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The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage
Open accessAbstract
Summary The transcriptional control of CD1d-restricted NKT cell development has remained elusive. We report that PLZF (promyelocytic leukemia zinc finger; Zbtb16), a member of the BTB/POZ-ZF family of transcription factors which includes the CD4 lineage-specific c-Krox (Th-POK, Zbtb7b), is exquisitely specific to CD1d-restricted NKT cells and human MR1-specific MAIT cells. PLZF was induced immediately after positive selection of NKT cell precursors and PLZF-deficient NKT cells failed to undergo the intrathymic expansion and effector differentiation that characterize their lineage. Instead, they preserved a naïve phenotype and were directed to lymph nodes. Conversely, transgenic expression of PLZF induced CD4 thymocytes to acquire effector differentiation and migrate to non-lymphoid tissues. We suggest that PLZF is a transcriptional signature of NKT cells that directs their innate-like effector differentiation during thymic development.
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“…) regulates B-cell differentiation at early progenitor stages 75 , while PLZF (encoded by ZBTB16 ) directs differentiation of the NKT cell lineage 52 and ZBTB16 translocations have been reported critical in driving leukemogenesis, such as ZBTB16-RARA in acute promyelocytic leukemia (APL) 76 and…”
Metadata
- Authors
- Savage, A. K., Constantinides, M. G., Han, J., Picard, D., Martin, E., Li, B., Lantz, O., & Bendelac, A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 29
- Issue
- 3
- Pages
- 391-403
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2046746241
- Cited by
- 716
- References
- 2
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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