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Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations

Mabbott, Neil A., Kenneth Baillie, J., Hume, David A., Freeman, Tom C.·2010·Immunobiology
DOI 10.1016/j.imbio.2010.05.012
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Abstract

In order to address fundamental questions associated with the relationships between mononuclear phagocytes and other myeloid and lymphoid cell populations, we have taken advantage of the growing body of expression data available in the public domain. We collated a large number of published expression studies on mouse haemopoietic cell lineages comprising 304 cell samples from 29 independent experiments performed on a single microarray platform (Affymetrix MOE430-2). The data were subjected to network-based cluster analysis using Biolayout Express(3D). Genes with related function clustered together in distinct regions of the graph reaffirming many known associations between gene expression and role in specific pathways and defining most major cell types of the immune system. Promoters of genes within individual clusters were distinguished by over-representation of regulatory motifs recognised by specific transcription factors. However, these data indicate that commonly used myeloid subpopulation markers, such as CD11c (Itgax), do not correlate with expression of other genes, and further bring into question their use in defining myeloid cell lineage, activation (M1 vs. M2) and antigen-presenting cell function. In particular, there were few mRNA markers that clearly distinguished classical dendritic cells (DC) from macrophages, other than low expression of genes required for phagocytic activity. Bone marrow-derived DC, grown in GM-CSF, were clearly identified as phagocytes and d…

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Metadata

Authors
Mabbott, N. A., Kenneth Baillie, J., Hume, D. A., & Freeman, T. C.
Venue
Immunobiology
Publisher
Elsevier BV
Published
2010-09
Volume
215
Issue
9-10
Pages
724-736
ISSN
0171-2985
DOI
10.1016/j.imbio.2010.05.012
Cited by
77
References
6
Language
en
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