Cited by 346Diabetes and associated disordersT-cell and B-cell ImmunologyDiabetes Management and Research

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Prediction and Pathogenesis in Type 1 Diabetes

Open access

Ziegler, Anette-G., Nepom, Gerald T.·2010·Immunity

DOI 10.1016/j.immuni.2010.03.018PMC PMC2861716

Open this paper in CoChat — free account Open PDF

Abstract

A combination of genetic and immunological features is useful for prediction of autoimmune diabetes. Patterns of immune response correspond to the progression from a preclinical phase of disease to end-stage islet damage, with biomarkers indicating transition from susceptibility to active autoimmunity, and to a final loss of immune regulation. Here, we review the markers that provide evidence for immunological checkpoint failure and that also provide tools for assessment of individualized disease risk. When viewed in the context of genetic variation that influences immune response thresholds, progression from susceptibility to overt disease displays predictable modalities of clinical presentation resulting from a sequential series of failed homeostatic checkpoints for selection and activation of immunity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2010.03.018

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
Baekkeskov, S., Aanstoot, H.-J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P.-D. (1990) · Nature · doi:10.1038/347151a0 · Cited by 1,964
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J., Buist, N. R. M., Levy‐Lahad, E., Mazzella, M., Goulet, O., Perroni, L., et al. (2001) · Nature Genetics · doi:10.1038/83707 · Cited by 1,916
A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis
Begovich, A. B., Carlton, V. E. H., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K., Huang, Q., Smith, A. M., Spoerke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422827 · Cited by 1,501
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Bottini, N., Musumeci, L., Alonso, A., Rahmouni, S., Nika, K., Rostamkhani, M., MacMurray, J. P., Meloni, T., Lucarelli, P., Pellecchia, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1323 · Cited by 1,419
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley, J. B., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Moser, K. L., Tsao, B. P., Vyse, T. J., & Langefeld, C. D. (2008) · Nature Genetics · doi:10.1038/ng.81 · Cited by 1,309
Insulin antibodies in insulin-dependent diabetics before insulin treatment
Palmer, J. P., Asplin, C. M., Clemons, P., Lyen, K., Tatpati, O., Raghu, P. K., & Paquette, T. L. (1983) · Science · doi:10.1126/science.6362005 · Cited by 1,078
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
Wenzlau, J. M., Juhl, K., Yu, L., Moua, O., Sarkar, S. A., Gottlieb, P., Rewers, M., Eisenbarth, G. S., Jensen, J., Davidson, H. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705894104 · Cited by 1,014
Incidence of diabetes in youth in the United States
SEARCH for Diabetes in Youth Study Group*, T. W. G. F. T. (2007) · JAMA · doi:10.1001/jama.297.24.2716 · Cited by 991
The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945

