Aggressive behavior in humans: Genes and pathways identified through association studies

Fernàndez‐Castillo, Noèlia; Cormand, Bru

doi:10.1002/ajmg.b.32419

Cited by 87Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologyPsychopathy, Forensic Psychiatry, Sexual Offending

Aggressive behavior in humans: Genes and pathways identified through association studies

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Fernàndez‐Castillo, Noèlia, Cormand, Bru·2016·American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

DOI 10.1002/ajmg.b.32419

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Abstract

Aggressive behavior has both genetic and environmental components. Many association studies have been performed to identify genetic factors underlying aggressive behaviors in humans. In this review we summarize the previous work performed in this field, considering both candidate gene (CGAS) and genome‐wide association studies (GWAS), excluding those performed in samples where the primary diagnosis is a psychiatric or neurological disorder other than an aggression‐related phenotype. Subsequently, we have studied the enrichment of pathways and functions in GWAS data. The results of our searches show that most CGAS have identified associations with genes involved in dopaminergic and serotonergic neurotransmission and in hormone regulation. On the other hand, GWAS have not yet identified genome‐wide significant associations, but top nominal findings are related to several signaling pathways, such as axon guidance or estrogen receptor signaling, and also to neurodevelopmental processes and synaptic plasticity. Future studies should use larger samples, homogeneous phenotypes and standardized measurements to identify genes that underlie aggressive behaviors in humans. © 2016 Wiley Periodicals, Inc.

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GWAS of aggression have been underpowered to detect common variants of small penetrance associated with complex phenotypes.
“Genome-wide association studies (GWAS) of aggression have been underpowered to detect common variants of small penetrance associated with complex phenotypes [11, 12].”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [11]
Similar pathways such as synaptic development, axon guidance, and MAPK signaling emerge when examining genes from the top GWAS findings (p ≤ 5e−05).
“Nevertheless, similar pathways such as synaptic development, axon guidance, and MAPK signaling emerge when examining genes from the top GWAS findings (p ≤ 5e−05, ref. [11]).”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [11]
Several recent reviews in human and animals have consistently identified these pathways.
“Indeed, several recent reviews in human and animals have consistently identified these pathways [11, 15, 51].”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [11]

