The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance
Open accessAbstract
Summary Members of the Forkhead box O (Foxo) family of transcription factors are key regulators of cellular responses, but their function in the immune system remains incompletely understood. Here we show that T cell-specific deletion of Foxo1 gene in mice led to spontaneous T cell activation, effector T cell differentiation, autoantibody production, and the induction of inflammatory bowel disease in a transfer model. In addition, Foxo1 was critical for the maintenance of naïve T cells in the peripheral lymphoid organs. Transcriptome analyses of T cells identified Foxo1-regulated genes encoding, among others, cell surface molecules, signaling proteins, and nuclear factors that control gene expression. Functional studies validated interleukin 7 receptor-α as a Foxo1 target gene essential for Foxo1 maintenance of naïve T cells. These findings reveal crucial functions of Foxo1-dependent transcription in control of T cell homeostasis and tolerance.
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Self-citationSignaling by the Phosphoinositide 3-Kinase Family in Immune Cells
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Metadata
- Authors
- Ouyang, W., Beckett, O., Flavell, R. A., & Li, M. O.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 30
- Issue
- 3
- Pages
- 358-371
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2083554435
- Cited by
- 306
- References
- 57
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ouyang, W., Beckett, O., Flavell, R. A., & Li, M. O. (2009). An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance. Immunity. https://doi.org/10.1016/j.immuni.2009.02.003
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