The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Master sensors of pathogenic RNA – RIG-I like receptors
Open accessAbstract
Initiating the immune response to invading pathogens, the innate immune system is constituted of immune receptors (pattern recognition receptors, PRR) that sense microbe-associated molecular patterns (MAMPs). Detection of pathogens triggers intracellular defense mechanisms, such as the secretion of cytokines or chemokines to alarm neighboring cells and attract or activate immune cells. The innate immune response to viruses is mostly based on PRRs that detect the unusual structure, modification or location of viral nucleic acids. Most of the highly pathogenic and emerging viruses are RNA genome-based viruses, which can give rise to zoonotic and epidemic diseases or cause viral hemorrhagic fever. As viral RNA is located in the same compartment as host RNA, PRRs in the cytosol have to discriminate between viral and endogenous RNA by virtue of their structure or modification. This challenging task is taken on by the homologous cytosolic DExD/H-box family helicases RIG-I and MDA5, which control the innate immune response to most RNA viruses. This review focuses on the molecular basis for RIG-I like receptor (RLR) activation by synthetic and natural ligands and will discuss controversial ligand definitions.
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Citations
Cites
A Toll-like receptor recognizes bacterial DNA
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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“Even though poly I:C also binds and can stimulate RIG-I in certain cell lines and experimental settings in vitro (Kato et al. 2008; Yoneyama et al. 2004), it is important to note that poly I:C indeed fails to induce IFN-alpha when injected intravenously into MDA5-deficient mice or transfected in vitro into MDA5-defici…”
BackgroundInfluentialCpG motifs in bacterial DNA trigger direct B-cell activation
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BackgroundIPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
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Cited by
Li, B., Zhu, L., Lu, C., Wang, C., Wang, H., Jin, H., Ma, X., Cheng, Z., Yu, C., Wang, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20527-z · Cited by 697
Advances in mRNA Vaccines for Infectious Diseases
Zhang, C., Maruggi, G., Shan, H., & Li, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00594 · Cited by 665
Discriminating self from non-self in nucleic acid sensing
Schlee, M., & Hartmann, G. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.78 · Cited by 593
Self-citationAntiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates
Goubau, D., Schlee, M., Deddouche, S., Pruijssers, A. J., Zillinger, T., Goldeck, M., Schuberth, C., Van der Veen, A. G., Fujimura, T., Rehwinkel, J., et al. (2014) · Nature · doi:10.1038/nature13590 · Cited by 557
Wicherska-Pawłowska, K., Wróbel, T., & Rybka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413397 · Cited by 409
Metadata
- Authors
- Schlee, M.
- Venue
- Immunobiology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 218
- Issue
- 11
- Pages
- 1322-1335
- ISSN
- 0171-2985 (ISSN-L)
- OpenAlex
- W2056623600
- Cited by
- 217
- References
- 12
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- green
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