The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Prediction and Pathogenesis in Type 1 Diabetes
Open accessAbstract
A combination of genetic and immunological features is useful for prediction of autoimmune diabetes. Patterns of immune response correspond to the progression from a preclinical phase of disease to end-stage islet damage, with biomarkers indicating transition from susceptibility to active autoimmunity, and to a final loss of immune regulation. Here, we review the markers that provide evidence for immunological checkpoint failure and that also provide tools for assessment of individualized disease risk. When viewed in the context of genetic variation that influences immune response thresholds, progression from susceptibility to overt disease displays predictable modalities of clinical presentation resulting from a sequential series of failed homeostatic checkpoints for selection and activation of immunity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“More than 90% of individuals with newly diagnosed type 1 diabetes have one or more of the following autoantibodies at disease onset:53 those reactive to insulin (IAA), glutamic acid decarboxylase (GADA), insulinoma-associated autoantigen 2 (IA2A), and zinc transporter 8 (ZnT8A).65”
From Type 1 diabetes (2014) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Baekkeskov, S., Aanstoot, H.-J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P.-D. (1990) · Nature · doi:10.1038/347151a0 · Cited by 1,964
Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J., Buist, N. R. M., Levy‐Lahad, E., Mazzella, M., Goulet, O., Perroni, L., et al. (2001) · Nature Genetics · doi:10.1038/83707 · Cited by 1,916
Begovich, A. B., Carlton, V. E. H., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K., Huang, Q., Smith, A. M., Spoerke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422827 · Cited by 1,501
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Bottini, N., Musumeci, L., Alonso, A., Rahmouni, S., Nika, K., Rostamkhani, M., MacMurray, J. P., Meloni, T., Lucarelli, P., Pellecchia, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1323 · Cited by 1,419
The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley, J. B., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Moser, K. L., Tsao, B. P., Vyse, T. J., & Langefeld, C. D. (2008) · Nature Genetics · doi:10.1038/ng.81 · Cited by 1,309
Insulin antibodies in insulin-dependent diabetics before insulin treatment
Palmer, J. P., Asplin, C. M., Clemons, P., Lyen, K., Tatpati, O., Raghu, P. K., & Paquette, T. L. (1983) · Science · doi:10.1126/science.6362005 · Cited by 1,078
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
Wenzlau, J. M., Juhl, K., Yu, L., Moua, O., Sarkar, S. A., Gottlieb, P., Rewers, M., Eisenbarth, G. S., Jensen, J., Davidson, H. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705894104 · Cited by 1,014
Incidence of diabetes in youth in the United States
SEARCH for Diabetes in Youth Study Group*, T. W. G. F. T. (2007) · JAMA · doi:10.1001/jama.297.24.2716 · Cited by 991
Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945
Cited by
Sorted by citations
Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,931
Diabetes mellitus: The epidemic of the century
Kharroubi, A. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i6.850 · Cited by 1,352
Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective
Zaccardi, F., Webb, D. R., Yates, T. E., & Davies, M. J. (2015) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133281 · Cited by 614
Gut microbiota, obesity and diabetes
Patterson, E., Ryan, P. M., Cryan, J. F., Dinan, T. G., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133285 · Cited by 552
Is autoimmunity the Achilles' heel of cancer immunotherapy?
