Function and biological roles of the Dickkopf family of Wnt modulators

Wnt signaling and cancer

Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183 · see citing works

Wnt signaling: a common theme in animal development

Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567 · see citing works

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235 · see citing works

WNT and β-catenin signalling: diseases and therapies

Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763 · see citing works

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608 · see citing works

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591 · see citing works

Secreted antagonists of the Wnt signalling pathway

Kawano, Y., & Kypta, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00623 · Cited by 1,584 · see citing works

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,499 · see citing works

Regulation of bone mass by Wnt signaling

Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407 · see citing works

Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

Mikels, A. J., & Nusse, R. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040115 · Cited by 1,244 · see citing works

WNT Signals Are Required for the Initiation of Hair Follicle Development

Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088 · see citing works

An LDL-receptor-related protein mediates Wnt signalling in mice

Pinson, K. I., Brennan, J., Monkley, S. J., Avery, B. J., & Skarnes, W. C. (2000) · Nature · doi:10.1038/35035124 · Cited by 1,086 · see citing works

<i>Cbfa1</i>-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

Kato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086 · see citing works

LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044 · see citing works

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042 · see citing works

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038 · see citing works

Notch1 functions as a tumor suppressor in mouse skin

Nicolas, M., Wolfer, A., Raj, K., Kummer, J. A., Mill, P., van Noort, M., Hui, C., Clevers, H. C., Dotto, G. P., & Radtke, F. (2003) · Nature Genetics · doi:10.1038/ng1099 · Cited by 969 · see citing works

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

Zeng, X., Tamai, K., Doble, B. W., Li, S., Huang, H., Habas, R., Okamura, H., Woodgett, J. R., & He, X. (2005) · Nature · doi:10.1038/nature04185 · Cited by 849 · see citing works

Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway

Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · cited 5× · see citing works

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772 · see citing works

The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway

Oishi, I., Suzuki, H., Onishi, N., Takada, R., Kani, S., Ohkawara, B., Koshida, I., Suzuki, K., Yamada, G., Schwabe, G. C., et al. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00662.x · Cited by 770 · see citing works

Wnt and calcium signaling: β-Catenin-independent pathways

Kohn, A. D., & Moon, R. T. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.022 · Cited by 730 · see citing works

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

Semënov, M. V., Tamai, K., Brott, B. K., Kühl, M., Sokol, S. Y., & He, X. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00290-1 · Cited by 700 · see citing works

DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN <i>XENOPUS</i> EMBRYOS

De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671 · see citing works

Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse

Mukhopadhyay, M., Shtrom, S., Rodrı́guez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D. W., Glinka, A., Grinberg, A., Huang, S.-P., et al. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00041-7 · Cited by 634 · see citing works

Wnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis

Aulehla, A., Wehrle, C., Brand‐Saberi, B., Kemler, R., Gossler, A., Kanzler, B., & Herrmann, B. G. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00055-8 · Cited by 593 · see citing works

Inhibition of Wnt activity induces heart formation from posterior mesodermPreprint

Marvin, M. J., Rocco, G. D., Gardiner, A., Bush, S. M., & Lassar, A. B. (2001) · Genes & Development · doi:10.1101/gad.855501 · Cited by 590 · see citing works

Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

Davidson, G. R., Wu, W., Shen, J., Bilić, J., Fenger, U., Stannek, P., Glinka, A., & Niehrs, C. (2005) · Nature · doi:10.1038/nature04170 · Cited by 581 · see citing works

Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

Pandur, P., Läsche, M., Eisenberg, L. M., & Kühl, M. (2002) · Nature · doi:10.1038/nature00921 · Cited by 536 · see citing works

Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass

Morvan, F., Boulukos, K. E., Clément-Lacroix, P., Roman‐Roman, S., Suc-Royer, I., Vayssière, B., Ammann, P., Martin, P., Pinho, S., Pognonec, P., et al. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060311 · Cited by 521 · see citing works

High Bone Mass in Mice Expressing a Mutant LRP5 Gene

Babij, P., Zhao, W., Small, C. G., Kharode, Y. P., Yaworsky, P. J., Bouxsein, M., Reddy, P. S., Bodine, P. V. N., Robinson, J. A., Bhat, B. M., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.6.960 · Cited by 497 · see citing works

Functional and structural diversity of the human Dickkopf gene family

Krupnik, V. E., Sharp, J., Jiang, C., Robison, K. E., Chickering, T. W., Amaravadi, L. S., Brown, D. E., Guyot, D. J., Mays, G. G., Leiby, K. R., et al. (1999) · Gene · doi:10.1016/s0378-1119(99)00365-0 · Cited by 490 · see citing works

