The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection
Open accessAbstract
Summary CD4+ T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for long-lived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh cell lineage after antigen clearance. Using adoptive transfer of antigen-specific memory CD4+ T cell subpopulations in the LCMV infection model, we found that there are distinct memory CD4+ T cell populations with commitment to either Tfh- or Th1-cell lineages. Our conclusions are based on gene expression profiles, epigenetic studies, and phenotypic and functional analyses. Our findings indicate that CD4+ memory T cells “remember” their previous effector lineage after antigen clearance, being poised to reacquire their lineage-specific effector functions upon antigen reencounter. These findings have important implications for rational vaccine design, where improving the generation and engagement of memory Tfh cells could be used to enhance vaccine-induced protective immunity.
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Bcl6 mediates the development of T follicular helper cells
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Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells
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Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function
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Cited by
T follicular helper cell differentiation, function, and roles in disease
Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847
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Locci, M., Havenar-Daughton, C., Landais, E., Wu, J., Kroenke, M. A., Arlehamn, C. L., Su, L. F., Cubas, R., Davis, M. M., Sette, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.031 · Cited by 868
Intravascular staining for discrimination of vascular and tissue leukocytes
Anderson, K. G., Mayer-Barber, K., Sung, H., Beura, L., James, B. R., Taylor, J. J., Qunaj, L., Griffith, T. S., Vezys, V., Barber, D. L., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.005 · Cited by 812
Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer
Cillo, A. R., Kürten, C. H. L., Tabib, T., Qi, Z., Onkar, S., Wang, T., Liu, A., Duvvuri, U., Kim, S., Soose, R. J., et al. (2020) · Immunity · doi:10.1016/j.immuni.2019.11.014 · Cited by 668
Metadata
- Authors
- Hale, J. S., Youngblood, B., Latner, D. R., Mohammed, A. U. R., Ye, L., Akondy, R. S., Wu, T., Iyer, S. S., & Ahmed, R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 38
- Issue
- 4
- Pages
- 805-817
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2037088576
- Cited by
- 329
- References
- 39
- FWCI
- 17.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection. https://app.cochat.ai/papers/10.1016/j.immuni.2013.02.020
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- Hale, J. S., Youngblood, B., Latner, D. R., Mohammed, A. U. R., Ye, L., Akondy, R. S., Wu, T., Iyer, S. S., & Ahmed, R. (2013). Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection. Immunity. https://doi.org/10.1016/j.immuni.2013.02.020
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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