The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism
Open accessAbstract
Summary In the two signal model of T cell activation, the outcome of antigen recognition is determined by the integration of multiple cues in the immune microenvironment. mTOR is an evolutionarily conserved PI3-kinase family member that plays a central role in integrating environmental cues in the form of amino acids, energy, and growth factors. Recently, an increasingly important role for mTOR in directing T cell activation and differentiation has become apparent. Here we review recent findings demonstrating the ability of mTOR to interpret signals in the immune microenvironment and program the generation of CD4+ effector versus regulatory T cells, the generation of CD8+ effector versus memory cells, T cell trafficking, and T cell activation versus anergy. The key theme to emerge from these studies is that the central role of mTOR provides a direct link between T cell metabolism and function.
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Cites
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Cited by
Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803
Metabolic Regulation of T Lymphocytes
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Regulation and function of mTOR signalling in T cell fate decisions
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Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y.-B., Taylor, P. M., & Cantrell, D. A. (2013) · Nature Immunology · doi:10.1038/ni.2556 · Cited by 930
Regulation of Immune Responses by mTOR
Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075024 · Cited by 836
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Metadata
- Authors
- Powell, J. D., & Delgoffe, G. M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 33
- Issue
- 3
- Pages
- 301-311
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2059423024
- Cited by
- 486
- References
- 18
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