June, C. H., Warshauer, J. T., & Bluestone, J. A. (2017) · Nature Medicine · doi:10.1038/nm.4321 · Cited by 445
Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438
Wherrett, D. K., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Gottlieb, P. A., Greenbaum, C. J., Herold, K. C., Marks, J. B., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60895-7 · Cited by 371
Battaglia, M., Ahmed, S., Anderson, M. S., Atkinson, M. A., Becker, D., Bingley, P. J., Bosi, E., Brusko, T. M., DiMeglio, L. A., Evans-Molina, C., et al. (2020) · Diabetes Care · doi:10.2337/dc19-0880 · Cited by 351
Engin, F., Yermalovich, A. V., Nguyen, T., Hummasti, S., Fu, W., Eizirik, D. L., Mathis, D. J., & Hotamışlıgil, G. S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006534 · Cited by 326
The pathogenesis and natural history of type 1 diabetes.Preprint
Atkinson, M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007641 · Cited by 316
Song, Y., Li, J., & Wu, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01952-8 · Cited by 328
Inflammasomes and autoimmunity
Shaw, P. J., McDermott, M., & Kanneganti, T. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.11.001 · Cited by 240
Gut microbiome in type 1 diabetes: A comprehensive review
Zheng, P., Li, Z., & Zhou, Z. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3043 · Cited by 244
Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
von Boehmer, H., & Daniel, C. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3683 · Cited by 230
Hummel, S., Pflüger, M., Hummel, M., Bonifacio, E. E., & Ziegler, A. (2011) · Diabetes Care · doi:10.2337/dc10-2456 · Cited by 217
Self-citationPatterns of β-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life
Ilonen, J., Hammais, A., Laine, A., Lempainen, J., Vaarala, O., Veijola, R., Simell, O., & Knip, M. (2013) · Diabetes · doi:10.2337/db13-0300 · Cited by 206
Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes
Bonifacio, E. E., Ziegler, A., KLINGENSMITH, G. J., Schober, E., Bingley, P. J., Rottenkolber, M., Theil, A., Eugster, A., Puff, R., Peplow, C., et al. (2015) · JAMA · doi:10.1001/jama.2015.2928 · Cited by 198
Self-citationPredicting Type 1 Diabetes Using Biomarkers
Bonifacio, E. E. (2015) · Diabetes Care · doi:10.2337/dc15-0101 · Cited by 191
Circulating miR-375 as a Biomarker of β-Cell Death and Diabetes in Mice
Erener, S., Mojibian, M., Fox, J. K., Denroche, H. C., & Kieffer, T. J. (2013) · Endocrinology · doi:10.1210/en.2012-1744 · Cited by 184
Compromised Gut Microbiota Networks in Children With Anti-Islet Cell Autoimmunity
Endesfelder, D., zu Castell, W., Ardissone, A. N., Davis‐Richardson, A. G., Achenbach, P., Hagen, M., Pflueger, M., Gano, K. A., Fagen, J. R., Drew, J. C., et al. (2014) · Diabetes · doi:10.2337/db13-1676 · Cited by 176
Self-citationGene-environment interactions in chronic inflammatory disease
Renz, H., von Mutius, E., Brandtzæg, P., Cookson, W., Autenrieth, I. B., & Haller, D. (2011) · Nature Immunology · doi:10.1038/ni0411-273 · Cited by 172
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
Wiedeman, A. E., Muir, V. S., Rosasco, M. G., DeBerg, H. A., Presnell, S., Haas, B., Dufort, M. J., Speake, C., Greenbaum, C. J., Serti, E., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126595 · Cited by 168
Self-citationLatent autoimmune diabetes of the adult: current knowledge and uncertainty
Laugesen, E., Østergaard, J. A., & Leslie, R. D. (2015) · Diabetic Medicine · doi:10.1111/dme.12700 · Cited by 175
Ramos-Rodríguez, M., Raurell‐Vila, H., Colli, M. L., Alvelos, M. I., Subirana-Granés, M., Juan‐Mateu, J., Norris, R., Turatsinze, J., Nakayasu, E. S., Webb‐Robertson, B., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0524-6 · Cited by 158
Neurological Syndromes Associated with Anti-GAD Antibodies
Dade, M., Berzero, G., Izquierdo, C., Giry, M., Benazra, M., Delattre, J., Psimaras, D., & Alentorn, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103701 · Cited by 158
Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes
Winkler, C., Krumsiek, J., Buettner, F., Angermueller, C., Giannopoulou, E. Z., Theis, F. J., Ziegler, A., & Bonifacio, E. E. (2014) · Diabetologia · doi:10.1007/s00125-014-3362-1 · Cited by 143
Self-citationThe Influence of the Microbiome on Type 1 Diabetes
Paun, A., Yau, C., & Danska, J. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601519 · Cited by 130
Type 2 diabetes mellitus—an autoimmune disease?