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Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · see citing works
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993) · Science · doi:10.1126/science.8211186 · Cited by 1,644 · see citing works
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Cases, O., Seif, I., Grimsby, J. S., Gaspar, P., Chen, K., Vandormael‐Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., et al. (1995) · Science · doi:10.1126/science.7792602 · Cited by 1,225 · see citing works
MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: new evidence and a meta-analysis
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., & Moffitt, T. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001851 · Cited by 1,158 · see citing works
Childhood Adversity, Monoamine Oxidase A Genotype, and Risk for ConductDisorder
Foley, D. L., Eaves, L. J., Wormley, B., Silberg, J. L., Maes, H. H., Kuhn, J., & Riley, B. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.738 · Cited by 564 · see citing works
A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity
Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J. J., & Muldoon, M. F. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00162-1 · Cited by 486 · see citing works
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
Bagri, A., Marín, O., Plump, A., Mak, J., Pleasure, S., Rubenstein, J., & Tessier-Lavigne, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00561-5 · Cited by 467 · see citing works
The glucocorticoid responses are shaped by molecular chaperones
Grad, I., & Picard, D. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.018 · Cited by 423 · see citing works
MAOA, Childhood Maltreatment, and Antisocial Behavior: Meta-analysis of a Gene-Environment Interaction
Byrd, A. L., & Manuck, S. B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.004 · Cited by 378 · see citing works
MAOA and the “Cycle of Violence:” Childhood Abuse and Neglect, MAOA Genotype, and Risk for Violent and Antisocial Behavior
Widom, C. S., & Brzustowicz, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.039 · Cited by 349 · see citing works
Are there meaningful etiological differences within antisocial behavior? Results of a meta-analysis
Burt, S. A. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2008.12.004 · Cited by 305 · see citing works
Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene.
Manuck, S., Flory, J. D., Ferrell, R. E., Dent, K. M., Mann, J., & Muldoon, M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00375-8 · Cited by 284 · see citing works
Monoamine oxidase A (MAOA) and antisocial behaviors in the presence of childhood and adolescent maltreatment
Haberstick, B. C., Lessem, J. M., Hopfer, C. J., Smolen, A., Ehringer, M. A., Timberlake, D., & Hewitt, J. K. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30176 · Cited by 277 · see citing works
Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment
Reif, A., Rösler, M., Freitag, C. M., Schneider, M., Eujen, A., Kissling, C., Wenzler, D., Jacob, C. P., Retz-Junginger, P., Thome, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301359 · Cited by 277 · see citing works
Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression
Vassos, E., Collier, D. A., & Fazel, S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.31 · Cited by 234 · cited 4× · see citing works
“We selected 268 potential articles within those dates and added 263 articles from a previous review [Gunter et al., 2010] and from a meta-analysis [Vassos et al., 2014].”
BackgroundMethodResultInfluential
Understanding Genetic Risk for Aggression: Clues From the Brain’s Response to Social Exclusion
Eisenberger, N. I., Way, B. M., Taylor, S. E., Welch, W. T., & Lieberman, M. D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.007 · Cited by 229 · see citing works
Role of Monoamine Oxidase A Genotype and Psychosocial Factors in Male Adolescent Criminal Activity
Nilsson, K. W., Sjöberg, R. L., Damberg, M., Leppert, J., Öhrvik, J., Alm, P. O., Lindström, L., & Oreland, L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.024 · Cited by 223 · see citing works
A Replicated Molecular Genetic Basis for Subtyping Antisocial Behavior in Children With Attention-Deficit/Hyperactivity Disorder
Caspi, A., Langley, K., Milne, B., Moffitt, T. E., O’Donovan, M., Owen, M. J., Polo Tomas, M., Poulton, R., Rutter, M., Taylor, A., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.24 · Cited by 221 · see citing works
Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults
Guo, G., Roettger, M. E., & Shih, J. C. (2006) · Human Genetics · doi:10.1007/s00439-006-0244-8 · Cited by 220 · see citing works
Genetic background of extreme violent behavior
Tiihonen, J., Rautiainen, M.-R., Ollila, H. M., Repo‐Tiihonen, E., Virkkunen, M. E., Palotie, A. V., Pietiläinen, O. P. H., Kristiansson, K., Joukamaa, M. I., Lauerma, H., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.130 · Cited by 220 · see citing works
Association of serotonin transporter promoter gene polymorphism with violence: relation with personality disorders, impulsivity, and childhood ADHD psychopathology
Retz, W., Retz‐Junginger, P., Supprian, T., Thome, J., & Rösler, M. (2004) · Behavioral Sciences & the Law · doi:10.1002/bsl.589 · Cited by 218 · see citing works
RBFOX1 regulates both splicing and transcriptional networks in human neuronal development
Fogel, B. L., Wexler, E., Wahnich, A., Friedrich, T., Vijayendran, C., Gao, F., Parikshak, N., Konopka, G., & Geschwind, D. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds240 · Cited by 216 · see citing works
Genetics of human aggressive behaviour
Craig, I. W., & Halton, K. E. (2009) · Human Genetics · doi:10.1007/s00439-009-0695-9 · Cited by 213 · see citing works
Early Trauma and Increased Risk for Physical Aggression during Adulthood: The Moderating Role of MAOA Genotype
Frazzetto, G., Lorenzo, G. D., Carola, V., Proietti, L., Sokolowska, E., Siracusano, A., Gross, C. T., & Troisi, A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000486 · Cited by 195 · see citing works
MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of Trauma
Weder, N., Yang, B. Z., Douglas-Palumberi, H., Massey, J., Krystal, J. H., Gelernter, J., & Kaufman, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.013 · Cited by 190 · see citing works
A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits
Rujescu, D., Giegling, I., Gietl, A. F., Hartmann, A. M., & Möller, H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01831-0 · Cited by 189 · see citing works
Childhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype
Huizinga, D. H., Haberstick, B. C., Smolen, A., Menard, S., Young, S. E., Corley, R. P., Stallings, M. C., Grotpeter, J. K., & Hewitt, J. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.022 · Cited by 186 · see citing works
Genetic determinants of aggression and impulsivity in humans
Pavlov, K. A., Chistiakov, D. A., & Chekhonin, V. P. (2012) · Journal of Applied Genetics · doi:10.1007/s13353-011-0069-6 · Cited by 184 · see citing works
Candidate Genes for Aggression and Antisocial Behavior: A Meta-analysis of Association Studies of the 5HTTLPR and MAOA-uVNTR
Ficks, C. A., & Waldman, I. D. (2014) · Behavior Genetics · doi:10.1007/s10519-014-9661-y · Cited by 182 · see citing works
Interaction Between MAO-A Genotype and Maltreatment in the Risk for Conduct Disorder: Failure to Confirm in Adolescent Patients
Young, S. E., Smolen, A., Hewitt, J. K., Haberstick, B. C., Stallings, M. C., Corley, R. P., & Crowley, T. J. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1019 · Cited by 170 · see citing works
Serotonin Transporter Polymorphisms and Persistent, Pervasive Childhood Aggression
Beitchman, J. H., Baldassarra, L., Mik, H., De Luca, V., King, N., Bender, D., Ehtesham, S., & Kennedy, J. L. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1103 · Cited by 167 · see citing works
Role of GABRA2 in Trajectories of Externalizing Behavior Across Development and Evidence of Moderation by Parental Monitoring
Dick, D. M., Latendresse, S. J., Lansford, J. E., Budde, J., Goate, A., Dodge, K. A., Pettit, G. S., & Bates, J. E. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.48 · Cited by 164 · see citing works
The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity
Guo, G., Ou, X., Roettger, M. E., & Shih, J. C. (2008) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201999 · Cited by 160 · see citing works
A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors
Jensen, K. P., Covault, J., Conner, T. S., Tennen, H. A., Kranzler, H. R., & Furneaux, H. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.15 · Cited by 157 · see citing works
Are dopaminergic genes involved in a predisposition to pathological aggression?
Chen, T. J. H., Blum, K., Mathews, D., Fisher, L., Schnautz, N., Braverman, E. R., Schoolfield, J. D., Downs, B. W., & Comings, D. E. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.04.037 · Cited by 156 · see citing works
Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population
Cadoret, R. J., Langbehn, D., Caspers, K., Troughton, E. P., Yucuis, R., Sandhu, H. K., & Philibert, R. (2003) · Comprehensive Psychiatry · doi:10.1053/comp.2003.50018 · Cited by 152 · see citing works
Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population
Gonda, X., Fountoulakis, K. Ν., Juhász, G., Rihmer, Z., Lazáry, J., Lászik, A., Akiskal, H. S., & Bagdy, G. (2008) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0842-7 · Cited by 151 · see citing works
Influence of Functional Variant of Neuronal Nitric Oxide Synthase on Impulsive Behaviors in Humans
Reif, A., Jacob, C., Rujescu, D., Herterich, S., Lang, S., Gutknecht, L., Baehne, C. G., Strobel, A., Freitag, C. M., Giegling, I., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.510 · Cited by 149 · see citing works
Genetics of aggressive behavior: An overview
Veroude, K., Zhang‐James, Y., Fernàndez‐Castillo, N., Bakker, M. J., Cormand, B., & Faraone, S. V. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32364 · Cited by 147 · see citing works
Self-citation
Monoamine oxidase A genotype is associated with gang membership and weapon use
Beaver, K. M., DeLisi, M., Vaughn, M. G., & Barnes, J. C. (2009) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2009.03.010 · Cited by 147 · see citing works
Using Dimensional Models of Externalizing Psychopathology to Aid in Gene Identification
Dick, D. M., Alıev, F., Wang, J. C., Grucza, R. A., Schuckit, M. A., Samuel Kuperman, C., Kramer, J., Hinrichs, A. L., Bertelsen, S. E., Budde, J., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.3.310 · Cited by 146 · see citing works
Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study
Calati, R., Porcelli, S., Giegling, I., Hartmann, A. M., Möller, H., Ronchi, D. D., Serretti, A., & Rujescu, D. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.07.004 · Cited by 146 · see citing works
High Loading of Polygenic Risk for ADHD in Children With Comorbid Aggression
Hamshere, M. L., Langley, K., Martin, J., Agha, S. S., Stergiakouli, E., Anney, R. J. L., Buitelaar, J., Faraone, S. V., Lesch, K.-P., Neale, B. M., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12081129 · Cited by 144 · see citing works
Adolescent girls and criminal activity: Role of MAOA-LPR genotype and psychosocial factors