Wnt signaling: complexity at the surface

Cadigan, K. M., & Liu, Y. I. (2006) · Journal of Cell Science · doi:10.1242/jcs.02826 · Cited by 486 · see citing works

Wnt antagonism initiates cardiogenesis in Xenopus laevisPreprint

Schneider, V., & Mercola, M. A. (2001) · Genes & Development · doi:10.1101/gad.855601 · Cited by 483 · see citing works

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

Li, J., Sarosi, I., Cattley, R. C., Pretorius, J. K., Asuncion, F., Grisanti, M. S., Morony, S., Adamu, S., Geng, Z., Qiu, W., et al. (2006) · Bone · doi:10.1016/j.bone.2006.03.017 · Cited by 441 · see citing works

Wnt-mediated axon guidance via the Drosophila Derailed receptor

Yoshikawa, S., McKinnon, R. D., Kokel, M., & Thomas, J. B. (2003) · Nature · doi:10.1038/nature01522 · Cited by 416 · see citing works

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemüller, A. J. M., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G. C., & Nicoletti, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1381-04.2004 · Cited by 394 · see citing works

The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer

González‐Sancho, J. M., Aguilera, Ó., García, J. M., Pendás-Franco, N., Peña, C., Cal, S., de Herreros, A. G., Bonilla, F., & Múñoz, A. (2004) · Oncogene · doi:10.1038/sj.onc.1208303 · Cited by 366 · see citing works

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

Glinka, A., Wu, W., Onichtchouk, D., Blumenstock, C., & Niehrs, C. (1997) · Nature · doi:10.1038/39092 · Cited by 350 · see citing works

Growth factor regulation of lens development

Lovicu, F. J., & McAvoy, J. W. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.020 · Cited by 350 · see citing works

Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6

Holmen, S. L., Giambernardi, T. A., Diegel, C. R., Buckner-Berghuis, B. D., Resau, J. H., Hess, J. F., Glatt, V., Bouxsein, M., Ai, M., Warman, M. L., et al. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040907 · Cited by 344 · see citing works

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

Li, X., Liu, P., Liu, W., Maye, P. F., Zhang, J., Zhang, Y., Hurley, M. M., Guo, C., Boskey, A. L., Sun, L., et al. (2005) · Nature Genetics · doi:10.1038/ng1614 · Cited by 341 · see citing works

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

Aguilera, Ó., Fraga, M. F., Ballestar, E., Paz, M. F., Herranz, M., Espada, J., García, J. M., Múñoz, A., Esteller, M., & González‐Sancho, J. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209439 · Cited by 338 · see citing works

A genomewide survey of developmentally relevant genes in Ciona intestinalis

Yagi, K., Satou, Y., Mazet, F., Shimeld, S. M., Degnan, B. M., Rokhsar, D. S., Levine, M., Kohara, Y., & Satoh, N. (2003) · Development Genes and Evolution · doi:10.1007/s00427-003-0322-z · Cited by 332 · see citing works

Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling

Mao, B., & Niehrs, C. (2003) · Gene · doi:10.1016/s0378-1119(02)01106-x · Cited by 325 · see citing works

Wise, a context-dependent activator and inhibitor of Wnt signalling

Itasaki, N., Jones, C. M., Mercurio, S., Rowe, A., Domingos, P. M., Smith, J. C., & Krumlauf, R. (2003) · Development · doi:10.1242/dev.00674 · Cited by 321 · see citing works

FGF‐20 and DKK1 are transcriptional targets of β‐catenin and FGF‐20 is implicated in cancer and development

Chamorro, M. N., Schwartz, D. R., Vonica, A., Brivanlou, A. H., Cho, K. R., & VARMUS, H. E. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600460 · Cited by 299 · see citing works

EctodermalWnt3/β-cateninsignaling is required for the establishment and maintenance of the apical ectodermal ridgePreprint

Barrow, J. R., Thomas, K. R., Boussadia, O., Moore, R. H., Kemler, R., Capecchi, M. R., & McMahon, A. P. (2003) · Genes & Development · doi:10.1101/gad.1044903 · Cited by 299 · see citing works

Regionally specific induction by the Spemann–Mangold organizer

Niehrs, C. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1347 · Cited by 294 · see citing works