Flagged first, then by citations

Show all 101 references

Sorted by citations

Items 101–200 of 344

The Role of Heat Shock Proteins in Type 1 Diabetes
Moin, A. S. M., Nandakumar, M., Diané, A., Dehbi, M., & Butler, A. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.612584 · Cited by 34
Primary Stage of Diabetes Prediction using Machine Learning Approaches
Emon, M. U., Keya, M. S., Kaiser, M. S., Islam, M. A., Tanha, T., & Zulfiker, M. S. (2021) · International Conference on Artificial Intelligence and Smart Energy (ICAIS) · doi:10.1109/icais50930.2021.9395968 · Cited by 33
A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion
Bonifacio, E. E., Krumsiek, J., Winkler, C., Theis, F. J., & Ziegler, A. (2013) · Acta Diabetologica · doi:10.1007/s00592-013-0526-2 · Cited by 32
Self-citation
IL-33 Prevents MLD-STZ Induction of Diabetes and Attenuate Insulitis in Prediabetic NOD Mice
Pavlovic, S. M., Petrović, I., Jovicic, N. U., Ljujić, B., Kovačević, M. M., Arsenijević, N., & Lukić, M. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02646 · Cited by 32
Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?
Christen, U., & von Herrath, M. G. (2011) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.71 · Cited by 31
Humanized Mouse Model to Study Type 1 Diabetes
Luce, S., Guinoiseau, S., Gadault, A., Letourneur, F., Blondeau, B., Nitschké, P., Pasmant, É., Vidaud, M., Lemonnier, F. A., & Boîtard, C. (2018) · Diabetes · doi:10.2337/db18-0202 · Cited by 31
Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children
Rasoul, M. A., Haider, M. Z., Al-Mahdi, M., Alkandari, H., & Dhaunsi, G. S. (2019) · BMC Pediatrics · doi:10.1186/s12887-019-1448-0 · Cited by 31
Local, Controlled Release In Vivo of Vascular Endothelial Growth Factor Within a Subcutaneous Scaffolded Islet Implant Reduces Early Islet Necrosis and Improves Performance of the Graft
Gebe, J. A., Preisinger, A., Gooden, M. D., D’Amico, L., & Vernon, R. B. (2018) · Cell Transplantation · doi:10.1177/0963689718754562 · Cited by 30
Mechanistic basis of immunotherapies for type 1 diabetes mellitus
Chen, W., Xie, A., & Chan, L. (2013) · Translational research · doi:10.1016/j.trsl.2012.12.017 · Cited by 32
miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes
Scherm, M. G., & Daniel, C. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.606322 · Cited by 30
Recent Advances in Immune-Based Therapies for Type 1 Diabetes
Schweiger, D. Š. (2022) · Hormone Research in Paediatrics · doi:10.1159/000524866 · Cited by 29
The microbiology of human hygiene and its impact on type 1 diabetes
Chapman, N. M., Coppieters, K. T., von Herrath, M., & Tracy, S. (2012) · Islets · doi:10.4161/isl.21570 · Cited by 31
Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus
Yi, B., Huang, G., & Zhou, Z. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.163389 · Cited by 29
Fecal microbiota transplantation treatment of autoimmune-mediated type 1 diabetes: A systematic review
Zhang, S., Deng, F., Chen, J., Chen, F., Wu, Z., Li, L., & Hou, K. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1075201 · Cited by 30
Type 1 diabetes mellitus prevention: present and future
Henriques, F. L., Buckle, I., & Forbes, J. M. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01128-6 · Cited by 32
Immune Monitoring of Islet and Pancreas Transplant Recipients
Abreu, J., & Roep, B. O. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0399-3 · Cited by 26
Transcriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue’s extracellular milieu precede immune responses in Sjögren’s syndrome
Delaleu, N., Nguyen, C. Q., Tekle, K., Jonsson, R., & Peck, A. B. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4362 · Cited by 26
ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes
Kunkl, M., Porciello, N., Mastrogiovanni, M., Capuano, C., Lucantoni, F., Moretti, C., Persson, J. L., Galandrini, R., Buzzetti, R., & Tuosto, L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00502 · Cited by 28
Electrochemical and Surface-Plasmon Correlation of a Serum-Autoantibody Immunoassay with Binding Insights: Graphenyl Surface versus Mercapto-Monolayer Surface
Premaratne, G., Niroula, J., Patel, M. K., Zhong, W., Suib, S. L., Kalkan, A. K., & Krishnan, S. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01565 · Cited by 26
Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy
Pan, P., & Dobrowsky, R. T. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-39 · Cited by 27
Islet transplantation-immunological challenges and current perspectives