Velloso, L. A., Eizirik, D. L., & Cnop, M. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.131 · Cited by 124
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Serr, I., Fürst, R. W., Achenbach, P., Scherm, M. G., Gökmen, F., Haupt, F., Sedlmeier, E., Knopff, A., Shultz, L. D., Willis, R. A., et al. (2016) · Nature Communications · doi:10.1038/ncomms10991 · Cited by 124
Self-citationKrzewska, A., & Beń‐Skowronek, I. (2016) · BioMed Research International · doi:10.1155/2016/6219730 · Cited by 124
Winkler, C., Schober, E., Ziegler, A., & Holl, R. W. (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00829.x · Cited by 122
Self-citationSousa, G. R., Pober, D., Galderisi, A., Lv, H., Yu, L., Pereira, A. C., Doria, A., Kosiborod, M., & Lipes, M. A. (2019) · Circulation · doi:10.1161/circulationaha.118.036068 · Cited by 117
Prasad, S., Kohm, A. P., McMahon, J. S., Luo, X., & Miller, S. D. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.04.005 · Cited by 117
Prediction and Prevention of Type 1 Diabetes
Primavera, M., Giannini, C., & Chiarelli, F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00248 · Cited by 130
Pflueger, M., Seppänen-Laakso, T., Suortti, T., Hyötyläinen, T., Achenbach, P., Bonifacio, E., Orešič, M., & Ziegler, A.-G. (2011) · Diabetes · doi:10.2337/db10-1652 · Cited by 112
Self-citationStopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man
Skyler, J. S., & Ricordi, C. (2010) · Diabetes · doi:10.2337/db10-1114 · Cited by 109
Lowe, J. R., Perry, D. J., Salama, A. K. S., Mathews, C. E., Moss, L. G., & Hanks, B. A. (2016) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-016-0196-z · Cited by 110
Bonifacio, E. E., Warncke, K., Winkler, C., Wallner, M., & Ziegler, A. (2011) · Diabetes · doi:10.2337/db11-0729 · Cited by 100
Self-citationRole of immune system in type 1 diabetes mellitus pathogenesis
Szablewski, L. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.06.033 · Cited by 106
Hyaluronan in immune dysregulation and autoimmune diseases
Nagy, N., Kuipers, H. F., Marshall, P. L., Wang, E., Kaber, G., & Bollyky, P. L. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.022 · Cited by 94
Ziegler, A., Achenbach, P., Berner, R., Casteels, K., Danne, T., Gündert, M., Hasford, J., Hoffmann, V. S., Kordonouri, O., Lange, K., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028578 · Cited by 78
Self-citationThe Immunogenetic Architecture of Autoimmune DiseasePreprint
Goris, A., & Liston, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007260 · Cited by 96
Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes
Giannopoulou, E. Z., Winkler, C., Chmiel, R., Matzke, C., Scholz, M., Beyerlein, A., Achenbach, P., Bonifacio, E. E., & Ziegler, A. (2015) · Diabetologia · doi:10.1007/s00125-015-3672-y · Cited by 87
Self-citationNutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis
Berná, G., Oliveras‐López, M., Jurado‐Ruiz, E., Tejedo, J. R., Bedoya, F. J., Soria, B., & Martı́n, F. (2014) · Nutrients · doi:10.3390/nu6115338 · Cited by 95
Targeting type II diabetes with plant terpenes: the new and promising antidiabetic therapeutics
Panigrahy, S. K., Bhatt, R., & Kumar, A. (2020) · Biologia · doi:10.2478/s11756-020-00575-y · Cited by 87
The Long and Winding Road to Understanding and Conquering Type 1 Diabetes
Santamaría, P. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.003 · Cited by 87
Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis
Nagy, N., Kaber, G., Johnson, P. Y., Gebe, J. A., Preisinger, A., Falk, B. A., Sunkari, V. G., Gooden, M. D., Vernon, R. B., Bogdani, M., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79271 · Cited by 83
Ziegler, A., Pflueger, M., Winkler, C., Achenbach, P., Akolkar, B., Krischer, J. P., & Bonifacio, E. E. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.02.004 · Cited by 81
Self-citationBeyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes
Nielsen, D. S., Krych, Ł., Buschard, K., Hansen, C. H. F., & Hansen, A. K. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.010 · Cited by 79
T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives
Mallone, R., Brezar, V., & Boîtard, C. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/513210 · Cited by 81
Serum biomarkers for diagnosis and prediction of type 1 diabetes
Yi, L., Swensen, A., & Qian, W. (2018) · Translational research · doi:10.1016/j.trsl.2018.07.009 · Cited by 80
Marroquí, L., Lopes, M., dos Santos, R. S., Grieco, F. A., Roivainen, M., Richardson, S. J., Morgan, N. G., Beeck, A. O. D., & Eizirik, D. L. (2015) · eLife · doi:10.7554/elife.06990 · Cited by 70
Harmonization of immunoassays for biomarkers in diabetes mellitus
Hörber, S., Achenbach, P., Schleicher, E. D., & Peter, A. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.02.015 · Cited by 77
Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes
Hannelius, U., Beam, C. A., & Ludvigsson, J. (2020) · Diabetologia · doi:10.1007/s00125-020-05227-z · Cited by 68
Levy, H., Wang, X., Kaldunski, M. L., Jia, S., Kramer, J., Pavletich, S. J., Reske, M., Gessel, T., Yassai, M. B., Quasney, M. W., et al. (2012) · Genes and Immunity · doi:10.1038/gene.2012.41 · Cited by 72
Winkler, C., Lauber, C., Adler, K., Grallert, H., Illig, T., Ziegler, A.-G., & Bonifacio, E. (2011) · Diabetes · doi:10.2337/db10-1269 · Cited by 68
Self-citationZiegler, A., Danne, T., Dunger, D. B., Berner, R., Puff, R., Kiess, W., Agiostratidou, G., Todd, J., & Bonifacio, E. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.02.003 · Cited by 62
Self-citationAutoimmune responses and inflammation in type 2 diabetes
Prasad, M., Chen, E. W., Toh, S.-A. E. S., & Gascoigne, N. R. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0220-243r · Cited by 68
Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease
Paramel, G. V., Sirsjö, A., & Fransén, K. (2015) · Mediators of Inflammation · doi:10.1155/2015/846782 · Cited by 66
A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes
Serr, I., Scherm, M. G., Zahm, A. M., Schug, J., Flynn, V. K., Hippich, M., Kälin, S., Becker, M., Achenbach, P., Nikolaev, A., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aag1782 · Cited by 63
Self-citationRising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis
Long, A. E., Gillespie, K. M., Rokni, S., Bingley, P. J., & Williams, A. J. K. (2012) · Diabetes · doi:10.2337/db11-0962 · Cited by 60
Winkler, C., Haupt, F., Heigermoser, M., Zapardiel‐Gonzalo, J., Ohli, J., Faure, T., Kalideri, E., Hommel, A., Delivani, P., Berner, R., et al. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12870 · Cited by 63
Self-citationHyaluronan content governs tissue stiffness in pancreatic islet inflammation
Nagy, N., de la Zerda, A., Kaber, G., Johnson, P. Y., Hu, K. H., Kratochvil, M. J., Yadava, K., Zhao, W., Cui, Y., Navarro, G., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000148 · Cited by 60
MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research
Juan‐Mateu, J., Villate, O., & Eizirik, D. L. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-0916 · Cited by 59
Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes
Beyan, H., Riese, H., Hawa, M. I., Beretta, G., Davidson, H. W., Hutton, J. C., Burger, H., Schlosser, M., Snieder, H., Boehm, B. O., et al. (2012) · Diabetes · doi:10.2337/db11-0971 · Cited by 60
Serr, I., Fürst, R. W., Ott, V. B., Scherm, M. G., Nikolaev, A., Gökmen, F., Kälin, S., Zillmer, S., Bunk, M., Weigmann, B., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606646113 · Cited by 58
Self-citationBirth and coming of age of islet autoantibodies
Bonifacio, E. E., & Achenbach, P. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13360 · Cited by 60
Potential viral pathogenic mechanism in human type 1 diabetes
Schneider, D., & von Herrath, M. G. (2014) · Diabetologia · doi:10.1007/s00125-014-3340-7 · Cited by 58
Infection as a cause of type 1 diabetes?
