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Cited by 24Phagocytosis and Immune RegulationImmunotherapy and Immune ResponsesImmune Response and Inflammation

Efferocytosis in dendritic cells: an overlooked immunoregulatory process

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Ma, Yanyan, Jiang, Tangxing, Zhu, Xun, Xu, Yizhou, Wan, Ke, Zhang, Tingxuan, Xie, Miaorong·2024·Frontiers in Immunology
DOI 10.3389/fimmu.2024.1415573PMC PMC11148234
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Abstract

Efferocytosis, the process of engulfing and removing apoptotic cells, plays an essential role in preserving tissue health and averting undue inflammation. While macrophages are primarily known for this task, dendritic cells (DCs) also play a significant role. This review delves into the unique contributions of various DC subsets to efferocytosis, highlighting the distinctions in how DCs and macrophages recognize and handle apoptotic cells. It further explores how efferocytosis influences DC maturation, thereby affecting immune tolerance. This underscores the pivotal role of DCs in orchestrating immune responses and sustaining immune equilibrium, providing new insights into their function in immune regulation.

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  • Efferocytosis is seen as a major hurdle to using antigen presenting cells in cell-based therapies.

    “It is seen as a major hurdle to using antigen presenting cells in cell-based therapies (61–64).”

    From Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells (2026) · cites this paper as [61]

    The section on DC maturation and function describes using apoptotic cells to activate antitumor T-cell responses as a promising cancer-vaccine approach. The section on antigen cross-presentation likewise presents DC efferocytosis as informing new immunotherapies and vaccines, rather than as a major hurdle to APC-based therapies. Page numbers are unavailable in our copy. (LLM, conf=0.78)

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Cited by

Sorted by citations

Authors
Ma, Y., Jiang, T., Zhu, X., Xu, Y., Wan, K., Zhang, T., & Xie, M.
Affiliations
  • Capital Medical University (CN)
  • Shandong University (CN)
Corresponding author
Xie, Miaorong
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2024-05-21
Volume
15
Pages
1415573-1415573
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2024.1415573
PMC
PMC11148234
OpenAlex
W4398174391
Cited by
24
References
22
Citations by year
2026: 11 · 2025: 12 · 2024: 1
FWCI
1.06
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
General Hospital of People’s Liberation Army
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
efferocytosis, dendritic cells, dendritic cell maturation, immune tolerance, macrophages, immune regulation, inflammation, dendritic cell subsets
MeSH terms
Efferocytosis, Animals, Dendritic Cells, Humans, Immune Tolerance, Macrophages, Phagocytosis, Apoptosis

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