Sjöberg, R. L., Nilsson, K. W., Wargelius, H., Leppert, J., Lindström, L., & Oreland, L. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30360 · Cited by 143 · see citing works
MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.086991 · Cited by 141 · see citing works
The effects of child maltreatment on early signs of antisocial behavior: Genetic moderation by tryptophan hydroxylase, serotonin transporter, and monoamine oxidase A genes
Cicchetti, D., Rogosch, F. A., & Thibodeau, E. L. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000442 · Cited by 141 · see citing works
Human Aggression Across the Lifespan
Tuvblad, C., & Baker, L. A. (2011) · Advances in Genetics · doi:10.1016/b978-0-12-380858-5.00007-1 · Cited by 139 · cited 2× · see citing works
“Taken together, they show that about 50% of the variance in aggression is explained by genetic influences and the remaining 50% is explained by environmental factors not shared by family members [Tuvblad and Baker, 2011].”
Background
Interaction Between <emph type="ital">FKBP5</emph> and Childhood Trauma and Risk of Aggressive Behavior
Bevilacqua, L. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.152 · Cited by 137 · cited 2× · see citing works
“Additionally, the associated gene FKBP5, mentioned in the GCAS section, encodes a protein that works as a co-chaperone of HSP90 modulating glucocorticoid receptor action [Bevilacqua et al., 2012].”
Background
Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior
Wakschlag, L. S., Kistner, E. O., Pine, D. S., Biesecker, G., Pickett, K. E., Skol, A. D., Dukić, V., Blair, J., LEVENTHAL, B. L., Cox, N. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.22 · Cited by 135 · see citing works
Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study
Anney, R., Lasky-Su, J., O'Dushlaine, C., Kenny, E., Neale, B., Mulligan, A., Franke, B., Zhou, K., Chen, W., Christiansen, H., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30871 · Cited by 135 · see citing works
Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons
Lin, L., Rao, Y., & Isacson, O. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.11.009 · Cited by 135 · see citing works
Genetics of Aggression
Anholt, R. R. H., & Mackay, T. F. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155514 · Cited by 135 · see citing works
A gene × gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males
Beaver, K. M., Wright, J., DeLisi, M., Walsh, A., Vaughn, M. G., Boisvert, D., & Vaske, J. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-30 · Cited by 131 · see citing works
The role of oxytocin and oxytocin receptor gene variants in childhood‐onset aggression
Malik, A. I., Zai, C. C., Abu, Z., Nowrouzi, B., & Beitchman, J. H. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00776.x · Cited by 128 · cited 2× · see citing works
“SNPs in the oxitocin receptor gene (OXTR) have been associated with aggression [Malik et al., 2012, 2014], and also with conduct problems and CD [Sakai et al., 2012; Smearman et al., 2015], as well as CU [Beitchman et al., 2012; Dadds et al., 2014].”
Background
Anger- and aggression-related traits are associated with polymorphisms in the 5-HT-2A gene
Giegling, I., Hartmann, A. M., Möller, H., & Rujescu, D. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.05.016 · Cited by 120 · see citing works
Family-Based Association Test of the 5HTTLPR and Aggressive Behavior in a General Population Sample of Children
Haberstick, B. C., Smolen, A., & Hewitt, J. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.008 · Cited by 112 · see citing works
Association of anger-related traits with SNPs in the TPH gene
Rujescu, D., Giegling, I., Bondy, B., Gietl, A. F., Zill, P., & Möller, H. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001128 · Cited by 112 · see citing works
Polymorphisms in the oxytocin receptor gene are associated with the development of psychopathy
Dadds, M. R., Moul, C., Cauchi, A., Dobson‐Stone, C., Hawes, D. J., Brennan, J., Urwin, R., & Ebstein, R. P. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000485 · Cited by 108 · see citing works
A functional dopamine-β-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders
Hess, C., Reif, A., Strobel, A., Boreatti-Hümmer, A., Heine, M., Lesch, K.-P., & Jacob, C. P. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0138-0 · Cited by 104 · see citing works
The importance of stress and genetic variation in human aggression
Craig, I. (2007) · BioEssays · doi:10.1002/bies.20538 · Cited by 104 · see citing works
The Intersection of Genes and Neuropsychological Deficits in the Prediction of Adolescent Delinquency and Low Self-Control
Beaver, K. M., DeLisi, M., Vaughn, M. G., & WRIGHT, J. P. (2008) · International Journal of Offender Therapy and Comparative Criminology · doi:10.1177/0306624x08325349 · Cited by 104 · see citing works
Does parental expressed emotion moderate genetic effects in ADHD? an exploration using a genome wide association scan
Sonuga-Barke, E., Lasky-Su, J., Neale, B., Oades, R., Chen, W., Franke, B., Buitelaar, J., Banaschewski, T., Ebstein, R., Gill, M., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30860 · Cited by 104 · see citing works
Childhood aggression, callous-unemotional traits and oxytocin genes
Beitchman, J. H., Zai, C. C. H., Muir, K. E., Berall, L. E., Nowrouzi‐Kia, B., Choi, E., & Kennedy, J. L. (2012) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-012-0240-6 · Cited by 103 · see citing works
Dopamine transporter polymorphism associated with externalizing behavior problems in children.
Young, S., Smolen, A., Corley, R., Krauter, K., Defries, J., Crowley, T., & Hewitt, J. (2002) · American journal of medical genetics · doi:10.1002/ajmg.10155 · Cited by 101 · see citing works
Dopamine D3 receptor gene polymorphism and violent behavior: Relation to impulsiveness and ADHD-related psychopathology
Retz, W., R�sler, M., Supprian, T., Retz-Junginger, P., & Thome, J. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0805-5 · Cited by 100 · see citing works
Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder.
Beach, S. R. H., Brody, G. H., Gunter, T. D., Packer, H., Wernett, P., & Philibert, R. A. (2010) · Journal of Family Psychology · doi:10.1037/a0018074 · Cited by 100 · see citing works
Preliminary evidence that specific candidate genes are associated with adolescent‐onset antisocial behavior
Burt, S. A., & Mikolajewski, A. J. (2008) · Aggressive Behavior · doi:10.1002/ab.20251 · Cited by 98 · see citing works
Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity
Fowler, T., Langley, K., Rice, F. J., van den Bree, M. B. M., Ross, K., Wilkinson, L. S., Owen, M. J., O’Donovan, M. C., & Thapar, A. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283328df4 · Cited by 98 · see citing works
An Exploration of the Serotonin System in Antisocial Boys with High Levels of Callous-Unemotional Traits
Moul, C., Dobson‐Stone, C., Brennan, J., Hawes, D. J., & Dadds, M. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056619 · Cited by 98 · see citing works
Possible Association between Serotonin Transporter Promoter Region Polymorphism and Extremely Violent Crime in Chinese Males
Liao, D., Hong, C., Shih, H.-L., & Tsai, S. (2004) · Neuropsychobiology · doi:10.1159/000080953 · Cited by 97 · see citing works
Gender specific gene–environment interactions on laboratory-assessed aggression
Verona, E., Joiner, T. E., Johnson, F., & Bender, T. W. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2005.02.001 · Cited by 96 · see citing works
Moderating role of the MAOA genotype in antisocial behaviour
Fergusson, D. M., Boden, J. M., Horwood, L. J., Miller, A. L., & Kennedy, M. A. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.093328 · Cited by 96 · see citing works
The biological basis of anger: Associations with the gene coding for DARPP-32 (PPP1R1B) and with amygdala volume
Reuter, M., Weber, B., Fiebach, C. J., Elger, C. E., & Montag, C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.032 · Cited by 95 · see citing works
Identification of four variants in the tryptophan hydroxylase promoter and association to behavior
Rotondò, A., Schuebel, K. E., Bergen, A. W., Aragon, R., Virkkunen, M. E., Linnoila, M., Goldman, D. A., & Nielsen, D. A. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000578 · Cited by 94 · see citing works
Genetic and attachment influences on adolescents’ regulation of autonomy and aggressiveness
Zimmermann, P., Mohr, C., & Spangler, G. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02158.x · Cited by 94 · see citing works
A biosocial explanation of delinquency abstention.
Boutwell, B., & Beaver, K. (2008) · Criminal Behaviour and Mental Health · doi:10.1002/cbm.678 · Cited by 93 · see citing works
MAOA Genotype, Childhood Maltreatment, and Their Interaction in the Etiology of Adult Antisocial Behaviors
Haberstick, B. C., Lessem, J. M., Hewitt, J. K., Smolen, A., Hopfer, C. J., Halpern, C. T., Killeya‐Jones, L. A., Boardman, J. D., Tabor, J. W., Siegler, I. C., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.028 · Cited by 93 · see citing works
Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior
Rajender, S., Pandu, G., Sharma, J. D., Gandhi, K. P. C., Singh, L., & Kumarasamy Thangaraj, K. (2008) · International Journal of Legal Medicine · doi:10.1007/s00414-008-0225-7 · Cited by 91 · see citing works
Two Types of Aggression Are Differentially Related to Serotonergic Activity and the A779C TPH Polymorphism.
Hennig, J., Reuter, M., Netter, P., Burk, C., & Landt, O. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.1.16 · Cited by 91 · see citing works
Schizophrenia and smoking: Evidence for a common neurobiological basis?
Stassen, H. H., Bridler, R., H�gele, S., Hergersberg, M., Mehmann, B., Schinzel, A., Weisbrod, M., & Scharfetter, C. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000403)96:2 · Cited by 89 · see citing works
A Polymorphism of the MAOA Gene is Associated with Emotional Brain Markers and Personality Traits on an Antisocial Index
Williams, L. M., Gatt, J. M., Kuan, S. A., Dobson‐Stone, C., Palmer, D. M., Paul, R. H., Song, L., Costa, P. T., Schofield, P. R., & Gordon, E. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.1 · Cited by 88 · see citing works
Family‐based association study of serotonin transporter promoter in suicidal adolescents: No association with suicidality but possible role in violence traits
Zalsman, G., Frisch, A., Bromberg, M., Gelernter, J. E., Michaelovsky, E., Campino, A., Erlich, Z., Tyano, S., Apter, A. S., & Weizman, A. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1261 · Cited by 87 · see citing works
Behavioral genetics in antisocial spectrum disorders and psychopathy: A review of the recent literature
Gunter, T. D., Vaughn, M. G., & Philibert, R. A. (2010) · Behavioral Sciences & the Law · doi:10.1002/bsl.923 · Cited by 86 · see citing works
Attention Deficit Hyperactivity Disorder comorbid oppositional defiant disorder and its predominately inattentive type: evidence for an association with COMT but not MAOA in a Chinese sample
Qian, Q., Liu, J., Wang, Y.-F., Yang, L., Guan, L., & Faraone, S. (2009) · Behavioral and Brain Functions · doi:10.1186/1744-9081-5-8 · Cited by 86 · see citing works
Unraveling the Genetic Etiology of Adult Antisocial Behavior: A Genome-Wide Association Study
