The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Reverse Vaccinology: Developing Vaccines in the Era of Genomics
Open accessAbstract
The sequence of microbial genomes made all potential antigens of each pathogen available for vaccine development. This increased by orders of magnitude potential vaccine targets in bacteria, parasites, and large viruses and revealed virtually all their CD4+ and CD8+ T cell epitopes. The genomic information was first used for the development of a vaccine against serogroup B meningococcus, and it is now being used for several other bacterial vaccines. In this review, we will first summarize the impact that genome sequencing has had on vaccine development, and then we will analyze how the genomic information can help further our understanding of immunity to infection or vaccination and lead to the design of better vaccines by diving into the world of T cell immunity.
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Cites
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Cited by
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus
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Accelerating Next-Generation Vaccine Development for Global Disease Prevention
Koff, W. C., Burton, D. R., Johnson, P. R., Walker, B. D., King, C. R., Nabel, G. J., Ahmed, R., Bhan, M. K., & Plotkin, S. A. (2013) · Science · doi:10.1126/science.1232910 · Cited by 282
Kazi, A., Chuah, C., Majeed, A. B. A., Leow, C. H., Lim, B. H., & Leow, C. Y. (2018) · Pathogens and Global Health · doi:10.1080/20477724.2018.1446773 · Cited by 122
Metadata
- Authors
- Sette, A., & Rappuoli, R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 33
- Issue
- 4
- Pages
- 530-541
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2017321063
- Cited by
- 559
- References
- 135
- FWCI
- 14.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
