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Cited by 53Advanced Radiotherapy TechniquesRadiopharmaceutical Chemistry and ApplicationsRadiation Therapy and Dosimetry

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

A Treatment Planning Method for Sequentially Combining Radiopharmaceutical Therapy and External Radiation Therapy

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Hobbs, Robert F., McNutt, Todd, Baechler, Sébastien, He, Bin, Esaias, Caroline E., Frey, Eric C., Loeb, David M., Wahl, Richard L., Shokek, Ori, Sgouros, George·2011·International Journal of Radiation Oncology*Biology*Physics
DOI 10.1016/j.ijrobp.2010.08.022PMC PMC3090537
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Abstract

Purpose Effective cancer treatment generally requires combination therapy. The combination of external beam therapy (XRT) with radiopharmaceutical therapy (RPT) requires accurate three-dimensional dose calculations to avoid toxicity and evaluate efficacy. We have developed and tested a treatment planning method, using the patient-specific three-dimensional dosimetry package 3D-RD, for sequentially combined RPT/XRT therapy designed to limit toxicity to organs at risk.Methods and materials The biologic effective dose (BED) was used to translate voxelized RPT absorbed dose (D(RPT)) values into a normalized total dose (or equivalent 2-Gy-fraction XRT absorbed dose), NTD(RPT) map. The BED was calculated numerically using an algorithmic approach, which enabled a more accurate calculation of BED and NTD(RPT). A treatment plan from the combined Samarium-153 and external beam was designed that would deliver a tumoricidal dose while delivering no more than 50 Gy of NTD(sum) to the spinal cord of a patient with a paraspinal tumor.Results The average voxel NTD(RPT) to tumor from RPT was 22.6 Gy (range, 1-85 Gy); the maximum spinal cord voxel NTD(RPT) from RPT was 6.8 Gy. The combined therapy NTD(sum) to tumor was 71.5 Gy (range, 40-135 Gy) for a maximum voxel spinal cord NTD(sum) equal to the maximum tolerated dose of 50 Gy.Conclusions A method that enables real-time treatment planning of combined RPT-XRT has been developed. By implementing a more generalized conversion between the dose values from the two modalities and an activity-based treatment of partial volume effects, the reliability of combination therapy treatment planning has been expanded.

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  • Efforts to combine dose planning for radiopharmaceutical therapy of bone metastases with external beam radiation have been described for 153Sm-EDTMP.

    “Examples of efforts to combine dose planning for RPT of bone metastases with external beam radiation have been described for 153 Sm-EDTMP as an example ( 105 ).”

    From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [105]

    The Introduction and Abstract Methods describe combined radiopharmaceutical and external-beam dose planning using samarium-153. The Methods section identifies the agent as 153Sm-EDTMP and notes its use for bone metastases, but the planning example is a patient with osteogenic sarcoma and a paraspinal tumor, not a case identified as bone metastases. (LLM, conf=0.86)

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Metadata

Authors
Hobbs, R. F., McNutt, T., Baechler, S., He, B., Esaias, C. E., Frey, E. C., Loeb, D. M., Wahl, R. L., Shokek, O., & Sgouros, G.
Affiliations
  • Johns Hopkins University (US)
  • Institute of Radiation Physics (CH)
Corresponding author
Sgouros, George
ORCID
Venue
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier BV
Published
2011-07
Volume
80
Issue
4
Pages
1256-1262
ISSN
0360-3016 (ISSN-L)
DOI
10.1016/j.ijrobp.2010.08.022
PMC
PMC3090537
OpenAlex
W2165044684
Cited by
53
References
30
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 5
FWCI
3.98
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Radiation Oncology*Biology*Physics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion, other-oa)
Funders
  • National Institutes of Health
  • National Cancer Institute (R01CA116477, CA116477)
Topics
  • Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
  • Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords
radiopharmaceutical therapy, external beam radiotherapy, treatment planning, 3D dosimetry, biologically effective dose, samarium-153, spinal cord dose, paraspinal tumors, partial volume effect
MeSH terms
Adult, Algorithms, Combined Modality Therapy, Humans, Male, Organometallic Compounds, Organophosphorus Compounds, Radiation Injuries, Radioisotopes, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Relative Biological Effectiveness, Samarium, Osteosarcoma, Spinal Cord, Spinal Neoplasms, Tomography, X-Ray Computed, Tomography, Emission-Computed, Single-Photon, Organs at Risk

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