Tielbeek, J. J., Medland, S. E., Benyamin, B., Byrne, E. M., Heath, A. C., Madden, P. A. F., Martin, N. G., Wray, N. R., & Verweij, K. J. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045086 · Cited by 86 · see citing works
The Dopamine Receptor D4 Gene (DRD4) Moderates Family Environmental Effects on ADHD
Martel, M. M., Nikolas, M. A., Jernigan, K. A., Friderici, K. H., Waldman, I. D., & Nigg, J. T. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9439-5 · Cited by 86 · see citing works
Association of the serotonin transporter and 5HT1Dβ receptor genes with extreme, persistent and pervasive aggressive behaviour in children
Davidge, K. M., Atkinson, L., Douglas, L., Lee, V., Shapiro, S., Kennedy, J. L., & Beitchman, J. H. (2004) · Psychiatric Genetics · doi:10.1097/00041444-200409000-00004 · Cited by 84 · see citing works
HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers
Serretti, A., Mandelli, L., Giegling, I., Schneider, B., Hartmann, A. M., Schnabel, A., Maurer, K., Möller, H., & Rujescu, D. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30432 · Cited by 84 · see citing works
Monoamine oxidase A and childhood adversity as risk factors for conduct disorder in females
Prom‐Wormley, E. C., Eaves, L. J., Foley, D. L., Gardner, C. O., Archer, K. J., Wormley, B., MAES, H. H. M., Riley, B. P., & Silberg, J. L. (2008) · Psychological Medicine · doi:10.1017/s0033291708004170 · Cited by 83 · see citing works
In search of genes associated with risk for psychopathic tendencies in children: a two‐stage genome‐wide association study of pooled DNA
Viding, E., Hanscombe, K. B., Curtis, C. J. C., Davis, O. S. P., Meaburn, E. L., & Plomin, R. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02236.x · Cited by 83 · see citing works
The effect of the serotonin transporter polymorphism (5-HTTLPR) on empathic and self-conscious emotional reactivity.
Gyurak, A., Haase, C. M., Sze, J. A., Goodkind, M. S., Coppola, G., Lane, J. R., Miller, B. L., & LEVENSON, R. W. (2012) · Emotion · doi:10.1037/a0029616 · Cited by 80 · see citing works
Phenotype studies of the DRD4 gene polymorphisms in ADHD: Association with oppositional defiant disorder and positive family history
Kirley, A., Lowe, N., Mullins, C., McCarron, M., Daly, G., Waldman, I. D., Fitzgerald, M., Gill, M., & Hawi, Z. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30072 · Cited by 79 · see citing works
Dopaminergic system genes in childhood aggression: Possible role for DRD2
Zai, C. C., Ehtesham, S., Choi, E., Nowrouzi, B., de Luca, V., Stankovich, L., Davidge, K., Freeman, N., King, N., Kennedy, J. L., et al. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.543431 · Cited by 78 · see citing works
Gender-specific expression of the DRD4 gene on adolescent delinquency, anger and thrill seeking
Dmitrieva, J., Chen, C., Greenberger, E., Ogunseitan, O. A., & Ding, Y.-C. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq020 · Cited by 78 · see citing works
Impulsiveness, serotonin genes and repetition of deliberate self-harm (DSH)
Evans, J., Reeves, B. C., Platt, H., LEIBENAU, A., Goldman, D. A., JEFFERSON, K., & Nutt, D. (2000) · Psychological Medicine · doi:10.1017/s0033291799002822 · Cited by 77 · see citing works
The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide
Zouk, H., McGirr, A., Lebel, V., Benkelfat, C., Rouleau, G. A., & Turecki, G. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30521 · Cited by 77 · see citing works
Central nervous system serotonergic responsivity and aggressive disposition in men
Manuck, S. B., Flory, J. D., Muldoon, M. F., & Ferrell, R. E. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00922-8 · Cited by 75 · see citing works
Genome-Wide Association Study of the Child Behavior Checklist Dysregulation Profile
Mick, E., McGough, J., Loo, S., Doyle, A. E., Wozniak, J., Wilens, T. E., Smalley, S., McCracken, J., Biederman, J., & Faraone, S. V. (2011) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2011.05.001 · Cited by 75 · see citing works
Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self‐reported anger and hostility among young men
Conner, T. S., Jensen, K. P., Tennen, H. A., Furneaux, H. M., Kranzler, H. R., & Covault, J. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30955 · Cited by 75 · see citing works
Socioeconomic status mediates the genetic contribution of the dopamine receptor D4 and serotonin transporter linked promoter region repeat polymorphisms to externalization in preadolescence
Nobile, M., Giorda, R., Marino, C., Carlet, O., Pastore, V., Vanzin, L., Bellina, M., Molteni, M., & Battaglia, M. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000594 · Cited by 72 · see citing works
Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents
Gerra, G., Garofano, L., Castaldini, L., Rovetto, F., Zaimovic, A., Moi, G., Bussandri, M., Branchi, B., Brambilla, F., Friso, G., et al. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-004-0268-y · Cited by 71 · see citing works
MAOA-uVNTR genotype predicts interindividual differences in experimental aggressiveness as a function of the degree of provocation
Kuepper, Y., Grant, P. S., Wielpuetz, C., & Hennig, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.002 · Cited by 70 · see citing works
Case‐control and within‐family tests for an association between conduct disorder and 5HTTLPR
Sakai, J. T., Young, S. E., Stallings, M. C., Timberlake, D. S., Smolen, A., Stetler, G. L., & Crowley, T. J. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30278 · Cited by 69 · see citing works
MAOA genotype, social exclusion and aggression: an experimental test of a gene–environment interaction
Gallardo‐Pujol, D., Pueyo, A. A., & Maydeu‐Olivares, A. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00868.x · Cited by 68 · see citing works
Mothers' prenatal stress and their children's antisocial outcomes – a moderating role for the Dopamine D4 Receptor ( <scp>DRD</scp> 4) gene
Zohsel, K., Buchmann, A. F., Blomeyer, D., Hohm, E., Schmidt, M. H., Esser, G., Brandeis, D., Banaschewski, T., & Laucht, M. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12138 · Cited by 68 · see citing works
MAOA‐uVNTR and early physical discipline interact to influence delinquent behavior
Edwards, A. C., Dodge, K. A., Latendresse, S. J., Lansford, J. E., Bates, J. E., Pettit, G. S., Budde, J. P., Goate, A. M., & Dick, D. M. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02196.x · Cited by 67 · see citing works
Androgen receptor trinucleotide repeat polymorphism and personality traits
Jönsson, E. G., von Gertten, C., Gustavsson, P. J., Yuan, Q., Lindblad‐Toh, K., Forslund, K., Rylander, G., Mattila‐Evenden, M., Åsberg, M., & Schalling, M. (2001) · Psychiatric Genetics · doi:10.1097/00041444-200103000-00004 · Cited by 67 · see citing works
Study of the Catechol‐O‐Methyltransferase (COMT) Gene with High Aggression in Children
Hirata, Y., Zai, C. C., Nowrouzi, B., Beitchman, J. H., & Kennedy, J. L. (2013) · Aggressive Behavior · doi:10.1002/ab.21448 · Cited by 65 · see citing works
The effects of MAOA genotype, childhood trauma, and sex on trait and state‐dependent aggression
Verhoeven, F. E. A., Booij, L., Kruijt, A., Cerit, H., Antypa, N., & van der Does, W. A. J. (2012) · Brain and Behavior · doi:10.1002/brb3.96 · Cited by 64 · see citing works
NOS‐I and ‐III gene variants are differentially associated with facets of suicidal behavior and aggression‐related traits
Rujescu, D., Giegling, I., Mandelli, L., Schneider, B., Hartmann, A. M., Schnabel, A., Maurer, K., Möller, H., & Serretti, A. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30569 · Cited by 64 · see citing works
COMT but not serotonin‐related genes modulates the influence of childhood abuse on anger traits
Perroud, N. A., Jaussent, I., Guillaume, S., Bellivier, F., Baud, P., Jollant, F., Leboyer, M., Lewis, C. M., Malafosse, A., & Courtet, P. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00547.x · Cited by 62 · see citing works
COMT Val158Met Genotype as a Risk Factor for Problem Behaviors in Youth
Albaugh, M. D., Harder, V. S., Althoff, R. R., Rettew, D. C., Ehli, E. A., Lengyel-Nelson, T., Davies, G. E., Ayer, L., Sulman, J., Stanger, C., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.05.015 · Cited by 60 · see citing works
Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort
Smearman, E. L., Winiarski, D. A., Brennan, P. A., Najman, J., & Johnson, K. C. (2015) · Development and Psychopathology · doi:10.1017/s0954579414000649 · Cited by 60 · see citing works
ADHD and Disruptive behavior scores – associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents
Malmberg, K., Wargelius, H., Lichtenstein, P., Oreland, L., & Larsson, J. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-28 · Cited by 58 · see citing works
Reducing Aggression and Impulsivity Through School-Based Prevention Programs: A Gene by Intervention Interaction
Musci, R. J., Bradshaw, C. P., Maher, B. S., Uhl, G. R., Kellam, S. G., & Ialongo, N. S. (2013) · Prevention Science · doi:10.1007/s11121-013-0441-3 · Cited by 57 · see citing works
Harsh discipline, childhood sexual assault, and MAOA genotype: An investigation of main and interactive effects on diverse clinical externalizing outcomes
Derringer, J., Krueger, R., Irons, D., & Iacono, W. (2010) · Behavior Genetics · doi:10.1007/s10519-010-9358-9 · Cited by 57 · see citing works
CHRM2 , Parental Monitoring, and Adolescent Externalizing Behavior
Dick, D. M., Meyers, J. L., Latendresse, S. J., Creemers, H. E., Lansford, J. E., Pettit, G. S., Bates, J. E., Dodge, K. A., Budde, J., Goate, A., et al. (2011) · Psychological Science · doi:10.1177/0956797611403318 · Cited by 56 · see citing works
Perceived discrimination, serotonin transporter linked polymorphic region status, and the development of conduct problems
Brody, G. H., Beach, S. R. H., Chen, Y.-F., Obasi, E., Philibert, R. A., Kogan, S. M., & Simons, R. L. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000046 · Cited by 56 · see citing works
Analysis of monoaminergic genes, childhood abuse, and dimensions of psychopathy.
Sadeh, N., Javdani, S., & Verona, E. (2012) · Journal of Abnormal Psychology · doi:10.1037/a0029866 · Cited by 56 · see citing works
Polymorphism in the Serotonin Receptor 2a (HTR2A) Gene as Possible Predisposal Factor for Aggressive Traits
Bánlaki, Z., Elek, Z., Nánási, T., Székely, A., Nemoda, Z., Sasvári‐Székely, M., & Rónai, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117792 · Cited by 55 · see citing works
Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women
Westberg, L., Melke, J., Landén, M., Nilsson, S., Baghaei, F., Rosmond, R., Jansson, M., Holm, G., Björntorp, P. A., & Eriksson, E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001192 · Cited by 55 · see citing works
Oxytocin and vasopressin receptor polymorphisms interact with circulating neuropeptides to predict human emotional reactions to stress.
Moons, W. G., Way, B. M., & Taylor, S. E. (2014) · Emotion · doi:10.1037/a0035503 · Cited by 55 · see citing works
Personality Processes in Anger and Reactive Aggression: An Introduction
Robinson, M. D., & Wilkowski, B. M. (2010) · Journal of Personality · doi:10.1111/j.1467-6494.2009.00606.x · Cited by 53 · see citing works
Evidence for epistasis between the 5-HTTLPR and the dopamine D4 receptor polymorphisms in externalizing behavior among 15-year-olds
