The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
T cells and follicular dendritic cells in germinal center B‐cell formation and selection
Abstract
Summary: Germinal centers (GCs) are specialized microenvironments formed after infection where activated B cells can mutate their B‐cell receptors to undergo affinity maturation. A stringent process of selection allows high affinity, non‐self‐reactive B cells to become long‐lived memory B cells and plasma cells. While the precise mechanism of selection is still poorly understood, the last decade has advanced our understanding of the role of T cells and follicular dendritic cells (FDCs) in GC B‐cell formation and selection. T cells and non‐T‐cell‐derived CD40 ligands on FDCs are essential for T‐dependent (TD) and T‐independent GC formation, respectively. TD‐GC formation requires Bcl‐6‐expressing T cells capable of signaling through SAP, which promotes formation of stable T:B conjugates. By contrast, differentiation of B blasts along the extrafollicular pathway is less dependent on SAP. T‐follicular helper (Tfh) cell‐derived CD40L, interleukin‐21, and interleukin‐4 play important roles in GC B‐cell proliferation, survival, and affinity maturation. A role for FDC‐derived integrin signals has also emerged: GC B cells capable of forming an immune synapse with FDCs have a survival advantage. This emerges as a powerful mechanism to ensure death of B cells that bind self‐reactive antigen, which would not normally be presented on FDCs.
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Cites
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Kitano, M., Moriyama, S., Ando, Y., Hikida, M., Mori, Y., Kurosaki, T., & Okada, T. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.025 · Cited by 411
Generation of memory B cells and their reactivation
Inoue, T., Moran, I., Shinnakasu, R., Phan, T. G., & Kurosaki, T. (2018) · Immunological Reviews · doi:10.1111/imr.12640 · Cited by 181
Follicular dendritic cells: origin, phenotype, and function in health and disease
Aguzzi, A., Kranich, J., & Krautler, N. J. (2014) · Trends in Immunology · doi:10.1016/j.it.2013.11.001 · Cited by 176
B cell maintenance and function in aging
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Metadata
- Authors
- Vinuesa, C. G., Linterman, M. A., Goodnow, C. C., & Randall, K. L.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2010-08-19
- Volume
- 237
- Issue
- 1
- Pages
- 72-89
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1926329940
- Cited by
- 302
- References
- 10
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
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