The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis
Open accessAbstract
SUMMARY Fas is highly expressed in activated and germinal center (GC) B cells but can potentially be inactivated by misguided somatic hypermutation. We employed conditional Fas-deficient mice to investigate the physiological functions of Fas in various B cell subsets. B cell-specific Fas-deficient mice developed fatal lymphoproliferation due to activation of B cells and T cells. Ablation of Fas specifically in GC B cells reproduced the phenotype, indicating that the lymphoproliferation initiates in the GC environment. B cell-specific Fas-deficient mice also showed an accumulation of IgG1+ memory B cells expressing high amounts of CD80 and the expansion of CD28-expressing CD4+ Th cells. Blocking T cell-B cell interaction and GC formation completely prevented the fatal lymphoproliferation. Thus, Fas-mediated selection of GC B cells and the resulting memory B cell compartment is essential for maintaining the homeostasis of both T and B lymphocytes.
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Cites
CD28/B7 SYSTEM OF T CELL COSTIMULATION
Lenschow, D. J., Walunas, T. L., & Bluestone, J. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.233 · Cited by 2,717
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I., & Kroczek, R. A. (1999) · Nature · doi:10.1038/16717 · Cited by 1,482
Cited by
Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
The many roles of FAS receptor signaling in the immune system
Strasser, A., Jost, P. J., & Nagata, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.001 · Cited by 968
The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond
Dostert, C., Grusdat, M., Letellier, E., & Brenner, D. (2019) · Physiological Reviews · doi:10.1152/physrev.00045.2017 · Cited by 498
Mitochondrial cell death effectors
Brenner, D., & Mak, T. W. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.09.004 · Cited by 416
Self-citationT cells and follicular dendritic cells in germinal center B‐cell formation and selection
Vinuesa, C. G., Linterman, M. A., Goodnow, C. C., & Randall, K. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00937.x · Cited by 302
Metadata
- Authors
- Hao, Z., Duncan, G. S., Seagal, J., Su, Y.-W., Hong, C., Haight, J., Chen, N.-J., Elia, A., Wakeham, A., Li, W. Y., Liepa, J., Wood, G. A., Casola, S., Rajewsky, K., & Mak, T. W.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 29
- Issue
- 4
- Pages
- 615-627
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1970254108
- Cited by
- 212
- References
- 2
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Hao, Z., Duncan, G. S., Seagal, J., Su, Y.-W., Hong, C., Haight, J., Chen, N.-J., Elia, A., Wakeham, A., Li, W. Y., Liepa, J., Wood, G. A., Casola, S., Rajewsky, K., & Mak, T. W. (2008). Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis. Immunity. https://doi.org/10.1016/j.immuni.2008.07.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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