The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells
Open accessAbstract
Summary MicroRNA-155 (miR-155) is expressed by cells of the immune system following activation and has been shown to be required for antibody production following vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymus-dependent and independent antigens. B cells lacking miR-155 generated reduced extra-follicular and germinal center responses and failed to produce high affinity IgG1 antibodies. Gene expression profiling of activated B cells indicated that miR-155 regulates an array of genes with diverse function-many of which are predicted targets of miR-155. The transcription factor Pu.1 is validated as a direct target of miR155 mediated inhibition. When Pu.1 is over-expressed in wild type B cells fewer IgG1 cells are produced, indicating that loss of Pu.1 regulation is a contributing factor to the miR-155 deficient phenotype. Our results implicate post-transcriptional regulation of gene expression for establishing the terminal differentiation program of B cells.
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866
Requirement of bic/microRNA-155 for Normal Immune Function
Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833
Self-citationZebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689 · Cited by 1,647
Self-citationRegulation of B lymphocyte and macrophage development by graded expression of PU.1
DeKoter, R. P., & Singh, H. (2000) · Science · doi:10.1126/science.288.5470.1439 · Cited by 749
Phospholipase Cγ2 Provides Survival Signals via Bcl2 and A1 in Different Subpopulations of B Cells
Wen, R., Chen, Y., Xue, L., Schuman, J., Yang, S., Morris, S. W., & Wang, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307318200 · Cited by 41 · cited 2×
“Stable cell lines with bicistronic expression of bcl-2 and GFP or GFP alone were kindly provided by Demin Wang (Wen et al., 2003).”
Method
Cited by
The evolution of gene regulation by transcription factors and microRNAs
Chen, K., & Rajewsky, N. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1990 · Cited by 1,547
The generation of antibody-secreting plasma cells
Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3795 · Cited by 1,454
Physiological and pathological roles for microRNAs in the immune system
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature Reviews Immunology · doi:10.1038/nri2708 · Cited by 1,378
Dynamics of B cells in germinal centres
De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084
MicroRNA Control in the Immune System: Basic Principles
Xiao, C., & Rajewsky, K. (2009) · Cell · doi:10.1016/j.cell.2008.12.027 · Cited by 1,018
Metadata
- Authors
- Vigorito, E., Perks, K. L., Abreu-Goodger, C., Bunting, S., Xiang, Z., Kohlhaas, S., Das, P. P., Miska, E. A., Rodriguez, A., Bradley, A., Smith, K. G. C., Rada, C., Enright, A. J., Toellner, K.-M., MacLennan, I. C. M., & Turner, M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 27
- Issue
- 6
- Pages
- 847-859
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1966054625
- Cited by
- 763
- References
- 6
- FWCI
- 17.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vigorito, E., Perks, K. L., Abreu-Goodger, C., Bunting, S., Xiang, Z., Kohlhaas, S., Das, P. P., Miska, E. A., Rodriguez, A., Bradley, A., Smith, K. G. C., Rada, C., Enright, A. J., Toellner, K.-M., MacLennan, I. C. M., & Turner, M. (2007). microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells. Immunity. https://doi.org/10.1016/j.immuni.2007.10.009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
