Cited by 145Advancements in Transdermal Drug DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Tretinoin-loaded nanocapsules: Preparation, physicochemical characterization, and photostability study

Ourique, A.F., Pohlmann, A.R., Guterres, S.S., Beck, R.C.R.·2008·International Journal of Pharmaceutics

Abstract

The aim of this study was to prepare and characterize tretinoin-loaded nanocapsules as well as to evaluate the influence of this nanoencapsulation on tretinoin photostability. Tretinoin-loaded nanocapsules (0.5 mg ml(-1)) were prepared by interfacial deposition of preformed polymer (poly-epsilon-caprolactone) using two different oily phases: capric/caprylic triglycerides and sunflower seed oil. Tretinoin-loaded nanocapsules presented drug content close to the theoretical value, encapsulation efficiencies higher than 99.9%, nanometric mean size with a polydispersity index below 0.25, and pH values between 5.0 and 7.0. Regarding photodegradation studies, tretinoin methanolic solution showed a half-life time around 40 min according to a first order equation, whereas tretinoin nanocapsule suspensions showed a half-life between 85 and 100 min (twofold higher than in methanolic solution) according to a zero order equation. Tretinoin-loaded nanocapsules improved tretinoin photostability, independently on the type of oily phase used in this study, and represent a potential system to be incorporated in topical or systemic dosage forms containing tretinoin.

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Crossref · 10.1016/j.ijpharm.2007.12.035

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Authors
Ourique, A. F., Pohlmann, A. R., Guterres, S. S., & Beck, R. C. R.
Affiliations
  • Universidade Federal de Santa Maria (BR)
  • Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Beck, R.C.R.
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2008-03
Volume
352
Issue
1-2
Pages
1-4
ISSN
0378-5173 (ISSN-L)
OpenAlex
W2006560775
Cited by
145
References
29
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 10 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 12 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 12
FWCI
5.16
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Pharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
all-trans retinoic acid, nanocapsules, polycaprolactone, interfacial deposition, photostability, photodegradation, encapsulation efficiency, triglycerides, sunflower oil, topical drug delivery
MeSH terms
Sunflower Oil, Caprylates, Chemistry, Pharmaceutical, Decanoic Acids, Dermatologic Agents, Drug Compounding, Drug Stability, Feasibility Studies, Half-Life, Kinetics, Particle Size, Photolysis, Plant Oils, Polyesters, Solubility, Technology, Pharmaceutical, Tretinoin, Triglycerides, Ultraviolet Rays, Nanocapsules

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