The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy
Open accessAbstract
Summary The mechanisms that maintain human T cell memory during normal and perturbed homeostasis are not fully understood. The repeated induction of profound lymphocytopenia in patients undergoing multiple cycles of cytotoxic chemotherapy infrequently results in severe infections with viruses controlled by memory T cells, suggesting that some memory T cells survive chemotherapy and restore immunity. Here we identify a distinct subpopulation of memory CD8+ T cells with the ability to rapidly efflux and survive exposure to chemotherapy drugs in vitro and in vivo. T cells with high efflux capacity share expression of molecules with hematopoietic stem cells, are quiescent in non-lymphocytopenic individuals, and are induced to proliferate in patients rendered lymphocytopenic after chemotherapy. Effluxing T cells differentiate into non-effluxing subsets in response to antigen stimulation and inflammatory signals, thereby contributing to repopulation of memory cells after chemotherapy.
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Cites
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Cited by
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
The who's who of T ‐cell differentiation: Human memory T ‐cell subsets
Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817
Early and nonreversible decrease of CD161++/MAIT cells in HIV infection
Cosgrove, C., Ussher, J. E., Rauch, A., Gärtner, K., Kurioka, A., Hühn, M. H., Adelmann, K., Kang, Y.-H., Fergusson, J. R., Simmonds, P., et al. (2013) · Blood · doi:10.1182/blood-2012-06-436436 · Cited by 316
Graef, P., Buchholz, V. R., Stemberger, C., Flossdorf, M., Henkel, L., Schiemann, M., Drexler, I., Höfer, T., Riddell, S. R., & Busch, D. H. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.018 · Cited by 311
Self-citationFuertes Marraco, S. A., Soneson, C., Cagnon, L., Gannon, P. O., Allard, M., Maillard, S. A., Montandon, N., Rufer, N., Waldvogel, S., Delorenzi, M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3700 · Cited by 206
Metadata
- Authors
- Turtle, C. J., Swanson, H. M., Fujii, N., Estey, E. H., & Riddell, S. R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 31
- Issue
- 5
- Pages
- 834-844
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2036378796
- Cited by
- 179
- References
- 6
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Turtle, C. J., Swanson, H. M., Fujii, N., Estey, E. H., & Riddell, S. R. (2009). A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy. Immunity. https://doi.org/10.1016/j.immuni.2009.09.015
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