Christen, U., Bender, C., & von Herrath, M. G. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283533719 · Cited by 56
The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes
Kachapati, K., Adams, D., Bednar, K., & Ridgway, W. M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-62703-068-7_1 · Cited by 54
It’s Time to Bring Dendritic Cell Therapy to Type 1 Diabetes
Creusot, R. J., Giannoukakis, N., Trucco, M., Clare-Salzler, M. J., & Fathman, C. G. (2013) · Diabetes · doi:10.2337/db13-0886 · Cited by 51
Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes
Bagge, S. L., Fotheringham, A. K., Leung, S. S., & Forbes, J. M. (2020) · Medicinal Research Reviews · doi:10.1002/med.21654 · Cited by 54
Miani, M., Barthson, J., Colli, M. L., Brozzi, F., Cnop, M., & Eizirik, D. L. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.236 · Cited by 50
Jacobsen, L. M., Larsson, H. E., Tamura, R. N., Vehik, K., Clasen, J., Sosenko, J., Hagopian, W. A., She, J., Steck, A. K., Rewers, M., et al. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12812 · Cited by 48
Self-citationThe case for an autoimmune aetiology of type 1 diabetes
Mannering, S. I., Pathiraja, V., & Kay, T. W. H. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12699 · Cited by 51
Wolden-Kirk, H., Rondas, D., Bugliani, M., Korf, H., Lommel, L. V., Brusgaard, K., Christesen, H. T., Schuit, F. C., Proost, P., Masini, M., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1409 · Cited by 48
Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression
Xhonneux, L.-P., Knight, O., Lernmark, Å., Bonifacio, E. E., Hagopian, W., Rewers, M., She, J., Toppari, J., Parikh, H. M., Smith, K. G. C., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd5666 · Cited by 48
Self-citationProtection against or triggering of Type 1 diabetes? Different roles for viral infections
Boettler, T., & von Herrath, M. (2010) · Expert Review of Clinical Immunology · doi:10.1586/eci.10.91 · Cited by 48
Hippich, M., Beyerlein, A., Hagopian, W., Krischer, J. P., Vehik, K., Knoop, J., Winker, C., Toppari, J., Lernmark, Å., Rewers, M., et al. (2019) · Diabetes · doi:10.2337/db18-0882 · Cited by 48
Self-citationCan 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?
Diallo, K., Oppong, A. K., & Lim, G. E. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.021 · Cited by 41
Green-Mitchell, S. M., Tersey, S. A., Cole, B. K., Ma, K., Kuhn, N. S., Cunningham, T. D., Maybee, N. A., Chakrabarti, S. K., MCDUFFIE, M. J., Taylor, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056763 · Cited by 43
Boîtard, C. (2012) · La Presse Médicale · doi:10.1016/j.lpm.2012.10.003 · Cited by 48
Differential effect of DJ-1/PARK7 on development of natural and induced regulatory T cells
Singh, Y., Chen, H., Zhou, Y., Föller, M., Mak, T. W., Salker, M. S., & Lang, F. J. W. (2015) · Scientific Reports · doi:10.1038/srep17723 · Cited by 45
Incomplete immune response to coxsackie B viruses associates with early autoimmunity against insulin
Ashton, M. P., Eugster, A., Walther, D., Daehling, N., Riethausen, S., Kuehn, D., Klingel, K., Beyerlein, A., Zillmer, S., Ziegler, A., et al. (2016) · Scientific Reports · doi:10.1038/srep32899 · Cited by 43
Self-citationChallenges in diagnosis and management of diabetes in the young
Ranjit Unnikrishnan, I., Shah, V. N., & Mohan, V. (2016) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-016-0036-6 · Cited by 43
Immunology of β-Cell Destruction
Torre, D. L., & Lernmark, Å. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_24 · Cited by 43
Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes
the TEDDY study group, Lee, H.-S., Briese, T., Winkler, C., Rewers, M., Bonifacio, E. E., Hyöty, H., Pflueger, M., Simell, O., She, J., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2924-y · Cited by 42
