Recent developments of nanoparticle-delivered dosage forms for buccal delivery
Abstract
The improvement of mucoadhesive buccal formulations has attracted profound interest in recent years. Drug permeability and controlled drug release via this route of administration are still a concern for effective therapy, although various strategies have been proposed. Advanced developments in nanotechnology have been investigated with promising clinical applications. The incorporation of nanoparticles in dosage forms for buccal delivery not only ensures efficient delivery but also reduces side effects to biological systems. Many approaches have been suggested to load and deliver nanoparticles containing drugs to the buccal mucosa both in topical and systemic administrations. This paper describes recent advanced concepts to include nanoparticles in dosage forms with improving drug delivery or targeting. The classification and discussion of these technologies are aimed at providing an overview of current strategies for applying controlled drug delivery. All remarkable findings will encourage innovative nanoparticle-delivered dosage forms for buccal delivery in clinical applications.
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Nanoscale formulations can facilitate better penetration into biofilms, which are often associated with chronic infections and resistance mechanisms.
“The nanoscale formulations can facilitate better penetration into biofilms, which are often associated with chronic infections and resistance mechanisms [134].”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [134]
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- Authors
- Tran, P. H. L., Duan, W., & Tran, T. T. D.
- Affiliations
- Deakin University (AU)
- Ton Duc Thang University (VN)
- Corresponding author
- Tran, Thao T.D.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 571
- Pages
- 118697
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2973028089
- Cited by
- 51
- References
- 113
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 9 · 2020: 5 · 2019: 1
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Australian Research Council
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- buccal drug delivery, nanoparticles, mucoadhesive dosage forms, controlled drug release, buccal mucosa, topical drug delivery, systemic drug delivery, targeted drug delivery, nanotechnology drug delivery
- MeSH terms
- Drug Development, Adhesiveness, Administration, Buccal, Animals, Delayed-Action Preparations, Drug Carriers, Drug Evaluation, Preclinical, Humans, Mouth Mucosa, Solubility, Models, Animal, Nanoparticles, Inventions, Drug Liberation
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