Aggression and 5HTT polymorphism in females: Study of synchronized swimming and control groups
Abstract
Aggression is a heterogeneous heritable psychological trait, also influenced by environmental factors. Previous studies, mostly conducted on male population, have found some associations of the aggression with the polymorphisms of genes, regulating the activity of serotonin (5-HT) in the brain. However, psychological as well as biochemical manifestations of the aggression are different in males and females. Our study aimed to investigate the association of 5-HTT gene polymorphism with different facets of aggression (BDHI) in females. Two groups: the synchronized swimming and non-athlete control, - were examined to study the possible modulation effect of sport on the association between 5-HTT gene polymorphism and aggression. It was found that in both groups the low-active 5-HTT polymorphism (SS) was associated with increased scores on Indirect Hostility scale and decreased scores on Negativism scale, compared to LL genotype. No interaction effect between sport and 5-HTT polymorphism was found. The higher percentage of LL-carriers and lower of LS-carriers in the synchronized swimming group compared to the control one was observed. This may be the sign of the importance of LL polymorphism of 5-HTT gene, previously associated with higher resistance to stress factors, for being an athlete, although this result has to be taken cautiously keeping in mind the stratification problem. Synchronized swimmers had lower scores on Assault, Negativism, Irritability and Verbal Hostility compared to age-matched control girls (in general and for each 5-HTT genotype separately), suggesting that they may have more matured emotional system (older control group has also lower scores on these scales).
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The S-allele was associated with increased aggressive behaviors and hostility in a group of female Caucasian Russian swimmers.
“Similarly, the S-allele was significantly associated with teacher reported aggressive behaviors at age 9 for both boys and girls [87] and with increased aggressive behaviors and hostility in a group of female Caucasian Russian swimmers [88].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [88]
Cites
A Handbook of Child Psychology
(1932) · Nature · doi:10.1038/130331a0 · Cited by 10,133 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
(1998) · Cited by 1,257 · see citing works
Differences between males and females in rates of serotonin synthesis in human brain
Nishizawa, S., Benkelfat, C., Young, S. N., Leyton, M., Mzengeza, S., de Montigny, C., Blier, P., & Dikšić, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5308 · Cited by 901 · see citing works
Impulsivity, aggression, and serotonin: a molecular psychobiological perspective
Lesch, K., & Merschdorf, U. (2000) · Behavioral Sciences & the Law · doi:10.1002/1099-0798(200010)18:5 · Cited by 364 · see citing works
Eley, T. C., Lichtenstein, P., & Stevenson, J. (1999) · Child Development · doi:10.1111/1467-8624.00012 · Cited by 274 · see citing works
Frankle, W. G., Lombardo, I., New, A. S., Goodman, M. S., Talbot, P. S., Huang, Y. H., Hwang, D., Slifstein, M., Curry, S. D., Abi‐Dargham, A., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.5.915 · Cited by 262 · see citing works
Sjöberg, R. L., Nilsson, K. W., Nordquist, N., Öhrvik, J., Leppert, J., Lindström, L., & Oreland, L. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005936 · Cited by 251 · see citing works
From genes to aggressive behavior: the role of serotonergic system
Popova, N. K. (2006) · BioEssays · doi:10.1002/bies.20412 · Cited by 236 · see citing works
Willis‐Owen, S. A. G., Turri, M. G., Munafo, M. R., Surtees, P. G., Wainwright, N. W. J., Brixey, R. D., & Jonathan Flint, C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.050 · Cited by 210 · see citing works
Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior
Gorwood, P. A. P. M., Batel, P., Adès, J., Hamon, M., & Boni, C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00840-4 · Cited by 198 · see citing works
Testosterone and aggressiveness.
