The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Systems Vaccinology
Open accessAbstract
Vaccination is one of the greatest triumphs of modern medicine, yet we remain largely ignorant of the mechanisms by which successful vaccines stimulate protective immunity. Two recent advances are beginning to illuminate such mechanisms: realization of the pivotal role of the innate immune system in sensing microbes and stimulating adaptive immunity, and advances in systems biology. Recent studies have used systems biology approaches to obtain a global picture of the immune responses to vaccination in humans. This has enabled the identification of early innate signatures that predict the immunogenicity of vaccines, and identification of potentially novel mechanisms of immune regulation. Here we review these advances, and critically examine the potential opportunities and challenges posed by systems biology in vaccine development.
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“Vaccination can induce the proliferation and differentiation of antigenspecific T cells into effector cells that secrete cytokines such as IFNg, IL-4, IL-17, IL-10, IL-9, or effectormemory cells and central memory cells, all of which play key roles in mediating short- and/ or long-term protective immunity to the patho…”
BackgroundComputational systems biology.
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A N EW A PPROACH TO D ECODING L IFE : Systems Biology
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Cited by
Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans
Hagan, T., Cortese, M., Rouphael, N., Boudreau, C., Linde, C., Maddur, M. S., Das, J., Wang, H., Guthmiller, J., Zheng, N.-Y., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.010 · Cited by 572
Self-citationSenescent cell clearance by the immune system: Emerging therapeutic opportunities
Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T., & Kirkland, J. L. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2019.04.003 · Cited by 497
Delany, I., Rappuoli, R., & De Gregorio, E. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201403876 · Cited by 420
Nakaya, H. I., Hagan, T., Duraisingham, S. S., Lee, E. K., Kwissa, M., Rouphael, N., Frasca, D., Gersten, M., Mehta, A. K., Gaujoux, R., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.012 · Cited by 337
Self-citationAccelerating Next-Generation Vaccine Development for Global Disease Prevention
Koff, W. C., Burton, D. R., Johnson, P. R., Walker, B. D., King, C. R., Nabel, G. J., Ahmed, R., Bhan, M. K., & Plotkin, S. A. (2013) · Science · doi:10.1126/science.1232910 · Cited by 282
Metadata
- Authors
- Pulendran, B., Li, S., & Nakaya, H. I.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 33
- Issue
- 4
- Pages
- 516-529
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4238854650
- Cited by
- 380
- References
- 96
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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