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Cited by 446PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingNF-κB Signaling Pathways

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

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Okkenhaug, Klaus·2013·Annual Review of Immunology
DOI 10.1146/annurev-immunol-032712-095946PMC PMC4516760
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Abstract

Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell development, differentiation, and function. Mammals have eight PI3K catalytic subunits that are divided into three classes based on similarities in structure and function. Specific roles for the class I PI3Ks have been broadly investigated and are relatively well understood, as is the function of their corresponding phosphatases. More recently, specific roles for the class II and class III PI3Ks have emerged. Through vertebrate evolution and in parallel with the evolution of adaptive immunity, there has been a dramatic increase not only in the genes for PI3K subunits but also in genes for phosphatases that act on 3-phosphoinositides and in 3-phosphoinositide-binding proteins. Our understanding of the PI3Ks in immunity is guided by fundamental discoveries made in simpler model organisms as well as by appreciating new adaptations of this signaling module in mammals in general and in immune cells in particular.

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Authors
Okkenhaug, K.
Affiliations
Babraham Institute (GB)
Corresponding author
Okkenhaug, Klaus
ORCID
Okkenhaug, Klaus
Venue
Annual Review of Immunology
Publisher
Annual Reviews
Published
2013-03-21
Volume
31
Issue
1
Pages
675-704
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
DOI
10.1146/annurev-immunol-032712-095946
PMC
PMC4516760
OpenAlex
W2116879609
Cited by
446
References
17
Citations by year
2026: 21 · 2025: 34 · 2024: 34 · 2023: 44 · 2022: 31 · 2021: 40 · 2020: 40 · 2019: 29 · 2018: 40 · 2017: 27 · 2016: 35 · 2015: 39 · 2014: 24 · 2013: 7
FWCI
3.29
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Wellcome Trust (095691)
  • Biotechnology and Biological Sciences Research Council (BBS/E/B/0000C236, BBS/E/B/0000H262, BB/E009867/1, BBS/E/B/0000H329, BBS/E/B/0000M979, BB/F015461/1, JF19128, BB/C509890/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords
phosphatidylinositol 3-kinase, PI3K signaling, immune cells, class I PI3K, class II PI3K, class III PI3K, phosphoinositide phosphatase, adaptive immunity evolution, immune cell development, immune cell differentiation
MeSH terms
Animals, Endocytosis, Multigene Family, Humans, Phagocytosis, Signal Transduction, Phosphatidylinositol 3-Kinases, Catalytic Domain, Protein Transport, Multiprotein Complexes

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