Hohmann, S., Becker, K., Fellinger, J., Banaschewski, T., Schmidt, M. H., Esser, G., & Laucht, M. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0290-1 · Cited by 53 · see citing works
Lack of association between the serotonin transporter promoter gene polymorphism and impulsivity or aggressive behavior among suicide attempters and healthy volunteers
Baca‐García, E., Vaquero, C., Díaz-Sastre, C., Garcı́a-Resa, E., Sáiz, P. A., Fernández‐Piqueras, J., & de León, J. (2004) · Psychiatry Research · doi:10.1016/j.psychres.2003.10.007 · Cited by 53 · see citing works
Differential Susceptibility to Adolescent Externalizing Trajectories: Examining the Interplay Between CHRM2 and Peer Group Antisocial Behavior
Latendresse, S. J., Bates, J. E., Goodnight, J. A., Lansford, J. E., Budde, J., Goate, A., Dodge, K. A., Pettit, G. S., & Dick, D. M. (2011) · Child Development · doi:10.1111/j.1467-8624.2011.01640.x · Cited by 53 · see citing works
Observed parenting behaviors interact with a polymorphism of the brain-derived neurotrophic factor gene to predict the emergence of oppositional defiant and callous–unemotional behaviors at age 3 years
Willoughby, M. T., Mills-Koonce, R., Propper, C. B., & Waschbusch, D. A. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000266 · Cited by 52 · see citing works
Association between the adrenergic α2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects
Comings, D. E., Johnson, J., Gonzalez, N. S., et al. (2000) · Psychiatric Genetics · doi:10.1097/00041444-200010010-00007 · Cited by 51 · see citing works
A polymorphic region in the human transcription factor AP-2β gene is associated with specific personality traits
Damberg, M., Garpenstrand, H., Alfredsson, J., Ekblom, J., Forslund, K., Rylander, G., & Oreland, L. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000691 · Cited by 49 · see citing works
Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse
Reti, I. M., Xu, Z., Yanofski, J., McKibben, J. B. A., Uhart, M., Cheng, Y.-J., Zandi, P. P., Bienvenu, O. J., SAMUELS, J. F., Willour, V. L., et al. (2010) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2010.05.005 · Cited by 48 · see citing works
Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents
DeYoung, C. G., Getchell, M., Koposov, R. A., Yrigollen, C. M., Haeffel, G. J., af Klinteberg, B., Oreland, L., Ruchkin, V. V., PAKSTIS, A. J., & Grigorenko, E. L. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833511e4 · Cited by 48 · see citing works
Association of dopamine transporter genotype with disruptive behavior disorders in an eight‐year longitudinal study of children and adolescents
Lee, S. S., Lahey, B. B., Waldman, I. D., Hulle, C. A. V., Rathouz, P. J., Pelham, W. E., Loney, J., & Cook, E. H. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30447 · Cited by 47 · see citing works
Interaction between prenatal stress and dopamine D4 receptor genotype in predicting aggression and cortisol levels in young adults
Buchmann, A. F., Zohsel, K., Blomeyer, D., Hohm, E., Hohmann, S., Jennen-Steinmetz, C., Treutlein, J., Becker, K., Banaschewski, T., Schmidt, M. H., et al. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3484-7 · Cited by 47 · see citing works
No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover
Mann, J. J., Currier, D., Murphy, L., Huang, Y.-Y., Galfalvy, H., Brent, D. A., Greenhill, L. L., & Oquendo, M. A. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.05.031 · Cited by 47 · see citing works
Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness
Pickles, A., Hill, J., Breen, G., Quinn, J., Abbott, K., Jones, H., & Sharp, H. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12081 · Cited by 47 · see citing works
Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study
Hakulinen, C., Jokela, M., Hintsanen, M., Merjonen, P., Pulkki-Råback, L., Seppälä, I., Lyytikäinen, L.-P., Lehtimäki, T., Kähönen, M., Viikari, J., et al. (2013) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9452-y · Cited by 47 · see citing works
Genome-Wide Association Study of Proneness to Anger
Mick, E. O., McGough, J. J., Deutsch, C. K., Frazier, J. A., Kennedy, D. N., & Goldberg, R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087257 · Cited by 46 · see citing works
The 2-Repeat Allele of the MAOA Gene Confers an Increased Risk for Shooting and Stabbing Behaviors
Beaver, K. M., Barnes, J. C., & Boutwell, B. B. (2013) · Psychiatric Quarterly · doi:10.1007/s11126-013-9287-x · Cited by 46 · see citing works
Gene environment interactions with a novel variable Monoamine Oxidase A transcriptional enhancer are associated with antisocial personality disorder
Philibert, R. A., Wernett, P., Plume, J., Packer, H., Brody, G. H., & Beach, S. R. H. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.04.007 · Cited by 46 · see citing works
MAOA and MAOB polymorphisms and anger-related traits in suicidal participants and controls
Antypa, N., Giegling, I., Calati, R., Schneider, B., Hartmann, A. M., Friedl, M., Konte, B., Lia, L., Ronchi, D. D., Serretti, A., et al. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0378-8 · Cited by 44 · see citing works
Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality
Reuter, M., & Hennig, J. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30153 · Cited by 44 · see citing works
Self‐Reported Family Socioeconomic Status, the 5‐HTTLPR Genotype, and Delinquent Behavior in a Community‐Based Adolescent Population
Åslund, C., Comasco, E., Nordquist, N., Leppert, J., Oreland, L., & Nilsson, K. W. (2012) · Aggressive Behavior · doi:10.1002/ab.21451 · Cited by 43 · see citing works
Possible genetic association between vasopressin receptor 1B and child aggression
Zai, C. C., Muir, K. E., Nowrouzi, B., Shaikh, S. A., Choi, E., Berall, L., Trépanier, M.-O., Beitchman, J. H., & Kennedy, J. L. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.07.031 · Cited by 43 · see citing works
Increased severity of suicidal behavior in impulsive aggressive patients exposed to familial adversities
López‐Castromán, J., Jaussent, I., Béziat, S., Guillaume, S., Baca‐García, E., Genty, C., Olié, É., & Courtet, P. (2014) · Psychological Medicine · doi:10.1017/s0033291714000646 · Cited by 43 · see citing works
Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms
Garcı́a, L. F., Aluja, A., Fibla, J., Cuevas, L., & Garcı́a, Ó. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2008.12.018 · Cited by 42 · see citing works
A gene‐based evolutionary explanation for the association between criminal involvement and number of sex partners
Beaver, K. M., WRIGHT, J. P., & Walsh, A. (2008) · Biodemography and Social Biology · doi:10.1080/19485565.2008.9989131 · Cited by 41 · see citing works
Coaction of Stress and Serotonin Transporter Genotype in Predicting Aggression at the Transition to Adulthood
Conway, C., Keenan‐Miller, D., Hammen, C. L., Lind, P. A., Najman, J. M., & Brennan, P. A. (2012) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2012.632351 · Cited by 41 · see citing works
Variants of the serotonin transporter gene and NEO‐PI‐R Neuroticism: No association in the BLSA and SardiNIA samples
Terracciano, A., Balaci, L., Thayer, J., Scally, M., Kokinos, S., Ferrucci, L., Tanaka, T., Zonderman, A. B., Sanna, S., Olla, N., et al. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30932 · Cited by 41 · see citing works
Developmental Differences in Early Adolescent Aggression: A Gene × Environment × Intervention Analysis
Schlomer, G. L., Cleveland, H. H., Vandenbergh, D. J., Feinberg, M. E., Neiderhiser, J. M., Greenberg, M. T., Spoth, R. L., & Redmond, C. R. (2014) · Journal of Youth and Adolescence · doi:10.1007/s10964-014-0198-4 · Cited by 40 · see citing works
The Association Between Peer and Own Aggression is Moderated by the BDNF Val‐Met Polymorphism
Kretschmer, T., Vitaro, F., & Barker, E. D. (2013) · Journal of Research on Adolescence · doi:10.1111/jora.12050 · Cited by 40 · see citing works
Gene–environment interaction in externalizing problems among adolescents: evidence from the Pelotas 1993 Birth Cohort Study
Kieling, C., Hutz, M. H., Genro, J. P., Polanczyk, G. V., Anselmi, L., Camey, S. A., Hallal, P. C., Barros, F. C., Victora, C. G., Menezes, A. M. B., et al. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12022 · Cited by 39 · see citing works
Association analysis of 15 polymorphisms within 10 candidate genes for antisocial behavioural traits
Prichard, Z. M., Jorm, A. F., Mackinnon, A. J., & Easteal, S. (2007) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32816ebc9e · Cited by 39 · see citing works
NF-κB determines axonal re- and degeneration by cell-specific balance of RelA and p50 subunits in the adult CNS
Haenold, R., Weih, F., Herrmann, K., Schmidt, K.-F., Krempler, K., Engelmann, C., Nave, K., Reichenbach, J. R., Löwel, S., Witte, O. W., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.140731 · Cited by 39 · see citing works
Search for the influence of the tyrosine hydroxylase (TCAT)n repeat polymorphism on personality traits
Persson, M.-L., Wasserman, D., Jönsson, E. G., Bergman, H., Terenius, L. Y., Gyllander, A., Neiman, J., & Geijer, T. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00160-8 · Cited by 38 · see citing works
Prediction of Preschool Aggression from DRD4 Risk, Parental ADHD Symptoms, and Home Chaos
Farbiash, T., Berger, A., Atzaba-Poria, N., & Auerbach, J. G. (2014) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-013-9791-3 · Cited by 37 · cited 2× · see citing works
“…delinquency, externalizing behavior [Nobile et al., 2007; Boutwell and Beaver, 2008; Hohmann et al., 2009; Dmitrieva et al., 2011; Buchmann et al., 2014; Farbiash et al., 2014; Schlomer et al., 2015] and with ODD and CD [Kirley et al., 2004; Nikitopoulos et al., 2014; Zohsel et al., 2014].”
Background
The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity
Logue, M. W., Solovieff, N., Leussis, M. P., Wolf, E. J., Melista, E., Baldwin, C. T., Koenen, K. C., Petryshen, T. L., & Miller, M. W. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.04.013 · Cited by 37 · see citing works
A latent modeling approach to genotype–phenotype relationships: maternal problem behavior clusters, prenatal smoking, and MAOA genotype
McGrath, L. M., Mustanski, B. S., Metzger, A., Pine, D. S., Kistner‐Griffin, E., Cook, E. H., & Wakschlag, L. S. (2012) · Archives of Women s Mental Health · doi:10.1007/s00737-012-0286-y · Cited by 36 · see citing works
Aggression and 5HTT polymorphism in females: Study of synchronized swimming and control groups
Sysoeva, O. V., Maluchenko, N. V., Timofeeva, M. A., Portnova, G. V., Kulikova, M. A., Tonevitsky, A. G., & Ivanitsky, A. M. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2008.12.005 · Cited by 36 · see citing works
The interactive effect of MAOA ‐ LPR genotype and childhood physical neglect on aggressive behaviors in Italian male prisoners
Gorodetsky, E. K., Bevilacqua, L. M., Carli, V., Sarchiapone, M., Roy, A., Goldman, D. A., & Enoch, M. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12140 · Cited by 36 · see citing works
The serotonin 2A −1438 G/A receptor polymorphism in a group of Swedish male criminals
Berggård, C., Damberg, M., Longato-Stadler, E., et al. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00699-2 · Cited by 35 · see citing works