Kabakchieva, P., Assyov, Y. S., Gerasoudis, S., Vasilev, G., Peshevska-Sekulovska, M., Sekulovski, M., Lazova, S., Miteva, D., Gulinac, M., Tomov, L., et al. (2023) · World Journal of Transplantation · doi:10.5500/wjt.v13.i4.107 · Cited by 30
miRNA Regulation of T Cells in Islet Autoimmunity and Type 1 Diabetes
Scherm, M. G., & Daniel, C. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01325-9 · Cited by 27
The β-Cell Genomic Landscape in T1D: Implications for Disease Pathogenesis
Ramos-Rodríguez, M., Pérez-González, B., & Pasquali, L. (2021) · Current Diabetes Reports · doi:10.1007/s11892-020-01370-4 · Cited by 26
Association of TCR/CD3, PTPN22, CD28 and ZAP70 gene polymorphisms with type 1 diabetes risk in Tunisian population: Family based association study
Zouidi, F., Bouzid, D., Fourati, H., Stayoussef, M., Abida, O., Kammoun, T., Hachicha, M., Penha‐Gonçalves, C., & Masmoudi, H. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.11.005 · Cited by 26
Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy
Cano-Cano, F., Alcalde‐Estévez, E., Gómez-Jaramillo, L., Iturregui, M., Sánchez‐Fernández, E. M., Fernández, J. M. G., Mellet, C. O., Campos‐Caro, A., López‐Tinoco, C., Aguilar‐Diosdado, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632132 · Cited by 27
Where genes meet environment—integrating the role of gut luminal contents, immunity and pancreas in type 1 diabetes
Scott, F. W., Pound, L. D., Patrick, C., Eberhard, C. E., & Crookshank, J. A. (2016) · Translational research · doi:10.1016/j.trsl.2016.09.001 · Cited by 24
Guts, Germs, and Meals: The Origin of Type 1 Diabetes
Beyan, H., Li, W., & Leslie, R. D. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0298-z · Cited by 22
Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis
Williams, M. D., Bacher, R. L., Perry, D. J., Grace, C. R., MCGRAIL, K. M., Posgai, A. L., MUIR, A. B., Chamala, S., Haller, M. J., Schatz, D., et al. (2021) · Diabetes · doi:10.2337/db20-0937 · Cited by 21
Follicular Helper T Cells in Autoimmunity
Scherm, M. G., Ott, V. B., & Daniel, C. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0770-2 · Cited by 23
Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates
Bogdani, M., Speake, C., Dufort, M. J., Johnson, P. Y., Larmore, M. J., Day, A. J., Wight, T. N., Lernmark, Å., & Greenbaum, C. J. (2020) · Diabetologia · doi:10.1007/s00125-019-05066-7 · Cited by 22
Immunization with 60 kD Ro peptide produces different stages of preclinical autoimmunity in a Sjögren's syndrome model among multiple strains of inbred mice
Kurien, B. T., Dsouza, A., Igoe, A., Lee, Y., Maier‐Moore, J. S., Gordon, T. P., Jackson, M., & Scofield, R. H. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12094 · Cited by 21
Characterization of immune response to novel HLA-A2-restricted epitopes from zinc transporter 8 in type 1 diabetes
Xu, X., Gu, Y., Bian, L., Shi, Y., Cai, Y., Chen, Y., Chen, H., Li, Q., Wu, X., Xu, K., et al. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.10.108 · Cited by 21
Humoral Responses to Islet Antigen-2 and Zinc Transporter 8 Are Attenuated in Patients CarryingHLA-A*24Alleles at the Onset of Type 1 Diabetes
Long, A. E., Gillespie, K. M., Aitken, R. J., Goode, J. C., Bingley, P. J., & Williams, A. J. K. (2013) · Diabetes · doi:10.2337/db12-1468 · Cited by 21
Proteomic profiling of human islets collected from frozen pancreata using laser capture microdissection
Zhang, L., Lanzoni, G., Battarra, M., Inverardi, L., & Zhang, Q. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.09.002 · Cited by 20
Extracellular matrix and the maintenance and loss of peripheral immune tolerance in autoimmune insulitis
Medina, C. O., Nagy, N., & Bollyky, P. L. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.006 · Cited by 20
Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background
Bour-Jordan, H., Thompson, H. L., Giampaolo, J. R., Davini, D. W., Rosenthal, W. L., & Bluestone, J. A. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.06.005 · Cited by 22
Predictors of progression to Type 1 diabetes: preparing for immune interventions in the preclinical disease phase
Gorus, F., Keymeulen, B., Veld, P. I. '., & PIPELEERS, D. G. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.856757 · Cited by 20
Extrathymic Generation of Regulatory T Cells—Chances and Challenges for Prevention of Autoimmune Disease
Daniel, C., & von Boehmer, H. (2011) · Advances in immunology · doi:10.1016/b978-0-12-387827-4.00005-x · Cited by 21
The case for virus-induced type 1 diabetes
Spagnuolo, I., Patti, A., Sebastiani, G., Nigi, L., & Dotta, F. (2013) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328362a7d7 · Cited by 20
