Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

Doedens, Andrew L.; Stockmann, Christian; Rubinstein, Mark P.; Liao, Debbie; Zhang, Na; DeNardo, David G.; Coussens, Lisa M.; Karin, Michael; Goldrath, Ananda W.; Johnson, Randall S.

doi:10.1158/0008-5472.can-10-1439

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

T cells can inhibit tumor growth, but their function in the tumor microenvironment is often suppressed. Many solid tumors exhibit abundant macrophage infiltration and low oxygen tension, yet how hypoxic conditions may affect innate immune cells and their role in tumor progression is poorly unders…