Association study of androgen receptor CAG repeat polymorphism and male violent criminal activity
Cheng, D., Hong, C., Liao, D., & Tsai, S. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.11.004 · Cited by 35 · see citing works
Association of a functional variant of neuronal nitric oxide synthase gene with self-reported impulsiveness, venturesomeness and empathy in male offenders
Retz, W., Reif, A., Freitag, C., Retz-Junginger, P., & Rösler, M. (2010) · Journal of neural transmission · doi:10.1007/s00702-009-0352-4 · Cited by 34 · see citing works
Interaction of COMT val158met and externalizing behavior: Relation to prefrontal brain activity and behavioral performance
Shehzad, Z. E., DeYoung, C. G., Kang, Y., Grigorenko, E. L., & Gray, J. R. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.097 · Cited by 32 · see citing works
Association of DRD4 and COMT polymorphisms with anger and forgiveness traits in healthy volunteers
Kang, J. I., Namkoong, K., & Kim, S. J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.005 · Cited by 32 · see citing works
Hostility in adolescents and adults: a genome-wide association study of the Young Finns
Merjonen, P., Keltikangas‐Järvinen, L., Jokela, M. M., Seppälä, I., Lyytikäinen, L., Pulkki-Råbäck, L., Mika Kivimaki, B., Elovainio, M. J., Kettunen, J., Ripatti, S., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.13 · Cited by 30 · see citing works
Exploring epistasis in candidate genes for antisocial personality disorder
Arias, J. M. C., Acosta, C. A. P., Valencia, J. G., Montoya, G., Viana, J. C. A., Campo, O., Flórez, A. F., Medellin, B. E. C., Montoya, W. R., López‐Jaramillo, C., et al. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283437175 · Cited by 30 · see citing works
ABCG1 gene variants in suicidal behavior and aggression-related traits
Gietl, A. F., Giegling, I., Hartmann, A. M., Schneider, B., Schnabel, A., Maurer, K., Möller, H., & Rujescu, D. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.11.004 · Cited by 30 · see citing works
Effect of functional catechol-O-methyltransferase Val158Met polymorphism on physical aggression
Kulikova, M. A., Maluchenko, N. V., Timofeeva, M. A., Shlepzova, V. A., Schegolkova, J. V., Sysoeva, O., Ivanitsky, A. M., & Tonevitsky, A. (2008) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-008-0006-9 · Cited by 30 · see citing works
The role of genetic variants in genes regulating the oxytocin–vasopressin neurohumoral system in childhood-onset aggression
Malik, A. I., Zai, C. C., Berall, L., Abu, Z., Din, F., Nowrouzi, B., Chen, S., & Beitchman, J. H. (2014) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000044 · Cited by 29 · see citing works
A Potential Role for a Genetic Variation of AKAP5 in Human Aggression and Anger Control
Richter, S., Gorny, X., Marco‐Pallarés, J., Krämer, U. M., Machts, J., Barman, A., Bernstein, H., Schüle, R., Schöls, L. J., Rodríguez‐Fornells, A., et al. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00175 · Cited by 29 · see citing works
Monoamine oxidase A genotype, childhood adversity, and criminal behavior in an incarcerated sample
Armstrong, T. A., Boutwell, B. B., Flores, S., Symonds, M., Keller, S., & Gangitano, D. A. (2014) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000033 · Cited by 29 · see citing works
High activity of Monoamine oxidase A is associated with externalizing behaviour in maltreated and nonmaltreated adoptees
van der Vegt, E. J. M., Oostra, B. A., Vásquez, A. A., van der Ende, J., Verhulst, F. C., & Tiemeier, H. W. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32832a5084 · Cited by 29 · see citing works
Are infants differentially sensitive to parenting? Early maternal care, DRD4 genotype and externalizing behavior during adolescence
Nikitopoulos, J. A., Zohsel, K., Blomeyer, D., Buchmann, A. F., Schmid, B., Jennen-Steinmetz, C., Becker, K., Schmidt, M. H., Esser, G., Brandeis, D., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.012 · Cited by 29 · see citing works
Association of a polymorphism of the dopamine transporter gene with externalizing behavior problems and associated temperament traits: A longitudinal study from infancy to the mid‐teens
Jorm, A. F., Prior, M. R., Sanson, A. V., Smart, D., Zhang, Y., & Easteal, S. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1355 · Cited by 28 · see citing works
Association between a polymorphism of the vasopressin 1B receptor gene and aggression in children
Luppino, D., Moul, C., Hawes, D. J., Brennan, J., & Dadds, M. R. (2014) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000036 · Cited by 27 · see citing works
The CRHR1 Gene Contributes to Genetic Susceptibility of Aggressive Behavior Towards Others in Chinese Southwest Han Population
Chen, B.-F., Gu, T., Ma, B., Zheng, G., Ke, B., Zhang, X., Zhang, L., Wang, Y.-Y., Hu, L.-P., Chen, Y., et al. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0160-z · Cited by 27 · see citing works
Externalizing Behaviors are Associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster
Stephens, S. H., Hoft, N. R., Schlaepfer, I. R., Young, S. E., Corley, R., McQueen, M. B., Hopfer, C. J., Crowley, T. J., Stallings, M. C., Hewitt, J. K., et al. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9514-x · Cited by 27 · see citing works
Genetic variation in the hypothalamic–pituitary–adrenocortical axis regulatory factor, T‐box 19, and the angry/hostility personality trait
Wasserman, D., Geijer, T., Sokolowski, M., Rozanov, V. A., & Wasserman, J. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00259.x · Cited by 27 · see citing works
Serotonin receptor genes 5HT1A and 5HT2A modify the relation between childhood temperament and adulthood hostility
Keltikangas‐Järvinen, L., Puttonen, S., Mika Kivimaki, B., Elovainio, M. J., Pulkki-Råbäck, L., Koivu, M., Rontu, R., & Lehtimäki, T. J. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00324.x · Cited by 26 · see citing works
Polymorphisms in the maternal sex steroid pathway are associated with behavior problems in male offspring
Miodovnik, A., Diplas, A. I., Chen, J., Zhu, C., Engel, S. M., & Wolff, M. S. (2012) · Psychiatric Genetics · doi:10.1097/ypg.0b013e328351850b · Cited by 25 · see citing works
Impact of tryptophan hydroxylase 2 G-703T polymorphism on anger-related personality traits and orbitofrontal cortex
Yoon, H., Lee, H., Kim, L., Lee, M.-S., & Ham, B. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.001 · Cited by 24 · see citing works
Synaptosomal- Associated Protein 25 Gene Polymorphisms and Antisocial Personality Disorder: Association with Temperament and Psychopathy
Başoğlu, C., Öner, Ö., Ates, A. M., Algül, A., Bez, Y., Çetin, M., Herken, H., Erdal, M. E., & Münir, K. (2011) · The Canadian Journal of Psychiatry · doi:10.1177/070674371105600605 · Cited by 24 · see citing works
Case–control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample
Sakai, J. T., Lessem, J. M., Haberstick, B. C., Hopfer, C. J., Smolen, A., Ehringer, M. A., Timberlake, D. S., & Hewitt, J. K. (2007) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32809913c8 · Cited by 22 · see citing works
Biosocial Influences on Fraudulent Behaviors
Beaver, K., & Holtfreter, K. (2009) · The Journal of Genetic Psychology · doi:10.3200/gntp.170.2.101-114 · Cited by 22 · see citing works
The dopamine receptor D4 gene and familial loading interact with perceived parenting in predicting externalizing behavior problems in early adolescence: The TRacking Adolescents' Individual Lives Survey (TRAILS)
Marsman, R., Oldehinkel, A. J., Ormel, J., & Buitelaar, J. K. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.10.022 · Cited by 21 · see citing works
Age-dependent effect of the MAOA gene on childhood physical aggression
Pingault, J. B., Côté, S. M., Booij, L., Ouellet-Morin, I., Castellanos-Ryan, N., Vitaro, F., Turecki, G., & Tremblay, R. E. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.173 · Cited by 21 · see citing works
Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder
Sakai, J. T., Crowley, T. J., Stallings, M. C., McQueen, M. B., Hewitt, J. K., Hopfer, C. J., Hoft, N. R., & Ehringer, M. A. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32834c0cb2 · Cited by 20 · see citing works
ESR1 polymorphisms, daily hassles, anger expression, and depressive symptoms in adolescent boys and girls
Vermeersch, H., T'Sjoen, G. G., Kaufman, J., & Houtte, M. V. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.017 · Cited by 19 · see citing works
Using trajectory analyses to refine phenotype for genetic association: conduct problems and the serotonin transporter (5HTTLPR)
Sakai, J. T., Boardman, J. D., Gelhorn, H. L., Smolen, A., Corley, R. P., Huizinga, D. H., Menard, S., Hewitt, J. K., & Stallings, M. C. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32833a20f1 · Cited by 19 · see citing works
Interaction between Serotonin Transporter and Serotonin Receptor 1 B genes polymorphisms may be associated with antisocial alcoholism
Wang, T., Lee, S.-Y., Chen, S., Chang, Y., Chen, S., Chu, C., Huang, S., Tzeng, N., Wang, C., Lee, I. H., et al. (2012) · Behavioral and Brain Functions · doi:10.1186/1744-9081-8-18 · Cited by 18 · see citing works
Association between Tryptophan Hydroxylase 2 Polymorphism and Anger-Related Personality Traits among Young Korean Women
Yang, J.-W., Lee, M., Lee, S. H., Lee, B., Kim, S. H., Joe, S.-H., Jung, I., Choi, I., & Ham, B. (2010) · Neuropsychobiology · doi:10.1159/000318572 · Cited by 17 · see citing works
Irritable assault and variation in the COMT gene
Flory, J. D., Xu, K., New, A. S., Finch, T., Goldman, D. A., & Siever, L. J. (2007) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3281c8f126 · Cited by 16 · see citing works
Serotonin system genes and childhood-onset aggression
Mik, H., Ehtesham, S., Baldassarra, L., Luca, V. D., Davidge, K. M., Bender, D., Tharmalingam, S., Kennedy, J. L., & Beitchman, J. H. (2006) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3280114103 · Cited by 16 · see citing works
Replication of a ROBO2 polymorphism associated with conduct problems but not psychopathic tendencies in children
Dadds, M. R., Moul, C., Cauchi, A., Hawes, D. J., & Brennan, J. (2013) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283650f83 · Cited by 15 · see citing works
Association between Monoamine Oxidase A Polymorphisms and Anger-Related Personality Traits in Korean Women
Yang, J.-W., Lee, S. H., Ryu, S., Lee, B., Kim, S. H., Joe, S.-H., Jung, I., Choi, I., & Ham, B. (2007) · Neuropsychobiology · doi:10.1159/000109973 · Cited by 12 · see citing works
Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters
Sokolowski, M., Wasserman, J., & Wasserman, D. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.70 · Cited by 12 · see citing works
The Secret Ingredient for Social Success of Young Males: A Functional Polymorphism in the 5HT2A Serotonin Receptor Gene
Dijkstra, J. K., Lindenberg, S. M., Zijlstra, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054821 · Cited by 8 · see citing works
Effect of BDNF Val66Met and serotonin transporter 5-HTTLPR polymorphisms on psychopathological characteristics in a sample of university students
Kourmouli, N., Samakouri, M. A., Mamatsiou, A., Trypsianis, G., Livaditis, M., & Veletza, S. V. (2013) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283643629 · Cited by 6 · see citing works