Islet Autoantibody Analysis: Radioimmunoassays
Wyatt, R. C., & Williams, A. J. K. (2015) · Methods in molecular biology · doi:10.1007/7651_2015_292 · Cited by 20
Caesarean section and risk of type 1 diabetes: whole‐of‐population study
Begum, M., Pilkington, R. M., Chittleborough, C., Lynch, J. W., Penno, M. A. S., & Smithers, L. G. (2019) · Diabetic Medicine · doi:10.1111/dme.14131 · Cited by 20
Vaccines against Group B Coxsackieviruses and Their Importance
Mone, K., Lasrado, N., Sur, M., & Reddy, J. (2023) · Vaccines · doi:10.3390/vaccines11020274 · Cited by 22
Attention-Oriented CNN Method for Type 2 Diabetes Prediction
Zhao, J. H., Gao, H., Chen, Y., An, T., Kuang, Z., & Shi, L. (2024) · Applied Sciences · doi:10.3390/app14103989 · Cited by 21
From Microbes to Metabolites: Advances in Gut Microbiome Research in Type 1 Diabetes
Blok, L. C. H. M., Hanssen, N. M. J., Nieuwdorp, M., & Rampanelli, E. (2025) · Metabolites · doi:10.3390/metabo15020138 · Cited by 21
IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease
d'Hennezel, E. B., Kornete, M., & Piccirillo, C. A. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-113 · Cited by 18
Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies
Maziarz, M., Hagopian, W., Palmer, J. P., Sanjeevi, C. B., Kockum, I. S., Breslow, N. E., Lernmark, Å., Graham, J., MacNeney, B., Arnqvist, H. J., et al. (2015) · Genes and Immunity · doi:10.1038/gene.2015.43 · Cited by 19
Cardiac Autoimmunity as a Novel Biomarker, Mediator, and Therapeutic Target of Heart Disease in Type 1 Diabetes
Lipes, M. A., & Galderisi, A. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0598-1 · Cited by 18
Mesenchymal Stromal Cells to Halt the Progression of Type 1 Diabetes?
Carlsson, P., Korsgren, O., & Blanc, K. L. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0616-3 · Cited by 18
Fecal microbiota transplantation in autoimmune diseases – An extensive paper on a pathogenetic therapy
Seida, I., Shawaf, M. A., & Mahroum, N. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103541 · Cited by 17
Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait
Jahromi, M., & Al‐Ozairi, E. (2019) · Disease Markers · doi:10.1155/2019/9786078 · Cited by 18
SERS-based detection of early Type 1 diabetes mellitus biomarkers: Glutamate decarboxylase antibody and insulin autoantibody
Wang, J., Zhao, J., Liu, Y., Meng, Z., Han, X., Xu, B., Liu, R., He, C., Cheng, Z., & Zhao, B. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.133456 · Cited by 16
Juvenile Diabetes Research Foundation: Mission, Strategy, and Priorities
Insel, R. A., Deecher, D. C., & Brewer, J. M. (2011) · Diabetes · doi:10.2337/db11-1398 · Cited by 17
Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets
Tran, D. T., Pottekat, A., Lee, K., Raghunathan, M., Loguercio, S., Mir, S. A., Paton, A. W., Paton, J. C., Arvan, P., Kaufman, R. J., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac493 · Cited by 13
Genetics of Type 1 Diabetes
Zemunik, T., & Borask, V. (2011) · InTech eBooks · doi:10.5772/21880 · Cited by 18
Association analysis of PTPN22 , CTLA4 and IFIH1 genes with type 1 diabetes in C olombian families在哥伦比亚家族中进行的PTPN22、CTLA4以及IFIH1基因与1型糖尿病的相关性分析
Rodríguez, A. M., Alfaro, J. M. E., Balthazar, V., & Pineda-Trujillo, N. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12192 · Cited by 16
First reported case of diabetes mellitus type 1 as a possible secondary autoimmune disease following alemtuzumab treatment in MS
Malmeström, C., Andersson, B. A., & Lycke, J. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7448-y · Cited by 16
A Rule-Based Prognostic Model for Type 1 Diabetes by Identifying and Synthesizing Baseline Profile Patterns
Lin, Y., Qian, X., Krischer, J. P., Vehik, K., Lee, H., & Huang, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091095 · Cited by 16
Risk genes and autoantibodies in Egyptian children with type 1 diabetes – low frequency of autoantibodies in carriers of the HLA‐DRB1*04:05‐DQA1*03‐DQB1*02 risk haplotype
El‐Amir, M. I., El‐Feky, M. A., Laine, A., Härkönen, T., El‐Badawy, O., Eltayeb, A. A., ElMelegy, T. T. H., Kiviniemi, M., Knip, M., & Ilonen, J. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2609 · Cited by 17
Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope
Dahan, R., Gebe, J. A., Preisinger, A., James, E. A., Tendler, M., Nepom, G. T., & Reiter, Y. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.08.009 · Cited by 16
Self-citation