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

Kelly, O., Pinson, K. I., & Skarnes, W. C. (2004) · Development · doi:10.1242/dev.01137 · Cited by 291 · see citing works

Functional Epigenomics Identifies Genes Frequently Silenced in Prostate Cancer

Lodygin, D., Epanchintsev, A., Menssen, A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4407 · Cited by 287 · see citing works

Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling

Fedi, P., Bafico, A., Nieto, A., Burgess, W. H., Miki, T., Bottaro, D. P., Kraus, M. H., & Aaronson, S. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19465 · Cited by 274 · see citing works

Dickkopf 3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-β-Catenin Pathway

Hoang, B. H., Kubo, T., Healey, J. H., Yang, R., Nathan, S. S., Kolb, E. A., Mazza, B., Meyers, P. A., & Gorlick, R. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1952 · Cited by 261 · see citing works

Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development.Preprint

Greco, T. L., Takada, S., Newhouse, M. M., McMahon, J. A., McMahon, A. P., & Camper, S. A. (1996) · Genes & Development · doi:10.1101/gad.10.3.313 · Cited by 253 · see citing works

Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling

Ai, M., Holmen, S. L., Hul, W. V., Williams, B. O., & Warman, M. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.4946-4955.2005 · Cited by 253 · see citing works

Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins

Brott, B. K., & Sokol, S. Y. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6100-6110.2002 · Cited by 234 · see citing works

Mesenchymal–epithelial interactions in the skin

Yamaguchi, Y., Itami, S., Watabe, H., Yasumoto, K., ABDEL‐MALEK, Z. A., Kubo, T., Rouzaud, F., Tanemura, A., Yoshikawa, K., & Hearing, V. J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311122 · Cited by 232 · see citing works

Segmentation in vertebrates: clock and gradient finally joinedPreprint

Aulehla, A., & Herrmann, B. G. (2004) · Genes & Development · doi:10.1101/gad.1217404 · Cited by 212 · see citing works

Non-canonical Wnt signalling and regulation of gastrulation movements

Tada, M., Concha, M. L., & Heisenberg, C. (2002) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(02)00052-6 · Cited by 209 · see citing works

The Wnt antagonist Dickkopf‐1 is regulated by Bmp signaling and c‐Jun and modulates programmed cell death

Grotewold, L., & Rüther, U. (2002) · The EMBO Journal · doi:10.1093/emboj/21.5.966 · Cited by 198 · see citing works

Canonical Wnt Signaling and Its Antagonist Regulate Anterior-Posterior Axis Polarization by Guiding Cell Migration in Mouse Visceral Endoderm

Kimura-Yoshida, C., Nakano, H., Okamura, D., Nakao, K., Yonemura, S., Belo, J. A., Aizawa, S., Matsui, Y., & Matsuo, I. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.011 · Cited by 193 · see citing works

Dickkopf genes are co-ordinately expressed in mesodermal lineages

Monaghan, A. P., Kioschis, P., Wu, W., Zúñiga, A., Bock, D., Poustka, A., Delius, H., & Niehrs, C. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00138-0 · Cited by 192 · see citing works

A REIC Gene Shows Down-Regulation in Human Immortalized Cells and Human Tumor-Derived Cell Lines

Tsuji, T., Miyazaki, M., Sakaguchi, M., Inoue, Y., & Namba, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.2067 · Cited by 191 · see citing works

Adenovirus-Mediated Overexpression of REIC/Dkk-3 Selectively Induces Apoptosis in Human Prostate Cancer Cells through Activation of c-Jun-NH2-Kinase

Abarzúa, F., Sakaguchi, M., Takaishi, M., Nasu, Y., Kurose, K., Ebara, S., Miyazaki, M., Namba, M., Kumon, H., & Huh, N.-H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0829 · Cited by 186 · see citing works

Evidence for 14 homeobox gene clusters in human genome ancestry

Pollard, S. L., & Holland, P. W. H. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00676-x · Cited by 185 · see citing works

Zebrafish Dkk1 Functions in Forebrain Specification and Axial Mesendoderm Formation

Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., & Hirano, T. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9537 · Cited by 184 · see citing works

Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/β-catenin signalling

Wu, W., Glinka, A., Delius, H., & Niehrs, C. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00868-x · Cited by 183 · see citing works

An ancient Wnt-Dickkopf antagonism inHydra

Guder, C., Pinho, S., Nacak, T. G., Schmidt, H. A., Hobmayer, B., Niehrs, C., & Holstein, T. W. (2006) · Development · doi:10.1242/dev.02265 · Cited by 171 · see citing works