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Research works printed but not linked: 2

Bevilacqua L, Carli V, Sarchiapone M, George DK, Goldman D, Roy A, Enoch MA. 2012. Interaction between FKBP5 and childhood trauma and risk of aggressive behavior. Arch Gen Psychiatry 69(1):62-70.
Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL. 2000. Association between the serotonin trans- porter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet 96(2):202-216.

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Eusebi, P. G., Sevane, N., O’Rourke, T., Pizarro, M., Boeckx, C., & Dunner, S. (2021) · BMC Genomics · doi:10.1186/s12864-021-07505-5 · Cited by 24 · see citing works
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Vevera, J., Zarrei, M., Hartmannová, H., Jedličková, I., Mušálková, D., Přistoupilová, A., Oliveriusová, P., Trešlová, H., Nosková, L., Hodaňová, K., et al. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12536 · Cited by 15 · see citing works
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Vollebregt, O., Koyama, E., Zai, C. C., Shaikh, S. A., Lisoway, A. J., Kennedy, J. L., & Beitchman, J. H. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.062 · Cited by 13 · see citing works
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Lok, S., Lau, T. N. H., Trost, B., Tong, A. H. Y., Wintle, R. F., Engstrom, M. D., Stacy, E., Waits, L. P., Scrafford, M., & Scherer, S. W. (2022) · G3 Genes|Genomes|Genetics · doi:10.1093/g3journal/jkac138 · Cited by 6 · see citing works