HERV-K Envelope Protein Induces Long-Lasting Production of Autoantibodies in T1DM Patients at Onset in Comparison to ZNT8 Autoantibodies
Noli, M., Meloni, T., Ruberto, S., Jasemi, S., Simula, E. R., Cossu, D., Bo, M., Palermo, M., & Sechi, L. A. (2022) · Pathogens · doi:10.3390/pathogens11101188 · Cited by 16
I-Ag7 β56/57 polymorphisms regulate non-cognate negative selection to CD4+ T cell orchestrators of type 1 diabetes
Stadinski, B. D., Cleveland, S. B., Brehm, M. A., Greiner, D. L., Huseby, P. G., & Huseby, E. S. (2023) · Nature Immunology · doi:10.1038/s41590-023-01441-0 · Cited by 15
Immune-evasive beta cells in type 1 diabetes: innovations in genetic engineering, biomaterials, and computational modeling
Karaoğlu, İ. C., Duymaz, D., Rashid, M. M., & Kızılel, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1618086 · Cited by 15
Auto-Antikörper-Diagnostik in der Diabetologie – Aktueller Stand der Analytik und klinische Anwendung in Deutschland
Thaler, M., Roos, M., Petersmann, A., Seißler, J., Peter, A., Landgraf, R., Müller, U., Müller‐Wieland, D., Nauck, M. A., Heinemann, L., et al. (2022) · Diabetologie und Stoffwechsel · doi:10.1055/a-1744-2856 · Cited by 14
The Molecular Effects of SGLT2i Empagliflozin on the Autophagy Pathway in Diabetes Mellitus Type 2 and Its Complications
Saad, R., Tadmor, H., Ertracht, O., Nakhoul, N., Nakhoul, F. M., Farber, E., & Atar, S. (2022) · Journal of Diabetes Research · doi:10.1155/2022/8337823 · Cited by 16
The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study
Roth, R., Lynch, K. F., Hyöty, H., Lönnrot, M., Driscoll, K. A., Johnson, S. B., & the TEDDY Study Group (2019) · Stress and Health · doi:10.1002/smi.2861 · Cited by 14
The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity
Scherm, M. G., Serr, I., Kaestner, K. H., & Daniel, C. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.06.009 · Cited by 15
Novel Biomarkers in Type 1 Diabetes
Jin, Y., & She, J. (2012) · The Review of Diabetic Studies · doi:10.1900/rds.2012.9.224 · Cited by 15
Concise Review: Cell-Based Therapies and Other Non-Traditional Approaches for Type 1 Diabetes
Creusot, R. J., Battaglia, M., Roncarolo, M., & Fathman, C. G. (2016) · Stem Cells · doi:10.1002/stem.2290 · Cited by 14
Clinical worthlessness of genetic prediction of common forms of diabetes mellitus and related chronic complications
Buzzetti, R., Prudente, S., Copetti, M., Dauriz, M., Zampetti, S., Garofolo, M., Penno, G., & Trischitta, V. (2016) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.08.005 · Cited by 14
Enteroviral Infections and Development of Type 1 Diabetes: The Brothers Karamazov Within the CVBs
Dotta, F., & Sebastiani, G. (2014) · Diabetes · doi:10.2337/db13-1441 · Cited by 13
Treg Vaccination in Autoimmune Type 1 Diabetes
Serr, I., Weigmann, B., Franke, R. K., & Daniel, C. (2013) · BioDrugs · doi:10.1007/s40259-013-0060-3 · Cited by 13
Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs
Haider, M. Z., Rasoul, M. A., Al-Mahdi, M., Alkandari, H., & Dhaunsi, G. S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198652 · Cited by 13
Endocrine Adverse Events Related with Immune Checkpoint Inhibitors: An Update for Clinicians
Deligiorgi, M. V., Panayiotidis, M. I., & Trafalis, D. T. (2020) · Immunotherapy · doi:10.2217/imt-2019-0132 · Cited by 13
Gevokizumab in type 1 diabetes mellitus: extreme remedies for extreme diseases?
Pafili, K., Παπάνας, Ν., & Maltezos, E. S. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.947026 · Cited by 13
Activated protein C and its potential applications in prevention of islet β-cell damage and diabetes.
Xue, M., & Jackson, C. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800174-5.00013-2 · Cited by 13
Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex
Bettini, M. L., & Bettini, M. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00351 · Cited by 11
Milieu of Diabetes in the 2nd Decade of 21st Century
Suneja, S., Christian, Y., & Chandra, N. C. (2018) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000804 · Cited by 11
The Raikas – A unique combination of high prevalence of type 1 diabetes susceptibility genes and near zero incidence of the disease
Bhat, D. K., Kanga, U., Kumar, N., Agrawal, R., Mourya, M. K., Kalaivani, M., Kaur, T., & Mehra, N. K. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.09.009 · Cited by 12
Regulatory T cells with CD62L or TNFR2 expression in young type 1 diabetic patients: relation to inflammation, glycemic control and micro-vascular complications
El-Samahy, M. H., Adly, A. A. M., Ismail, E. A. R., & Salah, N. Y. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.07.004 · Cited by 12