Skeletal defects inringelschwanzmutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

Kokubu, C., Heinzmann, U., Kokubu, T., Sakai, N., Kubota, T., Kawai, M., Wahl, M. B., Galcerán, J., Grosschedl, R., Ozono, K., et al. (2004) · Development · doi:10.1242/dev.01405 · Cited by 169 · see citing works

Dickkopf-3/REIC functions as a suppressor gene of tumor growth

Hsieh, S., Hsieh, P.-S., Chiu, C., & Chen, W.-Y. (2004) · Oncogene · doi:10.1038/sj.onc.1208138 · Cited by 168 · see citing works

Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled

Li, L., Mao, J., Sun, L., Liu, W., & Wu, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111131200 · Cited by 168 · see citing works

Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

Shou, J., Ali‐Osman, F., Multani, A. S., Pathak, S., Fedi, P., & Srivenugopal, K. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205138 · Cited by 164 · see citing works

Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer

Aung, P. P., Oue, N., Mitani, Y., Nakayama, H., Yoshida, K., Noguchi, T., Bosserhoff, A., & Yasui, W. (2005) · Oncogene · doi:10.1038/sj.onc.1209279 · Cited by 162 · see citing works

Wnt signalling during limb development

CHURCH, V. L., & Francis‐West, P. H. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.12455630 · Cited by 162 · see citing works

Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53

Wang, J., Shou, J., & Chen, X. (2000) · Oncogene · doi:10.1038/sj.onc.1203503 · Cited by 159 · see citing works

Serum concentrations of Dickkopf‐1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation

Politou, M., Heath, D. J., Rahemtulla, A., Szydlo, R., Anagnostopoulos, A., Dimopoulos, M. A., Croucher, P. I., & Terpos, E. (2006) · International Journal of Cancer · doi:10.1002/ijc.22033 · Cited by 155 · see citing works

Downregulation of Wnt Signaling by Increased Expression of Dickkopf-1 and -2 is a Prerequisite for Late-Stage Osteoblast Differentiation of KS483 Cells

van der Horst, G., van der Werf, S. M., Farih-Sips, H. C. M., van Bezooijen, R. L., Löwik, C. W. G. M., & Karperien, M. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050614 · Cited by 150 · see citing works

Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning

Davidson, G. R., Mao, B., Barrantes, I. D. B., & Niehrs, C. (2002) · Development · doi:10.1242/dev.00154 · Cited by 149 · see citing works

Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium

Mukhopadhyay, M., Gorivodsky, M., Shtrom, S., Grinberg, A., Niehrs, C., Morasso, M. I., & Westphal, H. (2006) · Development · doi:10.1242/dev.02381 · Cited by 144 · see citing works

Overexpression of Human Dickkopf-1, an Antagonist of wingless/WNT Signaling, in Human Hepatoblastomas and Wilms' Tumors

Wirths, O., Waha, A., Weggen, S., Schirmacher, P., Kühne, T., Goodyer, C. G., Albrecht, S., von Schweinitz, D., & Pietsch, T. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000059926.66359.bd · Cited by 143 · see citing works

The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning

Kazanskaya, O., Glinka, A., & Niehrs, C. (2000) · Development · doi:10.1242/dev.127.22.4981 · Cited by 143 · see citing works

Functional Characterization of WNT7A Signaling in PC12 Cells

Caricasole, A., Ferraro, T., Iacovelli, L., Barletta, E., Caruso, A., Melchiorri, D., Terstappen, G. C., & Nicoletti, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300191200 · Cited by 142 · see citing works

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Required for the Development of Ischemic Neuronal Death

Cappuccio, I., Calderone, A., Busceti, C. L., Biagioni, F., Pontarelli, F., Bruno, V., Storto, M., Terstappen, G. T., Gaviraghi, G., Fornai, F., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5230-04.2005 · Cited by 137 · see citing works

Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal–ventral axis in the limbPreprint

Soshnikova, N. V., Zechner, D., Huelsken, J., Mishina, Y. M., Behringer, R. R., Taketo, M. M., Crenshaw, E. B., & Birchmeier, W. (2003) · Genes & Development · doi:10.1101/gad.263003 · Cited by 136 · see citing works

An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma

Patil, M. A., Chua, M., Pan, K., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208479 · Cited by 133 · see citing works

Reduced expression of the REIC/Dkk-3 gene by promoter-hypermethylation in human tumor cells

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