The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways
Open accessAbstract
SUMMARY Inflammatory cytokines have been proposed to regulate epithelial homeostasis during intestinal inflammation. We report here that interferon-γ (IFN-γ) regulates the crucial homeostatic functions of cell proliferation and apoptosis through serine-threonine protein kinase AKT-β-catenin and Wingless-Int (Wnt)-β-catenin signaling pathways. Short-term exposure of intestinal epithelial cells to IFN-γ resulted in activation of β-catenin through AKT, followed by induction of the secreted Wnt inhibitor Dkk1. Consequently, we observed an increase in Dkk1-mediated apoptosis upon extended IFN-γ treatment, and reduced proliferation through depletion of the Wnt co-receptor LRP6. These effects were enhanced by tumor necrosis factor-α (TNF)-α, suggesting synergism between the two cytokines. Consistent with these results, colitis in vivo was associated with decreased β-catenin-T-cell factor (TCF) signaling, loss of plasma membrane-associated LRP6, and reduced epithelial cell proliferation. Proliferation was partially restored in IFN-γ - deficient mice. Thus, we propose that IFN-γ regulates intestinal epithelial homeostasis by sequential regulation of converging β-catenin signaling pathways.
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Dickkopf-1 is a master regulator of joint remodeling
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Cytokine Tuning of Intestinal Epithelial Function
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The NLRP3 inflammasome: Contributions to intestinal homeostasis
Zaki, M. H., Lamkanfi, M., & Kanneganti, T.-D. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.02.002 · Cited by 290
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
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Metadata
- Authors
- Nava, P., Koch, S., Laukoetter, M. G., Lee, W. Y., Kolegraff, K., Capaldo, C. T., Beeman, N., Addis, C., Gerner-Smidt, K., Neumaier, I., Skerra, A., Li, L., Parkos, C. A., & Nusrat, A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 32
- Issue
- 3
- Pages
- 392-402
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2031352506
- Cited by
- 337
- References
- 55
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Nava, P., Koch, S., Laukoetter, M. G., Lee, W. Y., Kolegraff, K., Capaldo, C. T., Beeman, N., Addis, C., Gerner-Smidt, K., Neumaier, I., Skerra, A., Li, L., Parkos, C. A., & Nusrat, A. (2010). Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling Pathways. Immunity. https://doi.org/10.1016/j.immuni.2010.03.001
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