The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways
Open accessAbstract
SUMMARY The nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed Nlrx1−/− mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, OAS1 and IL-6 after influenza virus infection. Consistent with increased inflammation, Nlrx1−/− mice exhibited marked morbidity and histopathology. Infection of these mice with an influenza strain that carries a mutated NS-1 protein, which normally prevents IFN induction by interaction with RNA and the intracellular RNA sensor RIG-I, further exacerbated IL-6 and type I IFN signaling. NLRX1 also weakened cytokine responses to the 2009 H1N1 pandemic influenza virus in human cells. Mechanistically, Nlrx1 deletion led to constitutive interaction of MAVS and RIG-I. Additionally, an inhibitory function is identified for NLRX1 during LPS-activation of macrophages where the MAVS-RIG-I pathway was not involved. NLRX1 interacts with TRAF6 and inhibits NF-κB activation. Thus, NLRX1 functions as a checkpoint of overzealous inflammation.
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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
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RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates
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Allen, I. C., Scull, M. A., Moore, C. B., Holl, E. K., McElvania-TeKippe, E., Taxman, D. J., Guthrie, E. H., Pickles, R. J., & Ting, J. P.-Y. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.005 · Cited by 1,113
Self-citationMitofusin 2 Inhibits Mitochondrial Antiviral Signaling
Yasukawa, K., Oshiumi, H., Takeda, M., Ishihara, N., Yanagi, Y., Seya, T., Kawabata, S.-I., & Koshiba, T. (2009) · Science Signaling · doi:10.1126/scisignal.2000287 · Cited by 255
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Mitochondria: master regulators of danger signalling
Galluzzi, L., Kepp, O., & Kroemer, G. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3479 · Cited by 733
Nlrp6 regulates intestinal antiviral innate immunity
Wang, P., Zhu, S., Yang, L., Cui, S., Pan, W., Jackson, R., Zheng, Y., Rongvaux, A., Sun, Q., Yang, G., et al. (2015) · Science · doi:10.1126/science.aab3145 · Cited by 304
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Self-citationNegative regulation of type I IFN signaling
Arimoto, K.-I., Miyauchi, S., Stoner, S. A., Fan, J.-B., & Zhang, D.-E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mir0817-342r · Cited by 117
Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors
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Metadata
- Authors
- Allen, I. C., Moore, C. B., Schneider, M., Lei, Y., Davis, B. K., Scull, M. A., Gris, D., Roney, K. E., Zimmermann, A. G., Bowzard, J. B., Ranjan, P., Monroe, K. M., Pickles, R. J., Sambhara, S., & Ting, J. P. Y.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 34
- Issue
- 6
- Pages
- 854-865
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1987433340
- Cited by
- 364
- References
- 6
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Allen, I. C., Moore, C. B., Schneider, M., Lei, Y., Davis, B. K., Scull, M. A., Gris, D., Roney, K. E., Zimmermann, A. G., Bowzard, J. B., Ranjan, P., Monroe, K. M., Pickles, R. J., Sambhara, S., & Ting, J. P. Y. (2011). NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways. Immunity. https://doi.org/10.1016/j.immuni.2011.03.026
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