The Potential Role of Dendritic Cells in the Therapy of Type 1 Diabetes
Lee, C., Lew, A. M., & Wu, L. (2013) · Immunotherapy · doi:10.2217/imt.13.48 · Cited by 10
National Asthma Education and Prevention Program 2020 Guidelines: What’s Important for Primary Care
Murphy, M. (2021) · The Journal of Family Practice · doi:10.12788/jfp.0219 · Cited by 14
Stress Hyperglycemia in Children and Adolescents as a Prognostic Indicator for the Development of Type 1 Diabetes Mellitus
Argyropoulos, T., Korakas, E., Gikas, A., Kountouri, A., Kostaridou, S., Raptis, A. E., & Lambadiari, V. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.670976 · Cited by 11
Prevalence of Autoantibodies and HLA DR, DQ in Type 1 Diabetes Mellitus
Singh, S. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/18657.8163 · Cited by 11
Using spatio-temporal surveillance data to test the infectious environment of children before type 1 diabetes diagnosis
Bougneres, P. F., Fur, S. L., Isis-Diab collaborative group, Valtat, S., Kamatani, Y., Lathrop, M. G., & Valleron, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170658 · Cited by 10
Prevalence of autoantibodies in type 1 diabetes mellitus pediatrics in Mazandaran, North of Iran
Zamanfar, D., Aarabi, M., Amini, M., & Monajati, M. (2020) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2019-0396 · Cited by 10
Autoimmune Diabetes: Caught in a NET
Leslie, R. D., & Bradford, C. M. (2014) · Diabetes · doi:10.2337/db14-1382 · Cited by 10
Regulation of T Follicular Helper Cells in Islet Autoimmunity
Serr, I., & Daniel, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01729 · Cited by 10
Metabolomics Makes a Mark: Early Changes Associated With Autoimmune Diabetes
Leslie, R. D., & Beyan, H. (2011) · Diabetes · doi:10.2337/db11-1177 · Cited by 10
Feasibility and organization of a population-based screening for pre-symptomatic type 1 diabetes in children — evaluation of the Fr1da study
Kick, K., Hoffmann, V. S., Lange, K., Lang, M., Laub, O., Pozza, S. B., Böcker, D., Braig, S., Dietz, B., Dunstheimer, D., et al. (2018) · Journal of Public Health · doi:10.1007/s10389-018-0981-x · Cited by 9
Self-citation
A Monovalent Mt10-CVB3 Vaccine Prevents CVB4-Accelerated Type 1 Diabetes in NOD Mice
Rasquinha, M. T., Lasrado, N., Sur, M., Mone, K., Qiu, H., Riethoven, J.-J. M., Sobel, R. A., & Reddy, J. (2022) · Vaccines · doi:10.3390/vaccines11010076 · Cited by 11
Frequency of Diabetes and Thyroid Autoantibodies in Patients with Type 1 Diabetes and Their Siblings
Oh, K. Y., Kim, Y. H., Yang, E. M., & Kim, C. J. (2016) · Chonnam Medical Journal · doi:10.4068/cmj.2016.52.2.136 · Cited by 9
IL-13Rα1 Expression on β-Cell–Specific T Cells in NOD Mice
Rasché, S., Phillips, M., McInerney, M. F., Sercarz, E. E., & Quinn, A. (2011) · Diabetes · doi:10.2337/db10-1229 · Cited by 8
Isolation of human monoclonal autoantibodies derived from pancreatic lymph node and peripheral blood B cells of islet autoantibody-positive patients
Catani, M., Walther, D., Christie, M. R., McLaughlin, K. A., Bonifacio, E. E., & Eugster, A. (2015) · Diabetologia · doi:10.1007/s00125-015-3792-4 · Cited by 8
Role of regulatory CD4+CD25+ Foxp3 T cells in bronchial asthma in Egyptian children.
Bakr, S. I., Mahran, M. Z., & Soliman, D. (2013) · PubMed · Cited by 8
Association of HLA Class II Alleles and Haplotypes with Type 1 Diabetes in Tunisian Arabs
Hajjej, A., Almawi, W. Y., Stayoussef, M., Hattab, L., & Hmida, S. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0754-5586 · Cited by 9
CD19+IgM+ cells demonstrate enhanced therapeutic efficacy in type 1 diabetes mellitus
Vonberg, A. D., Acevedo-Calado, M., Cox, A. R., Pietropaolo, S. L., Gianani, R., Lundy, S. K., & Pietropaolo, M. (2018) · JCI Insight · doi:10.1172/jci.insight.99860 · Cited by 8
Identifying Promising Immunomodulators for Type 1 Diabetes (T1D) and Islet Transplantation
Ajmal, N., Bogart, M. C., Khan, P., Max-Harry, I. M., Healy, A. M., & Nunemaker, C. S. (2024) · Journal of Diabetes Research · doi:10.1155/jdr/5151171 · Cited by 9
What Have Slow Progressors Taught Us About T1D—Mind the Gap!
Gillespie, K. M., & Long, A. E. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1219-1 · Cited by 8
Primary Prevention of CVD with Aspirin: Benefits vs Risks
Weisman (2021) · The Journal of Family Practice · doi:10.12788/jfp.0222 · Cited by 7
Prevention of Type 1 Diabetes in Children: A Worthy Challenge?
Ingrosso, D. M. F., Quarta, M. T., Quarta, A., & Chiarelli, F. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20115962 · Cited by 7

