CoChat
Sign Up
Cited by 101

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Chitosan nanoparticles as a dual drug/siRNA delivery system for treatment of colorectal cancer

Sadreddini, Sanam, Safaralizadeh, Reza, Baradaran, Behzad, Aghebati-Maleki, Leili, Hosseinpour-Feizi, Mohammad Ali, Shanehbandi, Dariush, Jadidi-Niaragh, Farhad, Sadreddini, Sevil, Kafil, Hossein Samadi, Younesi, Vahid, Yousefi, Mehdi·2017·Immunology Letters
DOI 10.1016/j.imlet.2016.11.013
Open this paper in CoChat — free account

Abstract

Nanoparticles are widely used to deliver anticancer drugs and inhibit tumor growth without systemic toxicity. Recently, chitosan has received much attention as a functional biopolymer for encapsulation of small interfering RNA (siRNA). Because of cationic nature, chitosan efficiently encapsulate siRNA and forming nanoparticles. Moreover, biocompatible and biodegradable properties represent chitosan as potential candidate for in vivo siRNA delivery. In the present study we designed carboxymethyl dextran (CMD) chitosan nanoparticles (ChNPs) to encapsulate snail siRNA and anticancer drug doxorubicin (DOX). The effect of ChNPs-drug/siRNA on cell growth and Epithelial mesenchymal transition (EMT) gene expression of HCT-116 cell lines were investigated. Furthermore the efficacy of dual agent nanoparticle to induce apoptosis and inhibit migration of colorectal cancer cells were assessed using Annexin-V and wound healing assays, respectively. The results demonstrated that treatment with dual agent nanoparticles led to significant changes of EMT genes (i.e down regulation of MMP-9 and Vimentin and up regulation of E-cadherin), apoptosis cell death and migration inhibition in HCT-116 cells. In conclusion, ChNPs encapsulating DOX and snail siRNA can be considered as an effective anti-cancer drugs delivery system for the treatment of colorectal cancer.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.imlet.2016.11.013

