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Cited by 272

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses

Open access
Yang, Kun, Puel, Anne, Zhang, Shenying, Eidenschenk, Céline, Ku, Cheng-Lung, Casrouge, Armanda, Picard, Capucine, von Bernuth, Horst, Senechal, Brigitte, Plancoulaine, Sabine, Al-Hajjar, Sami, Al-Ghonaium, Abdulaziz, Maródi, László, Davidson, Donald, Speert, David, Roifman, Chaim, Garty, Ben-Zion, Ozinsky, Adrian, Barrat, Franck J., Coffman, Robert L., Miller, Richard L., Li, Xiaoxia, Lebon, Pierre, Rodriguez-Gallego, Carlos, Chapel, Helen, Geissmann, Frédéric, Jouanguy, Emmanuelle, Casanova, Jean-Laurent·2005·Immunity
DOI 10.1016/j.immuni.2005.09.016
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Abstract

Summary Five TLRs are thought to play an important role in antiviral immunity, sensing viral products and inducing IFN-α/β and -λ. Surprisingly, patients with a defect of IRAK-4, a critical kinase downstream from TLRs, are resistant to common viruses. We show here that IFN-α/β and -λ induction via TLR-7, TLR-8, and TLR-9 was abolished in IRAK-4-deficient blood cells. In contrast, IFN-α/β and -λ were induced normally by TLR-3 and TLR-4 agonists. Moreover, IFN-β and -λ were normally induced by TLR-3 agonists and viruses in IRAK-4-deficient fibroblasts. We further show that IFN-α/β and -λ production in response to 9 of 11 viruses tested was normal or weakly affected in IRAK-4-deficient blood cells. Thus, IRAK-4-deficient patients may control viral infections by TLR-3- and TLR-4-dependent and/or TLR-independent production of IFNs. The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-α/β and -λ is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans.

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Metadata

Authors
Yang, K., Puel, A., Zhang, S., Eidenschenk, C., Ku, C.-L., Casrouge, A., Picard, C., von Bernuth, H., Senechal, B., Plancoulaine, S., Al-Hajjar, S., Al-Ghonaium, A., Maródi, L., Davidson, D., Speert, D., Roifman, C., Garty, B.-Z., Ozinsky, A., Barrat, F. J., Coffman, R. L., Miller, R. L., Li, X., Lebon, P., Rodriguez-Gallego, C., Chapel, H., Geissmann, F., Jouanguy, E., & Casanova, J.-L.
Venue
Immunity
Publisher
Elsevier BV
Published
2005-11
Volume
23
Issue
5
Pages
465-478
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2005.09.016
OpenAlex
W2022651196
Cited by
272
References
7
FWCI
9.12
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses. https://app.cochat.ai/papers/10.1016/j.immuni.2005.09.016
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Yang, K., Puel, A., Zhang, S., Eidenschenk, C., Ku, C.-L., Casrouge, A., Picard, C., von Bernuth, H., Senechal, B., Plancoulaine, S., Al-Hajjar, S., Al-Ghonaium, A., Maródi, L., Davidson, D., Speert, D., Roifman, C., Garty, B.-Z., Ozinsky, A., Barrat, F. J., . . . Casanova, J.-L. (2005). Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses. Immunity. https://doi.org/10.1016/j.immuni.2005.09.016

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.