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Patel, D. P., Pastuszak, A. W., & Hotaling, J. M. (2020) · International Journal of Impotence Research · doi:10.1038/s41443-020-00372-w · Cited by 8 · see citing works
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Kronenberg, F. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.09.005 · Cited by 44 · see citing works

Authors: Fernàndez‐Castillo, N., & Cormand, B.
Affiliations: Departament de Genètica Facultat de Biologia Universitat de Barcelona Catalonia Spain
Centre for Biomedical Network Research on Rare Diseases (ES)
Corresponding author: Cormand, Bru
ORCID: Cormand, Bru
Venue: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Publisher: Wiley
Published: 2016-01-15
Volume: 171
Issue: 5
Pages: 676-696
ISSN: 1552-4841 (ISSN-L)
1552-485X
DOI: 10.1002/ajmg.b.32419
OpenAlex: W2241824729
Cited by: 87
References: 198
Citations by year: 2026: 3 · 2025: 8 · 2024: 4 · 2023: 13 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 5
FWCI: 1.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: AGAUR (2014SGR932)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: aggression, genetic susceptibility, candidate gene association, genome-wide association study, dopamine signaling, serotonergic neurotransmission, hormonal regulation, axon guidance, estrogen receptor signaling, brain development, synaptic plasticity, signaling pathways
MeSH terms: Aggression, Humans, Social Behavior, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Association Studies

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Aggressive behavior in humans: Genes and pathways identified through association studies

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