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Cited by 486

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

Open access
Powell, Jonathan D., Delgoffe, Greg M.·2010·Immunity
DOI 10.1016/j.immuni.2010.09.002
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Abstract

Summary In the two signal model of T cell activation, the outcome of antigen recognition is determined by the integration of multiple cues in the immune microenvironment. mTOR is an evolutionarily conserved PI3-kinase family member that plays a central role in integrating environmental cues in the form of amino acids, energy, and growth factors. Recently, an increasingly important role for mTOR in directing T cell activation and differentiation has become apparent. Here we review recent findings demonstrating the ability of mTOR to interpret signals in the immune microenvironment and program the generation of CD4+ effector versus regulatory T cells, the generation of CD8+ effector versus memory cells, T cell trafficking, and T cell activation versus anergy. The key theme to emerge from these studies is that the central role of mTOR provides a direct link between T cell metabolism and function.

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Metadata

Authors
Powell, J. D., & Delgoffe, G. M.
Venue
Immunity
Publisher
Elsevier BV
Published
2010-09
Volume
33
Issue
3
Pages
301-311
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2010.09.002
OpenAlex
W2059423024
Cited by
486
References
18
FWCI
16.63
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.