Authors: Ziegler, A.-G., & Nepom, G. T.
Affiliations: TUM Klinikum (DE)
Benaroya Research Institute (US)
Corresponding author: Ziegler, Anette-G.
Nepom, Gerald T.
ORCID: Ziegler, Anette-G.
Nepom, Gerald T.
Venue: Immunity
Publisher: Elsevier BV
Published: 2010-04
Volume: 32
Issue: 4
Pages: 468-478
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2010.03.018
PMC: PMC2861716
OpenAlex: W2047768051
Cited by: 346
References: 101
Citations by year: 2026: 5 · 2025: 21 · 2024: 20 · 2023: 12 · 2022: 15 · 2021: 25 · 2020: 18 · 2019: 19 · 2018: 26 · 2017: 10 · 2016: 26 · 2015: 30 · 2014: 28 · 2013: 29 · 2012: 25
FWCI: 3.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1239 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Site cant be reached (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
National Institutes of Health
Juvenile Diabetes Research Foundation International
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 1 diabetes, autoimmune diabetes, disease prediction, pathogenesis, genetic susceptibility, immune response, biomarkers, immune checkpoint, immune regulation, islet autoimmunity, disease risk assessment, preclinical stage, immune homeostasis
MeSH terms: Animals, Diabetes Mellitus, Type 1, Humans, Risk Factors, Genetic Variation, Biomarkers, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prediction and Pathogenesis in Type 1 Diabetes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks