics · doi:10.7150/thno.108691 · Cited by 24 · see citing works

Spray-dried indomethacin-loaded polymeric micelles for the improvement of intestinal drug release and permeability

Sipos, B., Csóka, I., Ambrus, R., Schelz, Z., Zupkó, I., Balogh, G. T., & Katona, G. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106200 · Cited by 24 · see citing works

Polymeric nanomicelles based on inulin D α-tocopherol succinate for the treatment of diabetic retinopathy

Rassu, G., Pavan, B., Mandracchia, D., Tripodo, G., Botti, G., Dalpiaz, A., Gavini, E., & Giunchedi, P. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102286 · Cited by 23 · see citing works

Cytosine-functionalized bioinspired hydrogels for ocular delivery of antioxidant transferulic acid

Varela-García, A., Concheiro, Á., & Alvarez‐Lorenzo, C. (2020) · Biomaterials Science · doi:10.1039/c9bm01582e · Cited by 22 · see citing works

Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy

Tang, S., An, X., Sun, W., Zhang, Y., Yang, C., Kang, X., Sun, Y., Jiang, L., Zhao, X., Gao, Q., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1336123 · Cited by 22 · see citing works

Effect of melt extrudability and melt binding efficiency of polyvinyl caprolactam polyvinyl acetate polyethylene glycol graft copolymer (Soluplus®) on release pattern of hydrophilic and high dose drugs

Ayyub, K. T., Moravkar, K. K., Maniruzzaman, M., & Amin, P. D. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.01.126 · Cited by 21 · see citing works

Effects of the Topical Use of the Natural Antioxidant Alpha-Lipoic Acid on the Ocular Surface of Diabetic Patients with Dry Eye Symptoms

Roszkowska, A. M., Spinella, R., Oliverio, G. W., Postorino, E. I., Signorino, G. A., Rusciano, D., & Aragona, P. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2707202 · Cited by 19 · see citing works

The Role of Nano-ophthalmology in Treating Dry Eye Disease

Natesan, S., Boddu, S. H. S., Krishnaswami, V., & Shahwan, M. J. (2020) · Pharmaceutical Nanotechnology · doi:10.2174/2211738508666200628034227 · Cited by 19 · see citing works

Characterizing the Drug-Release Enhancement Effect of Surfactants on Megestrol-Acetate-Loaded Granules

Katona, G., Sipos, B., Ambrus, R., Csóka, I., & Szabó‐Révész, P. (2022) · Pharmaceuticals · doi:10.3390/ph15020113 · Cited by 19 · see citing works

A comprehensive review on alpha-lipoic acid delivery by nanoparticles

Mosallaei, N., Malaekeh-Nikouei, A., Shirazi, S. S., Behmadi, J., & Malaekeh‐Nikouei, B. (2024) · Bioimpacts · doi:10.34172/bi.2024.30136 · Cited by 18 · see citing works

Asymmetry in Drug Permeability through the Cornea

Toffoletto, N., Chauhan, A., Alvarez‐Lorenzo, C., Saramago, B., & Serro, A. P. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050694 · Cited by 17 · see citing works

Stimuli sensitive ocular drug delivery systems

Otero-Espinar, F. J., Fernández‐Ferreiro, A., González‐Barcia, M., Blanco-Méndez, J., & Álvarez, A. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813689-8.00006-9 · Cited by 17 · see citing works

Nanostructured Lipid Carriers Aimed to the Ocular Delivery of Mangiferin: In Vitro Evidence

Santonocito, D., Barbagallo, I. A., Distefano, A., Sferrazzo, G., Vivero-Lopez, M., Sarpietro, M. G., & Puglia, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030951 · Cited by 16 · see citing works

A Mini-review on New Developments in Nanocarriers and Polymers for Ophthalmic Drug Delivery Strategies

Sharma, Y., Patel, P., & Kurmi, B. D. (2023) · Current Drug Delivery · doi:10.2174/1567201820666230504115446 · Cited by 16 · see citing works

Kinetic and theoretical studies of novel biodegradable thermo-sensitive xerogels based on PEG/PVP/silica for sustained release of enrofloxacin

Ebadi, A., Rafati, A. A., Bavafa, S., & Mohammadi, M. (2017) · Applied Surface Science · doi:10.1016/j.apsusc.2017.07.046 · Cited by 16 · see citing works

A Novel Eyes Topical Drug Delivery System: CsA-LNC for the Treatment of DED

Zhang, A., Sun, R., Ran, M., Deng, Y., Ge, Y. C., Zhu, Y., Tao, X., Shang, L., Gou, J., He, H., et al. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02872-2 · Cited by 16 · see citing works

Monitoring the microenvironment inside polymeric micelles using the fluorescence probe 6-propionyl-2-dimethylaminonaphthalene (PRODAN)

Orellano, M. S., Chiappetta, D. A., Silber, J. J., Falcone, R. D., & Correa, N. M. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2021.117552 · Cited by 16 · see citing works

Diabetic eye: associated diseases, drugs in clinic, and role of self-assembled carriers in topical treatment

Kattar, A., Concheiro, Á., & Alvarez‐Lorenzo, C. (2021) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1953466 · Cited by 14 · see citing works

Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis

Chando, A., Basudkar, V., Gharat, S., Momin, M. M., & Khan, T. A. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01416-6 · Cited by 12 · see citing works

Polymeric Micelles for Drug Delivery

Paprikar, A., Soni, A., Kaushal, N., & Lin, S. (2021) · Nanotechnology in the life sciences · doi:10.1007/978-3-030-84262-8_12 · Cited by 11 · see citing works

Innovative formulations for the ocular delivery of coenzyme Q10

Signorini, S., Pescina, S., Ricci, C., Favero, E. D., Vivero-Lopez, M., Alvarez‐Lorenzo, C., Santi, P., Padula, C., & Nicoli, S. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01739-y · Cited by 10 · see citing works

Delivery of Fenofibrate to Ocular Tissues using 2-Hydroxypropyl-β-cyclodextrin-Based Micelles

Klahan, B., O’Reilly, N. J., Sigurðsson, H. H., Chauhan, A., Mering, S., & Fitzhenry, L. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125417 · Cited by 9 · see citing works

Eudragit Films as Carriers of Lipoic Acid for Transcorneal Permeability

Bierbrauer, K. L., Comini, L. R., Leonhard, V., Manzanelli, M. A. E., Castelli, G., Farfán, S., Alasino, R. V., & Beltramo, D. M. (2023) · Polymers · doi:10.3390/polym15071793 · Cited by 9 · see citing works

Nanotechnology in Pest Management

Akhtar, I., Iqbal, Z., & Saddiqe, Z. (2020) · Springer eBooks · doi:10.1007/978-3-030-41275-3_5 · Cited by 9 · see citing works

A water-soluble drug nanoparticle-loaded in situ gel for enhanced precorneal retention and its transduction mechanism of pharmacodynamic effects

Zhang, Y., Xiao, Z., Li, Q., Ke, Y., Gu, X., Pan, K., Long, Q., Guo, Y., Yu, X. J., Teng, X., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.125150 · Cited by 8 · see citing works

From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics

Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7 · see citing works

Efavirenz Repurposing Challenges: A Novel Nanomicelle-Based Antiviral Therapy Against Mosquito-Borne Flaviviruses

Maldonado, S., Fuentes, P., Bernabeu, E., Bertera, F. M., Opezzo, J. A. W., Lagomarsino, E., Lee, H. J., R., F. M., Choi, M. R., Salgueiro, M. J., et al. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020241 · Cited by 7 · see citing works

Thermosensitive in situ gel containing alpha-lipoic acid and rutin for the treatment of corneal neovascularization: formulation, characterization, and in vivo evaluation

Polat, H. K., Karakuyu, N. F., Ünal, S., Turanlı, Y., Pezik, E., Usta, G., & Sarman, E. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107538 · Cited by 7 · see citing works

In situ saxs characterization of thermoresponsive behavior of a poly(ethylene glycol)-graft-(poly(vinyl caprolactam)-co-poly(vinyl acetate)) amphiphilic graft copolymer

Kennedy, M. A., Zhang, Y., & Bhatia, S. R. (2022) · Nanotechnology · doi:10.1088/1361-6528/acab6d · Cited by 7 · see citing works

Antihyperglycemic Effect of the Moroccan Collard Green (Brassica oleracea var. viridis) in Streptozotocin-Induced Diabetic Rats

Amssayef, A., & Eddouks, M. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200929141140 · Cited by 7 · see citing works

Ex-vivo skin retention of crisaborole from microemulsion and micellar formulations

Concini, A., Nicoli, S., Pescina, S., Sissa, C., Santi, P., & Padula, C. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106082 · Cited by 6 · see citing works

Synthesis, self-assembly and functional activity of a new pyrrolidinium surfactant conjugated with lipoic acid

Vasilieva, E. A., Babkin, R. A., Valeeva, F. G., Kuznetsov, D. M., Nizameev, I. R., Lyubina, A. P., Voloshina, A. D., & Zakharova, L. Y. (2025) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2025.136110 · Cited by 6 · see citing works

Herbal bioactives for ocular drug delivery systems

Yapar, E. A., Durgun, M. E., Esentürk‐Güzel, İ., Güngör, S., & Özsoy, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824385-5.00006-6 · Cited by 6 · see citing works

Steering the Clinical Translation of Delivery Systems for Drugs and Health Products

Pignatello, R., & Matricardi, P. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040350 · Cited by 5 · see citing works

Highly effective inhalable voriconazole-loaded nanomicelles for fungal infections in cystic fibrosis patients: A promising therapeutic strategy for allergic bronchopulmonary aspergillosis

Briceño, V. F., Alava, K. H., Bernabeu, E., Fuentes, P., Devoto, T. B., Höcht, C., Chiappetta, D. A., Cuestas, M. L., & Moretton, M. A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106126 · Cited by 5 · see citing works

Ex vivo permeability study and in vitro solubility characterization of oral Canagliflozin self-nanomicellizing solid dispersion using Soluplus ® as a nanocarrier

Jassem, N. A., & Alhammid, S. N. A. (2024) · Acta Marisiensis. Seria Medica · doi:10.2478/amma-2024-0011 · Cited by 4 · see citing works

Development and characterization of self-assembling sirolimus-loaded micelles as a sublingual delivery system

Türkmen, Ö., & Baloğlu, E. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103836 · Cited by 4 · see citing works

Langmuir monolayer studies of non-ionic surfactants and DOTMA for the design of ophthalmic niosomes

Kattar, A., Lage, E. V., Casas, M., Concheiro, Á., & Alvarez‐Lorenzo, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25887 · Cited by 4 · see citing works

α-Lipoic acid nanomicelles in solution and in contact lenses for diabetes-associated corneal diseases

Concheiro, Á., Alvarez-Rivera, F., Varela-García, A., & Alvarez‐Lorenzo, C. (2017) · Investigative Ophthalmology & Visual Science

Eudragit Films as Carriers of Lipoic Acid for Transcorneal Permeability

Bierbrauer, K. L., Comini, L. R., Leonhard, V., Manzanelli, M. A. E., Castelli, G., Farfán, S., Alasino, R. V., & Beltramo, D. M. (2023) · Polymers · doi:10.3390/polym15071793 · Cited by 9 · see citing works

ALA nanoemulsion prepared by microfluidic for ocular delivery: In-vitro and in-vivo studies

Behmadi, J., Kheirieh, A., Mahmoudi, A., Abrishami, M., Shaegh, S. A. M., Abbasi, A., & Malaekeh‐Nikouei, B. (2026) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.46273

A grafted copolymer-based nanomicelles for topical ocular delivery of everolimus: formulation, characterization, ex-vivo permeation, in-vitro ocular toxicity, and stability study

Mehra, N., Aqil, M., & Sultana, Y. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105735 · Cited by 79 · see citing works

A novel FK506 loaded nanomicelles consisting of amino-terminated poly(ethylene glycol)-block-poly(D,L)-lactic acid and hydroxypropyl methylcellulose for ocular drug delivery

Liu, D., Wu, Q., Chen, W., Lin, H., Zhu, Y., Liu, Y., Liang, H., & Zhu, F. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.03.022 · Cited by 57 · see citing works