Giammanco, M., Tabacchi, G., Giammanco, S., Majo, D. D., & Guardia, M. L. (2005) · PubMed · Cited by 175 · see citing works
van Beijsterveldt, C. E. M., Bartels, M., Hudziak, J. J., & Boomsma, D. I. (2003) · Behavior Genetics · doi:10.1023/a:1025735002864 · Cited by 173 · see citing works
Serotonin Transporter Polymorphisms and Persistent, Pervasive Childhood Aggression
Beitchman, J. H., Baldassarra, L., Mik, H., De Luca, V., King, N., Bender, D., Ehtesham, S., & Kennedy, J. L. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1103 · Cited by 167 · see citing works
Gelernter, J. E., Kranzler, H. R., Coccaro, E. F., Siever, L. J., & New, A. S. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1332 · Cited by 166 · see citing works
Hudziak, J. J., van Beijsterveldt, C. E. M., Bartels, M., Rietveld, M. J. H., Rettew, D. C., Derks, E. M., & Boomsma, D. I. (2003) · Behavior Genetics · doi:10.1023/a:1025782918793 · Cited by 144 · see citing works
Du, L., Bakish, D., & Hrdina, P. D. (2000) · Psychiatric Genetics · doi:10.1097/00041444-200010040-00002 · Cited by 114 · see citing works
Life events, anxious depression and personality: a prospective and genetic study
Middeldorp, C. M., Cath, D. C., Beem, A. L., Willemsen, G. A. H. M., & Boomsma, D. I. (2008) · Psychological Medicine · doi:10.1017/s0033291708002985 · Cited by 114 · see citing works
Co-occurrence of aggressive behavior and rule-breaking behavior at age 12: Multi-rater analyses
Bartels, M., Hudziak, J. J., van den Oord, E. J. C. G., van Beijsterveldt, C. E. M., Rietveld, M. J. H., & Boomsma, D. I. (2003) · Behavior Genetics · doi:10.1023/a:1025787019702 · Cited by 87 · see citing works
Gerra, G., Garofano, L., Castaldini, L., Rovetto, F., Zaimovic, A., Moi, G., Bussandri, M., Branchi, B., Brambilla, F., Friso, G., et al. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-004-0268-y · Cited by 71 · see citing works
Heritability of hostility-related emotions, attitudes, and behaviors
Cates, D. S., Houston, B. K., Vavak, C. R., Crawford, M. H., & Uttley, M. (1993) · Journal of Behavioral Medicine · doi:10.1007/bf00844758 · Cited by 65 · see citing works
The Relationship Between Genotype and Positive Psychological Development in National-Level Swimmers
Golby, J., & Sheard, M. (2006) · European Psychologist · doi:10.1027/1016-9040.11.2.143 · Cited by 49 · see citing works
Serotonin Transporter Polymorphisms and Persistent, Pervasive Childhood Aggression
Beitchman, J. H. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.6.1103 · Cited by 46 · see citing works
Testosterone intake and aggressiveness: Real effect or anticipation?
Björkqvist, K., Nygren, T., Björklund, A.-C., & Björkqvist, S.-E. (1994) · Aggressive Behavior · doi:10.1002/1098-2337(1994)20:1 · Cited by 44 · see citing works
Middeldorp, C. M., Wray, N. R., Andrews, G., Martin, N. G., & Boomsma, D. I. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706778553507 · Cited by 28 · see citing works
Middeldorp, C. M., Wray, N. R., Andrews, G., et al. (2006) · Twin Research and Human Genetics · doi:10.1375/twin.9.5.632 · Cited by 22 · see citing works
Are there sex differences in the association between the 5HTT gene and neuroticism? A meta-analysis
Munafo, M. R., Clark, T. G., & Flint, J. (2003) · Personality and Individual Differences · doi:10.1016/j.paid.2003.09.031 · Cited by 16 · see citing works
[Effect of 5HTT genetic polymorphism on aggression in athletes].
Малюченко, Н. В., Sysoeva, O., Vediakov, A. M., et al. (2007) · PubMed · Cited by 15 · see citing works
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Pavlov, K. A., Chistiakov, D. A., & Chekhonin, V. P. (2012) · Journal of Applied Genetics · doi:10.1007/s13353-011-0069-6 · Cited by 184 · see citing works
Genetics of aggressive behavior: An overview
Veroude, K., Zhang‐James, Y., Fernàndez‐Castillo, N., Bakker, M. J., Cormand, B., & Faraone, S. V. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32364 · Cited by 147 · see citing works
Aggressive behavior in humans: Genes and pathways identified through association studies
Fernàndez‐Castillo, N., & Cormand, B. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32419 · Cited by 87 · see citing works
Genetics of child aggression, a systematic review
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33 · see citing works
- Authors
- Sysoeva, O. V., Maluchenko, N. V., Timofeeva, M. A., Portnova, G. V., Kulikova, M. A., Tonevitsky, A. G., & Ivanitsky, A. M.
- Affiliations
- Russian Academy of Sciences (RU)
- Lomonosov Moscow State University (RU)
- Federal Scientific Center of Physical Culture and Sports (RU)
- Corresponding author
- Sysoeva, Olga V.
- Venue
- International Journal of Psychophysiology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 72
- Issue
- 2
- Pages
- 173-178
- ISSN
- 0167-8760 (ISSN-L)
- OpenAlex
- W2098605584
- Cited by
- 36
- References
- 29
- Citations by year
- 2024: 2 · 2023: 4 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- aggression, 5-HTT polymorphism, serotonin, female, synchronized swimming, athletes, hostility, negativism, assault, irritability, verbal aggression, emotional maturity, stress tolerance
- MeSH terms
- Adolescent, Adult, Age Factors, Aggression, Analysis of Variance, Child, Female, Genotype, Humans, Polymorphism, Genetic, Swimming, Chi-Square Distribution, Case-Control Studies, Serotonin Plasma Membrane Transport Proteins, Young Adult
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