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 3 references

Research works printed but not linked: 26

  1. Hosseinzadeh, 2012, Chitosan-pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study, Int. J. Nanomed., 7, 1851
  2. Suri, 2007, Nanotechnology-based drug delivery systems, J. Occup. Med. Toxicol., 2, 16, 10.1186/1745-6673-2-16 · DOI
  3. Bahrami, 2015, Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy, Tumor Biol., 36, 5727, 10.1007/s13277-015-3706-6 · DOI
  4. Wang, 2011, Recent advances of chitosan nanoparticles as drug carriers, Int. J. Nanomed., 6, 765
  5. Shi, 2002, Advances in nanoparticle system for deliverying drugs across the biological barriers, J. China Pharm. Univ., 33, 169
  6. Dolati, 2016, Utilization of nanoparticle technology in rheumatoid arthritis treatment, Biomed. Pharmacother., 80, 30, 10.1016/j.biopha.2016.03.004 · DOI
  7. Ayala, 2013, Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles, J. Nanopart. Res., 15, 1, 10.1007/s11051-013-1874-0 · DOI
  8. Mikhaylov, 2011, Promising approaches in using magnetic nanoparticles in oncology, Biol. Chem., 392, 955, 10.1515/BC.2011.185 · DOI
  9. Wilhelm, 2003, Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating, Biomaterials, 24, 1001, 10.1016/S0142-9612(02)00440-4 · DOI
  10. Jere, 2009, Chitosan-graft-polyethylenimine for Akt1 siRNA delivery to lung cancer cells, Int. J. Pharm., 378, 194, 10.1016/j.ijpharm.2009.05.046 · DOI
  11. Kachalaki, 2015, Reversal of chemoresistance with small interference RNA (siRNA) in etoposide resistant acute myeloid leukemia cells (HL-60), Biomed. Pharmacother., 75, 100, 10.1016/j.biopha.2015.08.032 · DOI
  12. Park, 2009, Biodegradable luminescent porous silicon nanoparticles for in vivo applications, Nat. Mater., 8, 331, 10.1038/nmat2398 · DOI
  13. Ajaj, 2009, In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B, Cancer Chemother. Pharmacol., 64, 413, 10.1007/s00280-009-0942-8 · DOI
  14. Qi, 2010, Nanoparticles with dextran/chitosan shell and BSA/chitosan core—doxorubicin loading and delivery, Int. J. Pharm., 393, 177, 10.1016/j.ijpharm.2010.03.063 · DOI
  15. Zucker, 2004, Role of matrix metalloproteinases (MMPs) in colorectal cancer, Cancer Metastasis Rev., 23, 101, 10.1023/A:1025867130437 · DOI
  16. Satelli, 2011, Vimentin in cancer and its potential as a molecular target for cancer therapy, Cell. Mol. Life Sci., 68, 3033, 10.1007/s00018-011-0735-1 · DOI
  17. Ngan, 2007, Quantitative evaluation of vimentin expression in tumour stroma of colorectal cancer, Br. J. Cancer, 96, 986, 10.1038/sj.bjc.6603651 · DOI
  18. Batlle, 2000, The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells, Nat. Cell Biol., 2, 84, 10.1038/35000034 · DOI
  19. Eivazy, 2016, The impact of the codelivery of drug-siRNA by trimethyl chitosan nanoparticles on the efficacy of chemotherapy for metastatic breast cancer cell line (MDA-MB-231), Artif. Cells Nanomed. Biotechnol., 1, 10.1080/21691401.2016.1185727 · DOI
  20. Jadidi-Niaragh, 2016, Downregulation of CD73 in 4T1 breast cancer cells through siRNA-loaded chitosan-lactate nanoparticles, Tumor Biol., 1
  21. Massing, 2000, Liposomal formulations of anticancer drugs: selectivity and effectiveness, Drug Resist. Updates, 3, 171, 10.1054/drup.2000.0138 · DOI
  22. Mu, 2003, A novel controlled release formulation for the anticancer drug paclitaxel (Taxol®): PLGA nanoparticles containing vitamin E TPGS, J. Control. Release, 86, 33, 10.1016/S0168-3659(02)00320-6 · DOI
  23. Verdun, 1990, Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles, Cancer Chemother. Pharmacol., 26, 13, 10.1007/BF02940287 · DOI
  24. Orlichenko, 2008, Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development, Clin. Exp. Metastasis, 25, 593, 10.1007/s10585-008-9143-9 · DOI
  25. Jordà, 2005, Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor, J. Cell Sci., 118, 3371, 10.1242/jcs.02465 · DOI
  26. Jin, 2010, Snail is critical for tumor growth and metastasis of ovarian carcinoma, Int. J. Cancer, 126, 2102, 10.1002/ijc.24901 · DOI

Cited by

Sorted by citations

See all 101

Metadata

Authors
Sadreddini, S., Safaralizadeh, R., Baradaran, B., Aghebati-Maleki, L., Hosseinpour-Feizi, M. A., Shanehbandi, D., Jadidi-Niaragh, F., Sadreddini, S., Kafil, H. S., Younesi, V., & Yousefi, M.
Venue
Immunology Letters
Publisher
Elsevier BV
Published
2017-01
Volume
181
Pages
79-86
ISSN
0165-2478
DOI
10.1016/j.imlet.2016.11.013
Cited by
101
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
Immunology Research Center, Tabriz University of Medical Sciences (93-76)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Chitosan nanoparticles as a dual drug/siRNA delivery system for treatment of colorectal cancer. https://app.cochat.ai/papers/10.1016/j.imlet.2016.11.013
The paper
Sadreddini, S., Safaralizadeh, R., Baradaran, B., Aghebati-Maleki, L., Hosseinpour-Feizi, M. A., Shanehbandi, D., Jadidi-Niaragh, F., Sadreddini, S., Kafil, H. S., Younesi, V., & Yousefi, M. (2017). Chitosan nanoparticles as a dual drug/siRNA delivery system for treatment of colorectal cancer. Immunology Letters. https://doi.org/10.1016/j.imlet.2016.11.013