Self-citationEndesfelder, D., Hagen, M., Winkler, C., Haupt, F., Zillmer, S., Knopff, A., Bonifacio, E. E., Ziegler, A., zu Castell, W., & Achenbach, P. (2016) · Diabetologia · doi:10.1007/s00125-016-4050-0 · Cited by 43
Self-citationPrevention or acceleration of type 1 diabetes by viruses
Ghazarian, L., Diana, J., Simoni, Y., Beaudoin, L., & Lehuen, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1042-1 · Cited by 40
Beyerlein, A., Bonifacio, E. E., Vehik, K., Hippich, M., Winkler, C., Frohnert, B. I., Steck, A. K., Hagopian, W., Krischer, J. P., Lernmark, Å., et al. (2018) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2018-105532 · Cited by 40
Self-citationVernon, R. B., Preisinger, A., Gooden, M. D., D’Amico, L., Yue, B. B., Bollyky, P. L., Kuhr, C. S., Hefty, T. R., Nepom, G. T., & Gebe, J. A. (2012) · Cell Transplantation · doi:10.3727/096368912x636786 · Cited by 40
Self-citationUse of the Electronic Medical Record to Assess Pancreas Size in Type 1 Diabetes
Virostko, J. M., Hilmes, M. A., Eitel, K. B., Moore, D. J., & Powers, A. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158825 · Cited by 38
Eisenbarth, G. S., & Buse, J. B. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00032-8 · Cited by 39
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
Lugar, M., Eugster, A., Achenbach, P., Berge, T. V. D., Berner, R., Besser, R. E. J., Casteels, K., Larsson, H. E., Gemulla, G., Kordonouri, O., et al. (2023) · JAMA · doi:10.1001/jama.2023.16348 · Cited by 38
Self-citationMetabolomics in childhood diabetes
Frohnert, B. I., & Rewers, M. (2015) · Pediatric Diabetes · doi:10.1111/pedi.12323 · Cited by 38
Ziegler, A., Meier-Stiegen, F., Winkler, C., Bonifacio, E. E., & the TEENDIAB Study Group (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00763.x · Cited by 35
Self-citationGene-environment interaction in chronic disease: A European Science Foundation Forward Look
Renz, H., Autenrieth, I. B., Brandtzæg, P., Cookson, W., Holgate, S. T., von Mutius, E., Valenta, R., & Haller, D. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.09.039 · Cited by 35
Alagpulinsa, D. A., Cao, J. J. L., Sobell, D., & Poznansky, M. C. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.011 · Cited by 33
The Emerging Jamboree of Transformative Therapies for Autoimmune Diseases
Carballido, J. M., Regairaz, C., Rauld, C., Raad, L., Picard, D., & Kammuller, M. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00472 · Cited by 35
Challenges in the diagnosis of diabetes type in pediatrics
Siller, A. F., Tosur, M., Relan, S., Astudillo, M., McKay, S. V., Dabelea, D., & REDONDO, M. J. (2020) · Pediatric Diabetes · doi:10.1111/pedi.13070 · Cited by 34
Metadata
- Authors
- Ziegler, A.-G., & Nepom, G. T.
- Affiliations
- TUM Klinikum (DE)
- Benaroya Research Institute (US)
- Corresponding author
- Ziegler, Anette-G.
- Nepom, Gerald T.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 32
- Issue
- 4
- Pages
- 468-478
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC2861716
- OpenAlex
- W2047768051
- Cited by
- 346
- References
- 101
- Citations by year
- 2026: 5 · 2025: 21 · 2024: 20 · 2023: 12 · 2022: 15 · 2021: 25 · 2020: 18 · 2019: 19 · 2018: 26 · 2017: 10 · 2016: 26 · 2015: 30 · 2014: 28 · 2013: 29 · 2012: 25
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- National Institutes of Health
- Juvenile Diabetes Research Foundation International
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 1 diabetes, autoimmune diabetes, disease prediction, pathogenesis, genetic susceptibility, immune response, biomarkers, immune checkpoint, immune regulation, islet autoimmunity, disease risk assessment, preclinical stage, immune homeostasis
- MeSH terms
- Animals, Diabetes Mellitus, Type 1, Humans, Risk Factors, Genetic Variation, Biomarkers, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
