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Cited by 2,157

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Regulation of Adaptive Immunity by the Innate Immune System

Open access
Iwasaki, Akiko, Medzhitov, Ruslan·2010·Science
DOI 10.1126/science.1183021
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Abstract

Twenty years after the proposal that pattern recognition receptors detect invasion by microbial pathogens, the field of immunology has witnessed several discoveries that have elucidated receptors and signaling pathways of microbial recognition systems and how they control the generation of T and B lymphocyte–mediated immune responses. However, there are still many fundamental questions that remain poorly understood, even though sometimes the answers are assumed to be known. Here, we discuss some of these questions, including the mechanisms by which pathogen-specific innate immune recognition activates antigen-specific adaptive immune responses and the roles of different types of innate immune recognition in host defense from infection and injury.

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Citations

Cites

Show all 9 references

Research works printed but not linked: 50

  1. 10.1101/SQB.1989.054.01.003 · DOI · Paper page
  2. 10.1038/ni1112 · DOI · Paper page
  3. 10.1084/jem.20082818 · DOI · Paper page
  4. 10.1016/j.immuni.2007.08.012 · DOI · Paper page
  5. 10.1073/pnas.0606699104 · DOI · Paper page
  6. 10.1016/j.immuni.2008.07.009 · DOI · Paper page
  7. 10.1111/j.1600-065X.2008.00737.x · DOI · Paper page
  8. 10.1016/j.cell.2009.06.015 · DOI · Paper page
  9. 10.1038/ni.1779 · DOI · Paper page
  10. 10.1016/j.immuni.2007.10.002 · DOI · Paper page
  11. 10.1111/j.1600-065X.2008.00731.x · DOI · Paper page
  12. 10.4049/jimmunol.180.2.683 · DOI
  13. 10.1084/jem.20090247 · DOI · Paper page
  14. 10.4049/jimmunol.181.11.7670 · DOI
  15. 10.1016/j.immuni.2007.03.009 · DOI · Paper page
  16. 10.1126/science.1104911 · DOI · Paper page
  17. 10.1038/nature06537 · DOI · Paper page
  18. 10.4049/jimmunol.179.7.4711 · DOI · Paper page
  19. 10.1084/jem.20081667 · DOI · Paper page
  20. 10.1073/pnas.0804717105 · DOI
  21. 10.1038/ni.1782 · DOI · Paper page
  22. 10.4049/jimmunol.171.2.533 · DOI
  23. 10.1073/pnas.202476699 · DOI · Paper page
  24. 10.1016/j.imlet.2007.11.015 · DOI
  25. 10.1172/JCI26032 · DOI · Paper page
  26. 10.1371/journal.ppat.1000298 · DOI
  27. 10.1016/j.coi.2009.05.005 · DOI
  28. 10.1038/nature04596 · DOI · Paper page
  29. 10.1016/j.immuni.2006.07.015 · DOI
  30. 10.1126/science.271.5247.348 · DOI · Paper page
  31. 10.1016/j.immuni.2007.07.004 · DOI · Paper page
  32. 10.1016/j.cell.2008.06.032 · DOI · Paper page
  33. 10.1038/ni1162 · DOI · Paper page
  34. 10.1038/32588 · DOI · Paper page
  35. 10.1111/j.1365-2796.2008.02046.x · DOI
  36. 10.1128/JVI.74.2.914-922.2000 · DOI · Paper page
  37. 10.1016/j.it.2004.09.013 · DOI
  38. 10.1038/nature03326 · DOI · Paper page
  39. 10.1073/pnas.0406268101 · DOI
  40. 10.4049/jimmunol.176.12.7589 · DOI
  41. 10.1016/j.coi.2003.11.001 · DOI
  42. 10.1146/annurev.immunol.22.012703.104514 · DOI · Paper page
  43. 10.4049/jimmunol.168.10.5233 · DOI · Paper page
  44. 10.1007/s10456-008-9093-5 · DOI · Paper page
  45. 10.1084/jem.20042614 · DOI · Paper page
  46. 10.4049/jimmunol.166.12.7128 · DOI · Paper page
  47. 10.1074/jbc.M606352200 · DOI · Paper page
  48. 10.1038/nri2587 · DOI · Paper page
  49. 10.1146/annurev.immunol.25.022106.141627 · DOI · Paper page
  50. 10.1038/mi.2007.6 · DOI · Paper page

Cited by

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Metadata

Authors
Iwasaki, A., & Medzhitov, R.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2010-01-15
Volume
327
Issue
5963
Pages
291-295
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1183021
OpenAlex
W2138651252
Cited by
2,157
References
9
FWCI
79.38
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Regulation of Adaptive Immunity by the Innate Immune System. https://app.cochat.ai/papers/10.1126/science.1183021
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Iwasaki, A., & Medzhitov, R. (2010). Regulation of Adaptive Immunity by the Innate Immune System. Science. https://doi.org/10.1126/science.1183021

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.